HBOT Evidence Library

Curated hyperbaric oxygen therapy evidence, organised by indication and graded by study design. Every entry comes from Dr Gregory Weir's maintained HBOT clinical wiki — positive and null trials both included — and, where the source is indexed, links to its PubMed record and DOI.

How these appraisals were produced. The critical appraisals on this site — the risk-of-bias ratings, the GRADE and OCEBM judgements and the summaries — were generated by automated tooling (Anthropic Claude) working from the source documents, under Dr Weir's editorial direction and within his clinical wiki. They were not written up individually by hand. Each card names its appraiser. We publish this because a reader should learn it here rather than infer it: machine appraisal at this scale is what makes a library of this size possible, and it carries the failure modes of machine appraisal. Treat every rating as a starting point for your own reading of the paper, not as a substitute for it. What was checked, and how.

1058records1058 machine-appraised · 1027 with the full text held on file · 34 labelled abstract-only · 62 with every figure re-checked against the source by an automated verifier · 2 held but not citable
17recognised indications
291RCT / SR / metaA count of study DESIGN, not of study QUALITY. Of the 281 rated: 89 of 149 systematic reviews and meta-analyses are AMSTAR-2 critically low (60%), 35 low, 4 moderate, 17 high. Of 138 randomised trials, 41 are RoB 2 high risk, 91 some concerns, 4 low risk. 21 records — 7% — sit in the top band of their instrument; 10 carry no band. Scope: randomised trials, systematic reviews, meta-analyses, Cochrane, network and umbrella reviews in HUMAN subjects read from the full paper, out of 1058 records. Animal and laboratory work is excluded whatever its design, as is anything appraised only from a conference abstract, and so are 8 records in which hyperbaric oxygen is not the treatment being tested for benefit — 7 experimental exposures in healthy volunteers and 1 where HBO is the control arm. Those keep their true design badge.
304UNSW appraisalsA THIRD-PARTY corpus, imported with attribution from the UNSW HBO Evidence group and held separately in its own tab — not merged into this wiki's pages, not written by this unit, and not added to the 1058 above. Overlap is not known, and this page does not estimate it. The UNSW pages carry no PMID and no DOI, so the two collections cannot be reconciled by identifier; matching by citation text was built, tested and withdrawn because it paired papers sharing a first author and a year that are not the same paper. 300 of the 304 print their own citation on the card, so a reader can check any single paper directly; 4 print none. ⚠️ The UNSW host does not serve working HTTPS. Verified 31 August 2026: https:// fails with a certificate error, http:// returns the page. These links therefore point at http and your browser will mark them Not Secure — correctly, because the connection is not encrypted. It is a third-party, public, read-only wiki that asks for no credentials, and the citation printed on each card is there so you never have to follow the link to know what was appraised. Where a paper appears in both, the two appraisals are independent and may disagree — which is why they are kept apart.
1955–2026years covered

Last updated 2026-09-01 · built from the clinical wiki at commit da9f1ea · corrections to [email protected]

Indications

The SAUHMA/UHMS-recognised indications this unit treats. Select one to see its evidence.

Two different things are shown — please don't conflate them:

Acute Traumatic Ischaemias

Acute traumatic peripheral ischaemia — crush injury, compartment syndrome, threatened limbs/digits with marginal perfusion, and reperfusion injury. HBOT is adjunctive to surgical management (fasciotomy, revascularisation, debridement).
SAUHMA Grade B
ICD-10 T04.7, T04.8, T04.9
0 appraised sources

Air or Gas Embolism (AGE)

Arterial or venous gas embolism — iatrogenic (vascular/surgical procedures, central lines, cardiac bypass), diving-related (pulmonary barotrauma → cerebral AGE), or traumatic. Time-critical emergency.
SAUHMA Grade C
ICD-10 T79.0, T80.0, T88.9, O88.0
0 appraised sources

Avascular Necrosis (Aseptic Osteonecrosis)

Early-stage aseptic osteonecrosis (most evidence in femoral head), aiming to preserve the joint and delay/avoid arthroplasty before structural collapse. Benefit is stage-dependent — earlier (pre- collapse) stages respond best.
ICD-10 M87.05, M87.15, M87.25, M87.35, M87.85, M87.95
0 appraised sources

Carbon Monoxide Poisoning

Acute CO poisoning, especially with loss of consciousness, neurological signs, cardiac involvement, pregnancy, or significantly elevated carboxyhaemoglobin. Aim: reduce risk of delayed neurocognitive sequelae, not only to clear COHb.
SAUHMA Grade A
ICD-10 T58, G93.4
0 appraised sources

Central Retinal Artery Occlusion (CRAO)

Acute, non-arteritic CRAO presenting within the therapeutic window (hours). Time-critical — retinal tolerance to ischaemia is short. Exclude/treat giant cell arteritis separately.
SAUHMA Grade C
ICD-10 H34.1, H34.0, H34.2, H34.9
0 appraised sources

Complex / Problem Wounds

Adjunctive hyperbaric oxygen for non-healing wounds with a hypoxic component: chronic diabetic foot ulcers (Wagner 2–4), chronic lower-limb ulcers in peripheral arterial disease, and compromised post-operative or post-surgical wounds. Not for acute, uncomplicated, or adequately perfused wounds expec
ICD-10 I70.20, I70.21, L97, E10.5, E11.5, E14.5, I73.9, T87.5
0 appraised sources

Compromised Grafts and Flaps

Tissue grafts/flaps that are compromised but not yet necrotic — failing perfusion, venous congestion, arterial insufficiency, ischaemia-reperfusion injury — and irradiated or otherwise hypoxic graft beds at high risk of failure. Grafts (avascular, dependent on recipient-bed quality) and flaps (inher
ICD-10 T86.8, T87.0
0 appraised sources

Decompression Sickness (DCS)

Decompression sickness from diving or other decompression exposures (Type I cutaneous/musculoskeletal; Type II neurological/cardiopulmonary). Time-critical. Closely related to AGE — see indications/air-gas-embolism.
SAUHMA Grade C
ICD-10 T70.3, T70.8, T70.9
0 appraised sources

Clostridial Myonecrosis (Gas Gangrene)

Clostridium perfringens (and related) myonecrosis — a fulminant, rapidly fatal surgical emergency. HBOT is adjunctive to immediate surgical debridement and antibiotics, never a substitute or a reason to delay surgery.
SAUHMA Grade C
ICD-10 A48.0, B96.7
0 appraised sources

Intracranial Abscess

Intracranial abscess (cerebral abscess, subdural/epidural empyema) as adjunct to neurosurgical drainage and culture-directed antibiotics. Adjunctive HBOT is considered, after CT/MRI diagnosis, for: multiple abscesses; deep or dominant location; compromised host (especially fungal); surgery contraind
ICD-10 G06.0, G06.2, G08
0 appraised sources

Late Radiation Soft-Tissue Injury

Established, refractory soft-tissue / mucosal late radiation injury, ≥6 months after pelvic or regional radiotherapy, symptomatic despite standard management: radiation cystitis, radiation proctitis, and soft-tissue radionecrosis. Osteoradionecrosis is covered separately — see indications/osteoradio
ICD-10 N30.4, K62.7, K52.0, L59.9, L59.8, J37.0, J70.1, L58.1, K13.5
0 appraised sources

Necrotising Soft-Tissue Infections

Necrotising fasciitis, Fournier gangrene, and other necrotising soft-tissue infections (often polymicrobial/synergistic). HBOT is adjunctive to aggressive surgical debridement and broad- spectrum antibiotics — and must not delay surgery.
SAUHMA Grade C
ICD-10 M72.66, M72.67, M72.65, N49.8, N76.8
0 appraised sources

Osteoradionecrosis (ORN)

Osteoradionecrosis of bone (most commonly mandible/maxilla/skull) after head-and-neck radiotherapy. Two distinct clinical scenarios with different protocols:
ICD-10 K10.8, K10.2, L59.8, M87.38, K02.8, K04.2, K13.5
0 appraised sources

Refractory Osteomyelitis

Chronic refractory osteomyelitis that has failed appropriate surgical debridement and antibiotic therapy — adjunct to ongoing surgical/antimicrobial management. Relates to but distinct from indications/osteoradionecrosis (irradiated bone).
SAUHMA Grade C
ICD-10 M86.47, M86.46, M86.45, M86.49
0 appraised sources

Severe Anaemia (Exceptional Blood Loss)

Life-threatening anaemia where transfusion is unavailable, refused (e.g. on religious grounds), or impossible (alloimmunisation) — HBOT as a temporising bridge to maintain tissue oxygenation while haemoglobin is restored by other means. Triggered by clinical signs of systemic or end-organ failure, n
ICD-10 D62, D64.9, D64.8
0 appraised sources

Sudden Sensorineural Hearing Loss (SSNHL)

Idiopathic SSNHL, typically as adjunct to corticosteroids, treated within the therapeutic window (earlier is better; benefit diminishes with delay). Often combined with intratympanic/systemic steroids.
SAUHMA Grade B
ICD-10 H91.2, H90.3, H90.4, H90.5, H91.9
0 appraised sources

Adjunctive Treatment of Thermal Burns

Serious deep partial- and full-thickness thermal burns as adjunct to fluid resuscitation, burns surgery, and critical-care management — aimed at preserving the zone of stasis and reducing ooedema, infection, and graft loss. Recommended for burns 20% TBSA and/or involving hands, face, feet, or perine
ICD-10 T29.3, T31.1, T31.2, T31.3, T31.4, T20.3, T21.3, T22.3, T23.3, T24.3, T25.3
0 appraised sources

Other — Non-Core / Exploratory HBO Topics (not SAUHMA/PMB indications)

Holds: - Off-scope primary studies the practice has obtained (e.g. HBO in glaucoma). - UNSW HBO Evidence CATs whose topic is not a core indication and which were previously bulk-mapped onto the nearest core page in error (chiefly the non-CRAO ophthalmology set — see the mapping correction on indicat
0 appraised sources

Cross-Cutting, Safety & Non-Core

Mechanism, chamber safety, middle-ear barotrauma, governance and non-core/exploratory topics that inform practice but are not themselves SAUHMA/UHMS-accepted indications — they are off-label.
0 appraised sources
How these sources were appraised — read this before citing

Authorship, stated plainly. These appraisals were generated by automated tooling — Anthropic Claude — reading the source documents, inside Dr Gregory Weir's clinical wiki and under his editorial direction. No claim is made that any individual appraisal was composed, or independently re-derived, by a clinician reading that paper. Where a card is stamped as reviewed or signed off, that is an editorial decision recorded on a date, not a re-appraisal. The appraiser named on each card is the truthful answer to "who wrote this?".

What follows from that, and what a reader should do with it: the instrument selection, the domain judgements and the certainty ratings are reproducible and each is shown with the sentence from the paper it rests on, so they can be checked. They are also subject to the failure modes of machine reading — a design can be misread from an ambiguous methods section, a direction of effect can be taken from an abstract that contradicts its own tables, and a paper can be summarised confidently and wrongly. Several such errors have been found and corrected here, and the corrections are dated in the wiki. Cite the paper, not this page. Where a rating matters to a decision, read the methods yourself.

This library holds 1058 records, of which 1056 are citable sources. 2 are held deliberately and labelled do not cite — one retracted, one withdrawn — because a reader who meets the paper elsewhere is better served by finding it here with the reason attached than by not finding it at all. They are shown, and they are excluded from the counts below. The records are not uniform, and the badge on each card says which kind it is.

  • 1058 carry a structured critical appraisal — every citable record does. For 204 of them the appraisal is a dated decision NOT to apply an instrument, with the reason given: a narrative review, a trial protocol, an economic evaluation, a guideline or a position statement is not a study whose risk of bias can be rated, and scoring one anyway would restate its design rather than measure its conduct.
  • 1027 have the full text held on file — 1022 as the publisher PDF, 5 as a PubMed Central full-text extract — and were appraised from it. This figure is counted by opening the files at build time, not by reading a field that says "full text". A record whose page asserts full text while nothing is on this disk is named in the build log, and 31 records in total hold no full text. Of all 1058 records, 62 have had every figure re-checked against the source file by an automated verifier — a figure appearing nowhere in the source fails the build. That re-check is automated, and it tests concordance, not clinical judgement: it confirms a number was copied correctly, not that it was the right number to report or that it was interpreted correctly.
  • What sits at the Guideline tier, and what does not — the rule, stated. The Guideline tier holds 34 records and its rule is a single test: a document belongs there only if it is a clinical practice guideline or society position statement about PATIENT CARE, and can therefore be scored with AGREE II. AGREE II assesses how such a document was developed — scope and purpose, stakeholder involvement, rigour of evidence synthesis, applicability, editorial independence. Every record on this tier carries an AGREE II rating, including the six UHMS and SPUMS/UKDMC position statements. 4 documents that are called "guidelines" are deliberately NOT on it — the British Hyperbaric Association fire-safety standards and the monoplace chamber safety monograph among them. They are normative engineering and facility documents a unit must comply with, they make no claim about whether a treatment works, and AGREE II has nothing in them to score. They carry their own Safety / facility standard badge rather than being filed as background reading, because "further reading" is the opposite of what a mandatory standard is. This rule is why the Guideline count fell as AGREE II ratings were applied across the corpus. Nothing left the library — every record is still here and still searchable; what changed is which tier a document sits on, and a document that moved off this tier carries a badge naming what it actually is.
  • The 291 "RCT / SR / meta" figure above counts DESIGN, and most of those studies are not good ones. Read on its own that number is an argument for the therapy; this library's own appraisals do not support reading it that way, so here is the split rather than leaving a reader to extract it. Of the 281 level-1 records carrying a band: 89 of the 149 systematic reviews and meta-analyses are AMSTAR-2 critically low — 60% of them — with 35 low, 4 moderate and 17 high; and of the 138 randomised trials, 41 are at high risk of bias on RoB 2, 91 raise some concerns and 4 are at low risk. 21 records in total — 7% — sit in the top band of their instrument. 10 carry no band and are counted as unrated rather than assumed. A further 8 randomised records are held out of this figure altogether, because hyperbaric oxygen is not the treatment being tested for benefit in them: 7 are experimental exposures in healthy volunteers — divers, induced wound models, and one trial whose subject is the blinding procedure rather than any treatment — and in 1 HBO is the control arm against which something else is measured. They keep their true design badge and their appraisal, but a randomised study in healthy people says nothing about whether hyperbaric oxygen treats disease, and it should not be counted as though it did. The accurate summary of hyperbaric medicine's evidence base is that it is large, active, and methodologically weak: small single-centre trials, reviews without registered protocols, and pooling across heterogeneous populations. That is a reason to read the individual appraisals, and a reason not to quote the headline alone in either direction.
  • 34 were appraised from the abstract, not from the paper's methods. They are marked Abstract Only — the chip and this figure are the same count, driven by the same field — and should not be cited as though the methods had been read. 3 of them now hold the full text on file, obtained after the appraisal was written; the label stays Abstract Only until the page is re-appraised, because holding a PDF does not change how an appraisal was made. That is also why the full-text-on-file figure above (1027) is larger than the 1024 records whose appraisal was actually written from the full paper. None of them is counted in the 291 figure above, even where the design is a randomised trial or a systematic review: the study keeps the design badge it earned, but a level-1 claim asserts a standard of CONDUCT, and RoB 2 and AMSTAR-2 both judge methods that were never published. Before 26 August 2026, 16 abstract-only records — 13 reviews and meta-analyses, 2 randomised trials and 1 network meta-analysis — were inside that total.
  • 1040 have had editorial sign-off. 16 are marked awaiting full text: their appraisal is complete to the limit of what is on file, but the full paper has not been obtained, so the methods have not been read.
  • Every source now carries a formal, instrument-based risk-of-bias rating on its own page (completed 6 August 2026). The instrument is chosen from what the paper's methods actually describe, not from its label: RoB 2 for randomised trials, ROBINS-I for non-randomised comparisons of treatments, ROBINS-E where the contrast is an exposure, AMSTAR-2 for systematic reviews, AGREE II for guidelines, JBI for case series and reports, SYRCLE for animal work, QUIPS for prognostic questions, QUADAS-2 for diagnostic accuracy and the Drummond checklist for economic evaluations. Every domain judgement is shown with the sentence from the paper it rests on. Where no instrument fits — a narrative review, a trial protocol, a position statement, a retracted paper — that is recorded as a dated abstention rather than left blank, because an unrated page is indistinguishable from an overlooked one.
  • One document per paper. Since 5 August 2026 each paper has a single page carrying both the sourced summary and its critical appraisal; the former separate CAT layer was merged in. The 304 UNSW records are a separate third-party corpus, attributed to that group, and are not merged.
  • The 2 do-not-cite records are HELD AND SHOWN, not hidden: they are counted in the 1058 total and excluded from the 1056 citable figure. A count on this page that includes them says so.

Positive and null results are both included by design. Where a source contradicts another, both are kept and the tension is stated rather than resolved silently.

Abid 2025

Eur J Case Rep Intern Med · 2025 · Commentary / case

Abid C, Gassara Z, Feki A, Benjemaa S, Kallel MH, Baklouti S, Fourati H. Carbon Monoxide Poisoning-Induced Myositis. Eur J Case Rep Intern Med 2025;12(12):005874.

PubMed · PMID 41377783 · DOI · PMC free full text

Abidia 2003

Eur J Vasc Endovasc Surg · 2003 · RCT

Abidia A, Laden G, Kuhan G, Johnson BF, Wilkinson AR, Renwick PM, Masson EA, McCollum PT. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: A double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg 2003;25(6):513–518.

PubMed · PMID 12787692 · DOI

Complete healing (epithelialisation): 5/8 ulcers (HBO) vs 1/8 (air). Median wound-area reduction at 6 weeks: 100% (HBO) vs 52% (air), P=0.027. By 6 months the difference in area reduction was not significant (100% vs 95%) — HBO produced

Açiksari 2019

Diving Hyperb Med · 2019 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Açiksari K, Eğin S, Hepgül G, Mirasoğlu B, Tanriverdi G, Kanber DS, Demirci S, Doğan H, Özüçelik DN, Toklu AS, Seçkin İ, Yanar HT. Protective effect of hyperbaric oxygen treatment on rat intestinal mucosa after mesenteric ischaemia and reperfusion. Diving Hyperb Med 2019;49(4):253-258.

PubMed · PMID 31828743 · DOI · PMC free full text

Adachi 2025

Clin Neurol Neurosurg · 2025 · Meta-analysis

Adachi K, et al. Procedure-related cerebral air embolism: Systematic review and individual participant data meta-analysis. Clin Neurol Neurosurg 2025;255:108982.

PubMed · PMID 40460700 · DOI

Adams 2025

Diving Hyperb Med · 2025 · Review / background

Adams B, Templeton A, Tsouras T, Sheldrake J, Roberts L, Lin ZC, Millar I, Orosz J, Birthisel T, Devaney B. The process, logistics and governance behind a high-stakes novel intervention: the use of extracorporeal membrane oxygenation (ECMO) in the hyperbaric chamber. Diving Hyperb Med 2025;55(4):315-322.

PubMed · PMID 41364854 · DOI · PMC free full text

Ahijón-Lana 2022

Reumatol Clin · 2022 · Cohort / series

Ahijón-Lana M, Baragaño-Ordóñez E, Veiga-Cabello R, de la Cruz-Tapidor C, Carreira PE. Treatment of Raynaud phenomenon and ischemic ulcers associated to systemic sclerosis with hyperbaric oxygen. Reumatol Clin 2022;18(4):246-248.

PubMed · PMID 34953734 · DOI

Ajayi 2020

Undersea Hyperb Med · 2020 · Cohort / series

Ajayi OD, Gaskill Z, Kelly M, Logue CJ, Hendricksen SM. A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4 ATA for 90 minutes in treating radiation-induced cystitis. Are these regimens equivalent? Undersea Hyperb Med 2020;47(4) (PMID 33227834; DOI 10.22462/10.12.2020.7).

PubMed · PMID 33227834 · DOI

Al Abri 2026

Oman Medical Journal · 2026 · Cohort / series

Al Abri SA, ALqartoobi H, Al Farsi B, AlBalushi Y, Hazra D. Clinical Outcomes of Carbon Monoxide Poisoning Managed with Hyperbaric Oxygen Therapy in Oman. Oman Medical Journal 2026.

DOI

Al Bazzal 2025

Int Arch Otorhinolaryngol · 2025 · Systematic review

Al Bazzal H, Hassan F, Tlais M, Tlaiss Y. Advancements in the Treatment of Necrotizing Otitis Externa with Hyperbaric Oxygen: A Systematic Review. Int Arch Otorhinolaryngol 2025;29(3):s00451809432.

PubMed · PMID 40937148 · DOI · PMC free full text

No effect estimate of any kind is produced. There is no meta-analysis, no pooled proportion, no HBOT protocols across the included studies were inconsistent "with variations in pressure, duration, Quality assessment is asserted but not shown. The Cochrane Risk of Bias tool (RoB 1) and the

ALBalawi 2026

J Clin Med · 2026 · Meta-analysis

ALBalawi HB, Magliyah MS, Alali NM, Alshehri MM, Alhewiti A, Almarek F, Shajry I, Hazzazi MA, Alotaibi YA. Therapeutic Efficacy of Hyperbaric Oxygen in Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. J Clin Med 2026;15(9):3530.

PubMed · PMID 42123263 · DOI · PMC free full text

Pooled efficacy favoured HBOT: OR 0.47 (95% CI 0.26–0.87, p=0.02) — but substantial heterogeneity Timing: studies initiating HBOT <12 h consistently reported greater visual improvement; delayed/ Safety: adverse-event rates not significantly different between HBOT and non-HBOT (OR 0.70, 95% CI

Alberta Provincial Gynecologic Oncology Tumour Team 2011

Alberta Health Services, CancerControl Alberta · 2011 · Guideline

Alberta Provincial Gynecologic Oncology Tumour Team. Hyperbaric oxygen therapy for late radiation tissue injury in cervical and other gynecological malignancies (Clinical Practice Guideline GYNE-003). Alberta Health Services, CancerControl Alberta 2011;GYNE-003:1-16.

HBOT 0054 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Alde 2023

Undersea Hyperb Med · 2023 · Cohort / series

Aldè M, Cantarella G, Piatti G, Ambrosetti U. Sudden hearing loss and early hyperbaric oxygen therapy: a preliminary study. Undersea Hyperb Med 2023;50(2):145-153.

PubMed · PMID 37302077

Alekseeva 2026

Biomedicines · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Alekseeva O, Zaripov K, Vasilev D, Demchenko I. Distinct Roles of NMDA and AMPA Receptors in the Pathogenesis of Hyperbaric Oxygen-Induced Seizures. Biomedicines 2026;14(8):1807.

PubMed · PMID 42652189 · DOI · PMC free full text

Alleva 2005

Biochem Biophys Res Commun · 2005 · RCT

Alleva R, Nasole E, Di Donato F, Borghi B, Neuzil J, Tomasetti M. α-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun 2005;333(2):404–410.

PubMed · PMID 15950945 · DOI

In chronic-wound patients undergoing HBO, α-lipoic acid reduced HBO-induced lipid and DNA oxidation (directly scavenging free radicals and recycling vitamin E) and lowered pro-inflammatory IL-6; the authors propose LA as an adjuvant to attenuate HBO's oxidative side-effects and support impaired wound healing.

Allocco 2025

Diving Hyperb Med · 2025 · RCT

Allocco A, van Waart H, Connell CJW, Wong NYE, Charukonda A, Gant N, Vrijdag XCE, Mitchell SJ. An unblinded training exposure to hypoxia enhances subsequent hypoxia awareness. Diving Hyperb Med 2025;55(2):136-144.

PubMed · PMID 40544141 · DOI · PMC free full text

Almomany 2026 myocardial

Cureus · 2026 · Systematic review

Almomany M, Rawashdeh Z, Alshyyab M, Alnabulsi A, Alodat L, Alshamaly S, et al. Effects of Hyperbaric Oxygen Therapy on Myocardial Injury and Inflammatory Biomarkers: A Systematic Review With Qualitative Synthesis. Cureus 2026 (PMID 42093774).

PubMed · PMID 42093774 · DOI · PMC free full text

Alqasmi 2026

eNeurologicalSci · 2026 · Commentary / case

Alqasmi H, Jawich B, Jarrah R, Ibrahim S, Khanji H, et al. The role of hyperbaric oxygen therapy for treating spinal cord injury: Mechanisms, considerations, and research outcomes. eNeurologicalSci 2026;43:100608.

PubMed · PMID 41938168 · DOI · PMC free full text

Alter 2026

Laryngoscope · 2026 · Meta-analysis

Alter IL, Hamiter M, Han J, Leu CS, Usseglio J, Lalwani AK (Columbia University). Hyperbaric Oxygen and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. Laryngoscope 2026;136(1):91–101 (Epub 2025 Aug 1).

PubMed · PMID 40747804 · DOI

HBOT + MT vs MT alone: OR 2.61 (95% CI 1.86–3.68, p<0.001) for hearing recovery. Holds in subgroups: HBOT+systemic steroids vs SS (OR 2.54, 1.63–3.97) and HBOT+SS+intratympanic

Altomare 2022

J Pers Med · 2022 · Commentary / case

Altomare M, Benuzzi L, Molteni M, Virdis F, Spota A, Cioffi SPB, Reitano E, Renzi F, Chiara O, Sesana G, Cimbanassi S. Negative pressure wound therapy for the treatment of Fournier's gangrene: a rare case with rectal fistula and systematic review of the literature. J Pers Med 2022;12(10):1695.

PubMed · PMID 36294834 · DOI · PMC free full text

Altun 2022

Diving Hyperb Med · 2022 · Commentary / case

Altun BD, Sümen SG, Dumlu A. A diving physician's experience of dental barotrauma during hyperbaric chamber exposure: case report. Diving Hyperb Med 2022;52(1):63-65.

PubMed · PMID 35313376 · DOI · PMC free full text

Altun 2024

Undersea Hyperb Med · 2024 · Cohort / series

Altun BD, Sümen SG, Öçbe M, Dumlu A. Effect of hyperbaric oxygen therapy on diabetes-related oral complications. Undersea Hyperb Med 2024;51(2):101-106 (DOI 10.22462/664).

DOI

Altunay 2014

Int Wound J · 2014 · Commentary / case

Altunay I, Kucukunal A, Sarikaya S, Tukenmez Demirci G. A favourable response to surgical intervention and hyperbaric oxygen therapy in pyoderma gangrenosum. Int Wound J 2014;11(4):350-353.

PubMed · PMID 23106966 · DOI · PMC free full text

Amonic 1969

JAMA · 1969 · Commentary / case

Amonic RS, Cockett AT, Lorhan PH, Thompson JC. Hyperbaric oxygen therapy in chronic hemorrhagic shock. JAMA 1969;208(11):2051-4.

PubMed · PMID 5305672

Single case report. A 26-year-old man of the Jehovah's Witness denomination, admitted with painless rectal bleeding, who refused all blood and blood products. A bleeding gastric leiomyoma was excised at eventual laparotomy; the haemoglobin fell to 2.2 gm/100 cc and on the third postoperative day he showed evidence of severe cerebral and myocardial ischaemia with congestive cardiac failure. He was

Anand 2022

J Pediatr Urol · 2022 · Meta-analysis

Anand S, et al. Utility and safety of hyperbaric oxygen therapy as a rescue treatment in complicated cases of hypospadias: A systematic review and meta-analysis. J Pediatr Urol 2022;18(1):39–46.

PubMed · PMID 34696963 · DOI

4 studies, 176 patients (101 in the HBO group) evaluating HBO as rescue for complications following hypospadias urethroplasty; studies at moderate risk of bias, heterogeneous. Suggests a possible role in salvaging compromised repairs, but the evidence is limited and non-definitive.

Anand 2025

Int J Occup Med Environ Health · 2025 · Guideline

Anand J, Pawlas N, Schetz D, Kot J. Management of acute intoxication with carbon monoxide – Polish Medical Society, Section of Clinical Toxicology position statement. Int J Occup Med Environ Health 2025;38(5):457–473.

PubMed · PMID 41185922 · DOI · PMC free full text

A national position statement of the Polish Medical Society, Section of Clinical Toxicology, on the management of acute CO poisoning — triage, normobaric oxygen, indications for HBOT, and long-term neurological follow-up. Note co-author J Kot (ECHM Secretary-General / National Center for Hyperbaric Medicine, Gdańsk).

Andel 1998

Anaesthesia · 1998 · Review / background · MIXED human and preclinical evidence

Andel H, Felfernig M, Andel D, Blaicher W, Schramm W. Hyperbaric oxygen therapy in osteomyelitis. Anaesthesia 1998;53(Suppl 2):68–69.

PubMed · PMID 9659075 · DOI

Reducing barometric pressure to 375 mmHg, which reduces ambient oxygen partial pressure from In infected bone, hypoxia was found with a mean of 2.7 kPa against 5.9 kPa in normal tissue, and In a rabbit model of Staphylococcus aureus osteomyelitis, eradication of bone infection by HBO alone

Anderson 2019

Diving and Hyperbaric Medicine · 2019 · Cohort / series

Anderson G, Ebersole D, Covington D, Denoble PJ. The effectiveness of risk mitigation interventions in divers with persistent (patent) foramen ovale. Diving and Hyperbaric Medicine 2019;49(2):80-87.

PubMed · PMID 31177513 · DOI · PMC free full text

Andren 2020 (pelvic LRTI)

Diving Hyperb Med · 2020 · Cohort / series

Andren J, Bennett MH. An observational trial to establish the effect of hyperbaric oxygen treatment on pelvic late radiation tissue injury due to radiotherapy. Diving Hyperb Med 2020;50(3):250-255 (PMID 32957127; DOI 10.28920/dhm50.3.250-255).

PubMed · PMID 32957127 · DOI · PMC free full text

Anguiano-Hernandez 2019

Undersea Hyperb Med · 2019 · Cohort / series

Anguiano-Hernandez YM, Contreras-Mendez L, Hernandez-Cueto MA, Alvarado-Yaah JE, Munoz-Medina JE, Santillan-Verde MA, Barbosa-Cabrera RE, Delgado-Quintana CA, Trejo-Rosas S, Santacruz-Tinoco CE, Gonzalez-Ibarra J, Gonzalez-Bonilla CR. Modification of HIF-1alpha, NF-kappaB, IGFBP-3, VEGF and adiponectin in diabetic foot ulcers treated with hyperbaric oxygen. Undersea Hyperb Med 2019;46(1):35-44.

PubMed · PMID 31154683

Annane 2001

Intensive Care Med · 2001 · Cohort / series

Annane D, Chevret S, Jars-Guincestre MC, Chillet P, Elkharrat D, Gajdos P, Raphael JC. Prognostic factors in unintentional mild carbon monoxide poisoning. Intensive Care Med 2001;27(11):1776–1781.

PubMed · PMID 11810122 · DOI

Observational cohort of unintentional mild CO poisoning assessing early predictors of persistent neurological sequelae at 1 month. Apathy and headache were the main moderate sequelae. Loss of consciousness (and a second clinical predictor) were jointly associated with persistent neurological sequelae on multivariate analysis — i.e. clinical risk-stratification markers in mild CO exposure.

Annane 2004

J Clin Oncol · 2004 · RCT

Annane D, Depondt J, Aubert P, Villart M, Géhanno P, Gajdos P, Chevret S (ORN96 study group). Hyperbaric Oxygen Therapy for Radionecrosis of the Jaw: A Randomized, Placebo-Controlled, Double-Blind Trial From the ORN96 Study Group. J Clin Oncol 2004;22(24):4893–4900.

PubMed · PMID 15520052 · DOI

The trial was stopped early at the second interim analysis (triangular test) for potentially 1-year recovery: 6/31 (19%) with HBO vs 12/37 (32%) with placebo — RR 0.60 (95% CI 0.25–1.41; Time to treatment failure HR 1.33 (95% CI 0.68–2.60; P=0.41); time to pain relief HR 1.00 (95% CI

Annane 2011

Intensive Care Med · 2011 · RCT

Annane D, Chadda K, Gajdos P, Jars-Guincestre MC, Chevret S, Raphael JC. Hyperbaric oxygen therapy for acute domestic carbon monoxide poisoning: two randomized controlled trials. Intensive Care Med 2011;37(3):486–492.

PubMed · PMID 21125215 · DOI

Trial A: no difference in 1-month complete recovery with vs without HBO — 58% vs 61%; OR 0.90 Trial B: two HBO sessions were worse than one — 47% vs 68%; OR 0.42 (95% CI 0.23–0.79).

Apolo-Arenas 2024

Int J Vasc Med · 2024 · Meta-analysis

Apolo-Arenas MD, Guerrero-Nogales L, Díaz-Muñoz CL, Caro-Puértolas B, Parraca JA, Caña-Pino A. Use of the Hyperbaric Chamber Versus Conventional Treatment for the Prevention of Amputation in Chronic Diabetic Foot and the Influence on Fitting and Rehabilitation: A Systematic Review. Int J Vasc Med 2024;2024:8450783.

PubMed · PMID 39764384 · DOI · PMC free full text

Across the included studies, HBOT + standard care was favourable versus standard care alone for Frames HBOT as usable for both primary and secondary prevention of the vascular complication, and

Arieli 2019

Diving and Hyperbaric Medicine · 2019 · Commentary / case · MIXED human and preclinical evidence

Arieli R. Gas micronuclei that underlie decompression bubbles and decompression sickness have most probably been identified - in response to the Letter to the Editor from Dr David Doolette. Diving and Hyperbaric Medicine 2019;49(4):311-312.

PubMed · PMID 31828752 · DOI · PMC free full text

Arieli 2019

Diving Hyperb Med · 2019 · Commentary / case

Arieli R. Calculated risk of pulmonary and central nervous system oxygen toxicity: a toxicity index derived from the power equation. Diving Hyperb Med 2019;49(3):154-160.

PubMed · PMID 31523789 · DOI · PMC free full text

Arieli 2020

Diving Hyperb Med · 2020 · Commentary / case

Arieli R. Effect of an air break on the occurrence of seizures in hyperbaric oxygen therapy may be predicted by the power equation for hyperoxia at rest. Diving Hyperb Med 2020;50(1):75-76.

PubMed · PMID 32187622 · DOI · PMC free full text

Arieli 2021 letter with Kohshi 2021 reply

Diving and Hyperbaric Medicine · 2021 · Commentary / case

Arieli R; with reply by Kohshi K. Diving-related disorders in breath-hold divers could be explained with the distal arterial bubble hypothesis [letter]; Reply: Diving-related disorders in breath-hold divers could be explained with the distal arterial bubble hypothesis. Diving and Hyperbaric Medicine 2021;51(4):382-384.

PubMed · PMID 34897605 · DOI · PMC free full text

Arnold 2019

Undersea Hyperb Med · 2019 · Commentary / case

Arnold JF, Marmolejo V. Visualization of angiogenesis and vasculogenesis in a late tissue radiation injury of the chest wall treated with adjuvant hyperbaric oxygen therapy using fluorescence angiography. Undersea Hyperb Med 2019;46(1):69-73.

PubMed · PMID 31154687

Aslan 2026

Ear Nose Throat J · 2026 · Cohort / series

Aslan Y, Aktas S, Vural P, Baki AM, Inci E. Serum HSP70 levels in sudden sensorineural hearing loss and their modulation after hyperbaric oxygen therapy: a prospective controlled study. Ear Nose Throat J 2026 (online ahead of print. DOI 10.1177/01455613261471930).

PubMed · PMID 42473918 · DOI

Astasio-Picado 2026

Medicina (Kaunas) · 2026 · Systematic review

Astasio-Picado Á, Jurado-Palomo J, Pozo-Aranda B, Cobos-Moreno P. Comparative Evidence on Negative Pressure Therapy and Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers: A Systematic Review of Independent Effectiveness and Clinical Applicability. Medicina (Kaunas) 2026;62(1):109.

PubMed · PMID 41597395 · DOI · PMC free full text

Both NPWT and HBOT are effective adjuncts in DFU management. No standardized head-to-head RCTs — the review cannot establish relative superiority or the optimal

Ata 2021

Diving and Hyperbaric Medicine · 2021 · Cohort / series

Ata N, Karaca E. Investigation of a cluster of decompression sickness cases following a high-altitude chamber flight. Diving and Hyperbaric Medicine 2021;51(1):82-85.

PubMed · PMID 33761546 · DOI · PMC free full text

Au 2025

World Journal of Methodology · 2025 · Cohort / series

Au SCL, Chong SSY. Prognostic factors for acute central retinal artery occlusion treated with hyperbaric oxygen: The Hong Kong study report number five. World Journal of Methodology 2025;15(2):96777.

PubMed · PMID 40548218 · DOI · PMC free full text

Au-Yeung 2022

Diving Hyperb Med · 2022 · Cohort / series

Au-Yeung KL, Selvaraj C, Amin T, et al. Effect of enriched oxygen inhalation on lower limb skin temperatures in diabetic and healthy humans: a pilot study. Diving Hyperb Med 2022;52(1):2-6.

PubMed · PMID 35313366 · PMC free full text

Aufgang 2026

Diving Hyperb Med · 2026 · Review / background

Aufgang Y, Devaney B, Chan J, Millar I, Tsouras T. Quantifying discrepancy between indicated and actual oxygen flow rates delivered by Comweld Ezi-flow low and standard flowmeters under hyperbaric conditions: a technical report. Diving Hyperb Med 2026;56(2):154-160.

PubMed · PMID 42290575 · DOI · PMC free full text

Aydin 2023

Diving and Hyperbaric Medicine Journal · 2023 · Cohort / series

Aydin F. Hyperbaric oxygen treatment in children: experience in 329 patients. Diving and Hyperbaric Medicine Journal 2023;53(3):203-209 (DOI 10.28920/dhm53.3.203-209).

PubMed · PMID 37718293 · DOI · PMC free full text

Azmi 2025

Syst Rev · 2025 · Commentary / case

Azmi YA, Alkaff FF, Soetanto KM, Wirjopranoto S, Postma MJ, Purba AKR. The impact of sodium-glucose cotransporter-2 inhibitors on the incidence, therapy, and outcomes of Fournier gangrene: insights from a systematic review of case reports. Syst Rev 2025;14(1):25.

PubMed · PMID 39871381 · DOI · PMC free full text

Azzopardi 2019

Diving Hyperb Med · 2019 · Cohort / series

Azzopardi CP, Caruana J, Matity L, Muscat S, Meintjes WAJ. Increasing prevalence of vestibulo-cochlear decompression illness in Malta: an analysis of hyperbaric treatment data from 1987-2017. Diving Hyperb Med 2019;49(3):161-166.

PubMed · PMID 31523790 · PMC free full text

Azzopardi 2021

Diving and Hyperbaric Medicine · 2021 · Commentary / case

Azzopardi CP, Magri K, Borg A, Schembri J, Sammut J. Echocardiography – techniques and pitfalls whilst diagnosing persistent (patent) foramen ovale as a risk factor in divers with a history of decompression sickness. Diving and Hyperbaric Medicine 2021;51(1):98-102.

PubMed · PMID 33761549 · DOI · PMC free full text

Babbage 2026

Diving Hyperb Med · 2026 · RCT

Babbage T, van Waart H, Connell CJW, Gant N, Mitchell SJ, Vrijdag XCE. Effect of a prior hypercapnia experience on recognition of hypercapnia in divers: a randomised controlled study. Diving Hyperb Med 2026;56(2):115-124.

PubMed · PMID 42290571 · DOI · PMC free full text

Babel 2025

Eur J Transl Myol · 2025 · Systematic review · MIXED human and preclinical evidence

Babel S, Bosco G, Camporesi E. Efficacy and safety of hyperbaric oxygen therapy in ligament and tendon injuries: a systematic review. Eur J Transl Myol 2025;35(4):14016.

PubMed · PMID 41036684 · DOI · PMC free full text

Bağlı 2018

Undersea Hyperb Med · 2018 · Commentary / case

Bağlı BS, Durgut O. Hyperbaric oxygen therapy as adjuvant therapy in necrotizing fasciitis of the face: case report. Undersea Hyperb Med 2018;45(6):695-699 (PMID 31158939).

PubMed · PMID 31158939

Bagli 2018

Undersea Hyperb Med · 2018 · Cohort / series

Bagli BS, Aygun H. Hyperbaric oxygen therapy decreases QTc dispersion that increased in CO poisoning. Undersea Hyperb Med 2018;45(6):673-677.

PubMed · PMID 31158934

Bagli 2020

Undersea Hyperb Med · 2020 · Cohort / series

Bagli BS. Clinical efficacy of hyperbaric oxygen therapy on idiopathic sudden sensorineural hearing loss. Undersea Hyperb Med 2020;47(1):51-57.

PubMed · PMID 32176946

Bahramnezhad 2026

J Cardiothorac Surg · 2026 · Review / background

Bahramnezhad F, Montaseri M, Jackson AC. Adjunctive hyperbaric oxygen therapy for poststernotomy deep sternal wound infection, mediastinitis, and sternal osteomyelitis after cardiac surgery: a scoping review. J Cardiothorac Surg 2026:in press.

PubMed · PMID 42449409 · DOI

Bai 2023

Asian J Surg · 2023 · Meta-analysis

Bai Z, Wang H, Sun H, Cui L. Effect of hyperbaric oxygen therapy on the patients with venous leg ulcer: A systematic review and meta-analysis. Asian J Surg 2023;46(10):4131–4137.

PubMed · PMID 36740520 · DOI

HBOT + surgery: smaller ulcer area (WMD −2.64, 95% CI −3.86 to −1.42), shorter ulcer healing HBOT + non-surgery: higher ulcer percent-area reduction (PAR) (WMD 20.82, 95% CI 5.86 to 35.79). Concludes adjunctive HBOT improves VLU healing metrics.

Baines 2021

Diving Hyperb Med · 2021 · Review / background

Baines C, Vicendese D, Cooper PD, McGuiness W, Miller C. Comparison of venous, capillary and interstitial blood glucose data measured during hyperbaric oxygen treatment from patients with diabetes mellitus. Diving Hyperb Med 2021;51(3):240-247.

PubMed · PMID 34547774 · PMC free full text

Baitule 2021

Medicina (Kaunas) · 2021 · Systematic review

Baitule S, Patel AH, Murthy N, Sankar S, Kyrou I, Ali A, Randeva HS, Robbins T. A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on Glycaemia in People with Diabetes Mellitus. Medicina (Kaunas) 2021;57(10):1134.

PubMed · PMID 34684171 · DOI · PMC free full text

Bakdalieh 2026

J Clin Med · 2026 · Meta-analysis

Bakdalieh A, Siddiqui D, Chen DG, Yu M. Hyperbaric Oxygen Therapy Versus Intravenous Thrombolysis in the Treatment of Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. J Clin Med 2026;15(7):2628.

PubMed · PMID 41976928 · DOI · PMC free full text

Both treatments improved BCVA, comparably: HBOT MD −0.57 logMAR; IVT MD −0.53 logMAR. Clinically meaningful improvement: 45.8% (HBOT) vs 42.0% (IVT). Adverse events similar in rate (HBOT 11.3% vs IVT 10.2%) but different in type — ear barotrauma

Banham 2022

Diving Hyperb Med · 2022 · RCT

Banham N, Hawkings P, Gawthrope I. A prospective single-blind randomised clinical trial comparing two treatment tables for the initial management of mild decompression sickness. Diving Hyperb Med 2022;52(2):85–91.

PubMed · PMID 35732279 · DOI · PMC free full text

Median treatments to resolution: 1 (IQR 1–1) FH01 vs 2 (IQR 1–2) TT6m (P=0.01) — fewer with the Complete resolution after the first treatment: 17/20 (85%) FH01 vs 8/21 (38%) TT6m (P=0.003). Final outcomes comparable: 19/20 (FH01) vs 20/21 (TT6m) asymptomatic at completion (P=0.97); all

Bapteste 2021

Diving Hyperb Med · 2021 · Commentary / case

Bapteste L, Kamar Z, Mazaud A, Balança B. Air embolism during lumbar surgery in the prone position. Diving Hyperb Med 2021;51(3):303-305.

PubMed · PMID 34547783 · DOI · PMC free full text

Baptista 2025

Diving Hyperb Med · 2025 · Commentary / case

Baptista LA, Guincho J, Donato M, Araújo P, Amaro CE, Escada PA. Hyperbaric oxygen therapy as salvage treatment for post-traumatic sudden sensorineural hearing loss: a case report. Diving Hyperb Med 2025;55(4):423-426 (DOI 10.28920/dhm55.4.423-426).

PubMed · PMID 41364867 · DOI · PMC free full text

Barnes 2025

Diving Hyperb Med · 2025 · Systematic review

Barnes LD, Hallum LE, Vrijdag XCE. Electroencephalographic (EEG) changes accompanying normal breathing of concentrated oxygen (hyperoxic ventilation) by healthy adults: a systematic review. Diving Hyperb Med 2025;55(2):154-163.

PubMed · PMID 40544143 · DOI · PMC free full text

Bartek 2016

Acta Neurochir (Wien) · 2016 · Cohort / series

Bartek J, Jakola AS, Skyrman S, Förander P, Alpkvist P, Schechtmann G, Glimåker M, Larsson A, Lind F, Mathiesen T. Hyperbaric oxygen therapy in spontaneous brain abscess patients: a population-based comparative cohort study. Acta Neurochir (Wien) 2016;158(7):1259–1267.

PubMed · PMID 27113742 · DOI

Reoperations: 10% (HBOT) vs 45% (non-HBOT), P=0.03. Recurrence (of those who did/didn't get HBO after first surgery): 14% vs 58%, P<0.01. Good outcome (Glasgow Outcome Score 5): 80% (HBOT) vs 45% (non-HBOT), P=0.04. HBOT well tolerated

Beevor & Frawley 2016

Diving Hyperb Med · 2016 · Cohort / series

Beevor H, Frawley G. Iatrogenic cerebral gas embolism: analysis of the presentation, management and outcomes of patients referred to The Alfred Hospital Hyperbaric Unit. Diving Hyperb Med 2016;46(1):15–21.

PubMed · PMID 27044457

Time to first HBOT was the ONLY independent predictor of good neurological outcome (OR 0.94 per hour, Mean time from recognition to HBOT was 15 h — the authors' central problem: treatment was impeded by Mortality 4/45 (8.9%); good outcome (GOS-E 7–8) in 27, moderate disability in 13.

Beilharz 2025

Diving Hyperb Med · 2025 · Review / background

Beilharz AG, Banham N, Gawthrope I. The incidence of cardiac arrest requiring defibrillation and defibrillation protocols in Australasian hyperbaric units. Diving Hyperb Med 2025;55(4):338-342 (DOI 10.28920/dhm55.4.338-342).

PubMed · PMID 41364857 · DOI · PMC free full text

Bell 2000

Anaesthesia · 2000 · Commentary / case

Bell MDD. The use of hyperbaric oxygen in the management of severe anaemia in a Jehovah's Witness. Anaesthesia 2000;55(3):293.

PubMed · PMID 10744564 · DOI

A letter to the Editor. It is not a research paper. It enrols nobody, measures nothing and reports no outcome. Its content is an argument in four parts about a case report published the previous year. It is filed here because it is the only published dissent attached to that case, and because a page that presented the case report alone would misrepresent the record.

Bell 2014

Undersea Hyperb Med · 2014 · Cohort / series

Bell J, Thombs PA, Davison WJ, et al. Decompression tables for inside chamber attendants working at altitude. Undersea Hyperb Med 2014;41(6):505-513.

PubMed · PMID 25562942

Benites Condezo 2021

Br J Oral Maxillofac Surg · 2021 · Meta-analysis

Benites Condezo AF, Araujo RZ, Koga DH, Curi MM, Cardoso CL. Hyperbaric oxygen therapy for the placement of dental implants in irradiated patients: systematic review and meta-analysis. Br J Oral Maxillofac Surg 2021;59(6):625–632.

PubMed · PMID 33952404 · DOI

No evidence that the risk of implant failure differed between irradiated patients who received HBOT Implant-failure risk did not depend on anatomical site.

Benix 2025

Cureus · 2025 · Cohort / series

Benix L, Sukumaran MT, Lakshmanan V, Sankaran R, Kumar V. The impact of adjunct hyperbaric oxygen therapy on healing diabetic foot ulcers: a retrospective case-control study at a tertiary care center. Cureus 2025.

PubMed · PMID 41552219 · DOI · PMC free full text

Bennett 2003

Undersea Hyperb Med · 2003 · RCT

Bennett M, Mitchell S, Dominguez A. Adjunctive treatment of decompression illness with a non-steroidal anti-inflammatory drug (Tenoxicam) reduces compression requirement. Undersea Hyperb Med 2003;30(3):195-205.

PubMed · PMID 14620099

Primary recovery outcome — no significant difference. Health status score 1 at discharge was Number of recompressions — significantly fewer with tenoxicam. Median treatments to discharge Subjects requiring more than two treatments: 53 (61%) placebo versus 35 (40%) tenoxicam, a 21%

Bennett & Heard 2004

Cochrane Database Syst Rev · 2004 · Cochrane review

Bennett M, Heard R. Hyperbaric oxygen therapy for multiple sclerosis. Cochrane Database Syst Rev 2004;2004(1):CD003057.

PubMed · PMID 14974004 · DOI · PMC free full text

9 trials, 504 participants (ten reports). Two trials broadly positive, seven showed no treatment Conclusion: "no consistent evidence to confirm a beneficial effect… we do not believe routine use is COI (disclosed): lead author is a hyperbaric-facility medical director (does not routinely treat MS);

Bennett 2005

J Laryngol Otol · 2005 · Systematic review

Bennett MH, Kertesz T, Yeung P. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss and tinnitus: a systematic review of randomized controlled trials. J Laryngol Otol 2005;119(10):791–798.

PubMed · PMID 16259656 · DOI

6 RCTs, 304 subjects. Significantly increased chance of a 25% PTA hearing-threshold improvement — RR 1.39

Bennett 2012

Cochrane Database Syst Rev · 2012 · Cochrane review

Bennett MH, Lehm JP, Mitchell SJ, Wasiak J. Recompression and adjunctive therapy for decompression illness. Cochrane Database Syst Rev 2012;5:CD005277.

PubMed · PMID 22592704 · DOI · PMC free full text

Recompression is the universally accepted standard treatment of DCI — but there is NO randomised Two RCTs (268 patients) addressed adjuncts: adding the NSAID tenoxicam did not improve recovery

Bennett 2012

Cochrane Database Syst Rev · 2012 · Cochrane review

Bennett MH, Stanford RE, Turner R. Hyperbaric oxygen therapy for promoting fracture healing and treating fracture non-union. Cochrane Database Syst Rev 2012;11(11):CD004712.

PubMed · PMID 23152225 · DOI · PMC free full text

No randomised controlled trials met the inclusion criteria — an empty review. Three RCTs were Conclusion: the review "failed to locate any relevant clinical evidence to support or refute" HBOT

Bennett 2012

Cochrane Database Syst Rev · 2012 · Cochrane review

Bennett MH, Kertesz T, Perleth M, Yeung P, Lehm JP. Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus. Cochrane Database Syst Rev 2012;10:CD004739.

PubMed · PMID 23076907 · DOI · PMC free full text

No significant effect on the chance of a 50% improvement in pure-tone average (RR 1.53, 95% CI Significant effect on the chance of a 25% improvement in pure-tone average (RR 1.39, 95% CI Absolute audiometric gain 15.6 dB greater with HBOT (95% CI 1.5–29.8; P=0.03).

Bennett 2015

Cochrane Database Syst Rev · 2015 · Cochrane review

Bennett MH, French C, Schnabel A, Wasiak J, Kranke P, Weibel S. Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Cochrane Database Syst Rev 2015;2015(12):CD005219.

PubMed · PMID 26709672 · DOI · PMC free full text

Cochrane systematic review/meta-analysis of normobaric (NBOT) and hyperbaric (HBOT) oxygen for migraine and cluster headache (update of the 2008 review). 11 trials, 209 participants; trial quality poor-to-moderate.

Bennett 2016

Cochrane Database Syst Rev · 2016 · Cochrane review

Bennett MH, Feldmeier J, Hampson NB, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 2016;Issue 4:CD005005 (searches to Dec 2015; re-published Issue 11, 2018 — edited, no change to conclusions).

PubMed · PMID 27123955 · DOI · PMC free full text

Osteoradionecrosis — mucosal coverage: RR 1.30 (95% CI 1.1–1.6, P = 0.003), NNTB 5 (246 Wound breakdown after operative treatment for ORN: significantly more likely without HBOT — Radiation proctitis (improvement/cure): RR 1.72 (95% CI 1.0–2.9, P = 0.04), NNTB 5 (single

Bennett 2018

Cochrane Database Syst Rev · 2018 · Cochrane review

Bennett MH, Feldmeier J, Smee R, Milross C. Hyperbaric oxygenation for tumour sensitisation to radiotherapy. Cochrane Database Syst Rev 2018;(4):CD005007.

PubMed · PMID 29637538 · DOI · PMC free full text

19 trials, 2286 participants (1103 HBOT, 1153 control). HBOT during radiotherapy improved local tumour control, mortality and local tumour recurrence in head-and-neck cancer (mortality reduced at 1 and 5 years; less local recurrence at 1 and 5 years). Benefits may only occur with unusual radiotherapy fractionation schemes; HBOT was associated with severe radiation tissue injury (and oxygen-toxicity seizures). Results demand ca…

Bent 2000

Undersea Hyperb Med · 2000 · Cohort / series

Bent JP, April MM, Ward RF, Packard AM. Role of otoscan-assisted laser myringotomy in hyperbaric oxygen therapy. Undersea Hyperb Med 2000;27(3):159-161.

PubMed · PMID 11191162

Berland & Blumenberg 2026

Clin Toxicol (Phila) · 2026 · Review / background

Berland N, Blumenberg A. Comment on the effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning. Clin Toxicol (Phila) 2026:online ahead of print.

PubMed · PMID 42340353 · DOI

Bernardo 2026

International Journal of Special Education · 2026 · Review / background

Bernardo ATB, et al. Global Competency of Hyperbaric Nurses: An Integrative Literature Review. International Journal of Special Education 2026;41(11s):330-349.

HBOT 0045 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Bernbeck 2004

Klin Padiatr · 2004 · Cohort / series

Bernbeck B, Christaras A, Krauth K, Lentrodt S, Strelow H, Schaper J, Janssen G, Mödder U, Göbel U. Bone marrow oedema and aseptic osteonecrosis in children and adolescents with acute lymphoblastic leukaemia or non-Hodgkin-lymphoma treated with hyperbaric-oxygen-therapy (HBO): an approach to cure? -- BME/AON and hyperbaric oxygen therapy as a treatment modality. Klin Padiatr 2004;216(6):370–378.

PubMed · PMID 15565553 · DOI

Between 11/1988 and 01/2001, 291 patients with acute lymphoblastic leukaemia or non-Hodgkin lymphoma (264 ALL, 27 NHL) were treated at the Clinic for Paediatric Oncology, Haematology and Immunology, University of Düsseldorf. 27 (9.3%) were diagnosed with bone marrow oedema (BME) and/or aseptic osteonecrosis (AON) on MRI, and it is these 27 who form the study. 19 of 27 received HBO; the remaining 8

Berntsson 2024

Clin Oncol (R Coll Radiol) · 2024 · Meta-analysis

Berntsson H, Thien A, Hind D, Stewart L, Mahzabin M, Tung WS, et al. Interventions for Managing Late Gastrointestinal Symptoms Following Pelvic Radiotherapy: a Systematic Review and Meta-analysis. Clin Oncol (R Coll Radiol) 2024;36(5):318–334.

PubMed · PMID 38431427 · DOI

RCTs (1990–2023) of interventions for late GI symptoms after pelvic radiotherapy. HBO showed conflicting results; sucralfate + argon plasma coagulation increased endoscopic markers of improvement in one comparison; no firm conclusions on pain, incontinence, diarrhoea, tenesmus or QoL. Overall: small study sizes, methodological quality and heterogeneity limit support for any individual intervention.

Berry 1979 (Leeds)

Clin Radiol · 1979 · RCT

Berry GH, Dixon B, Ward AJ. The Leeds results for radiotherapy in HBO for carcinoma of the head and neck. Clin Radiol 1979;30(6):591–592.

PubMed · PMID 466964 · DOI

Significant gain in local tumour control (P<0.001) and survival (P<0.05) with HBO radiotherapy vs No increase in early or late tissue reactions or morbidity between groups.

Bessereau 2010

Intensive Care Med · 2010 · Cohort / series

Bessereau J, Genotelle N, Chabbaut C, Huon A, Tabah A, Aboab J, Chevret S, Annane D. Long-term outcome of iatrogenic gas embolism. Intensive Care Med 2010;36(7):1180–1187.

PubMed · PMID 20221749 · DOI

Crude mortality 14/119 (12%) at ICU discharge, rising to 25/119 (21%) at 1 year. Neurological sequels in 45/105 ICU survivors (42.9%) at discharge (vegetative state, focal motor Independent predictors of 1-year mortality: cardiac arrest at the accident and at ICU admission, and

Bessereau 2010

Undersea Hyperb Med · 2010 · Cohort / series

Bessereau J, Tabah A, Genotelle N, Français A, Coulange M, Annane D. Middle-ear barotrauma after hyperbaric oxygen therapy. Undersea Hyperb Med 2010;37(4):203-208.

PubMed · PMID 20737927

Bevers 1995

Lancet · 1995 · Cohort / series

Bevers RF, Bakker DJ, Kurth KH. Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. Lancet 1995;346(8978):803-805 (PMID 7674746. DOI 10.1016/s0140-6736(95)91620-2).

PubMed · PMID 7674746 · DOI

British Hyperbaric Association 1996

British Hyperbaric Association · 1996 · Safety / facility standard

British Hyperbaric Association Technical Working Party. Guide to Fire Safety Standards for Hyperbaric Treatment Centres. British Hyperbaric Association 1996:1-24.

HBOT 0043 · Not indexed in PubMed and no DOI — full text held in the practice wiki

BHA 2025 (fire safety guidelines, multiplace)

February · 2025 · Safety / facility standard

British Hyperbaric Association. Fire Safety Guidelines for Multiplace Hyperbaric Treatment Facilities. February 2025.

HBOT 0033 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Biadacz-Sadurska 2026

Eur J Case Rep Intern Med · 2026 · Commentary / case

Biadacz-Sadurska A, Krefta A, Tłustochowicz W. Effective treatment of audiovestibular involvement in Cogan's syndrome with biologics and hyperbaric oxygen therapy. Eur J Case Rep Intern Med 2026;13:007109.

PubMed · PMID 42466223 · DOI · PMC free full text

Bidstrup 2017

Undersea Hyperb Med · 2017 · Review / background

Bidstrup D, Jansen EC, Hyldegaard O. Quantitative Romberg's test in acute carbon monoxide poisoning treated by hyperbaric oxygen. Undersea Hyperb Med 2017;44(6):559-567.

PubMed · PMID 29281193

Binkley 2020

Undersea Hyperb Med · 2020 · Commentary / case

Binkley M, Kelly M, Hardy K. Cerebral arterial gas embolism in a patient with hypoplastic left heart syndrome treated with emergent hyperbaric oxygen: case report. Undersea Hyperb Med 2020;47(3):431-434.

DOI

Bion 2024

Diving Hyperb Med · 2024 · Cohort / series

Bion V, Jape D, Niesen R, Angliss M, Bruscino-Raiola F, Mitra B, Devaney B. Validation of necrotising infection clinical composite endpoint in a retrospective cohort of patients with necrotising soft tissue infections. Diving Hyperb Med 2024;54(3):155-161 (PMID 39288918. DOI 10.28920/dhm54.3.155-161).

PubMed · PMID 39288918 · DOI · PMC free full text

Bishop 2012

Int Wound J · 2012 · Cohort / series

Bishop AJ, Mudge E. A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. Int Wound J 2012;9(6):665-676.

PubMed · PMID 22372584 · PMC free full text

Blake 2024

Diving and Hyperbaric Medicine · 2024 · Cohort / series

Blake DF, Crowe M, Lindsay D, Turk R, Mitchell SJ, Pollock NW. Divers treated in Townsville, Australia: worse symptoms lead to poorer outcomes. Diving and Hyperbaric Medicine 2024;54(4):308-319.

PubMed · PMID 39675739 · DOI · PMC free full text

Blake 2025

Diving Hyperb Med · 2025 · Cohort / series

Blake DF, Crowe M, Lindsay D, Turk R, Mitchell SJ, Pollock NW. Oxygen treatment and retrieval pathways of divers with diving-related conditions in Townsville, Australia: a 15-year retrospective review. Diving Hyperb Med 2025;55(2):79-90.

PubMed · PMID 40544136 · DOI · PMC free full text

Blanc 2002

Intensive Care Med · 2002 · Cohort / series

Blanc P, Boussuges A, Henriette K, Sainty JM, Deleflie M. Iatrogenic cerebral air embolism: importance of an early hyperbaric oxygenation. Intensive Care Med 2002;28(5):559–563.

PubMed · PMID 12029402 · DOI

Patients treated with HBO <6 h had a better outcome than those treated later. Among those treated Beyond 6 h, the delay was shorter in patients who recovered than in those with sequelae/death Venous air embolism treated <6 h did better; the time-to-HBO was shorter for venous than arterial

Blatteau 2011

Diving Hyperb Med · 2011 · Cohort / series

Blatteau JE, Gempp E, Constantin P, Louge P. Risk factors and clinical outcome in military divers with neurological decompression sickness: influence of time to recompression. Diving Hyperb Med 2011;41(3):129-134.

PubMed · PMID 21948497

15 of 59 divers (25.4%) had incomplete resolution at one month, all involving spinal cord lesions. Time to recompression did not predict outcome on univariate analysis. With a ROC-derived cut-off of On multivariate analysis the association reached significance but was clinically negligible —

Blatteau 2020

Diving and Hyperbaric Medicine · 2020 · Commentary / case

Blatteau JE, Morin J, Roffi R, Druelle A, Sbardella F, Castagna O. Clinical problem solving: Mental confusion and hypoxaemia after scuba diving. Diving and Hyperbaric Medicine 2020;50(2):181-184.

PubMed · PMID 32557423 · DOI · PMC free full text

Blatteau 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

Blatteau JE, Lambrechts K, Ruffez J. Factors influencing the severity of long-term sequelae in fishermen-divers with neurological decompression sickness. Diving and Hyperbaric Medicine 2020;50(1):9-16.

PubMed · PMID 32187612 · DOI · PMC free full text

Blatteau 2025

Diving Hyperb Med · 2025 · Commentary / case

Blatteau JE, Roffi R, Valero B. Blurred vision after diving, what's your diagnosis? Diving Hyperb Med 2025;55(4):434-435.

PubMed · PMID 41364870 · DOI · PMC free full text

Bliss 2020

Undersea Hyperb Med · 2020 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Bliss C, Huang E, Savaser D. Safety of a continuous glucose monitoring device during hyperbaric exposure. Undersea Hyperb Med 2020;47(1):13-19.

PubMed · PMID 32176942

Blizzard 2026

Diving Hyperb Med · 2026 · Review / background

Blizzard EA, Grandin AA, Sims D. Exploring the use of full-face masks for ventilation in dive rescue. Diving Hyperb Med 2026;56(1):2-7.

PubMed · PMID 41875436 · DOI

Blogg 2017

Undersea and Hyperbaric Medicine · 2017 · Cohort / series

Blogg SL, Møllerløkken A, Gennser M. Observed decompression sickness and venous bubbles following 18-msw dive profiles using RN Table 11. Undersea and Hyperbaric Medicine 2017;44(3):211-219.

PubMed · PMID 28779578 · DOI

Blogg 2023

Diving and Hyperbaric Medicine · 2023 · Systematic review

Blogg SL, Tillmans F, Lindholm P. The risk of decompression illness in breath-hold divers: a systematic review. Diving and Hyperbaric Medicine 2023;53(1):31-41.

PubMed · PMID 36966520 · DOI · PMC free full text

Blogg 2025

Diving Hyperb Med · 2025 · Review / background

Blogg SL, Azarang A, Papadopoulou V, Lindholm P. Agreement of precordial and subclavian Doppler ultrasound venous gas emboli grades in a large diving data set. Diving Hyperb Med 2025;55(1):2-10.

PubMed · PMID 40090020 · DOI · PMC free full text

Blogg 2026

Diving Hyperb Med · 2026 · Review / background

Blogg SL, Azarang A, Lance R, Tillmans F, Moon R, Papadopoulou V, Lindholm P. An echo from the past: open access repository of over 10,000 annotated Doppler audio recordings of venous gas emboli. Diving Hyperb Med 2026;56(1):8-12.

PubMed · PMID 41875437 · DOI

A rescue operation. Doppler ultrasound recordings of post-dive venous gas emboli have been made since the 1970s and were stored on analogue audio cassettes and digital audio tape. In 2020 the US Office of Naval Research supported an effort to gather those tapes from around the world, digitise them, and put them online. Partners included UCSD, the University of North Carolina at Chapel Hill, the Di

Boerema 1959

J Cardiovasc Surg — year, volume and pages NOT ESTABLISHED; see 'Provenance' below · 1959 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Boerema I, Meyne NG, Brummelkamp WK, Bouma S, Mensch MH, Kamermans F, Stern Hanf M, van Aalderen W. Life Without Blood (A study of the influence of high atmospheric pressure and hypothermia on dilution of the blood). J Cardiovasc Surg — year, volume and pages NOT ESTABLISHED; see 'Provenance' below UNRESOLVED — the reprint says 1959; the paper is widely cited as 1960;UNRESOLVED:UNRESOLVED.

HBOT 0001 · Not indexed in PubMed and no DOI — full text held in the practice wiki

At normal atmospheric pressure — three pigs weighing about 12 Kg. When the haemoglobin fell At three atmospheres absolute on oxygen. "The same experiment was repeated in a high pressure Summary as printed: haemoglobin lowered in young pigs to 0.4 per cent, the blood exchanged for

Bojić 1993

Arh Hig Rada Toksikol · 1993 · RCT

Bojić L, Kovačević H, Andrić D, Romanović D, Petri NM. Hyperbaric oxygen dose of choice in the treatment of glaucoma. Arh Hig Rada Toksikol 1993;44(3):239–247.

PubMed · PMID 8311697

Visual acuity and IOP: no statistically significant difference between treated and control groups, Visual-field values increased after HBO in all subgroups, dose-dependently — the increase was Authors recommend a 20-session course for initial treatment (with re-treatment when fields decline).

Bonner 2025 (HBOT-UC)

Trials · 2025 · Review / background

Bonner LB, Sadler C, Lindholm P, Scholtens DM, Dulai PS; HBOT-UC Consortium. Hyperbaric oxygen therapy for ulcerative colitis patients hospitalized for moderate to severe flares (HBOT-UC): study protocol for a multi-center, randomized, double-blind, sham-controlled trial. Trials 2025;26(1):220.

PubMed · PMID 40545548 · DOI · PMC free full text

No efficacy data yet — protocol only; the trial to watch that would move UC from investigational Senior author Dulai also led the positive 2018 phase-2A UC RCT already on file

Bonnington 2021

Diving Hyperb Med · 2021 · Cohort / series

Bonnington S, Banham N, Foley K, Gawthrope I. Oxygen toxicity seizures during United States Navy Treatment Table 6: An acceptable risk in monoplace chambers? Diving Hyperb Med 2021;51(2):167-172.

PubMed · PMID 34157732 · DOI · PMC free full text

Borab 2017

J Plast Reconstr Aesthet Surg · 2017 · Systematic review

Borab Z, Mirmanesh MD, Gantz M, Cusano A, Pu LLQ. Systematic review of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis. J Plast Reconstr Aesthet Surg 2017;70(4):529–538.

PubMed · PMID 28081957 · DOI

8 articles (1 observational cohort, 5 case series, 2 case reports) — no controlled trials. They describe improvement in symptoms and wounds with HBO for radiation-induced skin necrosis. Pooled complete wound healing 79.6% (78/98) — from only six of the eight studies, 98 of the 720 patients, with no control arm and no formal meta-analysis. ⚠️ Added 31 Aug 2026: the review's own pooled headline figure was absent from this page,…

Bosco 2016

Diving Hyperb Med · 2016 · Cohort / series

Bosco G, Garetto G, Rubini A, Paoli A, Dalvi P, Mangar D, Camporesi EM. Safety of transport and hyperbaric oxygen treatment in critically-ill patients from Padua hospitals into a centrally-located, stand-alone hyperbaric facility. Diving Hyperb Med 2016;46(3):155-159.

PubMed · PMID 27723016

Bosco 2018

Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. · 2018 · Review / background

Bosco G, Rizzato A, Vezzani G, Zanon V, Camporesi E. Therapeutic Mechanisms of Action for Hyperbaric Oxygen on Femoral Head Necrosis. Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. IntechOpen 2018 (Chapter 2).

DOI

Mechanistic account for HBO in femoral head necrosis (FHN/AVN): increased oxygen tension in

Bose 2026

Diving Hyperb Med · 2026 · Commentary / case

Bose JG, Kumar S, Anand S, Mohanty C. The role of hyperbaric oxygen treatment in a case of pyomyositis. Diving Hyperb Med 2026;56(2):191-194.

PubMed · PMID 42290580 · DOI

Bothma 2012

Diving Hyperb Med · 2012 · Commentary / case

Bothma PA, Brodbeck AE, Smith BA. Cerebral venous air embolism treated with hyperbaric oxygen: a case report. Diving Hyperb Med 2012;42(2):101-103.

PubMed · PMID 22828820

Bouachour 1996

J Trauma · 1996 · RCT

Bouachour G, Cronier P, Gouello JP, Toulemonde JL, Talha A, Alquier P. Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial. J Trauma 1996 Aug;41(2):333–9.

PubMed · PMID 8760546 · DOI

Complete healing: 17/18 (HBOT) vs 10/18 (placebo), P < 0.01. Repeat surgery (skin flap/graft, vascular surgery, or amputation): 1 (HBOT) vs 6 (placebo), Effect concentrated by risk: in patients 40 years with grade III soft-tissue injury,

Bove 2008

In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 25 · 2008 · Review / background

Bove AA. Cardiovascular aspects of hyperbaric oxygen therapy. In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 25 2008:573-586.

DOI

Boyko & Carberry 2025

Can J Neurol Sci · 2025 · Commentary / case

Boyko M, Carberry R. Reviewer Comment on Elfil et al. "Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta-Analysis". Can J Neurol Sci 2025.

PubMed · PMID 40771122 · DOI

A commentary/peer-review note (not primary evidence) critically appraising the Elfil 2025 CRAO meta-analysis that this wiki cites as a positive synthesis. It accepts the physiological rationale (inner-retinal oxygen supply rises from ~50% to ~97% under hyperbaric oxygenation) but flags several limitations of the pooled evidence.

Bradley 2020

Undersea Hyperb Med · 2020 · Commentary / case

Bradley KR, Krassow JL, Richards MF, Beckstrand DP, Wolf EG. Chronic decompression illness cognitive dysfunction improved with hyperbaric oxygen: a case report. Undersea Hyperb Med 2020;47(1):131-137.

PubMed · PMID 32176954 · DOI

Brady 1981

Int J Radiat Oncol Biol Phys · 1981 · RCT

Brady LW, Plenk HP, Hanley JA, Glassburn JR, Kramer S, Parker RG. Hyperbaric oxygen therapy for carcinoma of the cervix--stages IIB, IIIA, IIIB and IVA: results of a randomized study by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981;7(8):991–998.

PubMed · PMID 7028700 · DOI

No significant difference in survival between the air and HBO arms. More deaths from complications / intercurrent disease in the HBO arm: 5/19 (HBO) vs 2/29 (air) — a (Added 31 Aug 2026.) 5/19 is an AS-TREATED denominator. Ten of the 29 patients randomised to oxygen

Brady 2022

Undersea Hyperb Med · 2022 · Commentary / case

Brady NJ, Patel PS, Moayedi S, Sward D. A novel source of carbon monoxide for suicide attempt. Undersea Hyperb Med 2022;49(3):329-331.

PubMed · PMID 36001565

Brampton 2021

Diving and Hyperbaric Medicine · 2021 · Commentary / case

Brampton W, Sayer MDJ. Decompression sickness after a highly conservative dive in a diver with known persistent foramen ovale: Case report. Diving and Hyperbaric Medicine 2021;51(1):111-115.

PubMed · PMID 33761552 · DOI · PMC free full text

Brenna 2024

Diving and Hyperbaric Medicine Journal · 2024 · Review / background

Brenna CT, Salvatori M, Khan S, Djaiani G, Schiavo S, Katznelson R. The role of routine cardiac investigations before hyperbaric oxygen treatment. Diving and Hyperbaric Medicine Journal 2024;54(2):120-126 (DOI 10.28920/dhm54.2.120-126).

PubMed · PMID 38870954 · DOI · PMC free full text

Briceño-Souza 2019

Undersea and Hyperbaric Medicine · 2019 · Commentary / case

Briceño-Souza E, Méndez-Domínguez N, Cárdenas-Dajdaj R, Chin W, Huchim-Lara O. Dysbaric osteonecrosis associated with decompression sickness in a fishing diver. Undersea and Hyperbaric Medicine 2019;46(2):217-220.

PubMed · PMID 31051069

Bronshteyn 2024

Undersea Hyperb Med · 2024 · Commentary / case

Bronshteyn V, Hendriksen SM, Lee SJ, Logue C. Surviving cardiac arrest after carbon monoxide poisoning treated with hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(1):37-40 (PMID 38615351).

PubMed · PMID 38615351

Brouwer 2020

J Vasc Surg · 2020 · Meta-analysis

e1. Brouwer RJ, Lalieu RC, Hoencamp R, van Hulst RA, Ubbink DT. A systematic review and meta-analysis of hyperbaric oxygen therapy for diabetic foot ulcers with arterial insufficiency. J Vasc Surg 2020;71(2):682–692.

PubMed · PMID 32040434 · DOI

11 studies, 729 patients (7 RCTs, 2 controlled clinical trials, 2 retrospective cohorts); 4 used for quantitative synthesis. DFU with arterial insufficiency (PAOD). Major amputations significantly fewer with HBO: 10.7% vs 26.0%; risk difference 15% (95% CI 6–25%); P=0.002; NNT 7 (95% CI 4–20). No significant difference for minor amputations.

Brouwer 2024

Diving Hyperb Med · 2024 · Review / background

Brouwer RJ, van Reijen NS, Dijkgraaf MG, Hoencamp R, Koelemay MJW, van Hulst RA, Ubbink DT. Economic analysis of hyperbaric oxygen therapy for the treatment of ischaemic diabetic foot ulcers. Diving Hyperb Med 2024;54(4):265–274.

PubMed · PMID 39675733 · DOI · PMC free full text

Cost (ITT): mean difference €3,791 in favour of higher HBOT cost, but the BCA 95% CI was very QALYs: 0.54 (HBOT+SC) vs 0.56 (SC); difference −0.02, not significant. No benefit for Wagner stage II; cost-per-limb-saved estimates were highly uncertain (very wide CIs).

Brown 1994

Am J Surg · 1994 · Cohort / series

Brown DR, Davis NL, Lepawsky M, Cunningham J, Kortbeek J. A multicenter review of the treatment of major truncal necrotizing infections with and without hyperbaric oxygen therapy. Am J Surg 1994;167(5):485–489.

PubMed · PMID 8185032 · DOI

Mortality 9/30 (30%) with HBO vs 10/24 (42%) without — NOT statistically significant. The study failed to show that HBO reduced mortality or the number of debridements. Selection bias acknowledged: the HBO group had more clostridial infections and was younger (i.e.

Brummelkamp 1963

Lancet · 1963 · Cohort / series

Brummelkamp WH, Boerema I, Hoogendyk L. Treatment of clostridial infections with hyperbaric oxygen drenching. A report on 26 cases. Lancet 1963;1(7275):235-8.

PubMed · PMID 14016240 · DOI

An uncontrolled consecutive series of 26 patients with clostridial infection (Clostridium welchii) treated in the hyperbaric chamber at the University Surgical Clinic, Wilhelmina Gasthuis, Amsterdam. The paper states that treatment of gas-gangrene and other anaerobic infections began in Amsterdam in November, 1960, as an offshoot of work on high atmospheric pressure in cardiac surgery that had bee

Brunner 2025

Neurosurgical Review · 2025 · Cohort / series

Brunner A, Lindenmann J, Pistracher K, Micko A, Pichler A, Enzinger C, Smolle-Jüttner F, Wolfsberger S, Kurschel-Lackner S. Hyperbaric oxygen therapy for brain abscesses: A useful adjuvant treatment for a faster recovery. Neurosurgical Review 2025;48:583 (article number 583; the journal does not print a page range or an issue number for this article).

PubMed · PMID 40731157 · DOI · PMC free full text

Radiological, 6 months — no residual abscess in 20 patients (80%) with HBOT vs 14 patients (46.7%) Radiological, 3 months — no residual abscess in 6 patients (24%) with HBOT vs 3 patients (10%) Radiological, 12 months — 20 patients (80%) vs 17 patients (56%), p = 0.477 (the difference had

Buckley 2011

Cochrane Database Syst Rev · 2011 · Cochrane review

Buckley NA, Juurlink DN, Isbister G, Bennett MH, Lavonas EJ. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev 2011;4:CD002041.

PubMed · PMID 21491385 · DOI · PMC free full text

Six RCTs (1361 participants). Pooled random-effects OR for neurological deficits 0.78 (95% CI Two trials found benefit at 1 month; four did not. Design/analysis flaws in all trials: the

Buettner 2007

Emerg Med Clin North Am · 2007 · Review / background

Buettner MF, Wolkenhauer D. Hyperbaric oxygen therapy in the treatment of open fractures and crush injuries. Emerg Med Clin North Am 2007;25(1):177–188.

PubMed · PMID 17400080 · DOI

A narrative review written by a hyperbaric physician and a hyperbaric technologist at a wound and hyperbaric clinic in Iowa, for the Emergency Medicine Clinics of North America. It is a teaching article: its stated purpose is that emergency physicians should familiarise themselves with hyperbaric oxygen because of their role in the early management of these injuries. It states no research question

Bulsara 2019

BMJ Open · 2019 · Review / background

Bulsara VM, Bulsara MK, Lewis E (Australia). Protocol for prospective randomised assessor-blinded pilot study comparing hyperbaric oxygen therapy with PENtoxifylline+TOcopherol± CLOdronate for the management of early osteoradionecrosis of the mandible. BMJ Open 2019;9(3):e026662.

PubMed · PMID 30837258 · DOI · PMC free full text

None — protocol only. Outcomes (ORN resolution, pain, quality of life) will appear in the results

Bulutlar 2024b

Diving Hyperb Med · 2024 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Bulutlar E, Yilmaz A, Uluutku Bulutlar GB, Aslan Y, Bozdağ HN, Küçükodaci Z. Effect of hyperbaric oxygen treatment on ischaemia-reperfusion injury in rats detorsioned after experimental ovarian torsion. Diving Hyperb Med 2024;54(1):16-22 (DOI 10.28920/dhm54.1.16-22).

PubMed · PMID 38507906 · DOI · PMC free full text

Burman 2009

Undersea Hyperb Med · 2009 · Review / background

Burman F, Sheffield R, Posey K. Decision process to assess medical equipment for hyperbaric use. Undersea Hyperb Med 2009;36(2):137-144.

PubMed · PMID 19462753

Burman 2019

S Afr Med J · 2019 · Commentary / case

Burman F. Low-pressure fabric hyperbaric chambers. S Afr Med J 2019;109(4):12574.

PubMed · PMID 31084683 · DOI

Burman 2025 (electrical safety in hyperbaric facilities)

2025 · Commentary / case

Burman F. Electrical safety in hyperbaric facility. 2025:11-13 (conference/《chapter》 material; no journal stated on the source).

HBOT 0034 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Butler 2018

Undersea Hyperb Med · 2018 · Commentary / case

Butler FK, Hagan C, Van Hoesen K, Murphy-Lavoie H. Management of central retinal artery occlusion following successful hyperbaric oxygen therapy: case report. Undersea Hyperb Med 2018;45(1):101-107.

PubMed · PMID 29571239

Cade 1967

Cancer · 1967 · RCT

Cade IS, McEwen JB. Megavoltage radiotherapy in hyperbaric oxygen: a controlled trial. Cancer 1967;20(5):817–821.

PubMed · PMID 4960773

No benefit at either site, and a harm signal in bladder: bronchus carcinoma showed "little if any (The UNSW appraisal cats/Cade records "no evidence of improved survival with the addition of HBO to

Cade 1978 (Cade2)

Br J Radiol · 1978 · RCT

Cade IS, McEwen JB, Dische S, Saunders MI, et al. (MRC Working Party). Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the bladder. Br J Radiol 1978;51(611):876–878.

PubMed · PMID 361143 · DOI

No benefit was shown with the use of hyperbaric oxygen (survival/local control) vs air.

Cakmak 2015

Undersea Hyperb Med · 2015 · Commentary / case

Cakmak T, Battal B, Kara K, Metin S, et al. A case of tension pneumothorax during hyperbaric oxygen therapy in an earthquake survivor with crush injury complicated by ARDS (adult respiratory distress syndrome). Undersea Hyperb Med 2015;42(1):9-13.

PubMed · PMID 26094299

Camporesi 2010

J Arthroplasty · 2010 · RCT

Camporesi EM, Vezzani G, Bosco G, Mangar D, Bernasek TL. Hyperbaric Oxygen Therapy in Femoral Head Necrosis. J Arthroplasty 2010;25(6 Suppl):118–123.

PubMed · PMID 20637561 · DOI

Significant pain improvement with HBO after 20 treatments; range of motion improved significantly At 7-year follow-up all patients remained substantially pain-free and none required hip

Camporesi 2017

Undersea Hyperb Med · 2017 · Guideline

Camporesi E, Vezzani G, Zanon V, Manelli D, Enten G, Quartesan S, Bosco G. Review on hyperbaric oxygen treatment in femoral head necrosis. Undersea Hyperb Med 2017;44(6):497-508.

PubMed · PMID 29281187 · DOI

Canarslan-Demir 2023

Undersea Hyperb Med · 2023 · Cohort / series

Canarslan-Demir K, Ozgok-Kangal K, Saatci-Yasar A, Akif Erdol M, Koc B. Analysis of the cardiovascular effects of hyperbaric oxygen therapy in diabetic patients. Undersea Hyperb Med 2023;50(4):425-431 (DOI 10.22462/01.01.2023.6).

DOI

Canarslan Demir 2023

Diving Hyperb Med · 2023 · Commentary / case

Canarslan Demir K, Turgut B, Ozgok Kangal K, Zaman T, Şimşek K. Hyperbaric oxygen treatment in delayed post-hypoxic encephalopathy following inhalation of liquefied petroleum gas: a case report. Diving Hyperb Med 2023;53(4):351-355 (DOI 10.28920/dhm53.4.351-355).

PubMed · PMID 38091596 · DOI · PMC free full text

Canarslan Demir 2024

Diving and Hyperbaric Medicine Journal · 2024 · Cohort / series

Canarslan Demir K, Turgut B, Sariyerli Dursun GB, Konyalioğlu FS, Zaman T. The role of hyperbaric oxygen treatment in the management of spondylodiscitis. Diving and Hyperbaric Medicine Journal 2024;54(3):162-167 (DOI 10.28920/dhm54.3.162-167).

PubMed · PMID 39288919 · DOI · PMC free full text

Canarslan Demir 2025

Diving Hyperb Med · 2025 · Cohort / series

Canarslan Demir K, Avci AU, Yüsra Abayli S, Konyalioglu FS, Turgut B. Longitudinal study of changes in pulmonary function among inside attendants of hyperbaric oxygen therapy. Diving Hyperb Med 2025;55(1):11-17 (DOI 10.28920/dhm55.1.11-17).

PubMed · PMID 40090021 · DOI · PMC free full text

Canarslan Demir 2025

Medicina (Kaunas) · 2025 · Cohort / series

Canarslan Demir K, Avci AU, Ozgok Kangal MK, Ceylan B, Abayli SY, Ozler I, Yilmaz KB. Hyperbaric oxygen therapy for managing cancer treatment complications: a safety evaluation. Medicina (Kaunas) 2025;61(3):385.

PubMed · PMID 40142196 · DOI · PMC free full text

Canarslan-Demir 2025

Diving Hyperb Med · 2025 · Commentary / case

Canarslan-Demir K, Yel AK, Aydın G, Zaman T. Healing fragile bones: a case report on hyperbaric oxygen therapy in pycnodysostosis. Diving Hyperb Med 2025;55(2):191-194 (PMID 40544148. DOI 10.28920/dhm55.2.191-194).

PubMed · PMID 40544148 · DOI · PMC free full text

Cao 2020

Undersea and Hyperbaric Medicine · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Cao PH, Dang BQ, Nguyen TV, Nguyen LT. Platelet activation in rabbits with decompression sickness. Undersea and Hyperbaric Medicine 2020;47(4):597-605.

PubMed · PMID 33227836 · DOI

Cao 2025

EFORT Open Rev · 2025 · Meta-analysis

Cao Y, Tang P, Tan H, Ma W, Chai H, Lin B, Zhu Y, Xiao W, Wen T, Zhang J, Li Y, Liu S. Application of hyperbaric oxygen therapy in femoral head necrosis: a systematic review and meta-analysis. EFORT Open Rev 2025;10(7):466–474.

PubMed · PMID 40591670 · DOI · PMC free full text

Pre-post (within HBO): significant improvement — VAS pain MD −2.94 (P<0.0001), SF-12 PCS MD +17.28, Between-group (HBO vs non-HBO): NOT significant — SF-12 PCS MD −0.39 (P=0.92), SF-12 MCS +0.76

Capelli-Schellpfeffer & Gerber 1999

J Urol · 1999 · Review / background

According to. Capelli-Schellpfeffer M, Gerber GS. THE USE OF HYPERBARIC OXYGEN IN UROLOGY. J Urol 1999;162(3 Pt 1):647–654.

PubMed · PMID 10458334 · DOI

HBO is a treatment alternative for ischaemic processes unresponsive to conventional therapy; particularly useful for intractable haemorrhagic cystitis after pelvic radiation. Patient-selection factors and absolute contraindications (active viral disease, untreated pneumothorax, concurrent doxorubicin/cisplatin) discussed. Further investigation warranted for necrotising fasciitis (Fournier's gangrene), post-traumatic ischaemic…

Cardinal 2018

Curr Urol Rep · 2018 · Meta-analysis

Cardinal J, Slade A, McFarland M, Keihani S, Hotaling JN, Myers JB (University of Utah). Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis. Curr Urol Rep 2018;19(6):38.

PubMed · PMID 29654564 · DOI

13 studies, 602 patients who received HBO for hemorrhagic radiation cystitis (HRC); 84% had partial or complete resolution. Only 1 randomised study (2012); recent series confirmed safety/efficacy and identified predictors of success vs failure. Earlier HBO initiation and lower-grade haematuria tend to predict better response (risk factors for success/failure identified).

Carlson 1992

Ann Emerg Med · 1992 · RCT

Carlson S, Jones J, Brown M, Hess C. Prevention of hyperbaric-associated middle ear barotrauma. Ann Emerg Med 1992;21(12):1468–1471.

PubMed · PMID 1443845 · DOI

No reduction in middle-ear barotrauma with the decongestant — approximately the same proportion in No subject developed gross haemorrhage or tympanic-membrane rupture (Teed 5).

Carter 2026

Plast Reconstr Surg Glob Open · 2026 · Meta-analysis

Carter MJ, Eckert KA, Fife CE, Gelly HB. Systematic Review of Comparative Studies Evaluating Hyperbaric Oxygen Therapy on Skin Flap and Graft Surgical Indications. Plast Reconstr Surg Glob Open 2026;14(5):e7750.

PubMed · PMID 42199243 · DOI · PMC free full text

Four RCTs → significant overall effect on flap/graft survival within 4 weeks (log-OR 1.045, SE 0.31, Evidence levels very-low to moderate; 11 strong + 13 conditional recommendations, including a

Casillas 2019

Cureus · 2019 · Meta-analysis

Casillas S, Galindo A, Camarillo-Reyes LA, Varon J, Surani SR. Effectiveness of Hyperbaric Oxygenation Versus Normobaric Oxygenation Therapy in Carbon Monoxide Poisoning: A Systematic Review. Cureus 2019;11(10):e5916.

PubMed · PMID 31788375 · DOI · PMC free full text

Concludes HBO is effective in moderate-to-high-risk CO poisoning and should be the therapy of choice Acknowledges the literature is heterogeneous and conflicting — trials differ in severity thresholds,

Cavaliere 2022

Medicina (Kaunas) · 2022 · RCT

Cavaliere M, De Luca P, Scarpa A, et al. Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late? Medicina (Kaunas) 2022;58(10):1421.

PubMed · PMID 36295581 · DOI · PMC free full text

HBOT + OS and HBOT-alone groups both improved auditory function (p<0.05). Timing-dependent: HBOT was the best choice when started ≤7 days from onset; HBOT + OS was best Audiogram-shape dependent: downsloping and flat SSNHL improved most with HBOT + OS; upsloping did

Cebrián-López 2025

Diving Hyperb Med · 2025 · Commentary / case

Cebrián-López J, Jover-Díaz F, Infante-Urrios A, Piqueras-Vidal PM, Ortiz de la Tabla-Duccasse V. Post-traumatic wound infection after diving caused by Vibrio alginolyticus: a case report. Diving Hyperb Med 2025;55(2):199-202.

PubMed · PMID 40544150 · DOI · PMC free full text

Çevik 2020

Undersea Hyperb Med · 2020 · Cohort / series

Çevik MÖ, Bağli BS, Çevik SG. Hyperbaric oxygen treatment results in a group of Turkish central retinal artery occlusion patients with a combined presence of thrombophilic mutations. Undersea Hyperb Med 2020;47(1):65-73.

PubMed · PMID 32176948 · DOI

Chambers 2011

J Wound Care · 2011 · Review / background · MIXED human and preclinical evidence

Chambers AC, Leaper DJ. Role of oxygen in wound healing: a review of evidence. J Wound Care 2011;20(4):160-164.

PubMed · PMID 21537302 · DOI

Chandrinou 2020

Undersea Hyperb Med · 2020 · Cohort / series

Chandrinou A, Korompeli A, Grammatopoulou E, Gaitanou K, Tsoumakas K, Fildissis G. Avascular necrosis of the femoral head: Evaluation of hyperbaric oxygen therapy and quality of life. Undersea Hyperb Med 2020;47(4):561-569.

PubMed · PMID 33227832 · DOI

Chang 1973

Am J Roentgenol Radium Ther Nucl Med · 1973 · RCT

Chang CH, Conley JJ, Herbert C Jr (New York). RADIOTHERAPY OF ADVANCED CARCINOMA OF THE OROPHARYNGEAL REGION UNDER HYPERBARIC OXYGENATION: AN INTERIM REPORT. Am J Roentgenol Radium Ther Nucl Med 1973;117(3):509–516.

PubMed · PMID 4571282 · DOI

An interim analysis reporting increased tumour regression / local response in the HBO-radiotherapy

Chang 2026

Life (Basel) · 2026 · Cohort / series

Chang GH, Wong CH, Lee AT, Cheng YC, Liu WC. Stellate ganglion block combined with hyperbaric oxygen therapy for sudden sensorineural hearing loss: a retrospective three-arm study. Life (Basel) 2026;16(8):1349.

DOI

Khandelwal 2013 [slug 'chaudhary' is a legacy misnomer; first author is Khandelwal S]

Clin Pract · 2013 · RCT

Khandelwal S, Chaudhary P, Poddar DD, Saxena N, Singh RA, Biswal UC. Comparative Study of Different Treatment Options of Grade III and IV Diabetic Foot Ulcers to Reduce the Incidence of Amputations. Clin Pract 2013;3(1):e9.

PubMed · PMID 24765502 · DOI · PMC free full text

Complete healing: 40% (antiseptic) vs 60% (HBO) vs 80% (rhPDGF) — difference across groups Mean healing time similar (6.75 / 6.83 / 7.6 weeks; ANOVA P = 0.6534, NS). Confounder: the PDGF arm had larger mean baseline ulcers (9.90 vs 14.91 vs 19.26 cm²; P=0.059),

Chaushu 2023

Clin Otolaryngol · 2023 · Meta-analysis

Chaushu H, Ungar OJ, Abu Eta R, Handzel O, Muhanna N, Oron Y. Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss: A systematic review and meta‐analysis. Clin Otolaryngol 2023;48(3):395–402.

PubMed · PMID 36640119 · DOI

Pooled spontaneous recovery ≈ 60.28% (95% CI 38.88–79.94%), heterogeneity I²=86.0%. Conclusion: spontaneous recovery of ISSNHL is high (close to 60%) and should not be overlooked —

Chen 2003

Chang Gung Med J · 2003 · Cohort / series

Chen CE, Shih ST, Fu TH, Wang JW, Wang CJ. Hyperbaric Oxygen Therapy in the Treatment of Chronic Refractory Osteomyelitis: A Preliminary Report. Chang Gung Med J 2003;26(2):114–21.

PubMed · PMID 12718388

The wounds healed in 11 patients, a 79% success rate. No recurrence at an average follow-up of 15 Average number of HBO treatments: 33.6 (range, 30 to 60). Surgical procedures during HBO averaged 1.6 (range, 0 to 3), on top of the 5.4 performed before it.

Chen 2017

J Wound Ostomy Continence Nurs · 2017 · RCT

Chen CY, Wu RW, Hsu MC, Hsieh CJ, Chou MC. Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs 2017;44(6):536–545.

PubMed · PMID 28968346 · DOI

Complete ulcer closure: 25% (5/20) HBOT vs 5.5% (1/18) control (P=.001). Amputation rate: 5% HBOT vs 11% control (χ²=15.204, P=.010). Statistically significant improvements in inflammation index, wound blood flow, and HRQoL (SF-36)

Chen 2021

Undersea Hyperb Med · 2021 · Cohort / series

Chen C, Hu H, Chen RY. Varied effects exerted on sudden sensorineural hearing loss through HBO2 therapeutic pressure. Undersea Hyperb Med 2021;48(4):417-423.

PubMed · PMID 34847305

Chen / IWGDF 2023

Diabetes Metab Res Rev · 2024 · Guideline

Chen P, Vilorio NC, Dhatariya K, Jeffcoate W, Lobmann R, McIntosh C, Piaggesi A, Steinberg J, Vas P, Viswanathan V, Wu S, Game F (IWGDF Editorial Board). Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev 2024;40(3):e3644 (published online 2023-05-25).

PubMed · PMID 37232034 · DOI

The current IWGDF evidence-based guideline (GRADE method: PICO questions, systematic review, summary-of- judgement tables) on wound-healing interventions for diabetes-related foot ulcers — 29 recommendations. It is the update of the 2019 IWGDF guideline and thus supersedes the 2016 systematic review (evidence/game-2016-iwgdf) as the standing IWGDF position.

Chen 2024

Diabetes Metab Res Rev · 2024 · Systematic review

Chen P, Vilorio NC, Dhatariya K, Jeffcoate W, Lobmann R, McIntosh C, Piaggesi A, Steinberg J, Vas P, Viswanathan V, Wu S, Game F (IWGDF). Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review. Diabetes Metab Res Rev 2024;40(3):e3786.

PubMed · PMID 38507616 · DOI

RCT-only methodology (re-evaluating older studies against modern reporting/RoB standards); the graded For HBO, the paired guideline conditionally recommends adjunctive HBO in ischaemic/neuro-ischaemic DFU

Chen 2024

Int Wound J · 2024 · Review / background

(Retracted Publication). Chen XC, Chen HR, Lu SJ, et al. Retracted. PDF on file (marked RETRACTED). RETRACTED: Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis. Int Wound J 2024.

PubMed · PMID 38531355 · DOI · PMC free full text

Cheung 2017

Undersea Hyperb Med · 2017 · Commentary / case

Cheung B, Oreopoulos G, Evans AW, Katznelson R. Hyperbaric oxygen therapy in the treatment of ischemia-reperfusion injury following dialysis access-steal syndrome: case report. Undersea Hyperb Med 2017;44(5).

DOI

Chevasutho 2022

Diving and Hyperbaric Medicine · 2022 · Cohort / series

Chevasutho P, Premmaneesakul H, Sujiratana A. Descriptive study of decompression illness in a hyperbaric medicine centre in Bangkok, Thailand from 2015 to 2021. Diving and Hyperbaric Medicine 2022;52(4):277-280.

PubMed · PMID 36525685 · DOI · PMC free full text

Chi 2018

J R Army Med Corps · 2018 · RCT

Chi T-H, Chiang MC, Chen RF, Yuan CH. Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss? J R Army Med Corps 2018 (accepted 31 Oct 2017).

PubMed · PMID 29431146 · DOI

Early recovery (Siegel's criteria, days 8 and 13): no significant difference between groups. Final outcome: Group B (HBOT) 80.0% partial/complete recovery vs Group A 46.7% (P<0.05). No significant side effects in either group.

Chi 2026

Diving Hyperb Med · 2026 · Cohort / series

Chi YJ, Pan HY, Chuang PC, Cheng CY, Li HY, Wu MH. Changes in lung ultrasound presentation induced by breath-hold diving in a simulated depth competition at Taiwan. Diving Hyperb Med 2026;56(1):13-20.

PubMed · PMID 41875438 · DOI

Chiabo 2024

Br J Ophthalmol · 2024 · Cohort / series

Chiabo J, Kauert A, Casolla B, Contenti J, Nahon-Esteve S, Baillif S, Arnaud M. Efficacy and safety of hyperbaric oxygen therapy monitored by fluorescein angiography in patients with retinal artery occlusion. Br J Ophthalmol 2024;108(7):956–962.

PubMed · PMID 37722767 · DOI · PMC free full text

Retinal revascularisation on FA: 48.4% by day 14, 87.1% by day 21. Mean BCVA 1.51 → 1.10 logMAR at 1 month; 15/31 (48.4%) achieved the ≥0.3 logMAR endpoint. Safety: 6/31 (19.4%) minor barotrauma, none requiring discontinuation. Better response in

Chin 2001

Undersea Hyperb Med · 2001 · RCT

Chin KF, Xie YS, Abidia A, Laden G, Greenman J, Monson JRT, Grout P, McCollum PT. The relationship of hyperbaric oxygen therapy and vascular endothelial growth factor in diabetic patients with leg ulcers: a double-blind randomised controlled trial. Undersea Hyperb Med 2001;28(Suppl):63, abstract Q112, UHMS Annual Scientific Meeting, 14-16 June 2001, San Antonio, Texas.

HBOT 0005 · Not indexed in PubMed and no DOI — full text held in the practice wiki

No baseline VEGF difference between arms (376.5 ± 184.6 vs 424.7 ± 317.8 pg/ml; P=0.08). Within the oxygen arm, a significant drop in serum VEGF after the first cycle (P=0.008); no But no significant between-group difference in the summary measures (maximum decrease/increase,

Chin 2017

Undersea Hyperb Med · 2017 · Cohort / series

Chin W, Joo E, Ninokawa S, Popa DA, Covington DB. Efficacy of the U.S. Navy Treatment Tables in treating DCS in 103 recreational scuba divers. Undersea Hyperb Med 2017;44(5):399-405.

PubMed · PMID 29116694

Chmelař 2026

Med Gas Res · 2026 · Review / background

Chmelař D, Jor O, Tlapák J, Hájek M. Synergistic application of antibiotics and hyperbaric oxygen therapy. Med Gas Res 2026;16(2):176-177.

PubMed · PMID 40826942 · DOI · PMC free full text

Cho 2018

Audiology & Neurotology · 2018 · RCT

Cho I, Lee H-M, Choi S-W, Kong S-K, Lee I-W, Goh E-K, Oh S-J. Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial. Audiology & Neurotology 2018;23(4):199–207.

PubMed · PMID 30380530 · DOI

Study (HBOT) group had significantly better thresholds at 500 Hz (p<0.05) at 1 month and 1 kHz (p<0.05) Average PTA and PTA at 2, 4, 8 kHz: no significant difference. WDS improvement significantly higher with HBOT at 3 months (ITT 66.4% vs 56.7%, p=0.029;

Choi 2021

Undersea Hyperb Med · 2021 · Commentary / case

Choi S, Kim HH, Oh SB, Jung YS. Repetitive hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity after acute carbon monoxide poisoning. Undersea Hyperb Med 2021;48(4).

PubMed · PMID 34847307

Choi 2026

Medicina (Kaunas) · 2026 · Meta-analysis

Choi KK, Kim Y, Yon DK, Kang WS. Adjunctive hyperbaric oxygen therapy for severe traumatic limb injuries: a systematic review and meta-analysis. Medicina (Kaunas) 2026;62(8):1589.

PubMed · PMID 42654485 · DOI

Chong 2004

BJU Int · 2004 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Chong KT, Hampson NB, Bostwick DG, Vessella RL, Corman JM. Hyperbaric oxygen does not accelerate latent in vivo prostate cancer: implications for the treatment of radiation-induced haemorrhagic cystitis. BJU Int 2004;94(9):1275-1278.

PubMed · PMID 15610104 · DOI

Chong 2005

Urology · 2005 · Cohort / series

Chong KT, Hampson NB, Corman JM. Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis. Urology 2005;65(4):649-653.

PubMed · PMID 15833500 · DOI

Chong 2011

Diving Hyperb Med · 2011 · RCT

Chong SJ, Tan MK, Liang W, Kim SJ, Soh CR. Maintenance of negative-pressure wound therapy while undergoing hyperbaric oxygen therapy. Diving Hyperb Med 2011;41(3):147–150.

PubMed · PMID 21948500

No difference in pain scores between HBOT-with-NPWT and HBOT-without. NPWT continued to extract exudate during HBOT (5–12 mL aspirated). 5/6 patients had better dressing appearance when NPWT was maintained during HBOT (P=0.006), i.e.

Chong 2013

Diving Hyperb Med · 2013 · RCT

Chong SJ, Kan EM, Song C, Soh CR, Lu J. Characterization of early thermal burns and the effects of hyperbaric oxygen treatment: a pilot study. Diving Hyperb Med 2013;43(3):157–161.

PubMed · PMID 24122191

WBC and IL-1β, IL-4, IL-6, IL-10, IFN-γ were significantly elevated 24 h post-burn, but no significant HBOT had no significant effect on burn depth (LDI/histology). Recruitment much slower than planned → far fewer patients than intended (underpowered).

Chu 2025

Diving Hyperb Med · 2025 · Commentary / case

Chu H, Zhang X, Zhao H, Meng X, Wang D, Wang Y. Hyperbaric oxygen therapy for hypoglycaemic encephalopathy due to insulinoma: a case report. Diving Hyperb Med 2025;55(4):430-433.

PubMed · PMID 41364869 · DOI · PMC free full text

Chu 2026

Immun Ageing · 2026 · Cohort / series

Chu HT, Zhao H, Wang SS, Meng X, Wang D, Zhu XB, Wang Y, Yang XW. Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis. Immun Ageing 2026.

DOI

Chua 2022

Int Urol Nephrol · 2022 · Meta-analysis

Chua ME, Kim JJK, Ming JM, De Jesus MJ, See MC 4th, Bagli DJ, Rickard M, Koyle MA, Lorenzo AJ. The utilization of hyperbaric oxygenation therapy in hypospadias repair: a systematic review and meta-analysis. Int Urol Nephrol 2022;54(2):273-285.

PubMed · PMID 35024997 · DOI

Overall, from 576 cases (301 HBO against 275 control):

Chuck 2008

Int J Technol Assess Health Care · 2008 · Cohort / series

Chuck AW, Hailey D, Jacobs P, Perry DC. Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. Int J Technol Assess Health Care 2008;24(2):178–183.

PubMed · PMID 18400121 · DOI

HBO was cost-saving AND more effective (dominant): 12-year cost CND$40,695 with HBOT vs CND$49,786 Budget impact of treating prevalent Canadian DFU cases estimated at CND$14.4–19.7 million/year over

Chung & Ahn 2017

Undersea and Hyperbaric Medicine · 2017 · Cohort / series

Chung JM, Ahn JY. Relationship between clinical and radiologic findings of spinal cord injury in decompression sickness. Undersea and Hyperbaric Medicine 2017;44(1):57-62.

PubMed · PMID 28768086 · DOI

Churchill-Davidson 1955

Lancet · 1955 · Cohort / series

Churchill-Davidson I, Sanger C, Thomlinson RH. High-pressure oxygen and radiotherapy. Lancet 1955;268(6874):1091–1095.

PubMed · PMID 14382503 · DOI

The first clinical paper of the hyperbaric-radiotherapy era, and, through it, the first clinical paper of modern hyperbaric medicine. Its opening sentence describes it as "A PRELIMINARY investigation" into irradiating carcinomata in patients breathing oxygen at a pressure of three atmospheres absolute (30 lb. per square inch gauge pressure). The idea came from Gray et al. (1953), whose work on pla

Cianci 2013

Undersea Hyperb Med · 2013 · Review / background · MIXED human and preclinical evidence

Cianci P, Slade JB Jr, Sato RM, Faulkner J. Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns. Undersea Hyperb Med 2013;40(1):89–108.

PubMed · PMID 23397872

Reports a "significant and consistently positive body of evidence" that HBO prevents dermal States the vast majority of clinical reports show reduced mortality, length of stay, number of surgeries

Cianci 2021

Undersea Hyperb Med · 2021 · Review / background

Cianci P, Sato RM, Faulkner J. Hyperbaric oxygen for thermal burns. Undersea Hyperb Med 2021;48(4):449-468.

PubMed · PMID 34847309 · DOI

Cihan 2009

J Surg Oncol · 2009 · Commentary / case

Cihan YB, Uzun G, Yildiz S, Dönmez H. Hyperbaric oxygen therapy for radiation-induced brain necrosis in a patient with primary central nervous system lymphoma. J Surg Oncol 2009;100(8):732-735.

PubMed · PMID 19722227

Clarke 2008

Int J Radiat Oncol Biol Phys · 2008 · RCT

Clarke RE, Tenorio LMC, Hussey JR, Toklu AS, Cone DL, Hinojosa JG, et al. Hyperbaric Oxygen Treatment of Chronic Refractory Radiation Proctitis: A Randomized and Controlled Double-Blind Crossover Trial With Long-Term Follow-Up. Int J Radiat Oncol Biol Phys 2008;72(1):134–143.

PubMed · PMID 18342453 · DOI

Mean SOMA-LENT improvement nearly double with HBOT (5.00 vs 2.61, p=0.0019); group mean lower Responders by clinical assessment: 88.9% vs 62.5% (p=0.0009). Absolute risk reduction 32%, NNT 3 after initial allocation; ITT analysis stronger (p=0.0006).

Clarke 2017

Undersea Hyperb Med · 2017 · Commentary / case

Clarke R. Health care worker decompression sickness: incidence, risk and mitigation. Undersea Hyperb Med 2017;44(6):509-519.

PubMed · PMID 29281188 · DOI

Clarke 2020

Diving Hyperb Med · 2020 · Commentary / case

Clarke R. Monoplace chamber treatment of decompression illness: review and commentary. Diving Hyperb Med 2020;50(3):264-272.

PubMed · PMID 32957129 · DOI · PMC free full text

Clarke & Van Meter 2024

Undersea Hyperb Med · 2024 · Commentary / case

Clarke RE, Van Meter K. Medical and surgical management of pneumothorax in diving and hyperbaric chambers. Undersea Hyperb Med 2024;51(1):17-28.

PubMed · PMID 38615349

Clarke 2025

Undersea Hyperb Med · 2025 · Review / background

Clarke RE. Transcutaneous oximetry optimizes clinical management and cost-effectiveness of diabetic foot ulcers treated with hyperbaric oxygen: a review of point-of-care vascular screening options. Undersea Hyperb Med 2025;52(4):521-535.

PubMed · PMID 41429030

Cochlear implant and scuba 2018

Undersea Hyperb Med · 2018 · Commentary / case

Zeitler DM, Almosnino G, Holm JR. Stability of residual hearing and cochlear implant function following multiple scuba dives. Undersea Hyperb Med 2018;45(3):371-376.

PubMed · PMID 30028923

Coletti Giesler 2025

Front Immunol · 2025 · Commentary / case

Coletti Giesler KL. Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing. Front Immunol 2025;16:1564788.

PubMed · PMID 40837587 · DOI · PMC free full text

Columbo 2015

J Vasc Surg · 2015 · Cohort / series

Columbo JA, Ptak JA, Buckey JC, Walsh DB. Hyperbaric oxygen for patients with above-knee amputations, persistent ischemia, and nonreconstructable vascular disease. J Vasc Surg 2015;63(4):1082–1084.

PubMed · PMID 26033012 · DOI

All four patients healed their amputation stumps and were fit with prostheses. At most-recent follow-up, all were ambulating and using their prostheses — hip disarticulation averted.

Colvin 2024

Diving and Hyperbaric Medicine · 2024 · Commentary / case

Colvin AP, Hogg R, Wilmshurst PT. Shunt-mediated decompression sickness in a compressed air worker with an atrial septal defect. Diving and Hyperbaric Medicine 2024;54(2):127-132.

PubMed · PMID 38870955 · DOI · PMC free full text

Commons 2013

Diving Hyperb Med · 2013 · Cohort / series

Commons KH, Blake DF, Brown LH. A prospective analysis of independent patient risk factors for middle ear barotrauma in a multiplace hyperbaric chamber. Diving Hyperb Med 2013;43(3):143-147.

PubMed · PMID 24122189

Cooper 2009 (Part I)

Diving Hyperb Med · 2009 · Cohort / series

Cooper PD, Van den Broek C, Smart DR, Nishi RY, Eastman D. Hyperbaric chamber attendant safety I: Doppler analysis of decompression stress in multiplace chamber attendants. Diving Hyperb Med 2009;39(2):63-70.

PubMed · PMID 22753198

Cooper 2009

Diving Hyperb Med · 2009 · Cohort / series

Cooper PD, Van den Broek C, Smart DR. Hyperbaric chamber attendant safety II: 14-year staff health review of multiplace chamber attendants. Diving Hyperb Med 2009;39(2):71-76.

PubMed · PMID 22753199

Cooper 2025 (StatPearls)

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing · 2025 · Review / background

Cooper JS, Hanley ME, Hendriksen S. Hyperbaric treatment of chronic refractory osteomyelitis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2025:NBK430785.

Not indexed in PubMed and no DOI — full text held in the practice wiki

Costa 2019

Diving Hyperb Med · 2019 · Cohort / series

Costa DA, Ganilha JS, Barata PC, Guerreiro FG. Seizure frequency in more than 180,000 treatment sessions with hyperbaric oxygen therapy — a single centre 20-year analysis. Diving Hyperb Med 2019;49(3):167-174.

PubMed · PMID 31523791 · DOI · PMC free full text

Cronje 1998

SADJ (South African Dental Journal) · 1998 · Review / background

Cronje FJ. A review of the Marx protocols: prevention and management of osteoradionecrosis by combining surgery and hyperbaric oxygen therapy. SADJ (South African Dental Journal) 1998;53(10):469-471.

PubMed · PMID 10023268

Cuccia 2026

Support Care Cancer · 2026 · Systematic review

Cuccia F, Cracchiolo AN, Piras A, et al. Between hope and uncertainty: the elusive evidence on hyperbaric oxygen therapy and radiotherapy. Support Care Cancer 2026;34(2):157.

PubMed · PMID 41627499 · DOI

42 studies, 2785 patients (28 retrospective, 5 RCTs); median 34.5 sessions at 2.45 atm. Pelvic district largest cohort; high response rates (67–100%) for haemorrhagic cystitis. Breast and head-and-neck: RCTs failed to show consistent benefit (QoL/toxicity improved only in retrospective reports).

CUHMA 2015

Canadian Undersea and Hyperbaric Medical Association, First Edition · 2015 · Guideline

LeDez KM (editor); Standards of Practice and Patient Safety Committee: LeDez K (Chair), Evans W, Wherrett C, Doherty P, Boisvert J, Bateman B, Linden R, Harrison D, Katznelson R. Other contributors: Burman F, LeGros T, Murphy PS, Gericke D. Guidelines to the Practice of Clinical Hyperbaric Medicine and Provision of Hyperbaric Oxygen Treatment. Canadian Undersea and Hyperbaric Medical Association, First Edition 2015:1-73.

HBOT 0060 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Currens 2025

Diving Hyperb Med · 2025 · Cohort / series

Currens JB, Doolette DJ, Murphy FG. Venous gas emboli (VGE) in 2-D echocardiographic images following movement: grading and association with cumulative incidence of decompression sickness. Diving Hyperb Med 2025;55(1):44-50.

PubMed · PMID 40090025 · DOI · PMC free full text

Currie 2024

Diving and Hyperbaric Medicine Journal · 2024 · Cohort / series

Currie JR, Gawthrope IC, Banham ND. The use of hyperbaric oxygen for avascular necrosis of the femoral head and femoral condyle: a single centre’s experience over 30 years. Diving and Hyperbaric Medicine Journal 2024;54(2):92-96 (DOI 10.28920/dhm54.2.92-96).

PubMed · PMID 38870950 · DOI · PMC free full text

Cvorovic 2013

Otology & Neurotology · 2013 · RCT

Cvorovic L, Jovanovic MB, Milutinovic Z, Arsovic N, Djeric D. Randomized Prospective Trial of Hyperbaric Oxygen Therapy and Intratympanic Steroid Injection as Salvage Treatment of Sudden Sensorineural Hearing Loss. Otology & Neurotology 2013;34(6):1021–1026.

PubMed · PMID 23820795 · DOI

Significant improvement in hearing thresholds at all frequencies before vs after HBO treatment. HBO and IT steroid gave similar salvage results overall. Subgroups with PTA <81 dB and age <60 responded better to HBO than profoundly deaf / elderly patients.

D'hoore 2025

Diving Hyperb Med · 2025 · RCT

D'hoore L, Germonpré P, Rinia B, Caeyers L, Stevens N, Balestra C. Effect of normobaric and hyperbaric hyperoxia treatment on symptoms and cognitive capacities in Long COVID patients: a randomised placebo-controlled, prospective, double-blind trial. Diving Hyperb Med 2025;55(2):104-113 (PMID 40544138. DOI 10.28920/dhm55.2.104-113).

PubMed · PMID 40544138 · DOI · PMC free full text

Dağ 2026

Diving Hyperb Med · 2026 · Commentary / case

Dağ U, Dertsiz Kozan B, Engin Egeren S, Öncül H, Çağlayan M, Fuat Alakuş M. Spontaneous resolution of choroidal neovascular membrane in the fellow eye during hyperbaric oxygen treatment for retinal artery occlusion: a case report. Diving Hyperb Med 2026;56(2):195-197.

PubMed · PMID 42290581 · DOI

Damineni 2025

Cureus · 2025 · Systematic review

Damineni U, Divity S, Gundapaneni SRC, Burri RG, Vadde T. Clinical outcomes of hyperbaric oxygen therapy for diabetic foot ulcers: a systematic review. Cureus 2025;17(2):e78655.

PubMed · PMID 40062051 · DOI · PMC free full text

da Mota Neto 2026 (HOTFy)

BMJ Open · 2026 · RCT

da Mota Neto J, et al. HOTFy: a randomised clinical trial for hyperbaric oxygen therapy in fibromyalgia. BMJ Open 2026 (DOI 10.1136/bmjopen-2025-112284).

PubMed · PMID 42225366 · DOI · PMC free full text

Danan 2025

Brain Behav · 2025 · Review / background

Danan D, Grosskopf Y, Mayo A, Efrati S, Kutz I, Lang E, Alon U, Doenyas-Barak K. Hyperbaric oxygen therapy for PTSD: threshold effect for sustained symptom improvement in a biologically based treatment. Brain Behav 2025;15(8):e70757.

PubMed · PMID 40847457 · DOI · PMC free full text

Daneshi 2026

Br J Surg · 2026 · Meta-analysis

Daneshi K, Dhariwal S, Najafali D, Gokani VJ, Egro FM. Assessing the Clinical Outcomes of Hyperbaric Oxygen Therapy in Burn Patients: A Systematic Review and Meta-Analysis. Br J Surg 2026;abstract 553(Abstract citation ID znag063.004):vi2.

DOI

Dapena 2020

Diving Hyperb Med · 2020 · Commentary / case

Dapena JC, Lansdorp CA, Mitchell SJ. Persistent extravascular bubbles on radiologic imaging after recompression treatment for decompression sickness: a case report. Diving Hyperb Med 2020;50(4):424-430.

PubMed · PMID 33325027 · DOI · PMC free full text

Dauwe 2014

Plast Reconstr Surg · 2014 · Systematic review

Dauwe PB, Pulikkottil BJ, Lavery L, Stuzin JM, Rohrich RJ (UT Southwestern, Dallas). Does Hyperbaric Oxygen Therapy Work in Facilitating Acute Wound Healing: A Systematic Review. Plast Reconstr Surg 2014;133(2):208e–215e.

PubMed · PMID 24469192 · DOI

Eight studies (level III and above) on adjunctive HBO for complicated acute wounds, flaps and grafts. HBO increases tissue oxygenation and aids difficult-wound healing; the literature supports chronic-wound use more strongly than acute-wound / flap / graft use.

de Guzman 2026

Preprints.org · 2026 · Review / background

de Guzman RC, Arora B, Kim SB, Shivji MA, de Guzman HC, Oropallo AR. Chronic wounds from skin biology to evidence-based management. Preprints.org 2026.

DOI

Dejonckheere 2026

CA Cancer J Clin · 2026 · Review / background

Dejonckheere CS, Käsmann L, Schmeel LC, Walter S, Anzböck T, Dreyer S, Sarria GR, Gkika E, Layer JP. Hyperbaric oxygen therapy for chronic radiotherapy-related adverse effects: A clinically focused review. CA Cancer J Clin 2026;76(1):e70058.

PubMed · PMID 41385271 · DOI · PMC free full text

Covers the shared hypoxia/fibrosis pathophysiology and HBOT's role across ORN, radiation cystitis, Notes the ECHM (European Committee for Hyperbaric Medicine) consensus recommends HBO use for these

Demir 2022

Undersea Hyperb Med · 2022 · Cohort / series

Demir L, Avci M. Effect of hyperbaric exposure on pulmonary functions in hyperbaric chamber inside attendants. Undersea Hyperb Med 2022;49(3).

PubMed · PMID 35580483

Demir 2024

Ulus Travma Acil Cerrahi Derg · 2024 · Cohort / series

Demir L, Öztürk M. Use of hyperbaric oxygen therapy in severe earthquake injuries. Ulus Travma Acil Cerrahi Derg 2024;30(3):185-191 (DOI 10.14744/tjtes.2024.60979 — journal, volume, issue and page range read off the publisher PDF on 2026-08-06; the Zotero record had no journal and gave the first page as 184).

PubMed · PMID 38506387 · DOI · PMC free full text

Demir 2024

Undersea Hyperb Med · 2024 · Commentary / case

Demir L. Does hyperbaric chamber attendance pose an asthma risk? Case report. Undersea Hyperb Med 2024;51(4):387-391 (DOI 10.22462/727).

DOI

DeMis 2023

Undersea Hyperb Med · 2023 · Commentary / case

DeMis J, Keuski BM, Due A. Hyperbaric treatment deviations for U.S. Navy divers: Spinal DCS. Undersea Hyperb Med 2023;50(4):383-390 (DOI 10.22462/613).

DOI

Denton 2002

Br J Cancer · 2002 · Systematic review

Denton AS, Andreyev HJN, Forbes A, Maher EJ. Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer 2002;87(2):134–143.

PubMed · PMID 12107832 · DOI · PMC free full text

63 studies (6 RCTs) of non-surgical late-radiation-proctitis interventions; RCTs covered anti-inflammatory combinations, rectal steroids, sucralfate, SCFA enemas and thermal therapy — not directly comparable, so no standard management could be recommended. HBO is reviewed as one non-surgical option (angiogenic mechanism; a results table of the then-available HBO series) but was not among the RCTs and yields no pooled comparati…

Dequanter 2013

Undersea Hyperb Med · 2013 · Cohort / series

Dequanter D, Jacobs D, Shahla M, Paulus P, Aubert C, Lothaire P. The effect of hyperbaric oxygen therapy on treatment of wound complications after oral, pharyngeal and laryngeal salvage surgery. Undersea Hyperb Med 2013;40(5).

PubMed · PMID 24224281

Dereli 2024

Diving Hyperb Med · 2024 · Commentary / case

Dereli D, Çakiroğlu S, Köse AA, Tokar B. Hyperbaric oxygen treatment in bilateral orchiopexy and post-circumcision haematoma in a thrombocytopenic patient with Noonan syndrome. Diving Hyperb Med 2024;54(2):133-136 (DOI 10.28920/dhm54.2.133-136).

PubMed · PMID 38870956 · DOI · PMC free full text

de Smet 2017

Wound Repair Regen · 2017 · Systematic review · MIXED human and preclinical evidence

de Smet GHJ, Kroese LF, Menon AG, Jeekel J, van Pelt AWJ, Kleinrensink GJ, Lange JF. Oxygen therapies and their effects on wound healing. Wound Repair Regen 2017;25(4):591–608.

PubMed · PMID 28783878 · DOI

65 studies: 17 local oxygen therapy (of which 7 tested an oxygen dressing), 29 HBOT, 16 perioperative inspired oxygen, 1 testing both TWO2 and HBOT and 2 testing other oxygen therapies. 18 of the 29 HBOT studies (62%) reported ≥1 significant positive wound-healing outcome; the abstract rounds this to 63%. The 77% figure in the abstract belongs to the local oxygen group, not to HBOT, and only "a minority" of the supplemental-in…

Devaney 2024

Diving Hyperb Med · 2024 · Commentary / case

Devaney B. Equipoise: an important ethical consideration when contemplating participation in a randomised controlled trial of hyperbaric oxygen treatment in necrotising soft tissue infections. Diving Hyperb Med 2024;54(1):57-60.

PubMed · PMID 38507910 · DOI · PMC free full text

Devaney 2025

Diving Hyperb Med · 2025 · Review / background

Devaney B, Wackett JPC, Ma N, Nguyen A, Yogaraj V, Hedetoft M, Hyldegaard O, Burrell A, Mitra B. Core outcome set for research in necrotising soft tissue infection patients: an international, multidisciplinary, modified Delphi consensus study. Diving Hyperb Med 2025;55(2):91-103.

PubMed · PMID 40544137 · DOI · PMC free full text

Devaney 2025b

Diving Hyperb Med · 2025 · Commentary / case

Devaney B, Mathew J, Ferris S, Roberts L, Covelli C, Orosz J, et al. Novel use of hyperbaric oxygen treatment for treatment-resistant disseminated Saksenaea and Fusarium in a patient on extracorporeal membrane oxygenation (ECMO): a case report. Diving Hyperb Med 2025;55(4):309-314 (DOI 10.28920/dhm55.4.309-314).

PubMed · PMID 41364853 · DOI · PMC free full text

De Wolde 2021

Biomolecules · 2021 · Systematic review

De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA. The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis. Biomolecules 2021;11(8):1210.

PubMed · PMID 34439876 · DOI · PMC free full text

✅ What the review actually reports, quoting its own abstract: HBOT-induced oxidative stress ⛔ HIF-1α and NF-κB were INHIBITED, not activated. The paper states it plainly: ⛔ "Hormetic" and "Nrf2" were this library's words, not the paper's. The word hormetic appears

Di Vincenzo 2022

Undersea Hyperb Med · 2022 · Cohort / series

Di Vincenzo H, Kauert A, Martiano D, Chiabo J, Di Vincenzo D, Sozonoff I, Baillif S, Martel A. Efficacy and safety of a standardized hyperbaric oxygen therapy protocol for retinal artery occlusion. Undersea Hyperb Med 2022;49(4):495-505.

PubMed · PMID 36446295 · DOI

Diacono 2022

Diving and Hyperbaric Medicine · 2022 · Commentary / case

Diacono E, Magri K. Recurrent dysbarism presenting with amnesia and hypoaesthesia in a professional breath-hold diver. Diving and Hyperbaric Medicine 2022;52(3):213-216.

PubMed · PMID 36100933 · DOI · PMC free full text

Dilip 2018

Undersea Hyperb Med · 2018 · Commentary / case

Dilip M, Bielawski A, Owen E. Hyperbaric oxygen therapy for cerebral air gas embolism following orthotopic heart transplant: case report. Undersea Hyperb Med 2018;45(6):685-688.

DOI

Diop 2026

Med Gas Res · 2026 · Review / background

Diop S, Mounier R. Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting. Med Gas Res 2026;16(1):53-58.

PubMed · PMID 40580189 · DOI · PMC free full text

Dische 1973

Br J Radiol · 1973 · RCT

Dische S. The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the bladder. Br J Radiol 1973;46(541):13–17.

PubMed · PMID 4566856 · DOI

No benefit was found from hyperbaric oxygen in the bladder-carcinoma series. (Some apparent differences were confounded by case selection; results did not reach a significant

Dische 1974

Br J Radiol · 1974 · RCT

Dische S. The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the uterine cervix. Br J Radiol 1974;47:99–107.

PubMed · PMID 4817463 · DOI

An early survival advantage of ~20% in favour of oxygen at 1 year was seen, but this was lost by 3 Local failure rate lower with oxygen in the early years, but not statistically significant. Significant late morbidity in small/large intestine (incl. rectum) in a few cases; no difference in

Dische 1999

Radiother Oncol · 1999 · RCT

Dische S, Saunders MI, Sealy R, Werner ID, Verma N, Foy C, Bentzen SM. Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial. Radiother Oncol 1999;53(2):93–98.

PubMed · PMID 10665784 · DOI

No advantage in tumour control was shown with hyperbaric oxygen. Evidence for an increase in late morbidity with hyperbaric oxygen.

Doctor 1992

J Postgrad Med · 1992 · RCT

Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med 1992;38(3):112–114.

PubMed · PMID 1303408

Faster control of infection with HBO: positive cultures fell from 19→3 in the study group vs Fewer major amputations: 2 (study) vs 7 (control), P<0.05. Average hospital stay was not significantly affected.

Doguchi 2014

J Toxicol Pathol · 2014 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Doguchi H, Saio M, Kuniyoshi S, Matsuzaki A, Yoshimi N. The enhancing effects of hyperbaric oxygen on mouse skin carcinogenesis. J Toxicol Pathol 2014;27(1):67-72.

PubMed · PMID 24791069 · DOI · PMC free full text

Domachevsky 2007

Eur Arch Otorhinolaryngol · 2007 · Commentary / case

Domachevsky L, Keynan Y, Shupak A, Adir Y. Hyperbaric oxygen in the treatment of sudden deafness. Eur Arch Otorhinolaryngol 2007;264:951-953.

DOI

Doolette 2004

SPUMS J · 2004 · Cohort / series

Doolette DJ, Goble SJ, Pirone CJ. Health outcome of hyperbaric-chamber inside attendants following compressed-air exposure and oxygen decompression. SPUMS J 2004;34(2):63-67.

HBOT 0037 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Doolette 2019 letter with Arieli 2019 reply

Diving and Hyperbaric Medicine · 2019 · Commentary / case · MIXED human and preclinical evidence

Doolette DJ. Gas micronuclei that underlie decompression bubbles and decompression sickness have not been identified [letter]; reply: Gas micronuclei that underlie decompression bubbles and decompression sickness have most probably been identified — in response to the Letter to the Editor from Dr David Doolette. Diving and Hyperbaric Medicine 2019;49(1):64.

PubMed · PMID 30856670 · DOI · PMC free full text

Dova 2022

Am J Otolaryngol · 2022 · Cohort / series

Dova S, Psillas G, Tsaligopoulos M, et al. The effectiveness of hyperbaric oxygen therapy on the final outcome of patients with sudden sensorineural hearing loss. Am J Otolaryngol 2022;43(5):103564.

PubMed · PMID 35952529 · DOI

No significant difference: hearing-improvement rate 64% (SS+HBOT) vs 56% (SS) — P=0.369. No significant difference within any disease-severity subgroup. A descending-type audiogram was an unfavourable prognostic factor (significantly lower gain,

Du 2024

Adv Skin Wound Care · 2024 · Meta-analysis

Du X, Zhang X, Liu J, Wang Z. Effects of Oxygen Therapy on Patients with a Chronic Wound: A Systematic Review and Meta-analysis. Adv Skin Wound Care 2024;37(5):1–9.

PubMed · PMID 38648247 · DOI

Short-term wound healing: RR 1.54 (95% CI 1.20–1.99) favouring oxygen therapy. Amputation rate: RR 0.53 — lower with oxygen therapy. Also: greater percentage reduction in ulcer size, shorter healing time, and higher post-study

Dubois 2026

Diving Hyperb Med · 2026 · Guideline

Dubois C, Hentzen C, Schnitzler A, Daubresse L, Morin J. Evidence-based guidelines for long-term care in spinal cord-related decompression illness. Diving Hyperb Med 2026;56(2):161-169.

PubMed · PMID 42290576 · DOI

Ducassé 1995

Undersea Hyperb Med · 1995 · RCT

Ducassé JL, Celsis P, Marc-Vergnes JP. Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation? Undersea Hyperb Med 1995;22(1):9–15.

PubMed · PMID 7742714

After the initial 2 h, the HBO group had significant improvement in clinical and biological Carboxyhaemoglobin normalised in both groups after the shared 10 h NBO — but at 3 weeks the NBO group Authors conclude HBO reduces time to initial recovery and the number of delayed functional

Dugrenot 2022

Diving and Hyperbaric Medicine · 2022 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Dugrenot E, Orsat J, Guerrero F. Blood pressure in rats selectively bred for their resistance to decompression sickness. Diving and Hyperbaric Medicine 2022;52(2):119-125.

PubMed · PMID 35732284 · DOI · PMC free full text

Dulai 2018

Am J Gastroenterol · 2018 · RCT

Dulai PS, Buckey JC Jr, Raffals LE, Swoger JM, Claus PL, O'Toole K, Ptak JA, Gleeson MW, Widjaja CE, Chang JT, Adler JM, et al. Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial. Am J Gastroenterol 2018;113(10):1516–1523.

PubMed · PMID 29453383 · DOI

Clinical remission at days 5 and 10: 50% (HBOT) vs 0% (sham), p=0.04. Less progression to second-line therapy during admission: 10% vs 63%, p=0.04. Fewer in-hospital colectomies: 0% vs 38%, p=0.07 (trend). No serious adverse events.

Dunford 2020

Undersea and Hyperbaric Medicine · 2020 · Cohort / series

Dunford RG, Denoble PD, Forbes R, Pieper CF, Howle LE, Vann RD. A study of decompression sickness using recorded depth-time profiles. Undersea and Hyperbaric Medicine 2020;47(1):75-91.

PubMed · PMID 32176949 · DOI

Duong-Quy 2026

Pulm Ther · 2026 · Systematic review

Duong-Quy S, Hoc TV, Nguyen-Duy T, Tang-Thi-Thao T, Nguyen-Van T, Huynh-Anh T, Mai-Xuan T, Tran-Quang P, Nguyen-Ba V, et al. Hyperbaric Oxygen Therapy and Its Physio-Mechanical Effects on Sleep Breathing Disorder: A Systematic Review. Pulm Ther 2026;12(1):39-55 (epub 28 Nov 2025; volume 12(1) is the 2026 issue).

PubMed · PMID 41315164 · DOI · PMC free full text

du Toit 1985

S Afr Med J · 1985 · Cohort / series

du Toit DF, Pretorius CF, Esterhuizen N, du Toit LB. Gasgangreen: 'n bespreking van 3 gevalle en literatuuroorsig. S Afr Med J 1985;68(10):760-2 (Authors, title, journal, year, volume and page range are ALL printed in the article itself — the English summary block on printed page 760 ends 'S Afr Med J 1985; 68: 760-762', and the running heads read '760 SAMJ VOLUME 68 9 NOVEMBER 1985', 'SAMT DEEL 68 9 NOVEMBER 1985 761' and '762 SAMJ VOLUME 68 9 NOVEMBER 1985' The ISSUE number 10 is the only field NOT printed in the scan; it comes from PubMed. There is NO DOI — SAMJ of 1985 predates DOI assignment and none is findable.).

PubMed · PMID 2865825

Duzgun 2008

J Foot Ankle Surg · 2008 · RCT

Duzgun AP, Satır HZ, Ozozan O, Saylam B, Kulah B, Coskun F. Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers. J Foot Ankle Surg 2008;47(6):515–519.

PubMed · PMID 19239860 · DOI

Major (proximal-to-MTPJ) amputation: 0% (HBOT) vs 34% (ST), P<0.05. Far less need for operating-room management: ~16% (HBOT) vs 100% (ST) required OR intervention to HBOT-group ulcers were more likely to heal; where amputation was still needed it was more distal

EBAss/ECHM 2008

EBAss / European Committee for Hyperbaric Medicine · 2008 · Review / background

European Baromedical Association for Nurses, Operators and Technicians (EBAss). Education of nurses, operators and technicians in hyperbaric facilities in Europe: EBAss/ECHM Resources manual. EBAss / European Committee for Hyperbaric Medicine 2008:1-18.

HBOT 0042 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Eckert 2025

Undersea Hyperb Med · 2025 · Systematic review

Eckert KA, Fife CE, Carter MJ. Systematic Review of Hyperbaric Oxygen for Late Radiation Tissue Injury (Bowel, Bladder). Undersea Hyperb Med 2025;52(3):313–325.

PubMed · PMID 41223393

3 RCTs, 273 subjects — two double-blind (rectal symptoms), one open (cystitis). One low risk of bias, two Moderate certainty, weak recommendation for HBO for rectal complications or cystitis — decision is Beneficial effect on rectal and bladder LRTI confirmed at moderate certainty despite heterogeneity.

Edinguele 2020

Undersea Hyperb Med · 2020 · Cohort / series

Edinguele WFOP, Barberon B, Poussard J, Thomas E, Reynier JC, Coulange M. Middle-ear barotrauma after hyperbaric oxygen therapy: a five-year retrospective analysis on 2,610 patients. Undersea Hyperb Med 2020;47(2):217-228.

PubMed · PMID 32574438

Edney 2019

Undersea and Hyperbaric Medicine · 2019 · Cohort / series · MIXED human and preclinical evidence

Edney J, Loveman G, Seddon F, Thacker J, Jurd K. Prediction of signs/symptoms of decompression sickness following submarine tower escape. Undersea and Hyperbaric Medicine 2019;46(1):17-33.

PubMed · PMID 31154682

Edvinsson 2021

Diving and Hyperbaric Medicine · 2021 · Cohort / series

Edvinsson B, Thilén U, Nielsen NE, Christersson C, Dellborg M, Eriksson P, Hlebowicz J. Does persistent (patent) foramen ovale closure reduce the risk of recurrent decompression sickness in scuba divers? Diving and Hyperbaric Medicine 2021;51(1):63-67.

PubMed · PMID 33761542 · DOI · PMC free full text

Efrati 2009

Undersea Hyperb Med · 2009 · RCT

Efrati S, Gall N, Bergan J, Fishlev G, Bass A, Berman S, Abu-Hamad R, Feigenzon M, Weissgarten L. Hyperbaric oxygen, oxidative stress, NO bioavailability and ulcer oxygenation in diabetic patients. Undersea Hyperb Med 2009;36(1):1–12.

PubMed · PMID 19341122

34% (17/50) had an insufficient TcPO₂ rise during HBO; in them TAOS and NO fell and MDA rose — NAC attenuated these changes (raised TAOS/NO, lowered MDA) and improved oxygenation; in the In the 66% with a sufficient TcPO₂ rise, TAOS rose and MDA fell regardless of NAC; cure rate 82%

Eggert 2016

Undersea Hyperb Med · 2016 · Cohort / series

Eggert JV, Worth ER, Van Gils CC. Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner grade 3 or 4 diabetic foot ulcers. Undersea Hyperb Med 2016;43(1) (PMID 27000008).

PubMed · PMID 27000008

Eggleton 2015

Chronic Wound Care Manag Res · 2015 · Review / background

Eggleton P, et al. Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Manag Res 2015;2:81-93.

DOI

Ekici 2025

Diving Hyperb Med · 2025 · Cohort / series

Ekici M, Mazlum EC, Laçin MB, Akçin ME, Günay AE, Ozan F. The effect of hyperbaric oxygen therapy on lesion size in early-stage femoral head avascular necrosis. Diving Hyperb Med 2025;55(3):226-230 (DOI 10.28920/dhm55.3.226-230).

PubMed · PMID 40986917 · DOI · PMC free full text

El Hadji 2025

Radiat Oncol · 2025 · Systematic review

El Hadji S, Teguh DN, Ridderikhof ML. Hyperbaric oxygen therapy for late radiation tissue toxicity injury after head and neck cancer: a systematic review of the literature. Radiat Oncol 2025;20(1):149.

PubMed · PMID 41044659 · DOI · PMC free full text

HBOT presented across the included studies as a reliable and safe treatment for LRTTI in HNC; beneficial Includes the Annane ORN trial (RR 0.60; 95% CI 0.25–1.41; p=0.23 — not significant), illustrating the

Elder 2017

Diving Hyperb Med · 2017 · Cohort / series

Elder MJ, Rawstron JA, Davis M. Hyperbaric oxygen in the treatment of acute retinal artery occlusion. Diving Hyperb Med 2017;47(4):233-238.

PubMed · PMID 29241233 · DOI · PMC free full text

A retrospective clinical audit, not a trial. Between early 2003 and December 2012, every patient presenting to Christchurch Hospital with acute retinal artery occlusion (ARAO) was referred for consideration of hyperbaric oxygen; 31 consecutive patients' records were reviewed. The study was discussed formally with the New Zealand Ministry of Health and designated an audit. Follow-up ranged from one

Elfil 2025

Can J Neurol Sci · 2025 · Meta-analysis

Elfil M, Sabet H, Abbas A, Bayoumi A, Ghaith HS, et al. Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. Can J Neurol Sci 2025 (online ahead of print):1-10.

PubMed · PMID 40739887 · DOI

HBOT was associated with improved best-corrected visual acuity (BCVA): MD −0.63 (95% CI −1.14 to Lower rates of neovascular glaucoma (7.9% vs 15.8%) and stroke (4.3% vs 16.6%) in the HBOT

El-Rabbany 2019

Cochrane Database Syst Rev · 2019 · Cochrane review

El-Rabbany M, Duchnay M, Raziee HR, Zych M, Tenenbaum H, Shah PS, Azarpazhooh A. Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy. Cochrane Database Syst Rev 2019;(11):CD011559.

PubMed · PMID 31745986 · DOI · PMC free full text

HBO + antibiotics vs antibiotics alone after dental extraction: fewer ORN with HBO — RR 0.18 (Marx 1985: 2/37 vs 11/37 at 6 months). Very low certainty. HBO + antibiotics vs antibiotics alone before dental implant placement: no benefit — RR 3.00 (0/13 vs event in HBO arm; wide CI, 1-year). Very low certainty. Overall: evidence uncertain due to suboptimal reporting and inadequate sample sizes; more well-designed RCTs needed. Ma…

Elraiyah 2016

J Vasc Surg · 2016 · Meta-analysis

Elraiyah T, Tsapas A, Prutsky G, Domecq JP, Hasan R, Firwana B, Nabhan M, Prokop L, Hingorani A, Claus PL, Steinkraus LW, Murad MH. A systematic review and meta-analysis of adjunctive therapies in diabetic foot ulcers. J Vasc Surg 2016;63(2 Suppl):46S–58S.

PubMed · PMID 26804368 · DOI

Adding HBOT to conventional therapy (wound care + offloading) was associated with increased healing — Peto odds ratio 14.25 (wide 95% CI; large effect) — and with a reduced amputation rate versus conventional therapy. Overall: low- to moderate-quality evidence supports HBOT as an adjunct to enhance DFU healing and potentially prevent amputation (arterial pump/pharmacologic agents less supported).

Elsharnoby 2022

Int J Low Extrem Wounds · 2022 · Cohort / series

Elsharnoby AM, El-Barbary AH, Eldeeb AE, Hassan HA. Resistant Chronic Venous Leg Ulcers: Effect of Adjuvant Systemic Hyperbaric Oxygen Therapy Versus Venous Intervention Alone. Int J Low Extrem Wounds 2022;24(2):444–451.

PubMed · PMID 35578536 · DOI

Area reduction: no significant difference at 3 months; significant difference favouring HBO at 6 Complete closure at 12 months: 83.3% (HBO) vs 53.8% (venous intervention alone), P=0.02 (at 3 Mean time to complete closure significantly shorter with HBO (P=0.001); positive correlation

Emmerton 2024

Diving and Hyperbaric Medicine Journal · 2024 · Review / background

Emmerton W, Banham ND, Gawthrope IC. Survey comparing the treatment of central retinal artery occlusion with hyperbaric oxygen in Australia and New Zealand with the recommended guidelines as outlined by the Undersea and Hyperbaric Medical Society. Diving and Hyperbaric Medicine Journal 2024;54(2):97-104 (DOI 10.28920/dhm54.2.97-104).

PubMed · PMID 38870951 · DOI · PMC free full text

Ennis 2018

Adv Wound Care (New Rochelle) · 2018 · Cohort / series

Ennis WJ, Huang ET, Gordon H. Impact of Hyperbaric Oxygen on More Advanced Wagner Grades 3 and 4 Diabetic Foot Ulcers: Matching Therapy to Specific Wound Conditions. Adv Wound Care (New Rochelle) 2018;7 (Mary Ann Liebert).

PubMed · PMID 30671282 · DOI · PMC free full text

Population-level mITT healing across all 2,651,878 wounds of every aetiology was 74.2% (74.16% in Table 1); for wounds classified as diabetic it was 70.9% (328,158/462,888; 70.89% mITT); the Wagner 3–4 subgroup healed only 56.04%. ⚠️ Corrected 31 Aug 2026: this bullet previously read "Population-level DFU healing 74.2%". The paper's 74.2% is the population-level mITT healing rate for ALL wounds of every aetiology — "During the…

Ercan 2020

Undersea and Hyperbaric Medicine · 2020 · Cohort / series

Ercan E, Demir AE, Sabaner E, Toklu AS. Incidence of decompression sickness in hypobaric hypoxia training. Undersea and Hyperbaric Medicine 2020;47(2):203-210.

PubMed · PMID 32574436

Ersoz 2016

Undersea Hyperb Med · 2016 · RCT

Ersoz F, Arikan S, Sari S, Korpinar S, Ozcan O, Poyraz B, Purisa S, Toklu AS. Effect of hyperbaric oxygen treatment on pilonidal disease surgery. Undersea Hyperb Med 2016;43(7).

PubMed · PMID 28777519

Wound healing time significantly shorter with HBO: 50 ± 11 days (Group 2) vs 83 ± 18 days (Group 1),

Eryigit 2018

Eur Arch Otorhinolaryngol · 2018 · Systematic review

Eryigit B, Ziylan F, Yaz F, Thomeer HGXM (UMC Utrecht). The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review. Eur Arch Otorhinolaryngol 2018;275(12):2893–2904.

PubMed · PMID 30324404 · DOI · PMC free full text

Systematic review (studies 2002–2018; English/Dutch/German). Whole ISSHL group: no significant difference between HBO (+steroid) and control. Severe/profound (≥81 dB): significant benefit of HBO + systemic steroid (treatment effect p=0.005; higher mean

Escobar 2005

Undersea Hyperb Med · 2005 · Cohort / series

Escobar SJ, Slade JB Jr, Hunt TK, Cianci P. Adjuvant hyperbaric oxygen therapy (HBO2) for treatment of necrotizing fasciitis reduces mortality and amputation rate. Undersea Hyperb Med 2005;32(6) (PMID 16509286).

PubMed · PMID 16509286

Eskes 2013

Cochrane Database Syst Rev · 2013 · Cochrane review

Eskes A, Vermeulen H, Lucas C, Ubbink DT. Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds. Cochrane Database Syst Rev 2013;(12):CD008059.

PubMed · PMID 24343585 · DOI · PMC free full text

Cochrane systematic review of RCTs of HBOT for acute surgical and traumatic wounds. 4 trials, 229 participants — clinically heterogeneous, so no meta-analysis was possible.

Esposito 2013 (Cochrane, dental implants)

Cochrane Database Syst Rev · 2013 · Cochrane review

Esposito M, Worthington HV. Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants. Cochrane Database Syst Rev 2013;(9):CD003603 (PMID 24085641. DOI 10.1002/14651858.CD003603.pub3).

PubMed · PMID 24085641 · DOI · PMC free full text

Esterhai 1987

The Journal of Trauma · 1987 · Cohort / series

Esterhai JL Jr, Pisarello J, Brighton CT, Heppenstall RB, Gellman H, Goldstein G. Adjunctive Hyperbaric Oxygen Therapy in the Treatment of Chronic Refractory Osteomyelitis. The Journal of Trauma 1987;27(7):763–768.

PubMed · PMID 3612850 · DOI

The primary result is null and the authors state it twice, in the abstract and in the discussion: Whole series: 24 patients healed (86%); four failed to respond. By arm: "Three of the four failures had been treated with at least 20 days of adjunctive hyperbaric

Evanger 2018

Undersea Hyperb Med · 2018 · Cohort / series

Evanger K, Vaagbø G, Haugen OH. Short-term effects on ocular variables immediately after hyperbaric oxygen exposures. Undersea Hyperb Med 2018;45(4):395-402.

PubMed · PMID 30241118

Eynan 2020

Diving Hyperb Med · 2020 · Review / background

Eynan M, Arieli Y, Taran B, Yanir Y. Symptoms of central nervous system oxygen toxicity during 100% oxygen breathing at normobaric pressure with increasing inspired levels of carbon dioxide: a case report. Diving Hyperb Med 2020;50(1):70-74.

PubMed · PMID 32187621 · DOI · PMC free full text

Faglia 1996

Diabetes Care · 1996 · RCT

Faglia E, Favales F, Aldeghi A, et al. Adjunctive Systemic Hyperbaric Oxygen Therapy in Treatment of Severe Prevalently Ischemic Diabetic Foot Ulcer: A randomized study. Diabetes Care 1996;19(12):1338–1343.

PubMed · PMID 8941460 · DOI

Major amputation: 8.6% (3/35) HBOT vs 33.3% (11/33) control (P=0.016); RR 0.26 (95% CI 0.08–0.84). TcPO₂ (foot dorsum) rose significantly more with HBOT: +14.0 ± 11.8 vs +5.0 ± 5.4 mmHg (P=0.0002). Multivariate analysis confirmed s-HBOT protective (OR 0.084, P=0.033); low ankle-brachial index and

Faglia 2013

Int J Low Extrem Wounds · 2013 · Commentary / case

Faglia E, Clerici G, Caminiti M, Vincenzo C, Cetta F. Heel ulcer and blood flow: the importance of the angiosome concept. Int J Low Extrem Wounds 2013;12(3):226-230.

PubMed · PMID 24043681 · DOI

Fakkert 2023

Critical Care · 2023 · Meta-analysis

Fakkert RA, Karlas N, Schober P, Weber NC, Preckel B, van Hulst RA, Weenink RP (Amsterdam UMC). Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies. Critical Care 2023;27(1):282.

PubMed · PMID 37434172 · DOI · PMC free full text

Group-level (10 studies, 263 patients): patients with favourable outcome were treated 2.4 h earlier IPD (8 studies, 126 patients): a significant relationship between time-to-HBOT and probability of Magnitude: probability of favourable outcome falls from ≈65% when HBOT is started immediately to

Fakkert 2025

Diving Hyperb Med · 2025 · Cohort / series

Fakkert RA, van Beers L, Weber NC, Preckel B, van Hulst RA, Weenink RP (Amsterdam UMC). Functional outcome and quality of life after iatrogenic cerebral air embolism treated with hyperbaric oxygen: a prospective cohort study. Diving Hyperb Med 2025;55(4):330–337.

PubMed · PMID 41364856 · DOI · PMC free full text

Only about a third achieved good functional recovery. At 6 months, full recovery (GOS 5) in Mortality 23% (5/22) at 6 months. Quality of life: 9/17 survivors (53%) reported a decline in QoL versus their pre-incident status

Fan 2017

Undersea Hyperb Med · 2017 · Commentary / case

Fan D, Lv Y, Hu H, Pan S. Severe pulmonary edema following hyperbaric oxygen therapy for acute carbon monoxide poisoning: a case report and clinical experience. Undersea Hyperb Med 2017;44(3).

PubMed · PMID 28779586

Fang 2017

Undersea and Hyperbaric Medicine · 2017 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Fang Yiqun, You Pu, Wang Haitao, Bao Xiaochen, Ma Jun, Zhang Shi, Fan Yinghui. Metabonomic potential plasma biomarkers in abnormal fast buoyancy ascent escape-induced decompression sickness model and the protective effects of pyrrolidine dithiocarbamic acid. Undersea and Hyperbaric Medicine 2017;44(2):109-119.

PubMed · PMID 28777901 · DOI

Fang 2025

World Neurosurg · 2025 · Systematic review

Fang T, Xue Z, Yang L, et al. Cerebral Air Embolism After Percutaneous Kyphoplasty: A Case Report and Systematic Review of Mechanisms and Management. World Neurosurg 2025;199:124074.

PubMed · PMID 40368090 · DOI

HBOT is described as a cornerstone of CAE management. Among the analysed cases, all 3 patients who Mechanism: HBO raises ambient pressure → accelerates nitrogen resorption / bubble reduction and improves Limitations acknowledged: chamber accessibility and time-to-treatment, and HBOT risks (barotrauma,

Fattori 2001

Ear Nose Throat J · 2001 · RCT

Fattori B, Berrettini S, Casani A, Nacci A, De Vito A, De Iaco G (Pisa, Italy). Sudden hypoacusis treated with hyperbaric oxygen therapy: a controlled study. Ear Nose Throat J 2001.

PubMed · PMID 11579852

HOT group had a significantly greater mean PTA improvement than the vasodilator group — relative gain Improvement was independent of age and sex. Among HOT patients, 17/30 (56.7%) had a good recovery and 8/30 (26.7%) a significant recovery.

Faunø Thrane & Ovesen 2019

Infect Dis (Lond) · 2019 · Meta-analysis

Faunø Thrane J, Ovesen T. Scarce evidence of efficacy of hyperbaric oxygen therapy in necrotizing soft tissue infection: a systematic review. Infect Dis (Lond) 2019;51(7):485–492.

PubMed · PMID 30985236 · DOI

The included studies were few, heterogeneous and at high risk of bias; the review found a lack of Individual-study relative risks were reported but not pooled, given the quality and heterogeneity.

Fedorko 2016

Diabetes Care · 2016 · RCT

Fedorko L, Bowen JM, Jones W, Oreopoulos G, Goeree R, Hopkins RB, et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39(3):392–9.

PubMed · PMID 26740639 · DOI

Met criteria for major amputation: 11/49 (HBOT) vs 13/54 (sham); OR 0.91 (0.37–2.28), p=0.85. Healed: 20% (HBOT) vs 22% (sham); OR 0.90 (0.35–2.31), p=0.82. All wound-healing indices: no significant between-group difference.

Feldman-Idov 2011

Isr Med Assoc J · 2011 · Cohort / series

Feldman-Idov Y, Melamed Y, Ore L. Improvement of ischemic non-healing wounds following hyperoxygenation: the experience at Rambam-Elisha Hyperbaric Center in Israel, 1998-2007. Isr Med Assoc J 2011;13(9):524-529 (PMID 21991710).

PubMed · PMID 21991710

Feldmeier 1995

Undersea Hyperb Med · 1995 · Cohort / series

Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen as an adjunctive treatment for delayed radiation injury of the chest wall: a retrospective review of twenty-three cases. Undersea Hyperb Med 1995;22(4):383-393 (PMID 8574126).

PubMed · PMID 8574126

Feldmeier 2000

Undersea Hyperb Med · 2000 · Cohort / series

Feldmeier JJ, Heimbach RD, Davolt DA, McDonough MJ, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen in the treatment of delayed radiation injuries of the extremities. Undersea Hyperb Med 2000;27(1):15-19.

PubMed · PMID 10813435

Feldmeier 2003

Undersea Hyperb Med · 2003 · Review / background · MIXED human and preclinical evidence

Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med 2003;30(1):1-18.

PubMed · PMID 12841604

Feldmeier 2024

Undersea Hyperb Med · 2024 · Cohort / series

Feldmeier JJ, Kirby JP, Gelly HB, Robins M, Peters J, Gruhn P, Pal S. Controlled CMS data demonstrates a cost and clinical advantage for hyperbaric oxygen for radiation cystitis. Undersea Hyperb Med 2024;51(2):145-157.

PubMed · PMID 38985151

Feldmeier & Hampson 2002

Undersea Hyperb Med · 2002 · Systematic review

Feldmeier JJ, Hampson NB. A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: an evidence based approach. Undersea Hyperb Med 2002;29(1):4–30.

PubMed · PMID 12507182

74 publications reporting HBO in the treatment or prevention of delayed radiation injury, appraised with three established evidence-evaluation systems; all but 7 reported a positive result. Delayed radiation injury (soft-tissue and bony radionecrosis) is one of the (then thirteen) UHMS-approved HBO indications; the authors recommend HBO for delayed radiation injuries of soft tissue and bone at most sites, noting the benefit is…

Feng 2017

Medicine (Baltimore) · 2017 · RCT

Feng JJ, Li YH. Effects of hyperbaric oxygen therapy on depression and anxiety in the patients with incomplete spinal cord injury (a STROBE-compliant article). Medicine (Baltimore) 2017;96(29):e7334 (DOI:10.1097/MD.0000000000007334. First Affiliated Hospital of Zhengzhou University).

DOI

Feng 2022

Exp Ther Med · 2022 · RCT

Feng T, Zhang Q, Wei J, Wang X, Geng Y. Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Exp Ther Med 2022;23(3):242.

PubMed · PMID 35222719 · DOI · PMC free full text

HBO arm: significantly better recovery of tinnitus, aural fullness and vertigo (P<0.05) and Efficacy influenced by age, onset time, hearing threshold, tinnitus, plasma viscosity, CRP.

Ferreira 2017

Undersea Hyperb Med · 2017 · Cohort / series

Ferreira APP, Vide SS, Fernandes TDF, Coelho PMBS, Camacho OF. Hyperbaric oxygen therapy as an adjuvant to source control in necrotizing soft tissue infections. Undersea Hyperb Med 2017;44(6):535-542.

DOI

Ferreira Júnior 2020

Minerva Stomatol · 2020 · Commentary / case

Ferreira Júnior LH, dos Reis DC, Batista JD, Filice LS, Dechichi P, Rocha FS. Hyberbaric oxygen and bone reconstruction. Minerva Stomatol 2020;69(2):119–125.

PubMed · PMID 32181611 · DOI

Fiesseler 2006

Undersea Hyperb Med · 2006 · Cohort / series

Fiesseler FW, Silverman ME, Riggs RL, Szucs PA. Indication for hyperbaric oxygen treatment as a predictor of tympanostomy tube placement. Undersea Hyperb Med 2006;33(4):231-235.

PubMed · PMID 17004409

Fife 2002

Wound Repair Regen · 2002 · Cohort / series

Fife CE, Buyukcakir C, Otto GH, Sheffield PJ, Warriner RA, Love TL, Mader J. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1,144 patients. Wound Repair Regen 2002;10(4):198-207.

PubMed · PMID 12191001 · DOI

A retrospective, multicentre, prognostic-factor analysis. Six hyperbaric facilities contributed charts. - 1,144 records of diabetic patients: 1,006 reviewed by one physician from five Texas hyperbaric facilities, plus 79 from Travis Air Force Base, California, and 59 from Memorial Hermann Hospital, Texas, reviewed by a different examiner [derived: 1006 + 79 + 59]. - These were all diabetic patient

Fife 2016

Plast Reconstr Surg · 2016 · Review / background

Fife CE, Eckert KA, Carter MJ. An Update on the Appropriate Role for Hyperbaric Oxygen: Indications and Evidence. Plast Reconstr Surg 2016;138(3 Suppl):107S–116S.

PubMed · PMID 27556750 · DOI · PMC free full text

HBOT uniquely ameliorates tissue hypoxia, dampens pathologic inflammation, and mitigates ischaemia–reperfusion Numerous small RCTs are supportive, but sham/blinding and chamber logistics constrain trial design — hence the

Fijen 2016

Diving Hyperb Med · 2016 · Cohort / series

Fijen VA, Westerweel PE, van Ooij PJAM, van Hulst RA. Tympanic membrane bleeding complications during hyperbaric oxygen treatment in patients with or without antiplatelet and anticoagulant drug treatment. Diving Hyperb Med 2016;46(1):22-25.

PubMed · PMID 27044458

Filipo 2012

Acta Otolaryngol · 2012 · RCT

Filipo R, Attanasio G, Viccaro M, Russo FY, Mancini P, Rocco M, Pietropaoli P, Covelli E. Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss. Acta Otolaryngol 2012;132(5):475–481.

PubMed · PMID 22292673 · DOI

Severe (PTA 70–90 dB) and profound (90 dB) ISSNHL; one arm 10 days HBO + IV steroid, the other IT steroid + Overall success rate superior with IT steroid + HBO, but not statistically significant. IT steroid's excellent

Fitzpatrick 1999

Undersea Hyperb Med · 1999 · Cohort / series

Fitzpatrick DT, Franck BA, Mason KT, Shannon SG. Risk factors for symptomatic otic and sinus barotrauma in a multiplace hyperbaric chamber. Undersea Hyperb Med 1999;26(4):243-247.

PubMed · PMID 10642071

Flegg 2009

PLoS Comput Biol · 2009 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Flegg JA, McElwain DLS, Byrne HM, Turner IW. A three species model to simulate application of hyperbaric oxygen therapy to chronic wounds. PLoS Comput Biol 2009;5(7):e1000451.

PubMed · PMID 19649306 · PMC free full text

Flegg 2010

Bull Math Biol · 2010 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Flegg JA, Byrne HM, McElwain DLS. Mathematical model of hyperbaric oxygen therapy applied to chronic diabetic wounds. Bull Math Biol 2010;72(7):1867-1891.

PubMed · PMID 20204711 · DOI

Fletcher 1977

Cancer · 1977 · RCT

Fletcher GH, Lindberg RD, Caderao JB, Wharton JT (MD Anderson Hospital). Hyperbaric oxygen as a radiotherapeutic adjuvant in advanced cancer of the uterine cervix. Preliminary results of a randomized trial. Cancer 1977 (preliminary results of a randomized trial; advanced carcinoma of the uterine cervix).

PubMed · PMID 402186 · DOI

Absolute NED (no-evidence-of-disease) survival — no statistically significant difference between air An increase in complications was seen (especially with extended fields / added lymphadenectomy → more

Foley 2021

Diving Hyperb Med · 2021 · Cohort / series

Foley K, Banham N, Bonnington S, Gawthrope I. Oxygen toxicity seizure mimics. Diving Hyperb Med 2021;51(2):161-166.

PubMed · PMID 34157731 · DOI · PMC free full text

Foley 2025

Curr Rev Musculoskelet Med · 2025 · Review / background

Foley A, Confino J, Halvorson R, Petrie K, Torres A, Feeley B. Return To Sport Following ACL Reconstruction. Curr Rev Musculoskelet Med 2025;18(12):599-610.

PubMed · PMID 40676343 · DOI · PMC free full text

Forner 2019

Diving Hyperb Med · 2019 · Cohort / series

Forner L, Berkowicz A, Dickmeiss E, Hyldegaard O, Jansen EC, Fischer-Nielsen A. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen. Diving Hyperb Med 2019;49(3):175-185.

PubMed · PMID 31523792 · DOI · PMC free full text

Forner 2022

Radiother Oncol · 2022 · RCT

Forner LE, Dieleman FJ, Shaw RJ, Kanatas A, Butterworth CJ, et al. Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1. Radiother Oncol 2022;166:137–144.

PubMed · PMID 34843843 · DOI

Healing at 1 year: 70% (21/30) with HBO + surgery vs 51% (18/35) with surgery alone — HBO was The difference did NOT reach statistical significance — the combined study was underpowered

Foster & Butler 2009

Journal of Applied Physiology · 2009 · Review / background

Foster PP, Butler BD. Decompression to altitude: assumptions, experimental evidence, and future directions. Journal of Applied Physiology 2009;106(2):678-690.

PubMed · PMID 19074573 · DOI

Fox 2015

Oral Surg Oral Med Oral Pathol Oral Radiol · 2015 · Systematic review

Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA. Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;120(1):22–28.

PubMed · PMID 26093680 · DOI

7 studies, 246 patients (6 prospective, 1 retrospective; only 2 controlled). HBO may have utility for radiation-induced xerostomia refractory to other therapies and may produce long-term improvement in subjective xerostomia; objective/quality-of-life data more limited.

Fraga 2025

Cureus · 2025 · Cohort / series

Fraga Carvalho C, Lopes VC, Agareno G, Spessoto AC, Facio FN, Fava Spessoto LC. Hyperbaric Oxygen Therapy for Patients With Viral or Radiation-Induced Hemorrhagic Cystitis. Cureus 2025;17(3):e80755 (DOI 10.7759/cureus.80755).

PubMed · PMID 40248530 · DOI · PMC free full text

Francis 2017

Diving Hyperb Med · 2017 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Francis A, Baynosa R. Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms. Diving Hyperb Med 2017;47(2):110-117.

PubMed · PMID 28641323 · DOI · PMC free full text

Fredman 2014

Undersea Hyperb Med · 2014 · Commentary / case

Fredman R, Wiser I, Friedman T, Heller L, Karni T. Skin-sparing mastectomy flap ischemia salvage using urgent hyperbaric chamber oxygen therapy: a case report. Undersea Hyperb Med 2014;41(2):145-147.

PubMed · PMID 24851552

Freiberger 2007

Undersea Hyperb Med · 2007 · Commentary / case

Freiberger JJ, Padilla-Burgos R (Duke University). Update on the Duke randomised controlled trial of hyperbaric oxygen for osteonecrosis of the jaw in patients who have taken bisphosphonates. Undersea Hyperb Med 2007;34(4):241 — UHMS ASM abstract.

HBOT 0019 · Not indexed in PubMed and no DOI — full text held in the practice wiki

As of Feb 2007: IRB approval Aug 2006; 32 subjects interviewed, 7 enrolled, 2 treated, 1 withdrawn — Reasons for declining/ineligibility include "previous radiation treatment" — i.e. radiation ORN

Freiberger 2012

J Oral Maxillofac Surg · 2012 · RCT

Freiberger JJ, Padilla-Burgos R, McGraw T, Suliman HB, Kraft KH, Stolp BW, Moon RE, Piantadosi CA (Duke University). What Is the Role of Hyperbaric Oxygen in the Management of Bisphosphonate-Related Osteonecrosis of the Jaw: A Randomized Controlled Trial of Hyperbaric Oxygen as an Adjunct to Surgery and Antibiotics. J Oral Maxillofac Surg 2012;70(7):1573–1583.

PubMed · PMID 22698292 · DOI

46 patients (25 HBO, 21 standard; mean age 66, 57% women). Primary endpoint (change in oral lesion size and number): no significant difference between groups. But 17/25 HBO-treated (68%) improved, with better/faster healing on some secondary and longer-term measures.

Fritz 2010

J Oral Maxillofac Surg · 2010 · Systematic review

Fritz GW, Gunsolley JC, Abubaker O, Laskin DM. Efficacy of Pre- and Postirradiation Hyperbaric Oxygen Therapy in the Prevention of Postextraction Osteoradionecrosis: A Systematic Review. J Oral Maxillofac Surg 2010;68(11):2653–2660.

PubMed · PMID 20727635 · DOI

From 696 citations, 14 acceptable publications (1 RCT, 8 cohort-controlled, 5 observational) were analysed. Most had small samples, lacked clear inclusion/exclusion criteria, and under-reported the radiation-to-extraction interval. Conclusion: insufficient information to show HBO reduces the incidence of ORN in irradiated patients requiring tooth extraction — the prophylactic benefit is not established by the available evidenc…

Fu 2026

PeerJ · 2026 · RCT

Fu B, Li M, Liu Q, Zhou S, Zhu H, Wan L, Qian Y. Effects of hyperbaric oxygen therapy on EEG and sEMG signals after low-load exercise. PeerJ 2026;14:e21554.

PubMed · PMID 42516925 · DOI · PMC free full text

Fujita 2026

Acute Med Surg · 2026 · Meta-analysis

Fujita M, Todani M, Ajimi Y, Yatabe T, Yokobori S, Araki M, Chihara N, Nagayama M, Sakamoto T, Tsuruta R; Japan Resuscitation Council (JRC) Neuroresuscitation Task Force. Evaluating the Efficacy of Hyperbaric Oxygen Therapy for Acute Carbon Monoxide Poisoning: A Systematic Review and Meta‐Analysis. Acute Med Surg 2026;13(1):e70114.

PubMed · PMID 41624627 · DOI · PMC free full text

No significant benefit of HBO on mortality or neurological outcomes. The ≥2.5 ATA subgroup showed no advantage over control either. Moderate-to-substantial heterogeneity; GRADE certainty low to very low.

Fukami 2018

Langenbecks Arch Surg · 2018 · RCT

Fukami Y, Kobayashi S, Sekoguchi E, Kurumiya Y. Randomized controlled trial of hyperbaric oxygen therapy in adhesive postoperative small bowel obstruction. Langenbecks Arch Surg 2018.

PubMed · PMID 29808324 · DOI

No significant differences in time to oral intake, length of stay, need for long intestinal-tube Overall success of medical treatment 72.5% (no-HBO) vs 78.8% (HBO), p=0.594 — no benefit.

Gäde 2026

Clin Oral Investig · 2026 · Systematic review · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Gäde AHF, Schiegnitz E, Eckert AW, Sagheb K, Al-Nawas B, Kupka JR. The influence of hypoxia on tissue regeneration in oral and maxillofacial surgery – a systematic review. Clin Oral Investig 2026;30:125.

PubMed · PMID 41838239 · DOI · PMC free full text

9/5,790 studies; among the interventions studied, HBO consistently improved bone healing in

Gaio-Lima 2022 (radiation lesions)

Clin Transl Oncol · 2022 · Cohort / series

Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho O. The role of hyperbaric oxygen therapy in the treatment of radiation lesions. Clin Transl Oncol 2022;24(12):2466-2474 (PMID 35976581; DOI 10.1007/s12094-022-02892-x).

PubMed · PMID 35976581 · DOI

Gallego-Vilar 2011

Arch Esp Urol · 2011 · Systematic review

Gallego-Vilar D, García-Fadrique G, Povo-Martín IJ, Miralles-Aguado J, Garau-Perelló C, Sanchis-Verdú L, Gimeno-Argente V, Bosquet-Sanz M, Rodrigo-Aliaga M, Claramonte-Ramón FJ, Gallego-Gómez J. Hyperbaric oxygen treatment in urology. Arch Esp Urol 2011;64(6):507-516.

PubMed · PMID 21791717

Narrative review of urological HBO: strongest application intractable haemorrhagic radiation cystitis, plus Fournier's gangrene and ischaemic/wound-healing uses; typical course 4–44 sessions (mean ~19). Evidence level low — most underlying reports are case series; no comparative estimates.

Gallego-Vilar 2013

Urol Int · 2013 · RCT

Gallego-Vilar D, García-Fadrique G, Povo-Martin I, Salvador-Marin M, Gallego-Gomez J. Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. Urol Int 2013;90:411-416.

DOI

Game / IWGDF 2016

Diabetes Metab Res Rev · 2016 · Meta-analysis

Game FL, Apelqvist J, Attinger C, Hartemann A, Hinchliffe RJ, Löndahl M, Price PE, Jeffcoate WJ (IWGDF working group). Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review. Diabetes Metab Res Rev 2016;32(Suppl 1):154–168.

PubMed · PMID 26344936 · DOI

Heterogeneity prevented any pooled analysis. The overall conclusion is conservative: with the possible exception of negative-pressure wound Controlled studies remain few and mostly of poor methodological quality.

García 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

García E, Mitchell SJ. Bubbles in the skin microcirculation underlying cutis marmorata in decompression sickness: Preliminary observations. Diving and Hyperbaric Medicine 2020;50(2):173-177.

PubMed · PMID 32557421 · DOI · PMC free full text

Garcia-Bustos 2021

Undersea and Hyperbaric Medicine · 2021 · Cohort / series

Garcia-Bustos V, Cabañero-Navalón MD. Ten-year Spanish cohort of diving-related injuries in a non-hyperbaric tertiary hospital on the Spanish Mediterranean coast. Undersea and Hyperbaric Medicine 2021;48(4):382-390.

PubMed · PMID 34847301

Garcia-Covarrubias 2005

Am Surg · 2005 · Systematic review

Garcia-Covarrubias L, McSwain NE Jr, Van Meter K, Bell RM. Adjuvant Hyperbaric Oxygen Therapy in the Management of Crush Injury and Traumatic Ischemia: An Evidence-Based Approach. Am Surg 2005 Feb;71(2):144–151.

PubMed · PMID 16022014 · DOI

Method: MEDLINE/OVID/Cochrane search, 1966–Dec 2003; clinical papers with ≥5 patients; scored by a Yield: 9 documents, ~150 patients. Most were retrospective, uncontrolled case series lacking Result: 8 of 9 studies showed a beneficial effect of HBO, with only one major complication.

García Estévez 2026

Neurologia (Engl Ed) · 2026 · Commentary / case

García Estévez DA. Hyperbaric oxygen therapy as a therapeutic option for post-COVID syndrome fatigue. Neurologia (Engl Ed) 2026:502029, in press.

PubMed · PMID 42190806 · DOI

Gariel 2017

Undersea Hyperb Med · 2017 · Commentary / case

Gariel C, Delwarde B, Beroud S, Soldner R, Floccard B, Rimmelé T. Is decompression illness possible during hyperbaric therapy? A case report. Undersea Hyperb Med 2017;44(3):283-285.

PubMed · PMID 28779585 · DOI

Garrabou 2011

J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev · 2011 · RCT

Garrabou G, et al.; Cardellach F. Mitochondrial Injury in Human Acute Carbon Monoxide Poisoning: The Effect of Oxygen Treatment. J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev 2011;29(1):32–51.

PubMed · PMID 21424975 · DOI

Geçkil 2025

J Stomatol Oral Maxillofac Surg · 2025 · Meta-analysis

Geçkil N. Treatment approaches in cases of mandibular osteoradionecrosis: A systematic meta-analysis. J Stomatol Oral Maxillofac Surg 2025;126(3S):102316.

PubMed · PMID 40097107 · DOI

Success by modality: HBO + surgery 69% (95% CI 0.47–0.85) vs HBO alone 38% (0.20–0.61) vs No significant difference between HBO alone and surgery alone (z=0.139, p=0.889). Combination significantly better than either monotherapy (HBO vs HBO+surgery p=0.015; surgery vs

Geldof 2022

Radiat Oncol · 2022 · Systematic review

Geldof NI, van Hulst RA, Ridderikhof ML, Teguh DN. Hyperbaric oxygen treatment for late radiation-induced tissue toxicity in treated gynaecological cancer patients: a systematic review. Radiat Oncol 2022;17(1):164.

PubMed · PMID 36203216 · DOI · PMC free full text

Radiation cystitis: 3 of 4 studies reported decreased complaints with HBOT. Radiation proctitis: improvement reported. Wound complications: all studies reported improvement — the subgroup that benefits most.

Gelmann 2021

Undersea Hyperb Med · 2021 · Commentary / case

Gelmann D, Jasani G, Moayedi S, Sward D. Inner ear decompression sickness in a hyperbaric chamber inside tender: a case report. Undersea Hyperb Med 2021;48(4):443-448.

PubMed · PMID 34847308

Gempp 2010

J Crit Care · 2010 · Cohort / series

Gempp E, Blatteau JE. Risk factors and treatment outcome in scuba divers with spinal cord decompression sickness. J Crit Care 2010;25(2):236-242.

PubMed · PMID 19682840 · DOI

21 of 63 (33%) had incomplete resolution at one month, including 8 (12%) with severe disability Time to treatment did not predict outcome. Univariate P = .15: of those treated at ≤3 h, Choice of table did not predict outcome. At 2.8 ATA, 40 [derived: 30 + 10] patients gave

Gesell 2005

Undersea Hyperb Med · 2005 · Review / background

Gesell LB, Warnick RE, Breneman JC, Vogt CJ, Lindsell CJ. A randomized, controlled trial of hyperbaric oxygen therapy for brain radionecrosis. Undersea Hyperb Med 2005;32(4):235–236 — UHMS Annual Scientific Meeting abstracts.

HBOT 0018 · Not indexed in PubMed and no DOI — full text held in the practice wiki

A single-centre randomized controlled trial testing HBOT for PET-confirmed brain radionecrosis in patients with stable or worsening disease on a steroid dose that cannot be tapered. - Design: randomised to standardised steroid management alone vs steroid management + HBOT; steroids standardised over 3 months, titrated to oedema volume and Karnofsky score. HBOT arm = 60 treatments over 3 months on

Ghannam 2019

J Stroke Cerebrovasc Dis · 2019 · Systematic review

Ghannam M, Beran A, Ghazaleh D, Ferderer T, Berry B, Banna MA, Mohl L, Streib C, Thacker T, Matos I. Cerebral Air Embolism after Esophagogastroduodenoscopy: Insight on Pathophysiology, Epidemiology, Prevention and Treatment. J Stroke Cerebrovasc Dis 2019;28(12):104403.

PubMed · PMID 31563566 · DOI

Documents endoscopy as a specific iatrogenic route for CAE; presentation is stroke-like (focal deficit, HBOT features among treatment options for significant CAE, alongside supportive care and positioning; Case-report-based literature — establishes an uncommon procedural cause, not efficacy.

Giardiello 2025

Cureus · 2025 · Cohort / series

Giardiello F, De Medeiros Quirino L, Brigante R, Chumak M. Hyperbaric oxygen therapy for enhanced postoperative recovery in hair transplantation. Cureus 2025;17(12):e99635 (DOI 10.7759/cureus.99635).

PubMed · PMID 41556017 · DOI · PMC free full text

Glover 2016 (HOT2)

Lancet Oncol · 2016 · RCT

Glover M, Smerdon GR, Andreyev HJ, Benton BE, Bothma P, Firth O, Gothard L, et al. Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial. Lancet Oncol 2016;17(2):224–233.

PubMed · PMID 26703894 · DOI · PMC free full text

84 randomised (55 HBO, 29 sham). No significant difference in IBDQ bowel-component change (median No significant difference in IBDQ rectal-bleeding change among those bleeding at baseline Adverse events typical of HBO (refractive eye changes, ear pain); serious AEs not treatment-related.

Goh 2023

Br Dent J · 2023 · Review / background

Goh EZ, Beech N, Johnson NR, Batstone M. The dental management of patients irradiated for head and neck cancer. Br Dent J 2023;234(11):800–804.

PubMed · PMID 37291302 · DOI · PMC free full text

Covers the full dental picture in irradiated H&N cancer patients: mucositis, xerostomia, radiation caries, On HBO specifically: notes previous systematic reviews found weak to no evidence, and cites the combined

Goldman 2009

PM&R · 2009 · Systematic review

Goldman RJ. Hyperbaric Oxygen Therapy for Wound Healing and Limb Salvage: A Systematic Review. PM&R 2009;1(5):471–489.

PubMed · PMID 19627935 · DOI

Diabetic foot ulcers complicated by surgical infection: HBOT reduces amputation — OR 0.242 (95% CI Moderate evidence that HBOT helps refractory lower-extremity osteomyelitis (extent of effect Moderate level: HBOT promotes healing of arterial ulcers, calciphylactic & refractory vasculitic

Gong 2025

BMC Nurs · 2025 · Network MA

Gong J, Sun X, Fu H, Zhang Y, Gao T. Comparative efficacy and safety of non-pharmacological nursing interventions for diabetic foot ulcers: a systematic review and network meta-analysis. BMC Nurs 2025;24(1):1445.

PubMed · PMID 41299407 · DOI · PMC free full text

Gong 2026

J Stroke Cerebrovasc Dis · 2026 · RCT

Gong S, Tang M, He J, Wu X, Shi M, Yang M, Shi L, Huang L, Li L, Zhou D, Zhao Y. Efficacy of hyperbaric oxygen therapy for post-stroke depression: association with inflammatory biomarker reduction in a sham-controlled randomized trial. J Stroke Cerebrovasc Dis 2026;35(8):108685.

PubMed · PMID 42336256 · DOI

Gonzalez Flores 2026

Cureus · 2026 · Review / background

González Flores JE, et al. Hyperbaric oxygen therapy in surgical wound healing and tissue salvage: a structured narrative review. Cureus 2026.

PubMed · PMID 42037844 · DOI · PMC free full text

Goodrich 2018

Undersea Hyperb Med · 2018 · Commentary / case

Goodrich E, Goodrich RP, Reese CA. Sensorineural hearing loss after spine surgery treated with hyperbaric oxygen therapy: two case reports. Undersea Hyperb Med 2018;45(2):217-224.

PubMed · PMID 29734574

Gorman & Leitch 1988

South Pacific Underwater Medicine Society Journal (SPUMS J) · 1988 · Cohort / series

Gorman DF, Leitch IA. The role of HBO in treatment of thermal burn injuries. South Pacific Underwater Medicine Society Journal (SPUMS J) 1988;18(4):121-123.

HBOT 0066 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Gothard 2010

Radiother Oncol · 2010 · RCT

Gothard L, Haviland J, Bryson P, Laden G, Glover M, Harrison S, Woods M, Cook G, Peckitt C, Pearson A, Somaiah N, Stanton A, Mortimer P, Yarnold J (Royal Marsden). Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiother Oncol 2010;97(1):101–107.

PubMed · PMID 20605648 · DOI

No significant between-group difference in reduction of affected-arm volume at 12 months (standardised Secondary endpoints (lymphoscintigraphy, dielectric constant, etc.) were similar between groups.

Gottrup 2017

J Wound Care · 2017 · Guideline

Gottrup F, Dissemond J, Baines C, Frykberg R, Jensen PØ, Kot J, Kröger K, Longobardi P. Use of oxygen therapies in wound healing, with special focus on topical and hyperbaric oxygen treatment. J Wound Care 2017;26(Sup5):S1-S43.

PubMed · PMID 28475468 · DOI

Gouin 2025

Diving Hyperb Med · 2025 · Cohort / series

Gouin E, Dugrenot E, Gardette B. Extremely deep bounce dives: planning and physiological challenges based on the experiences of a sample of French-speaking technical divers. Diving Hyperb Med 2025;55(2):203-210.

PubMed · PMID 40544151 · DOI · PMC free full text

Gouin 2025

Diving Hyperb Med · 2025 · Cohort / series

Gouin E, Dugrenot E, Lance RM, Michot T, Marroni L, Tillmans F. Perceptions of airway protection tools: an international survey on the use of mouthpiece retaining straps in closed-circuit rebreather diving. Diving Hyperb Med 2025;55(4):369-375.

PubMed · PMID 41364860 · DOI · PMC free full text

Gouin 2025

Diving Hyperb Med · 2025 · Cohort / series

Gouin E, Monnot DPM, Michot T, Guerrero F, Blatteau JÉ. Diving practices in technical divers' community and behaviour towards self-reported unusual symptoms. Diving Hyperb Med 2025;55(2):114-125.

PubMed · PMID 40544139 · DOI · PMC free full text

Gouin 2026

Diving Hyperb Med · 2026 · Cohort / series

Gouin E, Caillard A, Veses C, Luciani M, Lecomte C, Dugrenot E, Guerrero F, Blatteau JÉ. Technical diving accidents in France: a 15-year retrospective study reporting a high prevalence of musculoskeletal decompression sickness. Diving Hyperb Med 2026;56(2):125-136.

PubMed · PMID 42290572 · DOI · PMC free full text

Graffeo 2013

Am J Emerg Med · 2013 · Commentary / case

e3–4. Graffeo C, Dishong W. Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy. Am J Emerg Med 2013;31(4):756.

PubMed · PMID 23380087 · DOI

Managed with ventilation, vasopressors, haemodialysis and 30 adjunctive HBO treatments (2.0 ATA, 90 Sustained improvement in all haemodynamic parameters, RBC volume, and renal/respiratory function;

Greene & Lambertsen 1980

Undersea Biomed Res · 1980 · Cohort / series

Greene KM, Lambertsen CJ. Nature and treatment of decompression sickness occurring after deep excursion dives. Undersea Biomed Res 1980;7(2):127-139.

PubMed · PMID 7404850

Grolman 2001

Am Surg · 2001 · Cohort / series

Grolman RE, Wilkerson DK, Taylor J, Allinson P, Zatina MA. Transcutaneous oxygen measurements predict a beneficial response to hyperbaric oxygen therapy in patients with nonhealing wounds and critical limb ischemia. Am Surg 2001;67(11):1072-1079 (discussion 1080. PMID 11730224).

PubMed · PMID 11730224

Guillén-Pino 2019

Diving and Hyperbaric Medicine · 2019 · Cohort / series

Guillén-Pino F, Morera-Fumero A, Henry-Benítez M, Alonso-Lasheras E, Abreu-González P, Medina-Arana V. Descriptive study of diving injuries in the Canary Islands from 2008 to 2017. Diving and Hyperbaric Medicine 2019;49(3):204-208.

PubMed · PMID 31523795 · DOI · PMC free full text

Gunes 2017

Acta Medica Mediterranea · 2017 · Review / background · MIXED human and preclinical evidence

Gunes AE, Aktas S. A review of hyperbaric oxygen therapy for avascular necrosis. Acta Medica Mediterranea 2017;33(1):29-34.

DOI

Gao 2025 [slug 'guo' is a legacy misnomer; first author is Gao Y]

J Craniofac Surg · 2025 · Systematic review

Gao Y, Yin L, Xiang T, Ni T, Shi J. Reduce Flap Necrosis After Autologous Breast Reconstruction: A Systematic Review. J Craniofac Surg 2025;36(6):e598–e605.

PubMed · PMID 39729252 · DOI · PMC free full text

Gupta 2013

Indian J Otolaryngol Head Neck Surg · 2013 · Cohort / series

Gupta P, Sahni T, Jadhav GK, Manocha S, Aggarwal S, Verma S. A retrospective study of outcomes in subjects of head and neck cancer treated with hyperbaric oxygen therapy for radiation induced osteoradionecrosis of mandible at a tertiary care centre: an Indian experience. Indian J Otolaryngol Head Neck Surg 2013;65(Suppl 1):S140-S143 (PMID 24427631. DOI 10.1007/s12070-013-0640-z).

PubMed · PMID 24427631 · DOI · PMC free full text

Gupta & Somasundaram 2023

Springer Nature Singapore (book) · 2023 · Review / background

Gupta M, Somasundaram I. Hyperbaric Oxygen Therapy: Principles and Applications. Springer Nature Singapore (book) 2023:153.

DOI

Gur 2026

Isr Med Assoc J (IMAJ) · 2026 · Cohort / series

Gur I, Gur I, Jerdev T, Nov Y. Hyperbaric Oxygen Therapy for Acute Acoustic Trauma: Blast versus Noise-Induced Hearing Loss. Isr Med Assoc J (IMAJ) 2026;28(6):369-375.

PubMed · PMID 42345228

Gur 2026

Eye (Lond) · 2026 · Cohort / series

Gur I, Gur I, Gitzman M, et al. Comparative effectiveness of varying hyperbaric oxygen protocols in the treatment of acute central retinal artery occlusion. Eye (Lond) 2026;40(6):821–826.

PubMed · PMID 41667662 · DOI · PMC free full text

Greater BCVA improvement with the higher initial dose (HBO18): median 0.62 vs 0.22 LogMAR Multivariate: HBO18 associated with +0.5 LogMAR improvement at 24 h (95% CI 0.3–0.7); greater initial Adverse events similar between protocols; none severe enough to stop HBO.

Gur 2026

Isr Med Assoc J (IMAJ) · 2026 · RCT

Gur I, Ofir D, Moravia A, Orenstein S, Kalla C. Knowledge Gaps in Our Understanding of Hyperbaric Oxygen Therapy in Post-traumatic Stress Disorder: Current Evidence, Proposed Solutions, and Preliminary Results. Isr Med Assoc J (IMAJ) 2026;28(6):376-382 (PMID 42345229).

PubMed · PMID 42345229

Hachmo 2020

Aging (Albany NY) · 2020 · Cohort / series

Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY) 2020;12(22):22445-22456.

PubMed · PMID 33206062 · DOI · PMC free full text

Hachmo 2021

Aging (Albany NY) · 2021 · Cohort / series

Hachmo Y, Hadanny A, Mendelovic S, Hillman P, Shapira E, Landau G, Gattegno H, Zrachya A, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial. Aging (Albany NY) 2021;13(22):24500-24510.

PubMed · PMID 34784294 · DOI · PMC free full text

Hadanny 2017

Clin Ophthalmol · 2017 · Cohort / series

Hadanny A, Maliar A, Fishlev G, Bechor Y, Bergan J, Friedman M, Avni I, Efrati S. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol 2017;11:115–125 (eCollection; published 29 Dec 2016).

PubMed · PMID 28096655 · DOI · PMC free full text

BCVA significantly improved after HBOT: 2.14±0.50 → 1.61±0.78 logMAR (P<0.0001). The cherry-red spot (CRS), not elapsed time, marks irreversibility: meaningful visual improvement in ⚠️ Corrected 31 Aug 2026: the two parenthetical flags above are new. The percentages and P values

Hájek 2026

Med Gas Res · 2026 · Commentary / case

Hájek M, Chmelař D, Poláčková A, Hodrová M, Dokulil M, Tlapák J, Jor O. Hyperbaric oxygen therapy: a novel treatment option in complex regional pain syndrome and other chronic pain conditions. Med Gas Res 2026;16(4):543-544.

PubMed · PMID 41964598 · DOI · PMC free full text

✅ A serviceable short account of CRPS — its pathophysiology, the diagnostic problem, and current treatment — from authors with real hyperbaric experience. As orientation to the condition, it reads well. ⚠️ The hyperbaric argument is mechanistic and asserted. CRPS is characterised by regional pain disproportionate to the injury, and the case made is that hyperbaric oxygen addresses the inflammatory

Hammarlund 1994

Plast Reconstr Surg · 1994 · RCT

Hammarlund C, Sundberg T (Helsingborg, Sweden). Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. Plast Reconstr Surg 1994;93(4):829–833.

PubMed · PMID 8134442

Mean wound-area decrease (oxygen group): 6% (wk 2), 22% (wk 4), 35.7% (wk 6) vs air group: 2.8%, The response was gradual over the 6 weeks of chamber treatment (dose-dependent pattern).

Hampson 1996

Undersea Hyperb Med · 1996 · Cohort / series

Hampson NB, Simonson SG, Kramer CC, Piantadosi CA. Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med 1996;23(4):215-219.

PubMed · PMID 8989851

Hampson 2006

Undersea Hyperb Med · 2006 · RCT

Hampson NB, Dunford RG, Ross DE, Wreford-Brown CE. A prospective, randomized clinical trial comparing two hyperbaric treatment protocols for carbon monoxide poisoning. Undersea Hyperb Med 2006;33(1):27–32.

PubMed · PMID 16602254

Abnormal neurocognitive screen immediately post-treatment: 4/18 (22%) at 2.4 ATA vs 2/12 (17%) at Delayed abnormality: 1 patient in each group (P=0.75). Mean COHb 24.8 ± 8.8%; mean delay to HBO Conclusion: it is feasible to randomise CO patients to different protocols; detecting a true

Hampson 2012

Cancer · 2012 · Cohort / series

Hampson NB, Holm JR, Wreford-Brown CE, Feldmeier J. Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury. Cancer 2012;118(15):3860-8 (The PDF on file is the ONLINE-FIRST version. It carries no volume, issue or page numbers — its own footer reads 'Cancer Month 00, 2011' and its abstract ends 'Cancer 2011;000:000-000' Volume 118, issue 15, pages 3860-8 and the journal year 2012 were LOOKED UP in PubMed (PMID 22139864), not read from this PDF.).

PubMed · PMID 22139864 · DOI

Hampson and Holm 2021

Undersea Hyperb Med · 2021 · Commentary / case

Hampson NB, Holm JR. Letter: HBO2 combined with steroid therapy for sudden sensorineural hearing loss within two weeks. Undersea Hyperb Med 2021;48(1):103-104.

PubMed · PMID 33648040 · DOI

Hampson & Holm 2021 letter with Inman reply

Undersea Hyperb Med · 2021 · Commentary / case

Hampson NB, Holm JR; with reply by Inman AL, Sorrell LP, Lagina AT. Delayed treatment of decompression sickness: letter and response. Undersea Hyperb Med 2021;48(2):207-208.

PubMed · PMID 33975414 · DOI

Hampson and Ocak 2017

Undersea Hyperb Med · 2017 · Cohort / series

Hampson NB, Ocak T. Comparison of normobaric vs. hyperbaric oxygen in the relief of carbon monoxide headache pain. Undersea Hyperb Med 2017;44(4):331-336.

PubMed · PMID 28783889

Han 2026

Sci Rep · 2026 · Cohort / series

Han SY, Seo HW, Lee SH, Chung JH. Semicircular canal dysfunction in profound sudden sensorineural hearing loss and its prognostic value: implications for the proper indication of hyperbaric oxygen therapy. Sci Rep 2026;16(1):53421.

PubMed · PMID 42230800 · DOI · PMC free full text

Hansen 2015

BMJ Open · 2015 · Review / background

Hansen MB, Simonsen U, Garred P, Hyldegaard O. Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation—the protocol of the prospective cohort BIONEC study. BMJ Open 2015;5(5):e006995.

PubMed · PMID 25967993 · DOI · PMC free full text

Harlan 2022

Undersea Hyperb Med · 2022 · Cohort / series

Harlan NP, Ptak JA, Rees JR, Cowan DR, Fellows AM, Moses RA, Kertis JA, Hannigan PM, Juggan SA, Peacock J, Bennett M, Buckey JC. International Multicenter Registry for Hyperbaric Oxygen Therapy: results through June 2021. Undersea Hyperb Med 2022;49(1):275-287.

PubMed · PMID 36001560 · DOI

Established 2011 (International Report Registered Identifier DERR1-10.2196/18857) to capture outcomes and complications for both UHMS-approved and selected unapproved indications — the "unapproved" arm being the unusual and valuable part. A REDCap template was distributed to participating centres for prospective, de-identified collection. | | | |---|---| | Contributing centres | 22 | | Patients |

Harrington & Moses 2026

Curr Urol Rep · 2026 · Review / background

Harrington SA, Moses RA. Role of hyperbaric oxygen therapy in radiation cystitis. Curr Urol Rep 2026;27(1):40.

PubMed · PMID 42608486 · DOI

Hart 1974 (JAMA, exceptional blood loss anaemia)

JAMA · 1974 · Cohort / series

Hart GB. Exceptional blood loss anemia. Treatment with hyperbaric oxygen. JAMA 1974;228(8):1028-9.

PubMed · PMID 4406342

Uncontrolled series of three patients with acute blood-loss anaemia who refused blood transfusion on religious grounds and were transferred to the Long Beach Naval Hospital in hypovolaemic shock for hyperbaric therapy. Reported by a single naval hyperbaric physician; this is the paper Wright 2002 cites as the origin of the practice.

Hart 1974 (secondary abstract-digest)

Surg Gynecol Obstet · 1974 · Commentary / case

Hart GB, O'Reilly RR, Broussard ND, Yanda RL. Treatment of burns with hyperbaric oxygen. Surg Gynecol Obstet 1974;139(5):693–696.

PubMed · PMID 4610853

The landmark early clinical burns series reporting HBO given during the first day of burn care. Only a brief third-party digest is held.

Hart 1983

J Trauma · 1983 · Cohort / series

Hart GB, Lamb RC, Strauss MB. Gas gangrene. J Trauma 1983;23(11):991–1000.

PubMed · PMID 6355502 · DOI

A collective review of gas gangrene combined with the authors' own HBO-treated case series. The central thesis: optimal care is the triad surgery + antibiotics + hyperbaric oxygen.

Hart 2021

Undersea Hyperb Med · 2021 · Guideline

Hart BB. Verbatim reprint of the UHMS Hyperbaric Oxygen Therapy Indications Manual, Chapter 12 (Refractory Osteomyelitis). Hyperbaric oxygen for refractory osteomyelitis. Undersea Hyperb Med 2021 Third Quarter;48(3):297–321.

PubMed · PMID 34390634

Definition: refractory osteomyelitis = chronic osteomyelitis that persists or recurs after Mechanism: the low oxygen tensions typical of infected bone are restored to normal by HBO₂ Central/high-risk sites deserve special consideration — sternal (often fatal; recurrence 3–8% even

Hassan 2010

Undersea Hyperb Med · 2010 · Cohort / series

Hassan Z, Mullins RF, Friedman BC, Shaver JR, Brandigi C, Alam B, Mian MAH. Treating necrotizing fasciitis with or without hyperbaric oxygen therapy. Undersea Hyperb Med 2010;37(2).

PubMed · PMID 20462144

Hatling 2019

Acta Anaesthesiol Scand · 2019 · Systematic review

Hatling D, Høgset A, Guttormsen AB, Müller B. Iatrogenic cerebral gas embolism–A systematic review of case reports. Acta Anaesthesiol Scand 2019;63(2):154–160.

PubMed · PMID 30203491 · DOI

A broad range of procedures cause ICGE — central venous catheter insertion/removal, haemodialysis Hyperbaric oxygen was the predominant specific treatment where a treatment was stated: of the 264 Latest reported outcome by treatment (GOS, Table 4) — uncontrolled:

Hauken 2026

J Sex Med · 2026 · Cohort / series

Hauken MA, Gjestad R, Sekse RJT, Müller B, Velure GK. Sexual health following hyperbaric oxygen treatment in pelvic cancer survivors with radiation injuries: a longitudinal observational study. J Sex Med 2026;23(7):qdag189 (DOI 10.1093/jsxmed/qdag189).

PubMed · PMID 42296275 · DOI

He 2026

J Wound Care · 2026 · Meta-analysis

He Z, Sun X, Chen J, Zhang M. Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis. J Wound Care 2026;35(2):193–200.

PubMed · PMID 41649920 · DOI

Flap survival: OR 8.57 (95% CI 5.54–13.26). Skin-flap O₂ saturation MD +19.94; post-op skin temperature MD +0.71; time to swelling resolution

Heck 2024

Clin Oral Investig · 2024 · Systematic review

Heck T, Lohana D, Mallela D, Mandil O, Sun L, Saxena P, Decker AM, Wang HL (University of Michigan). Hyperbaric oxygen therapy as an adjunct treatment of periodontitis, MRONJ, and ONJ: a systematic literature review. Clin Oral Investig 2024;28(1):77.

PubMed · PMID 38182685 · DOI

ORN prophylaxis: HBO superior to antibiotics in preventing ORN in patients with a history of high Established ORN (surgical excision): HBO does not yield significant benefit, but does not worsen Periodontitis (adjunct to SRP): mixed results; study variability precludes conclusions.

Hedetoft 2020

Diving Hyperb Med · 2020 · Cohort / series

Hedetoft M, Olsen NV, Smidt-Nielsen IG, et al. Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment. Diving Hyperb Med 2020;50(1):17-23.

PubMed · PMID 32187613 · PMC free full text

Hedetoft 2021

Diving Hyperb Med · 2021 · Meta-analysis

Hedetoft M, Bennett MH, Hyldegaard O. Adjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: A systematic review and meta-analysis. Diving Hyperb Med 2021;51(1):34–43.

PubMed · PMID 33761539 · DOI · PMC free full text

Mortality: pooled OR 0.44 (95% CI 0.33–0.58) in favour of HBOT — 4,770 deaths among 48,744 patients Major amputation: pooled OR 0.60 (95% CI 0.28–1.28) — favours HBOT in point estimate but not The authors judge the clinical evidence sparse and of generally low quality; HBOT for NSTI remains

Helms 2011

Undersea Hyperb Med · 2011 · Review / background

Helms A, Evans AW, Chu J, Sahgal A, Ostrowski R, Sosiak T, Wolf G, Gillett J, Whelan H. Hyperbaric oxygen for neurologic indications: action plan for multicenter trials in stroke, traumatic brain injury, radiation encephalopathy and status migrainosus. Undersea Hyperb Med 2011;38(5):309-319.

PubMed · PMID 22013758

Hendier 2025

Diving Hyperb Med · 2025 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Hendier L, Soule H, Abbas M, Pittet D, Pignel R, Boet S. Evaluation of bacterial survival on inert surfaces in a hyperbaric environment. Diving Hyperb Med 2025;55(3):231-235 (PMID 40986918. DOI 10.28920/dhm55.3.231-235).

PubMed · PMID 40986918 · DOI · PMC free full text

Henk 1977 (Henk2)

Lancet · 1977 · RCT

Henk JM, Kunkler PB, Smith CW (South Wales Radiotherapy and Oncology Service, Velindre Hospital, Cardiff). Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet 1977;2(8029):101–103.

PubMed · PMID 69191 · DOI

294 patients admitted between October 1964 and March 1972 — 143 allocated to hyperbaric No difference in survival. Actuarial survival curves were the same in both groups. Local tumour control was significantly better with HBO — recurrence-free rates by the actuarial

Henk 1986

Int J Radiat Oncol Biol Phys · 1986 · RCT

Henk JM. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers? Int J Radiat Oncol Biol Phys 1986;12(8):1339–1341.

PubMed · PMID 3531112 · DOI

Survival and local-control rates were significantly higher in the HBO group — one of the positive However, HBO was associated with greater morbidity (more normal-tissue reactions at the higher

Hess 2021

Undersea Hyperb Med · 2021 · Cohort / series

Hess HW, Wheelock CE, St James E, Stooks JL, Clemency BM, Hostler D. Variability in venous gas emboli following the same dive at 3,658 meters. Undersea Hyperb Med 2021;48(4):469-476.

PubMed · PMID 34847312

Hesthammer 2019

Undersea and Hyperbaric Medicine · 2019 · Commentary / case · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Hesthammer R, Eide T, Thorsen E, Svardal AM, Djurhuus R. Decrease of tetrahydrobiopterin and NO generation in endothelial cells exposed to simulated diving. Undersea and Hyperbaric Medicine 2019;46(2):159-169.

PubMed · PMID 31051061

Heyboer 2014

Undersea Hyperb Med · 2014 · Cohort / series

Heyboer M 3rd, Wojcik SM, Grant WD, Chambers P, Jennings S, Adcock P. Middle ear barotrauma in hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(5):393-397.

PubMed · PMID 25558548

Heyboer 2019

Undersea Hyperb Med · 2019 · Cohort / series

Heyboer M 3rd, Wojcik SM, et al. Blood glucose levels in diabetic patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med 2019;46(4):437-445.

PubMed · PMID 31509900

Hingorani 2016

J Vasc Surg · 2016 · Guideline

Hingorani A, LaMuraglia GM, Henke P, Meissner MH, Loretz L, Zinszer KM, Driver VR, Frykberg R, Carman TL, Marston W, Mills JL, Murad MH. The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. J Vasc Surg 2016;63(2 Suppl):3S-21S.

PubMed · PMID 26804367 · DOI

Hirai 2026

Respirol Case Rep · 2026 · Commentary / case

Hirai M, Kitajima T, Park SC, Inoue D, Fukui M. Bronchial Chondronecrosis After Proton Beam Therapy Successfully Treated With Hyperbaric Oxygen Therapy. Respirol Case Rep 2026;14:e70705.

PubMed · PMID 42592161 · DOI · PMC free full text

Hisamoto 2025

PLoS One · 2025 · Cohort / series

Hisamoto K, Okubo N, Fujita M, Fukushima H, Okizuka Y, Yamanaka T, Matsui T, Morihara T, Hojo T, Fukuoka Y, Takahashi K. Mild hyperbaric hyperoxia improves aerobic capacity and suppresses cardiopulmonary stress during the maximal cycle-ergometer test. PLoS One 2025;20(5):e0323885.

PubMed · PMID 40408365 · DOI · PMC free full text

Ho 2022

Healthcare (Basel) · 2022 · Network MA

Ho YW, Chung PY, Hou SK, Chang ML, Kang YN. Should We Use Hyperbaric Oxygen for Carbon Monoxide Poisoning Management? A Network Meta-Analysis of Randomized Controlled Trials. Healthcare (Basel) 2022;10(7):1311.

PubMed · PMID 35885838 · DOI · PMC free full text

HBO had no better outcomes than NBO overall. Two-session HBO was worse than one-session for general fatigue (RR 1.29, 95% CI 1.03–1.62),

Hoencamp 2019

Diving Hyperb Med · 2019 · Systematic review · MIXED human and preclinical evidence

Hoencamp E, van Dongen TTCF, van Ooij PJAM, Wingelaar TT, Vervelde ML, Koch DAA, van Hulst RA, Hoencamp R. Systematic review on the effects of medication under hyperbaric conditions: consequences for the diver. Diving Hyperb Med 2019;49(2):127–136.

PubMed · PMID 31177519 · DOI · PMC free full text

Hoggan & Cameron 2014

Support Care Cancer · 2014 · Systematic review

Hoggan BL, Cameron AL. Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries. Support Care Cancer 2014;22(6):1715–1726.

PubMed · PMID 24794980 · DOI

Protocol-driven SR of comparative studies of HBO vs observation/conventional/sham for non-neurological soft-tissue radiation injury. Benefit shown for radiation proctitis and for irradiated head/neck soft-tissue wounds; radiation cystitis showed little difference between groups. Safety and effectiveness assessed together; overall an encouraging but site-dependent signal on a limited comparative evidence base.

Howard 2020

Diving Hyperb Med · 2020 · Cohort / series

Howard AE, Buzzacott P, Gawthrope IC, Banham ND. Effect of antiplatelet and/or anticoagulation medication on the risk of tympanic barotrauma in hyperbaric oxygen treatment patients, and development of a predictive model. Diving Hyperb Med 2020;50(4):338-342.

PubMed · PMID 33325013 · DOI · PMC free full text

Hoyt 2025

Diving Hyperb Med · 2025 · Guideline

Hoyt J, Murphy FG, Pollock NW, Kernagis D, Bird N, Menduno M, Bright J, Mitchell SJ. Revised guideline for central nervous system oxygen toxicity exposure limits when using an inspired PO2 of 1.3 atmospheres. Diving Hyperb Med 2025;55(3):262-270.

PubMed · PMID 40986922 · DOI · PMC free full text

Hsia 2025

Adv Wound Care (New Rochelle) · 2025 · Guideline

Hsia HC, Eriksson E, Gurtner GC, Veves A, Hamdy O, Margolis DJ, Armstrong DG, Lavery LA, Grice EA, Schultz G, Conte MS, Kirsner RS, Attinger CE, Steinberg JS, Evans KK, Weir D, Kim PJ, Orgill DP, Liechty KW, Rubin JP. Management of diabetic wounds: expert panel consensus statement. Adv Wound Care (New Rochelle) 2025;15(7):487-519.

PubMed · PMID 40833358 · DOI

Hsieh 2025

Undersea Hyperb Med · 2025 · Cohort / series

Hsieh CH, Wen YW, Liao CT, Lee SR. Hyperbaric oxygen treatment after surgery and radiation for oral cancers does not increase the likelihood of a second primary development, nor reduce disease specific or overall survival. Undersea Hyperb Med 2025;52(3):271-278.

PubMed · PMID 41223388

Hsu 2010

Arch Orthop Trauma Surg · 2010 · Cohort / series

Hsu S-L, Wang C-J, Lee MS-S, Chan Y-S, Huang C-C, Yang KD. Cocktail therapy for femoral head necrosis of the hip. Arch Orthop Trauma Surg 2010;130(1):23–29.

PubMed · PMID 19557424 · DOI

Group A (cocktail) 74% improved / 16% unchanged / 10% worse; Group B (ESWT alone) 79.2% / 10.4% / 10.4% — p=0.717 across the three categories. ⚠️ Corrected 31 Aug 2026: this bullet previously read "Overall 74% improved, 16% unchanged (remainder worse)". Those are GROUP A's figures alone, not the overall result; presenting the cocktail arm's numbers as overall hid that the comparator arm did slightly better in every category. T…

Htay 2024

Diving Hyperb Med · 2024 · Commentary / case

Htay AM, Wilson E. Lateral ST-elevation myocardial infarction from systemic air embolism after CT guided lung biopsy. Diving Hyperb Med 2024;54(3):233-236 (DOI 10.28920/dhm54.3.233-236).

PubMed · PMID 39288930 · DOI · PMC free full text

Hu 2020

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg, China) · 2020 · RCT

Hu Y, Chen H, Xiong J, Sun W. [The efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg, China) 2020 Jun;34(6):521–523,527.

PubMed · PMID 32842183 · DOI · PMC free full text

"Effective" response (≥15 dB gain): A 78.9%, B 81.5%, C 61.9%; C vs A and C vs B both significant Mean threshold gain: A 27.2±17.5, B 26.9±16.7, C 17.6±18.5 dB HL → pooled +9.5 dB (95% CI 2.5–16.4) Two HBO schedules equivalent → scheduling can follow chamber capacity / patient convenience.

Hu 2024

Med Gas Res · 2024 · Systematic review

Hu Y, Ye Y, Ji X, Wu J. The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss. Med Gas Res 2024;14(4):180-185.

DOI

Hu 2025

J Physiol Anthropol · 2025 · RCT

Hu Z, Guo W, Wu H. A study on the effect of acute hyperbaric oxygen intervention on aerobic endurance. J Physiol Anthropol 2025;44(1):22.

PubMed · PMID 40676637 · DOI · PMC free full text

Hu 2025

PeerJ · 2025 · Network MA

Hu X, Meng H, Liang J, An H, Zhou J, Gao Y, You C, Zhang Z, Gong X, Liu Y. Comparison of the efficacy of 12 interventions in the treatment of diabetic foot ulcers: a network meta-analysis. PeerJ 2025;13:e19809.

PubMed · PMID 40821981 · DOI · PMC free full text

99 RCTs, 7,356 patients, 12 adjunctive interventions against standard of care or placebo — EGF, Wound healing rate — HBOT SIGNIFICANT (95 RCTs, 6,807 patients). Ten of the twelve interventions Amputation — HBOT SIGNIFICANT, and one of only two that were (30 RCTs, 2,526 patients, eight

Hua 2018

Cochrane Database Syst Rev · 2018 · Cochrane review

Hua C, Bosc R, Sbidian E, De Prost N, Hughes C, Jabre P, Chosidow O, Le Cleach L. Interventions for necrotizing soft tissue infections in adults. Cochrane Database Syst Rev 2018;5(5):CD011680.

PubMed · PMID 29851032 · DOI · PMC free full text

Huang/Tettelbach 2015

Undersea Hyperb Med · 2015 · Guideline

Huang ET (chair), Mansouri J, Murad MH, Joseph WS, Strauss MB, Tettelbach W, Worth ER; UHMS CPG Oversight Committee. A clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers. Undersea Hyperb Med 2015;42(3):205–247.

PubMed · PMID 26152105

Huang 2017

Undersea Hyperb Med · 2017 · Commentary / case

Huang E, Shah J, Pestell D, Kot J, Mathieu D, Smart D, Longobardi P, Sahni T, Rech FV, Löndahl M, Kawashima M, Weir G. An open letter to the American Diabetes Association board of directors: special commentary. Undersea Hyperb Med 2017;44(5):373-376.

PubMed · PMID 29116690

Huang 2019

Chronic Wound Care Manag Res · 2019 · Review / background

Huang E, Heyboer M 3rd, Savaser DJ. Hyperbaric oxygen therapy for the management of chronic wounds: patient selection and perspectives. Chronic Wound Care Manag Res 2019;6:27-37.

DOI

Huang 2023

World J Emerg Surg · 2023 · Meta-analysis

Huang C, Zhong Y, Yue C, He B, Li Y, Li J. The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis. World J Emerg Surg 2023;18(1):23.

PubMed · PMID 36966323 · DOI · PMC free full text

Mortality significantly lower with HBOT: RR 0.52 (95% CI 0.40–0.68; P<0.05). Multi-organ dysfunction (MODS) lower: RR 0.21 (95% CI 0.16–0.26). Amputation: no significant difference (RR 0.84, 95% CI 0.62–1.13); more debridements performed in

Patel & Batura 2026

Med Gas Res · 2026 · Meta-analysis

Patel A, Batura D. Hyperbaric oxygen therapy and Fournier’s gangrene: a systematic review and meta-analysis. Med Gas Res 2026;16(4):508–513.

PubMed · PMID 41575004 · DOI · PMC free full text

HBOT associated with significantly lower mortality vs controls. Hospital length of stay and number of surgical debridements: inconsistent, not significantly different.

Huang 2026

Cartilage · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Huang GS, Chiang SW, Chen CC, Peng YJ, Hsu YJ, Huang KL, Chou YC, Lin MH, Liu YC, Wang CY. Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2 Quantification Study. Cartilage 2026:online ahead of print, 1-12.

PubMed · PMID 42233693 · DOI · PMC free full text

Huang 2026 (Medicina)

Medicina (Kaunas) · 2026 · Meta-analysis

Huang C, Lin L, Tang T. Hyperbaric Oxygen Therapy Is Associated with Lower Mortality in Patients with Fournier’s Gangrene: A Meta-Analysis. Medicina (Kaunas) 2026;62(6):1199.

PubMed · PMID 42356211 · DOI · PMC free full text

Mortality: 9.55% (HBOT) vs 27.45% (control); RR 0.33 (95% CI 0.23–0.48, p<0.001). A large, significant

Huchim-Lara 2017

Undersea and Hyperbaric Medicine · 2017 · Cohort / series

Huchim-Lara O, Chin W, Salas S, Rivera-Canul N, Cordero-Romero S, Tec J, Joo E, Mendez-Dominguez N. Decompression sickness among diving fishermen in Mexico: observational retrospective analysis of DCS in three sea cucumber fishing seasons. Undersea and Hyperbaric Medicine 2017;44(2):149-156.

PubMed · PMID 28777905 · DOI

Hugon 2018

Diving and Hyperbaric Medicine · 2018 · Cohort / series

Hugon J, Metelkina A, Barbaud A, Nishi R, Bouak F, Blatteau J-E, Gempp E. Reliability of venous gas embolism detection in the subclavian area for decompression stress assessment following scuba diving. Diving and Hyperbaric Medicine 2018;48(3):132-140.

PubMed · PMID 30199887 · DOI · PMC free full text

Hulshof 2002

Strahlenther Onkol · 2002 · RCT

Hulshof MCCM, Stark NM, van der Kleij A, Sminia P, Smeding HMM, Gonzalez Gonzalez D. Hyperbaric oxygen therapy for cognitive disorders after irradiation of the brain. Strahlenther Onkol 2002;178(4):192–198.

PubMed · PMID 12040756 · DOI

All eligible patients completed HBO and testing (feasible). 1 of 7 patients had a meaningful improvement in neuropsychological functioning. At 3 months the HBO group showed a small but NOT significant benefit vs the untreated group.

Hussain 2024

Microorganisms · 2024 · Review / background

Hussain H, Fadel A, Garcia E, Hernandez RJ, Saadoon ZF, Naseer L, Casmartino E, Hamad M, Schnepp T, Sarfraz R, Angly S, Jayakumar AR. Clostridial myonecrosis: a comprehensive review of toxin pathophysiology and management strategies. Microorganisms 2024;12(7):1464.

PubMed · PMID 39065232 · DOI · PMC free full text

Hussain 2026

Diabetes · 2026 · Review / background

Hussain SA, Rehman R, Amin F, Abid A, Saleem N. Hyperbaric oxygen therapy as an adjunct to standard medical and surgical care for diabetic foot ulcers: an updated systematic review and meta-analysis of randomized controlled trials. Diabetes 2026;75(Suppl 1):1462-P (ADA Scientific Sessions abstract).

DOI

19 RCTs, 1269 participants (635 HBOT, 634 control). Ulcer healing RR 1.97 (95% CI 1.48–2.62), Major amputation RR 0.48 (0.24–0.97), 7 RCTs, 467 participants, I² 36.5%; no significant ⚠️⚠️ Publication-bias signal: funnel-plot asymmetry AND Egger's test p < 0.001.

Hwang 2016

J Craniofac Surg · 2016 · Commentary / case

Hwang K. Hyperbaric Oxygen Therapy to Avoid Blindness From Filler Injection. J Craniofac Surg 2016;27(8):2154–2155.

PubMed · PMID 28005776 · DOI

A brief technical-strategy note: reviews that of 98 filler/fat-injection blindness cases only 2 recovered vision, notes only 2 prior HBOT-in-ophthalmic-artery-occlusion cases (neither improved), and relays one favourable case (central retinal vein + cilioretinal artery occlusion) treated with HBOT (2-hour sessions at 253 kPa daily for 14 days) whose visual acuity returned from 20/200 to 20/20 — at

Hwang 2019

Undersea Hyperb Med · 2019 · Cohort / series

Hwang L, Song M, Lee Y, Shin TM. Methods for preventing middle ear barotrauma in computer-controlled pressurization of monoplace hyperbaric chambers. Undersea Hyperb Med 2019;46(2):107-116.

PubMed · PMID 31051055

Hyldegaard 2025

Infect Dis Ther · 2025 · Cohort / series

Hyldegaard O, Nekludov M, Arnell P, Nedrebø T, Karlsson Y, Madsen MB, Skrede S, … Norrby-Teglund A, Hedetoft M. Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort. Infect Dis Ther 2025;14:1715–1738.

PubMed · PMID 40613866 · DOI · PMC free full text

All-cause mortality — HBO₂ vs non-HBO₂: 30-day 22/325 (7%) vs 34/80 (43%); 90-day 36/325 (11%) In exploratory analysis, HBO₂ was associated with lower 30-day all-cause mortality — unadjusted and Critical caveat (authors' own): HBO₂-treated patients were LESS acutely ill (lower SAPS-2/SOFA)

Icme 2014

Eur Rev Med Pharmacol Sci · 2014 · Cohort / series

Icme F, Kozaci N, Ay MO, Avci A, Gumusay U, Yilmaz M, Satar S (Turkey). The relationship between blood lactate, carboxy-hemoglobin and clinical status in CO poisoning. Eur Rev Med Pharmacol Sci 2014;18(3):393–397.

PubMed · PMID 24563440

Lactate and COHb were significantly higher in patients with GCS < 15 than GCS = 15 (p < 0.01) — both track clinical severity in acute CO poisoning. Treatments recorded (NBOT/HBOT) but the study is a severity-biomarker analysis, not an efficacy comparison.

Imbert 2022

Diving Hyperb Med · 2022 · Cohort / series

Imbert JP, Massimelli JY, Kulkarni A, Matity L, Bryson P. A review of accelerated decompression from heliox saturation in commercial diving emergencies. Diving Hyperb Med 2022;52(4):245-259.

PubMed · PMID 36525682 · DOI · PMC free full text

Imbert 2026

Diving Hyperb Med · 2026 · Review / background

Imbert JP, Matity L, Massimelli JY, Cadieux C, Risberg J, Bryson P. Review of excursion procedures used in commercial heliox saturation diving. Diving Hyperb Med 2026;56(1):21-40.

PubMed · PMID 41875439 · DOI · PMC free full text

Inman 2020

Undersea Hyperb Med · 2020 · Commentary / case

Inman AL, Sorrell LP, Lagina AT. Decompression sickness responsive to delayed treatment with hyperbaric oxygen: a case report of two divers. Undersea Hyperb Med 2020;47(4):551-554.

PubMed · PMID 33227830 · DOI

Irgens 2013

Undersea Hyperb Med · 2013 · Cohort / series

Irgens A, Vaagbø G, Aanderud L. Quality of life — the effect of hyperbaric oxygen treatment on radiation injury. Undersea Hyperb Med 2013;40(6):479-485.

PubMed · PMID 24377190

Ivanov 2020

Undersea Hyperb Med · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Ivanov M, Brkic P, Vajic UJ, Mihailovic-Stanojevic N, Milacic D, Jovovic D, Karanovic D, Djelic M, Jeremic R, Miloradovic Z. Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. Undersea Hyperb Med 2020;47(1):21-30.

PubMed · PMID 32176943 · DOI

Jacoby 2024

Undersea Hyperb Med · 2024 · RCT

Jacoby H, Camporesi EM, Ross SB, Sucandy I, Bosco G, Syblis C, et al. Outcomes after pancreaticoduodenectomy with or without preoperative hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(1):7-15 (DOI 10.22462/648).

DOI

Jain 2017

Springer International Publishing · 2017 · Review / background

Jain KK. HBO therapy in the management of radionecrosis (Textbook of Hyperbaric Medicine, chapter 17). Springer International Publishing 2017;(ch 17):207-219.

DOI

Jain 2017 (chapter 16)

Textbook of Hyperbaric Medicine (Springer) · 2017 · Review / background

Jain KK. HBO therapy in wound healing, plastic surgery, and dermatology. Chapter 16 in: Textbook of hyperbaric medicine. Textbook of Hyperbaric Medicine (Springer) 2017:Chapter 16.

HBOT 0067 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Jalabi 2001

Undersea Hyperb Med · 2001 · RCT

Jalabi MW, Abidia A, Kuhan G, Laden G, Verma D, McCollum PT. The safety and effect of hyperbaric oxygen therapy in patients with diabetic retinopathy — a double-blind randomised controlled trial. Undersea Hyperb Med 2001;28(Suppl):abstract P99 (UHMS Annual Scientific Meeting, San Antonio).

HBOT 0006 · Not indexed in PubMed and no DOI — full text held in the practice wiki

A significant myopic shift developed with oxygen vs controls at 3 months (P=0.019 right eye, No significant change in ocular blood flow or tonometry in either group. No new vessel formation on retinal photography/angiography, and no regression or worsening of

Jang 2018

Intensive Care Med Exp · 2018 · Cohort / series

Jang DH, Khatri UG, Shortal BP, Kelly M, Hardy K, Lambert DS, et al. Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 2018;6(1):4.

PubMed · PMID 29383459 · DOI · PMC free full text

Jay 1997

Undersea Hyperb Med · 1997 · Cohort / series

Jay GD, McKindley DS. Alterations in pharmacokinetics of carboxyhemoglobin produced by oxygen under pressure. Undersea Hyperb Med 1997;24(3):165–173.

PubMed · PMID 9308139

COHb half-life: 26.3 ± 3.7 min on HBO vs 71.3 ± 9.9 min on NBO (P<0.05) — HBO roughly halved Elevated O₂ partial pressure shifted COHb elimination from zero-order to first-order kinetics Authors: HBO provides a pharmacokinetic advantage over non-rebreather-mask O₂ for clearing mild

Jiang 1997

Undersea Hyperb Med · 1997 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Jiang J, Tyssebotn I. Normobaric and hyperbaric oxygen treatment of acute carbon monoxide poisoning in rats. Undersea Hyperb Med 1997;24(2):107-116.

PubMed · PMID 9171469

Jingami 2024

Front Med (Lausanne) · 2024 · Commentary / case

Jingami N, Cho K, Nitta T, Takatani M, Kobayashi K, Takenaka R, Sugita N, Ohtsuru S. Case report: consecutive hyperbaric oxygen therapy for delayed post-hypoxic leukoencephalopathy resulting from CHANTER syndrome caused by opioid intoxication. Front Med (Lausanne) 2024;11:1364038 (PMID 38695031. DOI 10.3389/fmed.2024.1364038).

PubMed · PMID 38695031 · DOI · PMC free full text

Jingami 2025

Undersea Hyperb Med · 2025 · Commentary / case

Jingami N, Nitta T, Ishiguro Y, Takatani Y, Yunoki T, Ohtsuru S. Position change during hyperbaric oxygen therapy for arterial gas embolism. Undersea Hyperb Med 2025;52(2):157-161.

PubMed · PMID 40819357 · DOI

Johnson 2025

Diving Hyperb Med · 2025 · Commentary / case

Johnson G, Bryson P, Tabner A. Advances in the delivery of cardiopulmonary resuscitation in a diving bell. Diving Hyperb Med 2025;55(2):186-190.

PubMed · PMID 40544147 · DOI · PMC free full text

Johnson-Arbor 2014

Undersea Hyperb Med · 2014 · Commentary / case

Johnson-Arbor K. Does sensory neuropathy increase the risk for asymptomatic otic barotrauma during hyperbaric oxygen therapy? An editorial perspective. Undersea Hyperb Med 2014;41(4):265-266.

PubMed · PMID 25109077

Johnson-Arbor 2017

Undersea Hyperb Med · 2017 · Commentary / case

Johnson-Arbor K, Falola R, Kelty J, Barbour J, Attinger C. Use of indocyanine green fluorescent angiography in a hyperbaric patient with soft tissue radiation necrosis: a case report. Undersea Hyperb Med 2017;44(3):273-278.

PubMed · PMID 28779583

Johnson-Arbor 2023

Undersea Hyperb Med · 2023 · Commentary / case

Johnson-Arbor K. Treatment of pediatric cerebral radiation necrosis using hyperbaric oxygenation. Undersea Hyperb Med 2023;50(4):421-424.

PubMed · PMID 38055883 · DOI

Johnson-Arbor 2024

Undersea Hyperb Med · 2024 · Commentary / case

Johnson-Arbor K. Hyperbaric oxygen therapy for treatment of vascular occlusion after permanent dermal filler injection. Undersea Hyperb Med 2024;51(4):403-406 (DOI 10.22462/655).

DOI

Joshua 2022

JAMA Otolaryngol Head Neck Surg · 2022 · Meta-analysis

Joshua TG, Ayub A, Wijesinghe P, Nunez DA. Hyperbaric Oxygen Therapy for Patients With Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg 2022;148(1):5–11.

PubMed · PMID 34709348 · DOI · PMC free full text

Mean absolute hearing gain +10.3 dB (95% CI 6.5–14.1; I²=0%) favouring HBOT. Odds of hearing recovery (≥10 dB PTA gain) OR 4.3 (95% CI 1.6–11.7; I²=0%) favouring HBOT. Benefit was seen with HBOT as part of a combination regimen (with steroids).

Jüttner 2021

Ger Med Sci · 2021 · Guideline

Jüttner B, Busch HJ, Callies A, Dormann H, Janisch T, Kaiser G, Körner-Göbel H, Kluba K, Kluge S, Leidel BA, Müller O, Naser J, Pohl C, Reiter K, Schneider D, Staps E, Welslau W, Wißuwa H, Wöbker G, Muche-Borowski C. S2k guideline diagnosis and treatment of carbon monoxide poisoning. Ger Med Sci 2021;19:Doc13.

PubMed · PMID 34867135 · DOI · PMC free full text

100% normobaric oxygen is the immediate treatment for all symptomatic CO exposure; management is by On HBOT, the guideline is deliberately cautious: the evidence of benefit is regarded as

Jüttner 2023

Ger Med Sci · 2023 · Guideline

Jüttner B, Wölfel C, Camponovo C, et al. S2k guideline for diving accidents. Ger Med Sci 2023;21:Doc01.

PubMed · PMID 37033772 · DOI · PMC free full text

A multi-society S2k clinical practice guideline on the management of diving accidents — decompression illness (DCI): decompression sickness and arterial gas embolism. Covers pre-hospital 100% oxygen, fluids, and recompression / hyperbaric oxygen therapy.

Kaczerska 2019

Undersea Hyperb Med · 2019 · Commentary / case

Kaczerska D, Siermontowski P, Kozakiewicz M, Krefft K, Olszański R. Dehydration of a diver during a hyperbaric chamber exposure with oxygen decompression. Undersea Hyperb Med 2019;46(2):185-188.

PubMed · PMID 31051063

Kalani 2002

J Diabetes Complications · 2002 · Cohort / series

Kalani M, Jörneskog G, Naderi N, Lind F, Brismar K. Hyperbaric oxygen (HBO) therapy in treatment of diabetic foot ulcers. Long-term follow-up. J Diabetes Complications 2002;16(2):153–158.

PubMed · PMID 12039398 · DOI

Complete healing with intact skin at 3 years: 76% (Group A / HBO) vs 48% (Group B / conventional). Amputation: 2/17 (12%) HBO vs 7/21 (33%) conventional. Baseline blood pressure, HbA1c, diabetes duration and basal TcPO₂ were similar — but the groups

Kara 2021

Diving Hyperb Med · 2021 · Commentary / case

Kara S, İnci E, Gözen ED, Gülgün KC, Yener HM. Results of hyperbaric oxygen treatment in an at-risk nasal flap following trauma. Diving Hyperb Med 2021;51(2):207-209.

PubMed · PMID 34157737 · DOI · PMC free full text

Katsnelson 2025

Diving Hyperb Med · 2025 · Review / background

Katsnelson G, Salvatori M, Djaiani G, Greer E, Tarshis J, Katznelson R. Safety and efficacy of continuous glucose monitoring devices in individuals with diabetes undergoing hyperbaric oxygen therapy: a scoping review. Diving Hyperb Med 2025;55(2):164-172 (DOI 10.28920/dhm55.2.164-172).

PubMed · PMID 40544144 · DOI · PMC free full text

Kaur 2012

J Anaesthesiol Clin Pharmacol · 2012 · RCT

Kaur S, Pawar M, Banerjee N, Garg R. Evaluation of the efficacy of hyperbaric oxygen therapy in the management of chronic nonhealing ulcer and role of periwound transcutaneous oximetry as a predictor of wound healing response: A randomized prospective controlled trial. J Anaesthesiol Clin Pharmacol 2012;28(1):70–75.

PubMed · PMID 22345950 · DOI · PMC free full text

Wound area: 59% reduction (HT) vs a 26% increase (CT). Complete healing in 3 (HT) vs 0 (CT); wound-score improvement in 10 (HT) vs 5 (CT); surgical Amputation: 1 (HT) vs 5 (CT). A positive correlation was found between TcPO₂ and markers of

Kavram 2025

Diving Hyperb Med · 2025 · Cohort / series

Kavram G, Yasa B, Bor M, Bilgin L, Ince EZ, Mirasoglu B, et al. Hyperbaric oxygen treatment of neonates: a case series. Diving Hyperb Med 2025;55(3):284-288 (DOI 10.28920/dhm55.3.284-288).

PubMed · PMID 40986926 · DOI · PMC free full text

Kawashima 2020

2020 · Review / background

Kawashima M, Yamaguchi T, Tamura H, Kawashima M. Treatment of Osteomyelitis by Hyperbaric Oxygen Therapy. 2020:67–80.

DOI

A textbook chapter, and it must be cited as one. It is a narrative account of the rationale, the protocol and the older clinical literature for hyperbaric oxygen in osteomyelitis, written by the orthopaedic team at Kawashima Orthopaedic Hospital, Nakatsu, Japan. It has no methods section, no search strategy, no inclusion criteria and no synthesis. Embedded in it are the authors' own uncontrolled i

Keim 2018

Undersea Hyperb Med · 2018 · Commentary / case

Keim L, Koneru S, Ramos VFM, Murr N, Hoffnung DS, Murman DL, Cooper JS, Torres-Russotto D. Hyperbaric oxygen for late sequelae of carbon monoxide poisoning enhances neurological recovery: case report. Undersea Hyperb Med 2018;45(1):83-87 (PMID 29571236).

PubMed · PMID 29571236

UHMS 2021

Version 3, 26 March · 2021 · Guideline

Kelly M, Gelly H, Shapshak D; Undersea and Hyperbaric Medical Society. UHMS Position Statement: Office-based hyperbaric oxygen facility credentialing guidelines. Version 3, 26 March 2021.

HBOT 0029 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Kelly 2024

Undersea Hyperb Med · 2024 · Guideline

Kelly M, Gelly H, O'Neill O, Shapshak D. UHMS Position Statement: Physician's Duties in Hyperbaric Medicine - 99183. Undersea Hyperb Med 2024;51(2):v–viii.

PubMed · PMID 38985156

Physician oversight of HBO₂ delivery is central to safety and quality; the statement articulates the International-society governance guidance (authority tier), aligned with the SAUHMA policy that a

Kemper 2015

Diving and Hyperbaric Medicine · 2015 · Commentary / case · MIXED human and preclinical evidence

Kemper TCPM, Rienks R, van Ooij PJAM, van Hulst RA. Cutis marmorata in decompression illness may be cerebrally mediated: a novel hypothesis on the aetiology of cutis marmorata. Diving and Hyperbaric Medicine 2015;45(2):84-88.

PubMed · PMID 26165529

Keogh 1973

Postgrad Med J · 1973 · Commentary / case

Keogh AJ. Clostridial brain abscess and hyperbaric oxygen. Postgrad Med J 1973;49(567):64–66.

PubMed · PMID 4354408 · DOI · PMC free full text

A single case report — described by the author as the first case of "gas gangrene" of the brain treated with hyperbaric oxygen — with a short narrative review of the previously published cases. It is not a series, not a cohort, and contains no comparison group. This is the one paper in the wiki's intracranial-abscess set whose author argues AGAINST hyperbaric oxygen. The summary states: "It is sug

Keohane 2023

Vasc Endovascular Surg · 2023 · Systematic review

Keohane C, Westby D, Nolan FC, Twyford M, Tawfick W, Walsh SR. Hyperbaric Oxygen as an Adjunct in the Treatment of Venous Ulcers: A Systematic Review. Vasc Endovascular Surg 2023;57(6):607–616.

PubMed · PMID 36891617 · DOI · PMC free full text

Systematic review (PRISMA; RoB-2 / ROBINS-I) of HBOT for venous leg ulcer (VLU) — does HBOT increase complete VLU healing or reduce VLU area vs controls. Six studies, with significant heterogeneity (no standard control, outcome reporting, or follow-up duration).

Kessler 2003

Diabetes Care · 2003 · RCT

Kessler L, Bilbault P, Ortéga F, et al. Hyperbaric Oxygenation Accelerates the Healing Rate of Nonischemic Chronic Diabetic Foot Ulcers. Diabetes Care 2003;26(8):2378–2382.

PubMed · PMID 12882865 · DOI

Ulcer-area reduction at day 15 (end of HBO): 41.8% ± 25.5 (HBO) vs 21.7% ± 16.9 (control) — P=0.037 Benefit not sustained at day 30 (48.1% vs 41.7%, NS) — a time-dependent effect. Peri-ulcer TcPO₂ rose markedly during HBO (21.9 → 454.2 mmHg, P<0.001); complete healing in 2 (HBO) vs

Khallouli 2020

Diving Hyperb Med · 2020 · Commentary / case

Khallouli A, Khelifi K, Saidane R, Choura R, Maalej A, Ben Sassi R. Hyperbaric oxygen treatment of central retinal vein occlusion with cilioretinal artery occlusion secondary to hormonal treatment: Case report and review. Diving Hyperb Med 2020;50(4):431-436.

PubMed · PMID 33325028 · DOI · PMC free full text

Khan 2024

Diving and Hyperbaric Medicine Journal · 2024 · Review / background

Khan H, Islam MS, Kaur M, Burns JK, Etherington C, Dion PM, et al. Efficacy of searching in biomedical databases beyond MEDLINE in identifying randomised controlled trials on hyperbaric oxygen treatment. Diving and Hyperbaric Medicine Journal 2024;54(1):2-8 (DOI 10.28920/dhm54.1.2-8).

PubMed · PMID 38507904 · DOI · PMC free full text

Khan 2024

Hematol Rep · 2024 · Commentary / case

Khan S, Brenna CTA, Pendergrast J, Malinowski AK, Salvatori M, Katznelson R, Tarshis J. Hyperbaric Oxygen Therapy during Pregnancy for Critical Anemia Secondary to Sickle Cell Disease with Post-Transfusion Hyperhemolysis: A Case Report. Hematol Rep 2024;16(3):552–558.

PubMed · PMID 39311140 · DOI · PMC free full text

Baseline. Pre-pregnancy haemoglobin on hydroxyurea ranged from 90 to 100 g/L; the printed The transfusion reaction. Pre-exchange Hb was 93 g/L with HbS 73.4%; post-exchange Hb was 96 g/L HBOT prescription. 100% oxygen in a monoplace chamber at 2.8 ATA, reduced to 2.0 ATA for the

Kienitz 2026

Am J Vet Res · 2026 · Cohort / series · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Kienitz LT, McCoy AM, Robbins MA. Hyperbaric oxygen therapy does not improve recovery of deep pain perception in dogs after hemilaminectomy for intervertebral disk disease. Am J Vet Res 2026;87(8):ajvr.26.01.0009.

PubMed · PMID 42091082 · DOI

Kılınç 2025

Acta Orthop Belg · 2025 · Cohort / series

Kılınç O, Günaydın F, Sakarya B, Demirtaş İ, Aslan B. The Effect of Fasciotomy Timing on Limb Vitality and Functionality in Kahramanmaras/Turkey Earthquake. Acta Orthop Belg 2025;91(4):495–502.

PubMed · PMID 41928750 · DOI

Fasciotomy timing dominates outcome: mean RFT 25.1 h (good outcome) vs 47.1 h (poor), p<0.05; HBOT associated with better outcomes: good-outcome rate higher with HBOT (p=0.006); on logistic

Kim 2018

Undersea Hyperb Med · 2018 · Cohort / series

Kim DU, Rao A, Kaplan S, Baksh F, Caprioli R, Haight J, Ferguson RG, Pliskin M, Oropallo A. The use of indocyanine green fluorescence angiography to assess perfusion of chronic wounds in patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med 2018;45(6):663-671.

PubMed · PMID 31158933

Kim 2020

Undersea Hyperb Med · 2020 · Cohort / series

Kim YS, Nam MS, Park EJ, Lee Y, Kim H, Kim SH, Cha YS. The effect of adjunctive hyperbaric oxygen therapy in patients with central retinal artery occlusion. Undersea Hyperb Med 2020;47(1):57-64.

PubMed · PMID 32176947 · DOI

A registry-based observational study with a concurrent control group — the design most of this indication's literature lacks. Adults presenting within 24 hours of CRAO symptom onset between October 2016 and February 2019. Thirty-four consecutive patients were identified; 19 were included. Fourteen were excluded for presenting more than 24 hours after onset and one for failing to attend follow-up f

Kim 2020

Undersea Hyperb Med · 2020 · Commentary / case

Kim YS, Youn YJ, Cha YS. Successful use of hyperbaric oxygen therapy for limb salvage of acute limb ischemia as a complication of acute carbon monoxide poisoning. Undersea Hyperb Med 2020;47(2) (PMID 32574440; DOI 10.22462/04.06.2020.9).

PubMed · PMID 32574440 · DOI

Kim 2022

Undersea Hyperb Med · 2022 · Cohort / series

Kim HB, Nah S, Choi SW, Kim GW, Lee YH, Moon JE, Han S. Objective predictors of delayed neurological sequelae in patients with altered mental status after carbon monoxide poisoning. Undersea Hyperb Med 2022;49(1):83-91.

PubMed · PMID 35226979 · DOI

Kim 2025

J Korean Med Sci · 2025 · Meta-analysis

Kim Y, Kim JH. Fatality rate in hospitalized patients due to carbon monoxide poisoning in the Democratic People's Republic of Korea. J Korean Med Sci 2025;40(47):e312.

DOI

Kim 2026

J Transl Med · 2026 · Cohort / series

Kim L, Cammà G, Kedor Peters C, Mantwill M, Müller O, Leprêtre N, Heindrich C, Rust R, Krill M, Hartung TJ, Reeß LG, Krohn S, von Heymann C, Wittke K, Finke C, Scheibenbogen C. Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study. J Transl Med 2026;24:744.

PubMed · PMID 42249466 · DOI · PMC free full text

Kim 2026

Cancers (Basel) · 2026 · Cohort / series

Kim K, Kontoyiannis DP, Ahaneku H, McCue D, Adachi J, Ferrajoli A. Adjunct Hyperbaric Oxygen Therapy for Refractory Infections in Patients with Hematologic Malignancies: A Single-Center Retrospective Study. Cancers (Basel) 2026;18(13):2172.

PubMed · PMID 42449714 · DOI · PMC free full text

Kirk 1976

Clin Radiol · 1976 · Cohort / series

Kirk J, Wingate GWH, Watson ER. High-dose effects in the treatment of carcinoma of the bladder under air and hyperbaric oxygen conditions. Clin Radiol 1976;27(2):137–144.

PubMed · PMID 819200 · DOI

Despite the same modal dose, about one-third of patients showed exceptionally high "high-dose

Kjeld 2026

Physiol Rep · 2026 · Review / background

Kjeld T, Hansen EG, Arendrup HC, Højberg J, Nedergaard A, Krag T, Vissing J. Lactate increases oxygen unloading of preconditioned blood from male elite breath-hold divers. Physiol Rep 2026;14(1):e70698.

PubMed · PMID 41499326 · DOI · PMC free full text

Kjellberg 2025 (HOT-LoCO)

BMJ Open · 2025 · RCT

Kjellberg A, et al. (Karolinska). Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial. BMJ Open 2025;15(4):e094386.

PubMed · PMID 40228859 · DOI · PMC free full text

Primary endpoints (RAND-36 physical functioning & role-physical at 13 weeks): NO significant difference Harms: favourable — 43 AEs in 49% of HBOT vs 38 AEs in 44% of placebo (mostly cough, chest Conclusion: 10 HBOT sessions did not show more short-term benefit than placebo for long COVID.

Childers 2025

Undersea Hyperb Med · 2025 · Review / background

Childers EJ, Baynosa RC. The effect of hyperbaric oxygen on compromised grafts and flaps. Undersea Hyperb Med 2025;52(3):381-396.

PubMed · PMID 41223399

Kmiec 2026

Magn Reson Med · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Kmiec MM, Petryakov SV, Kheirollah A, Ubert CS, O'Connell RC, Kuppusamy P. Real-Time Monitoring of Tissue Oxygenation During Hyperbaric Oxygen Exposure Using In Vivo EPR Oximetry. Magn Reson Med 2026;96:2019-2028.

PubMed · PMID 42324649 · DOI · PMC free full text

Knighton 1983

Science · 1983 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 1983;221(4617):1283-1285.

PubMed · PMID 6612342 · DOI

Knighton 1984

Arch Surg · 1984 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Knighton DR, Halliday B, Hunt TK. Oxygen as an antibiotic. The effect of inspired oxygen on infection. Arch Surg 1984;119(2):199-204.

PubMed · PMID 6365032 · DOI

Knighton 1990

J Trauma · 1990 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Knighton DR, Phillips GD, Fiegel VD. Wound healing angiogenesis: indirect stimulation by basic fibroblast growth factor. J Trauma 1990;30(12 Suppl):S134-S144.

PubMed · PMID 1701493

Kohshi 2003

J Neurol Sci · 2003 · Commentary / case

Kohshi K, Imada H, Nomoto S, Yamaguchi R, Abe H, Yamamoto H. Successful treatment of radiation-induced brain necrosis by hyperbaric oxygen therapy. J Neurol Sci 2003;209(1-2):115-117.

PubMed · PMID 12686413

Kohshi 2017

Undersea and Hyperbaric Medicine · 2017 · Cohort / series

Kohshi K, Morimatsu Y, Tamaki H, Murata Y, Kohshi K, Ishitake T, Denoble PJ. Cerebrospinal vascular diseases misdiagnosed as decompression illness: the importance of considering other neurological diagnoses. Undersea and Hyperbaric Medicine 2017;44(4):309-313.

PubMed · PMID 28783886 · DOI

Kohshi 2021

Diving and Hyperbaric Medicine · 2021 · Review / background

Kohshi K, Tamaki H, Lemaître F, Morimatsu Y, Denoble PJ, Ishitake T. Diving-related disorders in commercial breath-hold divers (Ama) of Japan. Diving and Hyperbaric Medicine 2021;51(2):199-206.

PubMed · PMID 34157736 · DOI · PMC free full text

Kohshi 2021

Diving and Hyperbaric Medicine · 2021 · Commentary / case

Kohshi K. Reply: Diving-related disorders in breath-hold divers could be explained with the distal arterial bubble hypothesis. Diving and Hyperbaric Medicine 2021;51(4):383-384.

PubMed · PMID 34897606 · DOI · PMC free full text

Koren 2015

Orthopedics · 2015 · Cohort / series

Koren L, Ginesin E, Melamed Y, Norman D, Levin D, Peled E. Hyperbaric oxygen for stage I and II femoral head osteonecrosis. Orthopedics 2015;38(3):e200–e205.

PubMed · PMID 25760507 · DOI

Rambam Health Care Campus, Haifa. Clinical and MRI records were reviewed for 68 patients (78 joints) with symptomatic Steinberg stage I or II osteonecrosis of the femoral head treated with hyperbaric oxygen from July 1996 to August 2012. Staging was by the criteria of Steinberg et al, on MRI read by certified musculoskeletal radiologists.

Korhonen 1999

Ann Chir Gynaecol · 1999 · Cohort / series

Korhonen K, Klossner J, Hirn M, Niinikoski J. Management of clostridial gas gangrene and the role of hyperbaric oxygen. Ann Chir Gynaecol 1999;88(2):139–142.

PubMed · PMID 10392252

Mortality 12/53 (22.6%). HBO decreased systemic toxicity and prevented further extension of infection, improving overall

Korpinar 2022

Diving Hyperb Med · 2022 · Cohort / series

Korpinar S. Hyperbaric oxygen treatment in a rare complication of intramuscular injection: four cases of Nicolau syndrome. Diving Hyperb Med 2022;52(2):149-153.

PubMed · PMID 35732287 · DOI · PMC free full text

Kot 2005

Eur J Underwater Hyperb Med · 2005 · Review / background

Kot J. Medical equipment for multiplace hyperbaric chambers. Part I: Devices for monitoring and cardiac support. Eur J Underwater Hyperb Med 2005;6(4):115-120.

HBOT 0048 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Kot 2006

Eur J Underwater Hyperb Med · 2006 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Kot J. Medical equipment for multiplace hyperbaric chambers. Part II: Ventilators. Eur J Underwater Hyperb Med 2006;7(1):9-12.

HBOT 0050 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Kot 2006

Eur J Underwater Hyperb Med · 2006 · Review / background

Kot J. Medical equipment for multiplace hyperbaric chambers. Part III: Infusion pumps and syringes. Eur J Underwater Hyperb Med 2006;7(2):29-31.

HBOT 0049 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Kot 2014

Diving Hyperb Med · 2014 · Commentary / case

Kot J. Medical devices and procedures in the hyperbaric chamber. Diving Hyperb Med 2014;44(4):223-227.

PubMed · PMID 25596835

Kot 2015

Diving Hyperb Med · 2015 · Commentary / case

Kot J. Staffing and training issues in critical care hyperbaric medicine. Diving Hyperb Med 2015;45(1):47-50.

PubMed · PMID 25964039

Kot 2021

Diving Hyperb Med · 2021 · Commentary / case

Kot J, Lenkiewicz E, Lizak E, Góralczyk P, Chreptowicz U. Spinal cord decompression sickness in an inside attendant after a standard hyperbaric oxygen treatment session. Diving Hyperb Med 2021;51(1):103-106.

PubMed · PMID 33761550 · DOI · PMC free full text

Kot 2025 letter and Wilmshurst 2025 reply

Diving Hyperb Med · 2025 · Commentary / case

Kot J; with reply by Wilmshurst PT, Edge C. PFO and DCS of hyperbaric personnel [letter]; Reply — PFO and DCS of hyperbaric personnel. Diving Hyperb Med 2025;55(1):65-66.

PubMed · PMID 40090029 · DOI · PMC free full text

Kozakiewicz 2018

Undersea Hyperb Med · 2018 · Cohort / series

Kozakiewicz M, Kędziora-Kornatowska K, Kaczerska D, Siermontowski P, Olszański R, Krefft K. Influence of exposure in hyperbaric chambers on selected parameters of oxidative stress in professional divers. Undersea Hyperb Med 2018;45(1):49-54.

PubMed · PMID 29571232

Krajčovičová 2018

Undersea Hyperb Med · 2018 · Cohort / series

Krajčovičová Z, Meluš V, Zigo R, Matišáková I, Večeřa J, Kašlíková K. Efficacy of hyperbaric oxygen therapy as a supplementary therapy of sudden sensorineural hearing loss in the Slovak Republic. Undersea Hyperb Med 2018;45(3):363–370.

PubMed · PMID 30028922

HBO group: statistically significant improvement in auditory threshold in ALL frequency groups (P<0.001). Control group: significant mean auditory gain only in the 1,000–2,000 Hz zone (P=0.01), with complete ⚠️ Corrected 31 Aug 2026: this line previously read "with recovery seen only in the first two frequency

Kranke 2015

Cochrane Database Syst Rev · 2015 · Cochrane review

Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 2015;Issue 6:CD004123 (searches to 17 Feb 2015; re-published Issue 3, 2020 — edited, no change to conclusions).

PubMed · PMID 26106870 · DOI · PMC free full text

DFU healing at 6 weeks: pooled 5 trials (205 pts) — RR 2.35 (95% CI 1.19–4.62; P = 0.01) Major amputation (DFU): pooled 5 trials (312 pts) — RR 0.36 (95% CI 0.11–1.18), not Venous ulcers: 1 trial (16 pts) — significant ulcer-area reduction at 6 weeks only

Krimus 2023

Undersea Hyperb Med · 2023 · Commentary / case

Krimus L, Hasan Rizvi S, Marinov A, Clarke H, Katznelson R. Hyperbaric oxygen therapy for treatment of COVID-19-related parosmia: a case report. Undersea Hyperb Med 2023;50(4):433-435 (DOI 10.22462/01.01.2023.25).

DOI

Kuduban 2026

Eurasian J Med · 2026 · Cohort / series

Kuduban O, Özkan R. Short- and Long-Term Hearing Outcomes After Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss. Eurasian J Med 2026;58(4):1-5.

PubMed · PMID 42417092 · DOI · PMC free full text

Kumar 2020

J Anaesthesiol Clin Pharmacol · 2020 · RCT

Kumar A, Shukla U, Prabhakar T, Srivastava D. Hyperbaric oxygen therapy as an adjuvant to standard therapy in the treatment of diabetic foot ulcers. J Anaesthesiol Clin Pharmacol 2020;36(2):213–218.

PubMed · PMID 33013037 · DOI · PMC free full text

Complete healing without any surgical intervention: 78% (group H) vs 0% (group S), P=0.001. Amputation: 2 patients (group H) needed distal amputation vs 3 (group S) proximal amputation —

Kumar 2024

Diving and Hyperbaric Medicine Journal · 2024 · Commentary / case

Kumar S, Chaudhry H, Mohanty C, Bhutani S, Risham M, Lanjekar K. Hyperbaric oxygen treatment (HBOT) in a case of traumatic chondronecrosis of the cricoid cartilage. Diving and Hyperbaric Medicine Journal 2024;54(3):249-251 (DOI 10.28920/dhm54.3.249-251).

PubMed · PMID 39288933 · DOI · PMC free full text

Kuo 2022

Eur Arch Otorhinolaryngol · 2022 · Meta-analysis

Kuo TC, Chao WC, Yang CH, Tsai MS, Tsai YT, Lee YC. Intratympanic steroid injection versus hyperbaric oxygen therapy in refractory sudden sensorineural hearing loss: a meta-analysis. Eur Arch Otorhinolaryngol 2022;279(1):83–90.

PubMed · PMID 33751195 · DOI

No significant difference in mean post-treatment hearing gain between ITS and HBO salvage. Word discrimination and hearing gain across 250–8000 Hz were comparable between the two.

Kurschel 2006

Childs Nerv Syst · 2006 · Cohort / series

Kurschel S, Mohia A, Weigl V, Eder HG. Hyperbaric oxygen therapy for the treatment of brain abscess in children. Childs Nerv Syst 2006;22:38–42 (the article header prints volume 22, pages 38–42; no issue number is printed on the paper).

PubMed · PMID 15875200 · DOI

All five children improved clinically, with continuous regression of the inflammatory pathology on At 6 months all five were in good clinical condition without neurological sequelae, except one child No recurrence at a mean follow-up of 21 months (range 7–72 months).

Kutlay 2005

Neurosurgery · 2005 · Cohort / series

Kutlay M, Çolak A, Yıldız Ş, Demircan N, Akın ON. Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscesses. Neurosurgery 2005;57(6):1140–1146 (the PDF prints DOI 10.1227/01.NEU.0000186012.95462.E5 on the title page although the PubMed record carries no DOI).

PubMed · PMID 16331162 · DOI

All 13 patients achieved infection control and healing. Mortality 0%. Recurrence after completion of Two abscesses recollected within the first 2 weeks and were re-aspirated on days 6 and 9 — an early Outcome at end of follow-up: 12 patients in good condition — 9 (69.2%) without sequelae, 3 (23%) with

Kwee 2024

Eur J Trauma Emerg Surg · 2024 · Systematic review

Kwee E, Borgdorff M, Schepers T, Halm JA, Winters HAH, Weenink RP, Ridderikhof ML, Giannakópoulos GF (Amsterdam UMC). Adjunctive hyperbaric oxygen therapy in the management of severe lower limb soft tissue injuries: a systematic review. Eur J Trauma Emerg Surg 2024;50(3):1093–1100.

PubMed · PMID 38386077 · DOI · PMC free full text

7 studies, 229 patients — 2 RCTs, 1 retrospective cohort, 3 case series, 1 case report. The placebo-controlled RCT favoured HBO; the non-placebo RCT found early HBO reduced tissue necrosis and

Labmayr 2026

Trauma Case Rep · 2026 · Commentary / case

Labmayr V, Huetter K, Ornig M, Lanz P, Puchwein P, Holweg P. Functional recovery after open talar neck fracture with foot dislocation: A case report. Trauma Case Rep 2026;65:101419.

PubMed · PMID 42603992 · DOI · PMC free full text

Lakkis 2025

Cureus · 2025 · Review / background

Lakkis T, Elshoura AMA, Soria Behr GA, Eduardo Mauricio MC, Sil-Zavaleta S, Cai LY, Rai M. Central Retinal Artery Occlusion in Acute Care: Current Practices and Emerging Therapies. Cureus 2025;17(9):e92786.

PubMed · PMID 41127733 · DOI · PMC free full text

Positions HBOT and targeted thrombolysis as promising emerging therapies within a multidisciplinary

Lalieu 2020

Wound Repair Regen · 2020 · Systematic review

Lalieu RC, Brouwer RJ, Ubbink DT, Hoencamp R, Bol Raap R, van Hulst RA. Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review. Wound Repair Regen 2020;28(2):266–275.

PubMed · PMID 31667898 · DOI · PMC free full text

7 studies (2 RCTs) restricted to non-ischaemic diabetic foot ulcers. No significant difference in complete wound healing (5 studies), major amputation (2 no difference; 1 large retrospective study found 2% more major amputations with HBO, uncorrected for baseline), or minor amputation (2 studies). Conclusion: current evidence suggests HBO does not accelerate wound healing (or reduce amputation) in non-ischaemic diabetic ulcers…

Lalieu 2020

Diving Hyperb Med · 2020 · Commentary / case

Lalieu RC, Bol Raap RD, Dubois EFL, van Hulst RA. Sudden death after oxygen toxicity seizure during hyperbaric oxygen treatment: Case report. Diving Hyperb Med 2020;50(2):185-188.

PubMed · PMID 32557424 · DOI · PMC free full text

Lalieu 2021

Front Med (Lausanne) · 2021 · Cohort / series

Lalieu RC, Akkerman I, van Hulst RA. Hyperbaric Oxygen Therapy for Venous Leg Ulcers: A 6 Year Retrospective Study of Results of a Single Center. Front Med (Lausanne) 2021;8:671678.

PubMed · PMID 34395470 · DOI · PMC free full text

37/59 (63%) achieved complete or near-complete wound healing. Wound size decreased by ~94% (median decrease 7.5 cm²; IQR 16.2). Patients mostly reported

Lansdorp 2017

Undersea Hyperb Med · 2017 · Commentary / case

Lansdorp CA, Roukema GR, Boonstra O, Dokter J, van der Vlies CH. Delayed treatment of frostbite with hyperbaric oxygen: a report of two cases. Undersea Hyperb Med 2017;44(4):365-369.

PubMed · PMID 28783893 · DOI

Larsson 2012

Undersea Hyperb Med · 2012 · Cohort / series

Larsson AC, Uusijärvi J, Frånberg O, Eksborg S, Lindholm P. Nitrox permits direct exit for attendants during extended hyperbaric oxygen treatment. Undersea Hyperb Med 2012;39(1):605-612.

PubMed · PMID 22400451

Laspro 2024

Undersea Hyperb Med · 2024 · Commentary / case

Laspro M, Wei LW, Brydges HT, Gorenstein SA, Huang ET, Chiu ES. Hyperbaric oxygen therapy regimens, treated conditions, and adverse effect profile: an Undersea and Hyperbaric Medical Society survey study. Undersea Hyperb Med 2024;51(4):369-376.

PubMed · PMID 39821765

Latusek 2023

Undersea Hyperb Med · 2023 · Systematic review

Latusek K, Slotwinska A, Michniak A, Orzechowska-Wylegala B. Effects of hyperbaric oxygen therapy on periodontal disease: a literature review. Undersea Hyperb Med 2023;50(1):17-27 (DOI 10.22462/01.01.2023.17).

PubMed · PMID 36820803 · DOI

Laupland 2023

Diving Hyperb Med · 2023 · Review / background

Laupland BR, Laupland K, Thistlethwaite K, Webb R. Contemporary practices of blood glucose management in diabetic patients: a survey of hyperbaric medicine units in Australia and New Zealand. Diving Hyperb Med 2023;53(3):230-236 (DOI 10.28920/dhm53.3.230-236).

PubMed · PMID 37718297 · DOI · PMC free full text

Laupland 2024

Diving Hyperb Med · 2024 · Cohort / series

Laupland BR, Laupland KB, Thistlethwaite K. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss: a cohort study of 10 versus more than 10 treatments. Diving Hyperb Med 2024;54(4):275-280 (DOI 10.28920/dhm54.4.275-280).

PubMed · PMID 39675734 · DOI · PMC free full text

Lavery 2020

Int Wound J · 2020 · Cohort / series

Lavery LA, Killeen AL, Farrar D, Akgul Y, Crisologo PA, Malone M, Davis KE. The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers. Int Wound J 2020;17(6):1986-1995.

PubMed · PMID 32840063 · PMC free full text

Lawson-Smith 2010

Scand J Trauma Resusc Emerg Med · 2010 · Cohort / series

Lawson-Smith P, Jansen EC, Hilsted L, Hyldegaard O. Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents. Scand J Trauma Resusc Emerg Med 2010;18:32.

PubMed · PMID 20550698 · DOI · PMC free full text

Baseline WB-CN did not differ between fire and non-fire CO patients (p=0.42). HBO did not significantly change WB-CN (before-vs-after difference similar between groups, p=0.7);

Le 2013

Undersea Hyperb Med · 2013 · Review / background

Le PJ; with contributions from Fife CE and Gelly HB. Interpretation of the study "Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation". Undersea Hyperb Med 2013;40(3):307-310.

PubMed · PMID 23789566

Leder Macek 2024

Undersea Hyperb Med · 2024 · Cohort / series

Leder Macek AJ, Wang RS, Cottrell J, Kay-Rivest E, McMenomey SO, Roland JT, et al. Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens. Undersea Hyperb Med 2024;51(4):393-402 (DOI 10.22462/730).

DOI

LeDez 2016

Undersea Hyperb Med · 2016 · Commentary / case

LeDez KM; introduced by Camporesi EM. Serious concerns about the Toronto hyperbaric oxygen for diabetic foot ulcer study. Undersea Hyperb Med 2016;43(6):737-742.

PubMed · PMID 28768395

Lee 2020

Undersea Hyperb Med · 2020 · Commentary / case

Lee S, Han J, Heo T. Successful adjunctive treatment of compartment syndrome due to acute isocyanate inhalation using hyperbaric oxygen therapy: case report. Undersea Hyperb Med 2020;47(3):455-459.

PubMed · PMID 32931672 · DOI

Lee 2021

Crit Care Med · 2021 · Cohort / series

Lee Y, Cha YS, Kim SH, Kim H. Effect of Hyperbaric Oxygen Therapy Initiation Time in Acute Carbon Monoxide Poisoning. Crit Care Med 2021;49(10):e910–e919.

PubMed · PMID 34074856 · DOI

HBO within 6 h → significantly fewer poor 6-month neurocognitive outcomes than 6–24 h (p=0.027), and Dose-response: poor outcomes rose as the treatment interval lengthened (p=0.008); the early advantage

Lee 2021

Undersea Hyperb Med · 2021 · Commentary / case

Lee JS, Cha YS. Application of a new hyperbaric oxygen therapy protocol in patients with arterial and venous gas embolism due to hydrogen peroxide poisoning. Undersea Hyperb Med 2021;48(2):187-193.

PubMed · PMID 33975410 · DOI

Lee 2021

Undersea Hyperb Med · 2021 · Cohort / series

Lee CH, Choi JG, Lee JS, Lee Y, Kim H, Kim YS, Cha YS. Seizure during hyperbaric oxygen therapy: experience at a single academic hospital in Korea. Undersea Hyperb Med 2021;48(1).

PubMed · PMID 33648032 · DOI

Lee 2022

Undersea Hyperb Med · 2022 · Cohort / series

Lee YJ, Jung SK, Lee JH, Kang HD, Oh SH, Ban SD. Efficiency of a 24-hour on-call system for early recompression therapy for acute decompression sickness. Undersea Hyperb Med 2022;49(4):507-518.

PubMed · PMID 36446296

Lee 2025

Support Care Cancer · 2025 · RCT

Lee JY, Hyun MH, Yang G, Lee S. Efficacy and safety of hyperbaric oxygen therapy for radiation-induced dermatitis in patients with breast cancer: a randomized pilot study. Support Care Cancer 2025;33(5):399.

PubMed · PMID 40259026 · DOI

25/30 completed. Grade ≥2 RID 73.3% in both arms — no difference (p=0.700). No statistically significant differences in any primary or secondary endpoint; non-significant trends toward Authors: no significant reduction in RID; larger trials with optimized HBOT protocols needed.

Lee 2025

J Clin Med · 2025 · Cohort / series

Lee JH, Lee HY, Sun KH, Heo T, Lee SM. Risk Factors for Middle Ear Barotrauma in Patients with Carbon Monoxide Poisoning Undergoing Monoplace Hyperbaric Oxygen Therapy: A Retrospective Cohort Study. J Clin Med 2025;14(9):2984.

PubMed · PMID 40364015 · DOI · PMC free full text

Lee 2026

Diving Hyperb Med · 2026 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Lee A, Moore C, Griffiths A. Efficacy and safety of potential irrigation diluents following 'caustic cocktail' ingestion. Diving Hyperb Med 2026;56(1):83-87.

PubMed · PMID 41875445 · DOI

Lee 2026

Diving Hyperb Med · 2026 · Review / background

Lee D, Challen C, Lock G. Dual rebreathers in practice: example experiences from the Wetmules and COBRA Divers. Diving Hyperb Med 2026;56(1):88-94.

PubMed · PMID 41875446 · DOI

LeGros and Murphy-Lavoie 2020

Undersea Hyperb Med · 2020 · Guideline

LeGros TL, Murphy-Lavoie H. HBO2 for sudden sensorineural hearing loss (Hyperbaric Oxygen Therapy Indications, 14th edition, Chapter 9). Undersea Hyperb Med 2020;47(2):271-295.

PubMed · PMID 32574445

Lehm 2003

SPUMS J · 2003 · Cohort / series

Lehm JP, Bennett MH. Predictors of middle ear barotrauma associated with hyperbaric oxygen therapy. SPUMS J 2003;33(3):127-133.

HBOT 0036 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Leite 2026

Orthop J Sports Med · 2026 · Cohort / series

Leite CBG, Meirelles D, Morimoto LR, Ormond Filho AG, Cavalheiro CM, Leite MS, D'Elia CO, Demange MK. Effect of Hyperbaric Oxygen Therapy on Early MRI-Based Graft Healing Following ACL Reconstruction With Hamstring Autografts. Orthop J Sports Med 2026;14(2):23259671251413600.

PubMed · PMID 41727789 · DOI · PMC free full text

Lentrodt 2007

J Oral Maxillofac Surg · 2007 · Cohort / series

Lentrodt S, Lentrodt J, Kübler N, Mödder U. Hyperbaric oxygen for adjuvant therapy for chronically recurrent mandibular osteomyelitis in childhood and adolescence. J Oral Maxillofac Surg 2007;65(2):186–191.

PubMed · PMID 17236919 · DOI

All 3 patients have been free of any symptoms from 20 to 74 months (mean, 41 months) and "therefore Case 1 — an 11-year-old girl, chronic osteomyelitis on MRI, treated with penicillin G, Case 2 — a 13-year-old boy, the most instructive of the three. He had had the unerupted left

Levett 2015

Cochrane Database Syst Rev · 2015 · Cochrane review

Levett D, Bennett MH, Millar I. Adjunctive hyperbaric oxygen for necrotizing fasciitis. Cochrane Database Syst Rev 2015;1:CD007937.

PubMed · PMID 25879088 · DOI · PMC free full text

No trials met the inclusion criteria — there are no randomised/pseudo-randomised trials of The review therefore could neither support nor refute HBOT for NF; good-quality trials are needed.

Levin 1999

Exp Mol Pathol · 1999 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Levin D, Norman D, Zinman C, Rubinstein L, Sabo E, Misselevich I, Reis D, Boss JH. Treatment of experimental avascular necrosis of the femoral head with hyperbaric oxygen in rats: histological evaluation of the femoral heads during the early phase of the reparative process. Exp Mol Pathol 1999;67(2):99-108.

PubMed · PMID 10527761 · DOI

Levin 2025

Head Neck · 2025 · Cohort / series

Levin EG, Ritter A, Bachar G, Mizrachi A, Shoffel-Havakuk H, Kurman N, Popovtzer A, Hamzany Y. Management of laryngeal chondroradionecrosis: a single-center experience. Head Neck 2025;47(1):300-308.

PubMed · PMID 39138648 · PMC free full text

Lewis 2005

Undersea Hyperb Med · 2005 · RCT

Lewis AL, Hardy KR, Huang ET, Bolotin T, Clark JM, Thom SR. Hyperbaric oxygen therapy decreases gross hematuria and improves quality of life in patients with radiation cystitis. Undersea Hyperb Med 2005;32(4):236 — UHMS Annual Scientific Meeting abstract.

HBOT 0008 · Not indexed in PubMed and no DOI — full text held in the practice wiki

26 enrolled, 7 withdrew. Spontaneous resolution of gross haematuria (before HBOT): 3/19 (15.8%). Resolution after HBOT: 14/16 (87.5%).

Leys 2026 chronic pain

J Pain Res · 2026 · Systematic review

Leys AM, Hans GH, Saldien V, Wildemeersch D. Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes – A Systematic Review. J Pain Res 2026;19:597243 (PMID 41913797 DOI 10.2147/JPR.S597243).

PubMed · PMID 41913797 · DOI · PMC free full text

Li 2017

Orthopade · 2017 · Meta-analysis

Li W, Ye Z, Wang W, Wang K, Li L, Zhao D. Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis: A systematic review and meta-analysis. Orthopade 2017;46(5):440–446 (article in English).

PubMed · PMID 27928615 · DOI

Clinical effect strongly favoured HBO: OR 4.95 (95% CI 3.24–7.55, P<0.00001). Held in subgroups: Asian OR 4.77 (3.06–7.44); non-Asian OR 7.07 (1.77–28.27).

Li 2017

Biomed Res (India) · 2017 · RCT

Li N, Meng X-E, Guo D-Z, Fan D-F, Pan S-Y. Wound healing process and related laboratory indexes in patients with type 2 diabetes mellitus after hyperbaric oxygen intervention. Biomed Res (India) 2017;28(20):9005–9010.

HBOT 0012 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Wound area: significantly smaller in the HBO arm than control at weeks 2–5 of treatment (P<0.05). Markers at 30 days: HBO arm had lower CRP, IL-6, TNF-α, MDA and higher SOD-1, VEGF, Ang-2 than

Li 2020

Undersea Hyperb Med · 2020 · Commentary / case

Li H, Bai X, Pan S. Repetitive 1.6 ATA hyperbaric oxygen therapy for bilateral ARCO Stage II steroid-associated osteonecrosis of the femoral head. Undersea Hyperb Med 2020;47(4):625-633.

PubMed · PMID 33227839 · DOI

Li 2021

Undersea Hyperb Med · 2021 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Li Y, Xu X, Bao J, Wang W. Effects of hyperbaric oxygen pretreatment on brain antioxidant capacity in rats with decompression sickness. Undersea Hyperb Med 2021;48(3):287-295.

PubMed · PMID 34390633

Lifson 2021

Undersea Hyperb Med · 2021 · Cohort / series

Lifson N, Salloum G, Kurochkin P, Bivona M, Yin HY, Alpert S. Treatment outcomes on neovascularization after CRAO treated with hyperbaric oxygen. Undersea Hyperb Med 2021;48(4):425-430.

PubMed · PMID 34847306

Lim 2021

Diving Hyperb Med · 2021 · Commentary / case

Lim ML, Kim SJ, Tan MK, Lim KH, See HG. Provision of emergency hyperbaric oxygen treatment for a patient during the COVID-19 pandemic. Diving Hyperb Med 2021;51(1):78-81.

PubMed · PMID 33761545 · DOI · PMC free full text

Limberg 2026

J Orthop Res · 2026 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Limberg AK, Giurleo LM, Ruiz V, Anup A, Buckey JC, Faro FD, Van Citters DW, Hixon KR. In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy. J Orthop Res 2026;44(4):e70204.

PubMed · PMID 42001230 · DOI · PMC free full text

Lin 2001

Undersea Hyperb Med · 2001 · RCT

Lin TF, Chen SB, Niu KC. The vascular effects of hyperbaric oxygen therapy in treatment of early diabetic foot. Undersea Hyperb Med 2001;28(Suppl):abstract Q120.

HBOT 0007 · Not indexed in PubMed and no DOI — full text held in the practice wiki

After 30 sessions, the HBO group showed significantly improved TcPO₂ (57.7 vs 35.8 mmHg, control), ABI did not differ significantly between groups (p0.05) — the effect was on microvascular

Lin 2009

Int J Radiat Oncol Biol Phys · 2009 · Cohort / series

Lin HY, Ku CH, Liu DW, Chao HL, Lin CS, Jen YM. Hyperbaric oxygen therapy for late radiation-associated tissue necroses: is it safe in patients with locoregionally recurrent and then successfully salvaged head-and-neck cancers? Int J Radiat Oncol Biol Phys 2009;74(4):1077-1082.

PubMed · PMID 19327913 · DOI

Hermann 2010

Int J Radiat Oncol Biol Phys · 2010 · Commentary / case

Hermann RM, Carl UM. Hyperbaric oxygen therapy for late radiation-associated tissue necroses: is it safe in patients with locoregionally recurrent and then successfully salvaged head-and-neck cancers? (Int J Radiat Oncol Biol Phys 2009;74:1077-1082). Int J Radiat Oncol Biol Phys 2010;76(5):1600 (Letter to the Editor; author reply on the same page).

PubMed · PMID 20338483 · DOI

Lin 2018

Medicine (Baltimore) · 2018 · Systematic review

Lin CH, Su WH, Chen YC, Feng PH, Shen WC, Ong JR, Wu MY, Wong CS. Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: a systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore) 2018;97(39):e12456 (PMID 30278526. DOI 10.1097/MD.0000000000012456).

PubMed · PMID 30278526 · DOI · PMC free full text

Lin 2020

Undersea Hyperb Med · 2020 · Commentary / case

Lin LJ, Alfonso AR, Ross FL, Chiu ES, Fleisher KE. Management of stage 0 medication-related osteonecrosis of the jaw with hyperbaric oxygen therapy: a case report and review of the literature. Undersea Hyperb Med 2020;47(2):241-251.

PubMed · PMID 32574441 · DOI

Lin 2023

Cochrane Database Syst Rev · 2023 · Cochrane review

Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 2023;8(8):CD005005.

PubMed · PMID 37585677 · DOI · PMC free full text

Cochrane systematic review / meta-analysis of RCTs of HBOT vs no HBOT for treating or preventing late radiation tissue injury (LRTI). Eighteen studies, 1071 participants (publications 1985–2022) — four new studies added, with new evidence for radiation proctitis, radiation cystitis, and prevention & treatment of osteoradionecrosis (ORN). GRADE used for certainty.

Lin 2024

Int J Audiol · 2024 · Network MA

Lin CY, et al. Salvage therapy for refractory sudden sensorineural hearing loss (RSSNHL): a systematic review and network meta-analysis. Int J Audiol 2024 (online).

PubMed · PMID 38251843 · DOI

Lin 2025

Diving Hyperb Med · 2025 · Cohort / series

Lin N, Yu E, Lussier A, Gouin E, Lindholm P. Use of in-water recompression for decompression illness after deep freediving: a case series. Diving Hyperb Med 2025;55(4):376-383.

PubMed · PMID 41364861 · DOI · PMC free full text

Lin 2026

Travel Med Infect Dis · 2026 · RCT

Lin YX, Li D, Huang Z, Huang N, Shi SM, Xu F, Wu SZ, Chen L, et al. A randomized controlled trial of mild hyperbaric oxygen therapy on cognitive performance and sleep quality in healthy young adults at high altitude: Exploratory functional near-infrared spectroscopy study. Travel Med Infect Dis 2026;73:103008.

PubMed · PMID 42480892 · DOI

Lindblom 2021

Diving Hyperb Med · 2021 · Commentary / case

Lindblom U, Tosterud C. Pulmonary barotrauma with cerebral arterial gas embolism from a depth of 0.75−1.2 metres of fresh water or less: A case report. Diving Hyperb Med 2021;51(2):224-226.

PubMed · PMID 34157741 · DOI · PMC free full text

Lindenmann 2021

Int J Mol Sci · 2021 · Systematic review · MIXED human and preclinical evidence

Lindenmann J, Smolle C, Kamolz LP, Smolle-Juettner FM, Graier WF. Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair. Int J Mol Sci 2021;22(21):11754.

PubMed · PMID 34769182 · DOI · PMC free full text

Lindfors 2021

Diving and Hyperbaric Medicine · 2021 · Systematic review

Lindfors OH, Räisänen-Sokolowski AK, Hirvonen TP, Sinkkonen ST. Inner ear barotrauma and inner ear decompression sickness: a systematic review on differential diagnostics. Diving and Hyperbaric Medicine 2021;51(4):328-337.

PubMed · PMID 34897597 · DOI · PMC free full text

Lindfors 2021

Undersea and Hyperbaric Medicine · 2021 · Cohort / series

Lindfors OH, Lundell RV, Arola OJ, Hirvonen TP, Sinkkonen ST, Räisänen-Sokolowski AK. Inner ear decompression sickness in Finland: a retrospective 20-year multicenter study. Undersea and Hyperbaric Medicine 2021;48(4):399-408.

PubMed · PMID 34847303

Lippmann 2025

Diving Hyperb Med · 2025 · Cohort / series

Lippmann J. Diving-related fatalities in Victoria, Australia, 2000 to 2022. Diving Hyperb Med 2025;55(1):35-43.

PubMed · PMID 40090024 · DOI

Lippmann 2026

Diving Hyperb Med · 2026 · Review / background

Lippmann J. Scuba tank fill survey in Victoria, Australia, 1 July 2024 to 30 June 2025. Diving Hyperb Med 2026;56(1):48-51.

PubMed · PMID 41875441 · DOI

Lipsky & Berendt 2010

Diabetes Care · 2010 · Review / background

Lipsky BA, Berendt AR. Hyperbaric oxygen therapy for diabetic foot wounds: has hope hurdled hype? Diabetes Care 2010;33(5):1143-1145.

PubMed · PMID 20427686 · PMC free full text

Liu 2012

Undersea Hyperb Med · 2012 · Commentary / case

Liu WW, Liu K, Mao D, Xu WG, Tao HY. Claustrophobia during routine hyperbaric oxygen treatment. Undersea Hyperb Med 2012;39(1):619-620.

PubMed · PMID 22400453

Liu 2013

Mayo Clin Proc · 2013 · Meta-analysis

Liu R, Li L, Yang M, Boden G, Yang G. Systematic Review of the Effectiveness of Hyperbaric Oxygenation Therapy in the Management of Chronic Diabetic Foot Ulcers. Mayo Clin Proc 2013;88(2):166–175.

PubMed · PMID 23374620 · DOI

13 controlled trials, 624 patients (7 randomised), 1966–2012. Adjunctive HBO vs no-HBO: healed ulcers RR 2.33 (95% CI 1.51–3.60); major amputation RR 0.29 (0.19–0.44); minor amputation not significantly affected (P=.30). Adverse events rare and reversible, not more frequent than without HBO (P=.37). Conclusion: HBO improved healing and reduced major-amputation risk in chronic DFU.

Liu 2024

Undersea Hyperb Med · 2024 · Commentary / case

Liu A, Hou X, Nie J, Wen Q, Pan Z. Decompression sickness followed by diabetic ketoacidosis and sepsis shock: an unusual case report. Undersea Hyperb Med 2024;51(1):41-46.

PubMed · PMID 38615352

Liu 2024

Front Neurol · 2024 · Umbrella review

Liu X, Xu X, Lei Q, Jin X, Deng X, Xie H. Efficacy of hyperbaric oxygen therapy in treating sudden sensorineural hearing loss: an umbrella review. Front Neurol 2024;15:1453055.

PubMed · PMID 39193144 · DOI · PMC free full text

Aggregates the existing SSNHL systematic reviews rather than primary trials; concludes HBO has a Mechanistic rationale: HBO raises cochlear oxygenation and promotes tissue repair.

Liu 2026

BMC Oral Health · 2026 · Meta-analysis

Liu Y, Yang C, Song Y, Sun Y, Wang H, Zhang Y, Tang H, Li Y. Survival rate and risk factors of implants in patients with head and neck neoplasms: a systematic review and meta-analysis. BMC Oral Health 2026;26:1266.

PubMed · PMID 42092891 · DOI · PMC free full text

Irradiated bone: lower survival vs non-irradiated (18 studies, RR 0.95). HBO: significantly higher implant survival with HBO vs without (5 studies). Grafted bone also had lower survival (RR 0.92).

Liu 2026

Med Gas Res · 2026 · Guideline

Liu D, Li T, Chu Q, Zhu J, Xia DD, Li X, Wang C, et al. Oxygen physiology and mechanisms of oxygen toxicity: a narrative review. Med Gas Res 2026.

DOI

Liu 2026 post-stroke cognition

J Neuroeng Rehabil · 2026 · RCT

Liu J, Han T, Yan C, Ma Q, Yu L, et al. Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition in post-stroke cognitive impairment: a randomized controlled trial. J Neuroeng Rehabil 2026 (DOI 10.1186/s12984-026-01992-x).

PubMed · PMID 42050669 · DOI · PMC free full text

Löndahl 2010

Diabetes Care · 2010 · RCT

Löndahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients With Diabetes. Diabetes Care 2010;33(5):998–1003.

PubMed · PMID 20427683 · DOI · PMC free full text

Complete healing of the index ulcer at 1 year: 52% (HBOT) vs 29% (placebo), p=0.03 (ITT). Per-protocol (35 sessions completed): 61% vs 27%, p=0.009. Adverse-event frequency low.

Löndahl 2011

Curr Diab Rep · 2011 · Review / background

Löndahl M, Fagher K, Katzman P. What is the role of hyperbaric oxygen in the management of diabetic foot disease? Curr Diab Rep 2011;11(4):285–293.

PubMed · PMID 21534014 · DOI

Historic HBO use rested on "weak scientific ground" (few, small studies), but the consistency of Two well-designed randomised double-blind placebo-controlled trials have since put HBO on firmer TcPO₂ (transcutaneous oxygen) shows promise for predicting who will benefit — the reconciling

Löndahl and Boulton 2020

Diabetes Metab Res Rev · 2020 · Review / background

Löndahl M, Boulton AJM. Hyperbaric oxygen therapy in diabetic foot ulceration: useless or useful? A battle. Diabetes Metab Res Rev 2020;36(Suppl 1):e3233.

PubMed · PMID 31927787 · DOI

Longobardi 2020

Wound Repair Regen · 2020 · RCT

Longobardi P, Hartwig V, Santarella L, Hoxha K, Campos J, Laurino M, Salvo P, Trivella MG, Coceani F, Rocco M, et al. Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment. Wound Repair Regen 2020;28(6):856–866.

PubMed · PMID 32789935 · DOI

Design: RCT, 81 patients with hard-to-heal venous leg ulcers (73 completed; 511 NIRS images), 3 arms — A = 30 HBO sessions twice daily over 3 weeks + conventional; B = 30 HBO once daily over 6 weeks + conventional; C = conventional therapy only. HBO adjunctive. Healing: at 6 weeks, area reduction B 65.5% and C 56.8% vs A 29.7% (P<0.01) — the intensive twice-daily arm did worst, below conventional alone. Complete healing B 20%…

Lopes 2020

Trials · 2020 · Review / background

Lopes JRA, Dias MD, Correa JA, Batalha MAB, et al. Randomized controlled clinical trial evaluating the efficacy of hyperbaric oxygen therapy in facilitating the healing of chronic foot ulcers in diabetic patients: the study protocol. Trials 2020;21:816.

PubMed · PMID 32993766 · DOI · PMC free full text

None — protocol only. Outcomes will appear in the eventual results publication.

Louge 2023

Diving Hyperb Med · 2023 · RCT

Louge P, Pignel R, Serratrice J, Stirnemann J. Validation of sham treatment in hyperbaric medicine: a randomised trial. Diving Hyperb Med 2023;53(1):51–54.

PubMed · PMID 36966522 · DOI · PMC free full text

60 volunteers compressed to 1.1, 1.3 or 1.5 atm abs; then 25 more with added blinding (faster compression with 1.1 atm abs was distinguishable; 1.3 and 1.5 atm abs were not different from each other. A compression to

Lu 2018

Undersea and Hyperbaric Medicine · 2018 · Commentary / case

Lu LQ, Strauss MB, Miller SS. The Gradient Perfusion Model Part 3: An extraordinary case of decompression sickness. Undersea and Hyperbaric Medicine 2018;45(3):307-311.

PubMed · PMID 30028917

Lu 2026

Med Gas Res · 2026 · Review / background

Lu L, Zhao L, Xie Y, Wang L, Ji Y, Luo X, Zhang C. Research hotspots and trends of hyperbaric oxygen therapy in stroke: bibliometrics and visual analysis. Med Gas Res 2026;16(3):380-388.

PubMed · PMID 41575017 · DOI · PMC free full text

Lun 2026

Diving Hyperb Med · 2026 · Cohort / series

Lun CY, Au Yeung KL, Lau YF, Yan WW, Tang KB. Treatment success in relation to timing of hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss. Diving Hyperb Med 2026;56(1):41-47.

PubMed · PMID 41875440

Lundell 2019

Diving and Hyperbaric Medicine · 2019 · Cohort / series

Lundell RV, Arola O, Suvilehto J, Kuokkanen J, Valtonen M, Räisänen-Sokolowski AK. Decompression illness (DCI) in Finland 1999–2018: Special emphasis on technical diving. Diving and Hyperbaric Medicine 2019;49(4):259-265.

PubMed · PMID 31828744 · DOI · PMC free full text

Ma 2013

Ostomy Wound Manage · 2013 · RCT

Ma L, Li P, Shi Z, Hou T, Chen X, Du J. A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer. Ostomy Wound Manage 2013;59(3):18–24.

PubMed · PMID 23475448

Design: prospective randomised controlled pilot, n=36 (18 HBO + standard care vs 18 standard care only), DFU Wagner ≤III, TcPO₂ 30 mmHg at dorsum (severe arteriopathy excluded); HBO 2.5 ATA, 90 min twice daily, 5 d/wk × 2 weeks (20 sessions). No sham (control = standard care only). Healing (surrogate): day-14 ulcer-area reduction 42.4% ± 20.0% (HBO) vs 18.1% ± 6.5% (control), P<0.05; no ulcer fully healed in either arm within…

MacDonald 2006

Prehosp Emerg Care · 2006 · Systematic review

MacDonald RD, O'Donnell C, Allan GM, Breeck K, Chow Y, DeMajo W, Peerbaye Y, Sawadsky B, Wax R. Interfacility transport of patients with decompression illness: literature review and consensus statement. Prehosp Emerg Care 2006;10(4):482-487.

PubMed · PMID 16997779 · DOI

Macdonald 2007

Diving Hyperb Med · 2007 · Review / background

Macdonald HM. Hyperbaric oxygenation in the patient with malignancy: friend or foe? Diving Hyperb Med 2007;37(3):133-138.

HBOT 0063 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Magri Gatt 2023

Diving and Hyperbaric Medicine Journal · 2023 · Commentary / case

Magri Gatt P, Diacono E, Matity L, Magri K. Atypical distally distributed cutis marmorata decompression sickness associated with unconventional use of thermal protection in a diver with persistent foramen ovale. Diving and Hyperbaric Medicine Journal 2023;53(3):285-289 (DOI 10.28920/dhm53.3.285-289).

PubMed · PMID 37718304 · DOI · PMC free full text

Mahon 2021

Undersea Hyperb Med · 2021 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Cronin WA, Khan K, Hall AA, Bodo M, Mahon RT. The effect of the perfluorocarbon emulsion Oxycyte in an ovine model of severe decompression illness. Undersea Hyperb Med 2021;48(1):25-31.

PubMed · PMID 33648030 · DOI

Maier 2020

Chirurg · 2020 · Review / background

Maier S, Eckmann C. [Fournier's gangrene as special form of necrotizing fasciitis]. Chirurg 2020;91(4):307-312 (German. PMID 31965200. DOI 10.1007/s00104-019-01095-5).

PubMed · PMID 31965200 · DOI

Maken 2020

Undersea Hyperb Med · 2020 · Commentary / case

Maken K, Bland DK. Hyperbaric oxygen for refractory hemorrhagic cystitis after stem cell transplantation: case report. Undersea Hyperb Med 2020;47(1):125-129.

PubMed · PMID 32176953

Manheim 2025

Diving Hyperb Med · 2025 · Cohort / series

Manheim M, Mogilevsky L, Geva A, Knoll O, Zehavi G, Gur I. Effects of hyperbaric oxygen therapy initiation latency on auditory outcomes following acute acoustic trauma. Diving Hyperb Med 2025;55(2):126-135 (PMID 40544140. DOI 10.28920/dhm55.2.126-135).

PubMed · PMID 40544140 · DOI · PMC free full text

Marchioni 2022

Minerva Urol Nephrol · 2022 · Systematic review

Marchioni M, De Francesco P, Campi R, Carbonara U, Ferro M, Schips L, et al. Current management of radiation cystitis after pelvic radiotherapy: a systematic review. Minerva Urol Nephrol 2022;74(3):281–291.

PubMed · PMID 34714035 · DOI

Systematic review of radiation-cystitis treatments (HBO, formalin, aluminium, oral agents, laser, cystectomy). HBO complete-response ~52–87% across series — among the most effective non-invasive modalities. Radiation cystitis is under-reported; a stepwise approach with escalating aggressiveness is recommended, and ~10% ultimately need salvage cystectomy.

Marcinkowska 2022

Neuropsychology Review · 2022 · Systematic review

Marcinkowska AB, Mankowska ND, Kot J, Winklewski PJ. Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review. Neuropsychology Review 2022;32(1):99–126.

PubMed · PMID 33847854 · DOI · PMC free full text

Controversial / mixed results on HBOT efficacy for cognitive disturbance across conditions (CO poisoning, Marked heterogeneity of conditions, protocols and neuropsychological instruments; authors call for

Margolis 2013

Diabetes Care · 2013 · Cohort / series

Margolis DJ, Gupta J, Hoffstad O, Papadopoulos M, Glick HA, Thom SR, Mitra N. Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation. Diabetes Care 2013;36(7):1961–1966.

PubMed · PMID 23423696 · DOI · PMC free full text

Patients receiving HBO were less likely to heal (HR 0.68, 95% CI 0.63–0.73) and more likely to be After propensity-score and instrumental-variable analyses to address that selection, HBO neither

Markovitz 2022

Undersea Hyperb Med · 2022 · Commentary / case

Markovitz GH. Two cases of Bacillus Calmette-Guérin cystitis treated with hyperbaric oxygen. Undersea Hyperb Med 2022;49(2):191-195.

PubMed · PMID 35580486

Marshall 2007

Undersea Hyperb Med · 2007 · Cohort / series

Marshall GT, Thirlby RC, Bredfeldt JE, Hampson NB. Treatment of gastrointestinal radiation injury with hyperbaric oxygen. Undersea Hyperb Med 2007;34(1):35-42.

PubMed · PMID 17393937

Martín Pérez 2025

Muscles · 2025 · Systematic review

Martín Pérez SE, Iboleón Laynez E, Acevedo Rodríguez JA, Maggioni Torres MI, Pérez Betancort R, Díaz Rodríguez A, Cabezos Alonso D, García Camacho C, Martín Pérez IM. Effectiveness of Hyperbaric Oxygen Therapy for Musculoskeletal Pain Syndromes: A Systematic Review. Muscles 2025;4(4):63.

PubMed · PMID 41441449 · DOI · PMC free full text

Marx 1983

J Oral Maxillofac Surg · 1983 · Cohort / series

Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 1983;41(5):283-8.

PubMed · PMID 6572704 · DOI

A consecutive case series with pathology, from the Department of Oral and Maxillofacial Surgery, Wilford Hall USAF Medical Center, San Antonio, Texas. - 26 consecutive cases of osteoradionecrosis of the mandible. - Case-selection criterion, stated: an area greater than 1 cm of exposed bone in a field of irradiation that had failed to show any evidence of healing for at least six months. - Case his

Marx 1983

J Oral Maxillofac Surg · 1983 · Cohort / series

Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg 1983;41(6):351-7.

PubMed · PMID 6574217 · DOI

A single-arm consecutive case series from the Department of Oral and Maxillofacial Surgery, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas — the same department as the pathophysiology paper. The author is identified as Lieutenant Colonel, USAF, DC; Assistant Chairman of the department and Director of Dental Research. - 58 patients referred to Wilford Hall with a diagnosis of "ref

Marx 1985

J Am Dent Assoc · 1985 · RCT

Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc 1985;111(1):49–54.

PubMed · PMID 3897335 · DOI

74 patients (37 per arm) requiring tooth extraction in mandible irradiated to ≥6,000 rad. ORN incidence: 2/37 = 5.4% (HBO) vs 11/37 = 29.7% (penicillin — the paper itself prints 29.9%, in Table 1 and in the Discussion), P=0.005. (Reconciled 31 Aug 2026: this line read "29.9%" while this page's own CAT section uses 29.7%; 11/37 is 29.7%. Both figures are now shown so the two halves of the page agree.) Protocol (confirmed from f…

Marx 1990

Am J Surg · 1990 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Marx RE, Ehler WJ, Tayapongsak P, Pierce LW. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg 1990;160(5):519-24.

PubMed · PMID 2240387 · DOI

A three-arm controlled laboratory experiment from the Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine / Jackson Memorial Medical Center, with the Hyperbaric Medicine Division, Clinical Investigative Directorate, Wilford Hall U.S.A.F. Medical Center. The stated purpose: to quantitate the angiogenesis induced in irradiated tissue by hyperbaric oxygen at 2.4 ATA for

Mason 2023

Diving Hyperb Med · 2023 · Cohort / series

Mason JS, Buzzacott P, Gawthrope IC, Banham ND. A retrospective review of divers treated for inner ear decompression sickness at Fiona Stanley Hospital hyperbaric medicine unit 2014-2020. Diving Hyperb Med 2023;53(3):243-250 (DOI 10.28920/dhm53.3.243-250).

PubMed · PMID 37718299 · DOI · PMC free full text

Mason 2025

Diving and Hyperbaric Medicine · 2025 · Commentary / case

Mason JS, Wilmshurst P, Gawthrope IC, Banham ND. Severe neurological decompression sickness associated with right ventricular dilatation and a persistent foramen ovale. Diving and Hyperbaric Medicine 2025;55(1):59-64.

PubMed · PMID 40090028 · DOI · PMC free full text

Massey 2012

Journal of Surgical Research · 2012 · Cohort / series

Massey PR, Sakran JV, Mills AM, Sarani B, Aufhauser DD Jr, Sims CA, Pascual JL, Kelz RR, Holena DN. Hyperbaric oxygen therapy in necrotizing soft tissue infections. Journal of Surgical Research 2012;177(1):146-151.

PubMed · PMID 22487383 · DOI

Masters 2025

Undersea Hyperb Med · 2025 · Cohort / series

Masters T, Samson M, Tucci J, Lacey AM, Rogers C, Coward A, Punjab GV, Nygaard RM. The role of hyperbaric oxygen therapy for severe frostbite injury: insights from a retrospective cohort at a high volume burn center. Undersea Hyperb Med 2025;52(2):149-156.

PubMed · PMID 40819356 · DOI

Mathieu 2008

In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 26 · 2008 · Review / background

Mathieu D. Contraindications to hyperbaric oxygen therapy. In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 26 2008:587-598.

DOI

Mathieu 2016

Diving Hyperb Med · 2016 · Guideline

Mathieu D, Marroni A, Kot J. Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med 2016;46(2):122–123.

PubMed · PMID 27335005

No Type 1A indications were identified — the authors note that much clinical research is still Table 1 is the same accepted / "not-indicated" list that appears, expanded with an agreement-level

Mathieu 2017

Diving Hyperb Med · 2017 · Guideline

Mathieu D, Marroni A, Kot J. Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med 2017;47(1):24–32.

PubMed · PMID 28357821 · DOI · PMC free full text

The ECHM (European Committee for Hyperbaric Medicine) consensus on accepted/non-accepted HBOT indications, from the 10th European Consensus Conference (April 2016). Uses a modified GRADE system for evidence + DELPHI for consensus. The European counterpart to the UHMS Indications Manual. Authority tier — international society guidance (tier 4). Like UHMS, ECHM does not override SAUHMA 2023 (tier 2)

Matić 2019

Int J Diabetes Dev Ctries · 2019 · Cohort / series

Matić P, Radak Đ, et al. Results of simultaneous application of hyperbaric oxygen and negative pressure wound therapy in diabetic foot ulcers treatment. Int J Diabetes Dev Ctries 2019;39.

DOI

60 patients (56.7% men, mean age 60.6y); ulcers ischaemic 45%, neuropathic 30%, combined 25%. Only 3 minor amputations (5%) over the study. Authors conclude simultaneous HBO+NPWT gives the best healing

Matity 2023

Diving and Hyperbaric Medicine Journal · 2023 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Matity L, Burman F, Kot J, Caruana J. Effectiveness of hyperbaric chamber ventilation. Diving and Hyperbaric Medicine Journal 2023;53(2):85-91 (DOI 10.28920/dhm53.2.85-91).

PubMed · PMID 37365125 · DOI · PMC free full text

Mátity 2024

Undersea Hyperb Med · 2024 · Review / background

Mátity L, Burman F, Cronje F. Optimizing the hyperbaric chamber pressurization profile during standard hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(4):377-385 (DOI 10.22462/715).

DOI

Matveev 2025

Dela Press Book Series: Medical Sciences · 2025 · Review / background

Matveev DV, Kosheleva IV, Kuznetsov MR, Sorokina TV, Matveeva ED. Application of hyperbaric oxygen therapy in aesthetic surgery and cosmetology: current state of the issue, clinical outcomes, and prospects. Dela Press Book Series: Medical Sciences 2025;002:4 pp.

Not indexed in PubMed and no DOI — full text held in the practice wiki

Mazokopakis 2011

Dermatol Ther · 2011 · Commentary / case

Mazokopakis EE, Kofteridis DP, Pateromihelaki AT, Vytiniotis SD, Karastergiou PG. Improvement of ulcerative pyoderma gangrenosum with hyperbaric oxygen therapy. Dermatol Ther 2011;24(1):134-136.

PubMed · PMID 21276167 · DOI

McCabe 2004

Undersea Hyperb Med · 2004 · Commentary / case

McCabe JB, McGinn Merritt W, Olsson D, Wright V, Camporesi EM. Emphysematous cystitis: rapid resolution of symptoms with hyperbaric treatment: a case report. Undersea Hyperb Med 2004;31(3).

PubMed · PMID 15568415

McGlynn 2023

Undersea Hyperb Med · 2023 · Cohort / series

McGlynn J, Heyboer M. Successful treatment of radiation-induced vaginal soft tissue radionecrosis with HBO2. Undersea Hyperb Med 2023;50(1).

PubMed · PMID 36820802

McLoughlin 1999

Anaesthesia · 1999 · Commentary / case

McLoughlin PL, Cope TM, Harrison JC. Hyperbaric oxygen therapy in the management of severe acute anaemia in a Jehovah's witness. Anaesthesia 1999;54(9):891–895.

PubMed · PMID 10460565 · DOI

HBO prescription, stated exactly: pulsed hyperbaric oxygen, 90 min at 2 ATA with a Within-patient haemodynamic change (Table 1). Adrenaline requirement fell from 6 to 3 Acid-base: base excess improved from −5.6 to −0.8 mmol.l⁻¹ during the first treatment, from a

Meethale Thiruvoth 2022

Expert Rev Pharmacoecon Outcomes Res · 2022 · Review / background

Meethale Thiruvoth F, Rajasulochana SR, Mathan Kumar S, Saravanan E, Sivanantham P, Kar SS. Hyperbaric oxygen therapy as an adjunct to the standard wound care for the treatment of diabetic foot ulcers in Indian patients: a cost utility analysis. Expert Rev Pharmacoecon Outcomes Res 2022;22(7):1087-1094.

PubMed · PMID 35649289 · DOI

Meier 2021

Diving Hyperb Med · 2021 · Cohort / series

Meier EL, Hummelink S, Lansdorp N, Boonstra O, Ulrich DJO. Perioperative hyperbaric oxygen treatment and postoperative complications following secondary breast reconstruction after radiotherapy: a case-control study of 45 patients. Diving Hyperb Med 2021;51(3):288-294.

PubMed · PMID 34547780 · DOI · PMC free full text

Meier 2023

The Breast · 2023 · Systematic review

Meier EL, Mink van der Molen DR, Lansdorp CA, Batenburg MCT, van der Leij F, Verkooijen HM, Boonstra O, Hummelink S, Ulrich DJO. Hyperbaric oxygen therapy for local late radiation toxicity in breast cancer patients: A systematic review. The Breast 2023;67:46–54.

PubMed · PMID 36587606 · DOI · PMC free full text

Pain significantly reduced in 4/5 studies measuring it. Breast/arm lymphoedema reduced in 4/7 studies; fibrosis in some; skin problems and Conclusion: HBOT might be useful for reducing LRT symptoms in breast-cancer patients, but the

Meijering 2025

Diving Hyperb Med · 2025 · Systematic review

Meijering JR, Risvanoglu N, Nederhoed JH, Hoencamp R, van Hulst RA, Ubbink DT (Amsterdam UMC). Shared decision-making when considering hyperbaric oxygen therapy: a systematic review. Diving Hyperb Med 2025;55(2):180–185.

PubMed · PMID 40544146 · DOI · PMC free full text

A systematic review of shared decision-making in the context of HBOT — patient engagement, satisfaction and adherence when weighing a demanding multi-session therapy. A methods/decision-science synthesis, not a therapy efficacy review.

Meijering 2026

Diving Hyperb Med · 2026 · Cohort / series

Meijering JR, Risvanoglu N, van Waard JD, Nederhoed JH, Hoencamp R, van Hulst RA, Ubbink DT. Decision regret and shared decision-making in patients undergoing hyperbaric oxygen therapy. Diving Hyperb Med 2026;56(1):52-58.

PubMed · PMID 41875442 · DOI

Melessen 2024

Diving Hyperb Med · 2024 · Cohort / series

Melessen A, Wingelaar TT, van Ooij PJAM. Clinical utility of dipstick urinalysis in assessing fitness to dive in military divers, submariners, and hyperbaric personnel. Diving Hyperb Med 2024;54(2):105-109.

PubMed · PMID 38870952 · DOI · PMC free full text

Meliante 2025

Front Neurol · 2025 · Meta-analysis

Meliante PG, D'Avino L, Barba G, Covelli E, Petrella C, Barbato C, Minni A. Salvage treatment strategies for refractory sudden sensorineural hearing loss—a comprehensive review and meta-analysis with practical recommendations. Front Neurol 2025;16:1627892.

PubMed · PMID 40734818 · DOI · PMC free full text

HBO was effective as salvage, particularly at low frequencies. Combined ITS + HBO gave the best results in word recognition and pure-tone average, though not always ITS effective (methylprednisolone dexamethasone); early initiation improved outcomes.

Memar 2019

Biomed Pharmacother · 2019 · Review / background · MIXED human and preclinical evidence

Memar MY, Yekani M, Alizadeh N, Bannazadeh Baghi H. Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomed Pharmacother 2019;109:440-447.

PubMed · PMID 30399579 · DOI

Mendel 1999

Undersea Hyperb Med · 1999 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Mendel V, Reichert B, Simanowski HJ, Scholz HC. Therapy with hyperbaric oxygen and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. Undersea Hyperb Med 1999;26(3):169-174.

PubMed · PMID 10485518

Mendes 2018

Undersea Hyperb Med · 2018 · Commentary / case

Mendes AF Jr, da Mota Neto J, Heringer EM, de Simoni LF, Pires DD, Labronici PJ. Hyperbaric oxygen therapy as treatment for bilateral arm compartment syndrome after CrossFit: case report and literature review. Undersea Hyperb Med 2018;45(2):209-215.

DOI

Mendez 2017

Undersea and Hyperbaric Medicine · 2017 · Commentary / case

Mendez N, Huchim-Lara O, Rivera-Canul N, Chin W, Tec J, Cordero-Romero S. Fatal cardiopulmonary decompression sickness in an untrained fisherman diver in Yucatán, Mexico: a clinical case report. Undersea and Hyperbaric Medicine 2017;44(3):279-281.

PubMed · PMID 28779584

Mendez-Dominguez 2018

Undersea and Hyperbaric Medicine · 2018 · Cohort / series

Mendez-Dominguez N, Huchim-Lara O, Chin W, Carrillo-Arceo L, Camara-Koyoc I, Cárdenas-Dajdaj R, Dogre-Sansores O. Body mass index in association with decompression sickness events: cross-sectional study among small-scale fishermen-divers in southeast Mexico. Undersea and Hyperbaric Medicine 2018;45(4):445-451.

PubMed · PMID 30241124

Meng 2017

Undersea Hyperb Med · 2017 · RCT

Meng F-C, Shen C-H, Chu C-M, Shih C-P, Lin H-C, Peng C-K, Chang SC, Huang K-L. Dried salted plum consumption ameliorates hyperbaric oxygen therapy-induced otalgia severity at the first chamber session: a prospective randomized controlled study. Undersea Hyperb Med 2017;44(6) (PMID 29281192; DOI 10.22462/11.12.2017.6).

PubMed · PMID 29281192 · DOI

MEB incidence (Teed grade 1–4): NOT reduced — overall ~39.6% (21/53); severe MEB (Teed 3–4) 18.9% Otalgia severity reduced: VAS ≥4 otalgia in 5.7% (3/53) plum vs 10.8% (4/37) control (P=0.026).

Meng 2020

Diving and Hyperbaric Medicine · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Meng WT, Qing L, Zhou Q, Xu WG. Xuebijing attenuates decompression-induced lung injuries. Diving and Hyperbaric Medicine 2020;50(4):343-349.

PubMed · PMID 33325014 · DOI · PMC free full text

Miarczynski 2026

Quality in Sport · 2026 · Review / background

Miarczyński J, Górski S, Okupniarek J, Bartosik M, Jętasiewicz I, Oborski M, Oborski K, Barczyńska K. Pathophysiology of decompression sickness: current insights and emerging models. Quality in Sport 2026;49:67991.

DOI

Mikolašević 2026

Curr Oncol · 2026 · Commentary / case

Mikolašević I, Cotić P, Matulić Čubranić S, Franolić M, Skočilić I, Salopek T, Golčić M, Košić A, Radošić L, Josipović B, Lisica K, Juras L, Francetić S, Bešvir A, Belančić A. Hyperbaric oxygen therapy for late radiation-induced duodenal toxicity after stereotactic body radiotherapy in a patient with cholangiocellular carcinoma: a unique case report. Curr Oncol 2026;33(8):459.

PubMed · PMID 42645364 · DOI

Millar 2022 (HOLLT)

Diving Hyperb Med · 2022 · RCT

Millar IL, Lind FG, Jansson KÅ, Hájek M, Smart DR, Fernandes TD, et al. Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multi-centre randomised clinical trial. Diving Hyperb Med 2022;52(3):164–174.

PubMed · PMID 36100927 · DOI · PMC free full text

Primary composite (necrosis/infection ≤14 d): 25/58 (43%) HBOT vs 34/59 (58%) — OR 0.55 (95% CI Tissue necrosis: 29% vs 53% — OR 0.35 (95% CI 0.16–0.78; P=0.01) (significant). Fewer late complications: 6/53 vs 18/52 — OR 0.22 (95% CI 0.08–0.64; P=0.007), including delayed

HONEY (Mink van der Molen 2024)

JAMA Oncol · 2024 · RCT

Mink van der Molen DR, Batenburg MCT, Maarse W, van den Bongard DHJG, Doeksen A, de Lange MY, van der Pol CC, Evers DJ, Lansdorp CA, van der Laan J, van de Ven PM, van der Leij F, Verkooijen HM. Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial. JAMA Oncol 2024;10(4):464–474.

PubMed · PMID 38329746 · DOI · PMC free full text

Primary endpoint (pain) — NEGATIVE in ITT: moderate/severe pain at follow-up 50% (58/115) HBOT vs Fibrosis — POSITIVE in ITT: 33% vs 51%; OR 0.36 (95% CI 0.15–0.81), p=.02. No significant Completers (CACE): among the ~25% who actually completed HBOT, pain reduced (adjusted OR 0.34, 95%

Mirasoglu 2020

Diving and Hyperbaric Medicine · 2020 · Commentary / case

Mirasoglu B, Kirmizi S, Aktas S. Sphenoid sinus mucocele as an unusual differential diagnosis in diving injuries. Diving and Hyperbaric Medicine 2020;50(2):168-172.

PubMed · PMID 32557420 · DOI · PMC free full text

Miszewska & Kot 2026

J Clin Med · 2026 · Cohort / series

Miszewska A, Kot J. Staff-Reported Peri-Procedural Workflow Vulnerabilities and a Preliminary Checklist Prototype for Mechanically Ventilated Intensive Care Patients Undergoing Hyperbaric Oxygen Therapy: A Single-Centre Pilot Survey. J Clin Med 2026;15(14):5418.

PubMed · PMID 42513332 · DOI · PMC free full text

Mitchell 2018

Undersea Hyperb Med · 2018 · Guideline

Mitchell SJ, Bennett MH, Bryson P, Butler FK, Doolette DJ, Holm JR, Kot J, Lafère P. Consensus guideline: Pre-hospital management of decompression illness: expert review of key principles and controversies. Undersea Hyperb Med 2018;45(3):273-286.

PubMed · PMID 30028914 · DOI

Mitchell 2022

N Engl J Med · 2022 · Review / background

Mitchell SJ, Bennett MH, Moon RE. Decompression sickness and arterial gas embolism. N Engl J Med 2022;386(13):1254-1264.

PubMed · PMID 35353963 · DOI

Mitchell 2024

Diving Hyperb Med · 2024 · Review / background

Mitchell SJ. Decompression illness: a comprehensive overview. Diving Hyperb Med 2024;54(1 Suppl):1-53.

PubMed · PMID 38537300 · PMC free full text

Mladenov 2022

World J Emerg Surg · 2022 · Cohort / series

Mladenov A, Diehl K, Muller O, von Heymann C, Kopp S, Peitsch WK. Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years. World J Emerg Surg 2022;17(1):43 (PMID 35932075. DOI 10.1186/s13017-022-00448-6).

PubMed · PMID 35932075 · DOI · PMC free full text

Moen & Stuhr 2012

Target Oncol · 2012 · Review / background · MIXED human and preclinical evidence

Moen I, Stuhr LEB. Hyperbaric oxygen therapy and cancer — a review. Target Oncol 2012;7(4):233-242.

PubMed · PMID 23054400 · DOI · PMC free full text

Moghamis 2021

Ann Med Surg (Lond) · 2021 · Cohort / series

Moghamis I, Alhammoud AA, Kokash O, Alhaneedi GA. The outcome of hyperbaric oxygen therapy versus core decompression in the non-traumatic avascular necrosis of the femoral head: retrospective cohort study. Ann Med Surg (Lond) 2021;62:450-454.

DOI

Mohd Yazid 2017

Medicine & Health · 2017 · RCT

Mohd Yazid B, et al. The Physiological, Biochemical and Quality of Life Changes in Chronic Diabetic Foot Ulcer after Hyperbaric Oxygen Therapy. Medicine & Health Medicine & Health (Universiti Kebangsaan Malaysia) 2017;12(2):210–219.

HBOT 0013 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Complete ulcer healing at 6 months: 86.7% (26/30) HBOT vs 60% (18/30) control. Significant reduction in WCC and CRP across treatment in the HBOT group (p=0.046 and p=0.039). Significantly better mental and physical QoL (SF-36) in the HBOT group.

Molina-Vega 2026

J Burn Care Res · 2026 · Systematic review

Molina-Vega J, Pferdehirt RE, Vardanian AJ. Hyperbaric Oxygen Therapy in Burn Care: A Systematic Review of Current Evidence. J Burn Care Res 2026;47(3):917–922.

PubMed · PMID 41700783 · DOI · PMC free full text

Evidence inconsistent, no clear consensus on efficacy; protocols and outcome measures heterogeneous.

Molina-Vega 2026

Plast Reconstr Surg Glob Open · 2026 · Meta-analysis

Molina-Vega J, Cascavita CT, Pferdehirt RE, Vardanian AJ. Current Use of Hyperbaric Oxygen Therapy in Plastic Surgery: A Systematic Review. Plast Reconstr Surg Glob Open 2026;14:e7989.

PubMed · PMID 42559634 · DOI

Monis 2020

J Maxillofac Oral Surg · 2020 · Commentary / case

Monis PL, Bhat V, Shetty S, Salins PC. Hyperbaric Oxygen Therapy in the Management of Zygomatic Bone Osteomyelitis. J Maxillofac Oral Surg 2020;20(3):414–417.

PubMed · PMID 34408368 · DOI · PMC free full text

Facial swelling and pus discharge reduced with blood sugar control, before the HBO course is After 15 dives there was no more pus discharge from the left infraorbital fistula, though the After a total of 30 dives, repeat CT showed partial reconstitution of cortical bone with no

Monnot 2021

Diving and Hyperbaric Medicine · 2021 · Review / background

Monnot DPM, Boisvert J, Buteau D, Pollock NW. Retrospective review of enquiries to the Québec diving medicine call centre: 2004 through 2018. Diving and Hyperbaric Medicine 2021;51(2):152-160.

PubMed · PMID 34157730 · DOI · PMC free full text

Montrief 2019

J Emerg Med · 2019 · Review / background

Montrief T, Long B, Koyfman A, Auerbach J. Fournier gangrene: a review for emergency clinicians. J Emerg Med 2019;57(4):488-500 (PMID 31472943. DOI 10.1016/j.jemermed.2019.06.023).

PubMed · PMID 31472943 · DOI

Moon, McGraw & Blakey 2005

Undersea Hyperb Med · 2005 · Commentary / case

Moon RE, McGraw TA, Blakey G 3rd. Hyperbaric oxygen therapy for radiation necrosis of the jaw: comments on a randomized study. Undersea Hyperb Med 2005;32(3):145-147.

PubMed · PMID 16119305

Moon 2014

Undersea Hyperb Med · 2014 · Review / background

Moon RE. Hyperbaric oxygen treatment for decompression sickness. Undersea Hyperb Med 2014;41(2):151-157.

PubMed · PMID 24851553

Moon 2014

J Plast Reconstr Aesthet Surg · 2014 · Cohort / series

Moon KC, Han SK, Lee YN, Jeong SH, Dhong ES, Kim WK. Effect of normobaric hyperoxic therapy on tissue oxygenation in diabetic feet: a pilot study. J Plast Reconstr Aesthet Surg 2014;67(11):1580-1586.

PubMed · PMID 25086687

Moon 2019

Undersea Hyperb Med · 2019 · Guideline

Moon RE, Mitchell S. Hyperbaric treatment for decompression sickness: current recommendations. Undersea Hyperb Med 2019;46(5):685-693.

PubMed · PMID 31683368

Moreira da Cruz 2021

Int Angiol · 2021 · Meta-analysis

Moreira da Cruz DL, Oliveira-Pinto J, Mansilha A. The role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a systematic review with meta-analysis. Int Angiol 2021;41(1):63–73.

PubMed · PMID 34236155 · DOI

Major amputation: OR 0.53 (95% CI 0.32–0.90) favouring HBOT (I²=31%). Minor amputation: no difference (OR 0.89, I²=69%). Complete healing: OR 4.00 (95% CI 1.54–10.44) favouring HBOT (I²=70%).

Möring 2025

Gynecol Oncol · 2025 · Cohort / series

Möring MM, Valkenburg AC, Schuur-van't Hof N, van Beekhuizen HJ, Lansdorp CA. Reduced symptoms of late radiation tissue injury of the vagina after treatment with hyperbaric oxygen therapy: A retrospective analysis of 19 patients. Gynecol Oncol 2025;197:27–33.

PubMed · PMID 40267557 · DOI

19 patients (median age 42), average 40 sessions (80 min of 100% O₂ at 2.5 ATA). 15/19 (79%) responders at end of treatment (median 3 symptoms improving). Most responsive symptoms: Improvement maintained at 3 months in 14/15 responders. No major adverse events.

Morningstar 2026 (mild HBOT is not HBOT)

Med Sci (Basel) · 2026 · Review / background

Morningstar M, Strauchman M. Hyperbaric oxygen therapy and mild hyperbaric oxygen therapy are not synonymous: a narrative review. Med Sci (Basel) 2026;14(3):360 (DOI 10.3390/medsci14030360).

PubMed · PMID 42506329 · DOI · PMC free full text

Mozdzanowski 2014

Undersea Hyperb Med · 2014 · Cohort / series

Mozdzanowski C, Perdrizet GA. Peripheral neuropathy may increase the risk for asymptomatic otic barotrauma during hyperbaric oxygen therapy: research report. Undersea Hyperb Med 2014;41(4):267-272.

PubMed · PMID 25109078

Munjewar 2016

Hellenic Journal of Surgery · 2016 · Meta-analysis

Munjewar C, Nabi I, Gautam S, Ahirwar N, Chaudhary P, Kumar R, Arora MP, Ramteke VK. Evaluation of the role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a prospective comparative study. Hellenic Journal of Surgery 2016;88(4):219-224.

DOI

Murad 2014

J Clin Epidemiol · 2014 · Review / background

Murad MH, Altayar O, Bennett M, Wei JC, Claus PL, Asi N, Prokop LJ, Montori VM, Guyatt GH. Using GRADE for evaluating the quality of evidence in hyperbaric oxygen therapy clarifies evidence limitations. J Clin Epidemiol 2014;67(1):65–72.

PubMed · PMID 24189086 · DOI

Murao 2023

Undersea Hyperb Med · 2023 · Cohort / series

Murao N, Oyama A, Yamamoto Y, Funayama E, Ishikawa K, Maeda T. Efficacy of hyperbaric oxygen after microtia reconstruction using costal cartilage: A retrospective case-control study. Undersea Hyperb Med 2023;50(4):413-419 (DOI 10.22462/01.01.2023.45).

DOI

Muroya 2026

Kurume Med J · 2026 · Cohort / series

Muroya D, Nadayoshi S, Yamada K, Kai Y, Masuda T, Miyazaki D, Sasaki S, Shimokobe H, Shimokobe H, Okamoto K, Hiramatsu T, Inoue M, Konno T, Okamoto K. The Effects of Hyperbaric Oxygen Therapy in Postoperative Patients with Ulcerative Colitis: A Retrospective Study. Kurume Med J 2026;72:13-19.

PubMed · PMID 41605688 · DOI

Mutluoglu 2016

Undersea Hyperb Med · 2016 · Review / background

Mutluoglu M, Metin S, Arziman I, Uzun G, Yildiz S. The use of hyperbaric oxygen therapy for carbon monoxide poisoning in Europe. Undersea Hyperb Med 2016;43(1):49-56.

PubMed · PMID 27000013

Mutluoglu 2016

Diving Hyperb Med · 2016 · Commentary / case

Mutluoglu M, Uzun G, Bennett M, Germonpré P, Smart D, Mathieu D. Poorly designed research does not help clarify the role of hyperbaric oxygen in the treatment of chronic diabetic foot ulcers. Diving Hyperb Med 2016;46(3):133-134.

PubMed · PMID 27723012

Mutzbauer 2000

Undersea Hyperb Med · 2000 · Commentary / case

Mutzbauer TS, Mueller PHJ, Tetzlaff K, Neubauer B, Sigg O. Is Eustachian tube ventilatory function (ETVF) impairment after oxygen diving mediated by free radicals? Undersea Hyperb Med 2000;27(suppl):16 — UHMS ASM abstract.

HBOT 0004 · Not indexed in PubMed and no DOI — full text held in the practice wiki

ME impedance decreased overnight after the first dive (p=0.015) but not after the second (p=0.475), in No difference between vitamin and placebo groups after the first dive (p=0.827); if anything the vitamin

Myking 1974

JAMA · 1974 · Commentary / case

Myking O, Schreiner A. Hyperbaric oxygen in hemolytic crisis. JAMA 1974;227(10):1161-2.

PubMed · PMID 4405898

Single case report from the University of Bergen, Norway. A 55-year-old woman in previously good health developed acute autoimmune haemolytic anaemia with warm antibodies of unknown cause. The haemoglobin fell to approximately 3 gm/100 ml with signs of cerebral hypoxia, and despite numerous attempts, compatible blood could not be obtained. She was transferred to the Royal Norwegian Naval Base in B

Naaji 2026

Ann Biomed Eng · 2026 · Review / background

Naaji A, Ciobanu M, Popescu M. Advances in Hyperbaric Oxygen Therapy: Medical Benefits and Technical Perspectives. Ann Biomed Eng 2026;54(7):2318-2336.

PubMed · PMID 41709036 · DOI · PMC free full text

Nabil & Samman 2011

Int J Oral Maxillofac Surg · 2011 · Systematic review

Nabil S, Samman N (University of Hong Kong). Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg 2011;40(3):229–243.

PubMed · PMID 21115324 · DOI

Systematic review of ORN after post-radiation dental extraction. ORN incidence ~4% with hyperbaric-oxygen cover vs ~6% with antibiotics. Authors conclude HBO is effective in reducing the risk of ORN after post-radiation extractions.

Nagy 2026

Orv Hetil · 2026 · Commentary / case

Nagy ZZ, Vörös KM, Dormán P, Szolnoki N. Műtét utáni maculaoedema gyógyulásának gyorsítása túlnyomásos (hiperbárikus) oxigénterápiás módszerrel [Acceleration of postoperative macular edema recovery with hyperbaric oxygen therapy — Hungarian, English title as printed by the journal]. Orv Hetil 2026;167(28):1120-1126.

PubMed · PMID 42437467 · DOI

Nah 2021

Undersea Hyperb Med · 2021 · Commentary / case

Nah S, Choi S, Na H, Han S. Neurological symptoms improved by hyperbaric oxygen therapy in a post-cardiac arrest patient due to carbon monoxide poisoning: a case report. Undersea Hyperb Med 2021;48(2).

PubMed · PMID 33975408

Naiboğlu 2012

Otolaryngol Head Neck Surg · 2012 · RCT

Naiboğlu B, Külekçi S, Toros SZ, Verim A, Ertugay ÇK, Oysu C (Istanbul, Turkey). Efficacy of Multimodality Approach at Sudden Hearing Loss. Otolaryngol Head Neck Surg 2012;147(2 Suppl):P85–P86 — AAO-HNSF annual meeting oral-presentation abstract.

HBOT 0011 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Post-treatment hearing improvement was statistically significant in BOTH groups (PTA, Siegel's criteria, Success 55% (group I) vs 63% (group II) — the increase with added IT steroid was not statistically

Nakada 2012

Urol Int · 2012 · Cohort / series

Nakada T, Nakada H, Yoshida Y, Nakashima Y, Banya Y, Fujihira T, Karasawa K. Hyperbaric oxygen therapy for radiation cystitis in patients with prostate cancer: a long-term follow-up study. Urol Int 2012;89(2):208-214 (PMID 22797611. DOI 10.1159/000338910).

PubMed · PMID 22797611 · DOI

Nakao 2026

Sports (Basel) · 2026 · RCT

Nakao T, Hirata T, Adachi T, Fukuda J, Fukada T, Iino-Ohori K, Igarashi M, Yoshikawa K, Iwasa K, Saito A. Cognitive Processing Efficiency (Throughput) Improves with Aerobic Exercise and Is Independent of the Environmental Oxygenation Level: A Randomized Crossover Trial. Sports (Basel) 2026;14(1):30.

PubMed · PMID 41590972 · DOI · PMC free full text

Nakao 2026

Biology (Basel) · 2026 · Cohort / series

Nakao T, Hirata T, Saito A. Mild Hyperbaric Oxygen Exposure Is Associated with Calculation-Method-Dependent Changes in VE/VCO2 During Seated Rest. Biology (Basel) 2026;15(15):1254.

PubMed · PMID 42589120 · DOI · PMC free full text

Narozny 2004

Otol Neurotol · 2004 · Cohort / series

Narozny W, Sicko Z, Przewozny T, Stankiewicz C, Kot J, Kuczkowski J. Usefulness of high doses of glucocorticoids and hyperbaric oxygen therapy in sudden sensorineural hearing loss treatment. Otol Neurotol 2004;25(6):916-923.

PubMed · PMID 15547420

Nasole 2019

Undersea Hyperb Med · 2019 · Cohort / series

Nasole E, Zanon V, Marcolin P, Bosco G. Middle ear barotrauma during hyperbaric oxygen therapy; a review of occurrences in 5,962 patients. Undersea Hyperb Med 2019;46(2):101-106.

PubMed · PMID 31051054

Naude 2024

Wound Healing Southern Africa · 2024 · Cohort / series

Naude L, Cole W, Woodmansey E. The role of continuous topical oxygen therapy as an adjunctive treatment in non-healing chronic wounds: a South African perspective. Wound Healing Southern Africa 2024;17(1):15-21.

DOI

Navarro 2012

Newfoundland and Labrador Centre for Applied Health Research (NLCAHR) · 2012 · Meta-analysis

Navarro P, Bornstein S. Hyperbaric oxygen therapy for difficult wound healing in Newfoundland & Labrador. Newfoundland and Labrador Centre for Applied Health Research (NLCAHR) 2012 (Contextualized Health Research Synthesis Program report).

HBOT 0021 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Neheman 2005

BJU Int · 2005 · Cohort / series

Neheman A, Nativ O, Moskovitz B, Melamed Y, Stein A. Hyperbaric oxygen therapy for radiation-induced haemorrhagic cystitis. BJU Int 2005;96(1):107-109.

PubMed · PMID 15963131 · DOI

Neiberger 2023

Undersea Hyperb Med · 2023 · Commentary / case

Neiberger RJ, Waters ET. Hyperbaric oxygen treatment for paracentral acute middle maculopathy: a case study. Undersea Hyperb Med 2023;50(3):283-287 (DOI 10.22462/01.01.2023.9).

DOI

Neubauer 2001

Int Arch Occup Environ Health · 2001 · RCT

Neubauer B, Tetzlaff K, Staschen CM, Bettinghausen E. Cardiac output changes during hyperbaric hyperoxia. Int Arch Occup Environ Health 2001;74(2):119–122.

PubMed · PMID 11317704 · DOI

Newth 2025

Diving Hyperb Med · 2025 · Cochrane review

Newth A, Perleth M, Sherlock S, Romero L, Bennett MH. Hyperbaric oxygen therapy for acute idiopathic sudden sensorineural hearing loss; a systematic review with meta-analysis. Diving Hyperb Med 2025;55(4):398–406.

PubMed · PMID 41364864 · DOI · PMC free full text

Chance of improvement (HBO + steroids vs steroids): RR 1.6 (95% CI 1.3–2.0) (5 studies). Mean audiometric gain: +15.6 dB (95% CI 1.5–29.8) (4 trials). GRADE: moderate evidence that HBO improves hearing when applied up to 30 days after onset; pooling

Ng 2017

Undersea Hyperb Med · 2017 · RCT

Ng AWA, Muller R, Orton J. Incidence of middle ear barotrauma in staged versus linear chamber compression during hyperbaric oxygen therapy: a double blinded, randomized controlled trial. Undersea Hyperb Med 2017;44(2):101–107.

PubMed · PMID 28777900 · DOI

MEB incidence: staged 48% vs linear 62% (P=0.12) — not a statistically significant reduction. The staged protocol produced significantly less severe MEB deteriorations (severity, not incidence,

Nguyen 2025

Int Marit Health · 2025 · RCT

Nguyen NB, Nguyen Van T, Nguyen Thi Hai H, Nguyen Truong S. Results of treating patients with diabetic foot ulcers with hyperbaric oxygen. Int Marit Health 2025;76(4):259–267.

PubMed · PMID 41498373 · DOI

Granulation growth and infection control better with HBO (p<0.001); ulcer depth and diameter Amputation rate 4.6% (HBO) vs 11.7% (reference); treatment time 10.1 ± 4.6 vs 15.1 ± 7.8 days. ⚠️ Corrected 31 Aug 2026: this bullet previously read "The authors also report a significant odds

Niezgoda 1997

Plast Reconstr Surg · 1997 · RCT

Niezgoda JA, Cianci P, Folden BW, Ortega RL, Slade JB, Storrow AB. The effect of hyperbaric oxygen therapy on a burn wound model in human volunteers. Plast Reconstr Surg 1997;99(6):1620–1625.

PubMed · PMID 9145132

On day 2, wound size, hyperaemia and exudation differed significantly (p<0.05). The HBO group showed a No significant difference in epithelialization.

Nik 2019

Med J Malaysia · 2019 · RCT

Nik Ab Rahman NH, Wan Mohammad WMZ, Bajuri MY, Shafee R. Use of hyperbaric oxygen therapy (HBOT) in chronic diabetic wound - A randomised trial. Med J Malaysia 2019;74(5):418–424.

PubMed · PMID 31649219

Wound-size trajectory over the four time points was significantly better with HBOT (repeated-measures On logistic regression, the HBOT group had ~44× higher odds of achieving ≥30% wound-size reduction

Nikolić 2026

Int Wound J · 2026 · RCT

Nikolić D, Pasternak J, Manojlović V, Budinski S, Nikolić M, Batinić N. Hyperbaric Oxygen Therapy for Chronic Venous Leg Ulcers: A Prospective Randomised Controlled Trial. Int Wound J 2026;23(3):e70856.

PubMed · PMID 41734913 · DOI · PMC free full text

Area reduction: 62.1% ± 22.1% (HBO) vs 41.7% ± 21.5% (control); MD 20.4% (95% CI 10.1–30.7), Complete healing at 90 days: 62.5% vs 30.0% (NNT 3). TcPO₂ rose 26.1 → 150.3 mmHg in the HBO group (p<0.001); pain improved significantly more.

Niu 2026

Front Cell Dev Biol · 2026 · Network MA

Niu QY, Yang XQ, Liu XW, Yang F, He W. Comparative efficacy and safety of core decompression, cell-based therapy, hyperbaric oxygen therapy, extracorporeal shock wave therapy, and combined regimens for osteonecrosis of the femoral head: a network meta-analysis. Front Cell Dev Biol 2026;14:1876711.

PubMed · PMID 42529114 · DOI

Nöhl 2025

Diving Hyperb Med · 2025 · Review / background

Nöhl S, Burisch C, Gödde D, Sellmann T. 'Power under pressure' - defibrillation during hyperbaric oxygen therapy: a scoping review. Diving Hyperb Med 2025;55(4):407-418.

PubMed · PMID 41364865 · DOI · PMC free full text

Norton 2022

Undersea and Hyperbaric Medicine · 2022 · Commentary / case

Norton MN, Weaver LK. Decompression sickness with incidental pulmonary cyst. Undersea and Hyperbaric Medicine 2022;49(3):289-293.

PubMed · PMID 36001561

Obradovic 2026

Front Med (Lausanne) · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Obradovic A, Nenadovic A, Mitovic N, Jeremic R, Brkic P, Vidonja Uzelac TF, Vujacic UJ, Ivanov M, Jankovic S, Vukovic A, De Luka SR, Kovacevic S, Nesovic Ostojic J. Organ-specific redox and trace element modulation following hyperbaric oxygenation and physical activity in rats. Front Med (Lausanne) 2026;13:1820821.

PubMed · PMID 42445137 · DOI · PMC free full text

Oh 2019

Undersea Hyperb Med · 2019 · Commentary / case

Oh SH, Kang HD, Jung SK, Choi S. Successful treatment of decompression sickness complicated with acute hepatic infarction and acute kidney injury: a case report. Undersea Hyperb Med 2019;46(1):81-85.

PubMed · PMID 31154689

Oley 2021

Int J Surg Open · 2021 · RCT

Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Agustine, Faruk M, Kalangi JA. (verify). Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: A randomized controlled trial study. Int J Surg Open 2021;29:33–39.

DOI

Serum VEGF increased significantly in the HBO group vs control (p<0.05). The rise in VEGF is expected to translate into faster wound healing and a lower amputation rate — an

Oley 2024

Plast Reconstr Surg Glob Open · 2024 · Meta-analysis

Oley MH, Oley MC, Kepel BJ, Faruk M, Wagiu AMJ, Sukarno I, Tulong MT, Sukarno V. Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers Based on Wagner Grading: A Systematic Review and Meta-analysis. Plast Reconstr Surg Glob Open 2024;12(3):e5692.

PubMed · PMID 38528847 · DOI · PMC free full text

Wound healing (≥8 weeks after final treatment): RR 2.39 (95% CI 1.87–3.05; P<0.00001) favouring HBOT. Minor / distal amputation: RR 0.58 (95% CI 0.43–0.80; P<0.007). Major / proximal amputation: RR 0.31 (95% CI 0.18–0.52; P<0.00001).

Oley 2025

Int Marit Health · 2025 · Cohort / series

Oley MH, Oley MC, Kepel BJ, Prasetyo E, Kalitouw F, Kalesaran L, Aling DMR, Tulong MT, Islam AA, et al. A descriptive retrospective study on the various uses of hyperbaric oxygen therapy. Int Marit Health 2025;76(4):254-258 (DOI 10.5603/imh.103441).

PubMed · PMID 41498372 · DOI

Oley 2025

Arch Ital Urol Androl · 2025 · RCT

Oley MH, Oley MC, Iskandar AAA, Sukasah CL, Aulia I, Langi FLFG, Lampus HF, Sukarno I, Sukarno V, Faruk M. The effect of hyperbaric oxygen therapy on hypospadias reconstruction: a preliminary randomized controlled trial study of VEGF levels and HOPE score analysis. Arch Ital Urol Androl 2025;97(1):13342.

PubMed · PMID 40116238 · DOI

VEGF rose with successive HBO sessions — significant at 3 (p=0.038), 4 (p=0.002) and 5 (p=0.008) sessions. Total HOPE score improved (p=0.028) and penile-torsion sub-score (p=0.006) in the HBO group. Conclusion: HBO accelerates wound healing after urethroplasty; ≥3 sessions recommended.

Oley 2026

Dermatol Rep · 2026 · Cohort / series

Oley MH, Oley MC, Sukarno V, Suoth SC, Faruk M. Hyperbaric oxygen therapy in the reconstruction of giant rhinophyma: a case series. Dermatol Rep 2026:Epub ahead of print.

PubMed · PMID 42370426 · DOI

Omar 2018

Diving and Hyperbaric Medicine · 2018 · Commentary / case

Omar AR, Ibrahim M, Hussein A. Acute ophthalmic artery occlusion in decompression illness with underlying anterior cerebral artery A1 segment hypoplasia. Diving and Hyperbaric Medicine 2018;48(2):112-113.

PubMed · PMID 29888385 · DOI · PMC free full text

O'Neill 2015

Undersea Hyperb Med · 2015 · Review / background

O'Neill OJ, Weitzner ED. The O'Neill grading system for evaluation of the tympanic membrane: a practical approach for clinical hyperbaric patients. Undersea Hyperb Med 2015;42(3):265-271.

PubMed · PMID 26152108

O'Neill 2021

Undersea Hyperb Med · 2021 · Cohort / series

O'Neill OJ, Dayya D, Varughese L, Marker JA, Perez L, Dayya M. The effect of total compression time and rate (slope) of compression on the incidence of symptomatic Eustachian tube dysfunction and middle ear barotrauma: a Phase II prospective study. Undersea Hyperb Med 2021;48(3) (Phase II prospective study; 1,244 group patient-treatment exposures covering 5,072 individual patient-treatment exposures).

PubMed · PMID 34390625

The longer 15-minute compression interval produced significantly fewer compression stops and holds than the 10-minute interval (Table 3D: OR 0.66, 95% CI 0.49–0.89, p = 0.006), reproducing the same unit's Phase I result. The non-linear slope showed a 17% lower risk but did not reach significance (Table 3E: OR 0.80, 95% CI 0.59–1.1, p = 0.14). Note that the abstract's claim to be "the first to demonstrate a statistically signif…

Ontario HTA 2005

Ont Health Technol Assess Ser · 2005 · Cochrane review

Medical Advisory Secretariat (Ontario). Hyperbaric oxygen therapy for non-healing ulcers in diabetes mellitus: an evidence-based analysis. Ont Health Technol Assess Ser 2005;5(11):1–28.

PubMed · PMID 23074462 · PMC free full text

Citing the Cochrane analysis (3 studies, 118 patients): HBOT may prevent major amputation — RR 0.31 Evidence graded low quality (small trials, varying wound severity, HBOT regimens and endpoints);

Ontario Health Technology Assessment 2017

Ont Health Technol Assess Ser · 2017 · Systematic review

Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser 2017;17(5):1-142.

PubMed · PMID 28572866 · PMC free full text

O'Reilly 2013

Int J Technol Assess Health Care · 2013 · Meta-analysis

O'Reilly D, Pasricha A, Campbell K, Burke N, Assasi N, Bowen JM, Tarride JE, Goeree R. HYPERBARIC OXYGEN THERAPY FOR DIABETIC ULCERS: SYSTEMATIC REVIEW AND META-ANALYSIS. Int J Technol Assess Health Care 2013;29(3):269–281.

PubMed · PMID 23863187 · DOI

12 publications (6 RCTs + 6 comparative observational). Major amputation reduced 60% (RCTs, p=0.29 — NS) and 61% (observational, p=0.003) vs standard care. Unhealed-wound relative risk 0.54 (RCTs, p=0.10 — NS) and 0.24 (observational, p<0.001).

Orwig 2025

Am J Emerg Med · 2025 · Cohort / series

Orwig DM, Wang J, Li Z, McGlynn JJ, HajAissa N, Davis A, Hovingh M, Packard L, Kooistra JS, Min J. The effects of hyperbaric oxygen treatment for non-arteritic central retinal artery occlusion (HBOT-CRAO). Am J Emerg Med 2025;98:1–5 (Epub 5 Aug 2025).

PubMed · PMID 40784185 · DOI

65 patients: full-course HBOT 17 (twice daily × 5 days = 10 treatments), partial 16, none 32. No Full-course HBOT: significant BCVA improvement at discharge (p = 0.01); no benefit with partial or no Conclusion: HBOT may be considered for CRAO presenting within 24 h, with the full course important.

Oscarsson 2019

Lancet Oncol · 2019 · RCT

Oscarsson N, Müller B, Rosén A, Lodding P, Mölne J, Giglio D, et al. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. Lancet Oncol 2019;20(11):1602–1614.

PubMed · PMID 31537473 · DOI

Difference in change of mean EPIC urinary total score: +10.1 points favouring HBOT Adverse events: transient grade 1–2 (sight/hearing) in 41%.

Oscarsson 2025

EClinicalMedicine · 2025 · RCT

Oscarsson N, Rosén A, Müller B, Renström Koskela L, Giglio D, Kjellberg A, Ettala O, Seeman-Lodding H. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): long-term follow-up of a randomised controlled, phase 2–3 trial. EClinicalMedicine 2025;83:103214.

PubMed · PMID 40291346 · DOI · PMC free full text

Mean EPIC urinary total score improved 18.0 points (95% CI 14.2–21.8) from baseline to 6 months Responders (n=48; 68.6%) — defined as ≥9-point improvement post-HBO₂ — maintained a mean increase 9/70 (12.8%) received additional HBO₂ for recurring symptoms over the 5 years.

Osman 2025

Cureus · 2025 · Systematic review

Gafar Abubakir Osman H, Elbadri ME, Alhadi IAH, Ibrahim AS, Ayyub A, Mohamed A, Sahnon ASA, Alkhazendar JHJ, Alkhazendar AH, Awan M. Crush syndrome and systemic necrosis in trauma patients: a systematic review of pathophysiology, anatomical impact, and renal outcomes. Cureus 2025;17(8):e89592.

PubMed · PMID 40922840 · DOI · PMC free full text

Osmani 2017

Bull Hosp Jt Dis (2013) · 2017 · Systematic review

Osmani F, Thakkar S, Vigdorchik J. The Utility of Conservative Treatment Modalities in the Management of Osteonecrosis. Bull Hosp Jt Dis (2013) 2017;75(3):186–192.

PubMed · PMID 28902603

The biophysical modalities (HBO, ESWT, PEMF) all produced delay and partial reversal of disease Stage-dependent: Ficat I–II (pre-collapse) can be approached conservatively (pharmacological +

Otón-Sánchez 2013

Rep Pract Oncol Radiother · 2013 · RCT

Otón Sánchez C, González Lugo Y, Otón Sánchez L, Díaz-Flores Varela L, Jiménez Calero J, Puerto Romero P. Treatment of radiation-induced cervical fibrosis with pentoxifylline-tocoferol and hyperbaric oxygen. Rep Pract Oncol Radiother 2013;18(Suppl):S111 — SEOR/ESTRO congress abstract.

DOI

37 randomised, 26 completed (13 per arm); well tolerated (2 stopped for drug intolerance). Patients improving fibrosis by ≥1 LENT-SOMA grade: Arm 1 (drugs only): 1/13 at 3 months, 4/13 at 6 months.

O'Toole 2002

Operative Techniques in Orthopaedics · 2002 · Review / background

O'Toole K. Hyperbaric oxygen therapy and chronic refractory osteomyelitis. Operative Techniques in Orthopaedics 2002;12(4):282–285.

DOI

Definition adopted (from Strauss): chronic osteomyelitis is bone infection which, when adequately treated, persists longer than six weeks; it becomes refractory when it does not respond to adequate therapeutic intervention including antibiotics and surgery. The Esterhai, Waldvogel and Cierny-Mader classification systems are named as aids to treatment choice.

OuYang 2024

Front Endocrinol (Lausanne) · 2024 · Network MA

OuYang H, Yang J, Wan H, Huang J, Yin Y. Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis. Front Endocrinol (Lausanne) 2024;15:1452192.

PubMed · PMID 39377075 · DOI · PMC free full text

Versus SOC, HBOT — along with PRP, TOT, ADM and SCs — significantly increases the complete-healing HBOT is not the top-ranked modality: PRP (esp. PRP+NPWT) and combination regimens ranked highest No significant between-treatment differences for ulcer-area reduction.

Overgaard 2011

Radiother Oncol · 2011 · Meta-analysis

Overgaard J. Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – a systematic review and meta-analysis. Radiother Oncol 2011;100(1):22-32.

PubMed · PMID 21511351 · DOI

A systematic review and meta-analysis of randomised trials of hypoxic modification added to curative-intent primary radiotherapy alone. - 32 randomised trials, 4,805 patients. - Inclusion criterion, stated: the treatment had to be curative intended primary radiotherapy alone, with randomisation to a hypoxic modifier known only to influence hypoxic radioresistance and having no other cytotoxic effe

Oyaizu 2017

Undersea Hyperb Med · 2017 · Commentary / case

Oyaizu T, Enomoto M, Tsujimoto T, Kojima Y, Okawa A, Yagishita K. Elimination of CT-detected gas bubbles derived from decompression illness with abdominal symptoms after a short hyperbaric oxygen treatment in a monoplace chamber: a case report. Undersea Hyperb Med 2017;44(2):167-171.

PubMed · PMID 28777907 · DOI

Oyaizu 2018

Sci Rep · 2018 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Oyaizu T, Enomoto M, Yamamoto N, Tsuji K, Horie M, Muneta T, Sekiya I, Okawa A, Yagishita K. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep 2018;8(1):1288.

PubMed · PMID 29358697 · DOI · PMC free full text

Oedema/injury: HBO reduced early hindlimb volume and muscle wet weight (µCT volume lower at 6 h, Dual immuno-regenerative action: HBO suppressed the acute-phase rise in circulating macrophages, Pathway: early stimulation of the IL-6/STAT3 pathway in contused muscle.

Ozdemir 2016

Undersea Hyperb Med · 2016 · Cohort / series

Ozdemir A, Uzun G, Turker T, Ucar E, Yildiz S. Changes in pulmonary function in hyperbaric chamber inside attendants: a case-control study. Undersea Hyperb Med 2016;43(7):805-811.

PubMed · PMID 28777517

Özdemir 2023

Undersea Hyperb Med · 2023 · Cohort / series

Özdemir Ü, Akin M, Sözen I, Erkent M, Tatar S, Yasti AÇ. Effects of hyperbaric oxygen therapy on clinical and economic outcomes in patients with deep second-degree burns. Undersea Hyperb Med 2023;50(1):29-37 (DOI 10.22462/01.01.2023.18).

PubMed · PMID 36820804 · DOI

Ozgok-Kangal 2021

Diving Hyperb Med · 2021 · Cohort / series

Ozgok-Kangal K. Long-term infant outcomes after hyperbaric oxygen treatment for acute carbon monoxide poisoning during pregnancy. Diving Hyperb Med 2021;51(3):248-255.

PubMed · PMID 34547775 · DOI · PMC free full text

Ozgok Kangal 2024

Diving and Hyperbaric Medicine Journal · 2024 · Cohort / series

Ozgok Kangal K, Mirasoglu B. Hyperbaric oxygen treatment for infants: retrospective analysis of 54 patients treated in two tertiary care centres. Diving and Hyperbaric Medicine Journal 2024;54(1):9-15 (DOI 10.28920/dhm54.1.9-15).

PubMed · PMID 38507905 · DOI · PMC free full text

Ozturk 2022

Diving Hyperb Med · 2022 · Cohort / series

Ozturk H, Mirasoglu B, Aktas S. Hyperbaric oxygen treatment for refractory haemorrhagic cystitis occurring after chemotherapy and haematopoietic stem cell transplantation: retrospective analysis of 25 patients. Diving Hyperb Med 2022;52(1):27-34.

PubMed · PMID 35313370 · DOI · PMC free full text

Paderno 2021

Int J Environ Res Public Health · 2021 · Meta-analysis

Paderno E, Zanon V, Vezzani G, Giacon TA, Bernasek TL, Camporesi EM, Bosco G. Evidence-Supported HBO Therapy in Femoral Head Necrosis: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health 2021;18(6):2888.

PubMed · PMID 33808951 · DOI · PMC free full text

Overall clinical effect OR 3.84 (95% CI 2.10–7.02; P<0.00001) favouring HBO. Subgroup: Asian population OR 3.53 (95% CI 1.87–6.64; significant); non-Asian OR 7.41 (95% CI

Paganini 2022

J Appl Physiol (1985) · 2022 · Systematic review

Paganini M, Moon RE, Boccalon N, Melloni GEM, Giacon TA, Camporesi EM, Bosco G. Blood gas analyses in hyperbaric and underwater environments: a systematic review. J Appl Physiol (1985) 2022;132(2):283–293.

PubMed · PMID 34941439 · DOI

A systematic review of studies measuring blood gases in hyperbaric and underwater environments — a physiology and measurement-methodology synthesis.

Pagoldh 2013

Scand J Gastroenterol · 2013 · RCT

Pagoldh M, Hultgren E, Arnell P, Eriksson A. Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study. Scand J Gastroenterol 2013;48(9):1033–1040.

PubMed · PMID 23879825 · DOI

No statistically significant difference between the groups in any of the assessed variables — The UNSW appraisal notes the study was underpowered.

Pak 2021

Undersea Hyperb Med · 2021 · Commentary / case

Pak S, Valencia D, Lee C, Lach J, Ortiz G. Ingestion of food grade hydrogen peroxide with resultant gastrointestinal and neurologic symptoms treated with hyperbaric oxygen therapy: case report and review with emphasis on the therapeutic value of HBO2 in vascular gas embolism. Undersea Hyperb Med 2021;48(2):177-186.

PubMed · PMID 33975409 · DOI

Pandey 2022

Diving Hyperb Med · 2022 · Cohort / series

Pandey K, Teguh DN, van Hulst RA. Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patients. Diving Hyperb Med 2022;52(3):208-212.

PubMed · PMID 36100932 · PMC free full text

Pang 2026

Front Toxicol · 2026 · Cohort / series

Pang Y, Yuan J, Yuan X, Chai X, Li S. Hyperbaric oxygen therapy for ischemic encephalopathy following occupational exposure to high-concentration toxic gases: two cases. Front Toxicol 2026;8:1782213.

PubMed · PMID 42293282 · DOI · PMC free full text

Parsons 2024

Undersea Hyperb Med · 2024 · Commentary / case

Parsons D, Utz E, Kidd G, Virgilio G. Inner ear decompression sickness after a routine dive and recompression chamber drill. Undersea Hyperb Med 2024;51(2):129-135.

PubMed · PMID 38985149

Payne 2013

BJU Int · 2013 · Review / background

Payne H, Adamson A, Bahl A, Borwell J, Dodds D, Heath C, Huddart R, McMenemin R, Patel P, Peters JL, Thompson A. Chemical‐ and radiation‐induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013;112(7):885–897.

PubMed · PMID 24000900 · DOI · PMC free full text

Narrative/systematic overview of haemorrhagic-cystitis treatments (hydration, bladder irrigation, formalin, aluminium, hyperbaric oxygen, cystectomy). HBO presented as an effective option for RT-induced cystitis; hyperbaric protocols differ between reports and evidence is largely observational.

Pearl 2024

Undersea Hyperb Med · 2024 · Commentary / case

Pearl A, Pearl S. Hyperbaric oxygen therapy for avascular necrosis of the femoral head: A case report. Undersea Hyperb Med 2024;51(3):241-245 (DOI 10.22462/644).

DOI

Pekovic 2018

In: Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. IntechOpen · 2018 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Pekovic S, Dacic S, Krstic D, Jeremic R, Djelic M, et al. Hyperbaric oxygen therapy in traumatic brain injury: cellular and molecular mechanisms. In: Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. IntechOpen 2018 (book chapter 3. DOI 10.5772/intechopen.75025).

DOI

Peng 2017

Diving and Hyperbaric Medicine · 2017 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Peng B, Chen MM, Jiang ZL, Li X, Wang GH, Xu LH. Preventive effect of rosiglitazone on liver injury in a mouse model of decompression sickness. Diving and Hyperbaric Medicine 2017;47(1):17-23.

PubMed · PMID 28357820 · DOI · PMC free full text

Peng 2023

Diving and Hyperbaric Medicine Journal · 2023 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Peng X, Gao B, Wang X, Qin X, Peng M, Zeng X. Hyperbaric oxygen and treadmill exercise partially prevented bone loss and bone microarchitecture deterioration in ovariectomized rats. Diving and Hyperbaric Medicine Journal 2023;53(2):111-119 (DOI 10.28920/dhm53.2.111-119).

PubMed · PMID 37365128 · DOI · PMC free full text

Pereira 2020

Actas Urol Esp · 2020 · Cohort / series

Pereira D, Ferreira C, Catarino R, Correia T, Cardoso A, Reis F, Cerqueira M, Prisco R, Camacho O. Hyperbaric oxygen for radiation-induced cystitis: a long-term follow-up. Actas Urol Esp 2020;44(8):561-567.

PubMed · PMID 32736899 · DOI

Perez 2017

Diving Hyperb Med · 2017 · Commentary / case

Perez MFM, Ongkeko-Perez JV, Serrano AR, Andal MP, Aldover MCC. Delayed hyperbaric intervention in life-threatening decompression illness. Diving Hyperb Med 2017;47(4):257-259.

DOI

Perren 2018

Open Cardiovasc Med J · 2018 · RCT

Perren S, Gatt A, Papanas N, Formosa C (University of Malta). Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial. Open Cardiovasc Med J 2018;12:80–85.

PubMed · PMID 30258500 · DOI · PMC free full text

Both arms reduced ulcer area and depth (P<0.001). Group A (HBOT) showed superior improvement in both ulcer area (P<0.001) and depth (P<0.001)

Perrins 1967

Lancet · 1967 · RCT

Perrins DJ. Indexed as a Randomized Controlled Trial. Influence of hyperbaric oxygen on the survival of split skin grafts. Lancet 1967;1(7495):868–871.

PubMed · PMID 4164367 · DOI

Complete "take" (≥95% graft survival): 64% (≈15/24) HBO vs 17% (≈4/24) control — absolute increase ≥60% take: 100% (HBO) vs 64% (control) — no treated graft fell below 60% take; NNT ≈ 3. <br⚠️ Corrected 31 Aug 2026: the control figure previously read 62.5%. The paper's table (Proportion of treated and control cases in relation to graft survival, p. 869) gives 60%: treated 100%, control 64% (verified against the printed table b…

Peterson 2024

J Clin Oncol · 2024 · Guideline

Peterson DE, Koyfman SA, Yarom N, Lynggaard CD, Ismaila N, Forner LE, et al. (ISOO-MASCC-ASCO). Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline. J Clin Oncol 2024;42(16):1975–1996.

PubMed · PMID 38691821 · DOI

A multi-society clinical practice guideline (International Society of Oral Oncology – Multinational Association of Supportive Care in Cancer – American Society of Clinical Oncology) on prevention and management of osteoradionecrosis (ORN) in head-and-neck cancer treated with radiotherapy. The most authoritative recent guideline touching HBO for ORN — and it is cautious.

Phillips 2005

Plast Surg Nurs · 2005 · Review / background

Phillips JC. Understanding hyperbaric oxygen therapy and its use in the treatment of compromised skin grafts and flaps. Plast Surg Nurs 2005;25(2):72-80.

PubMed · PMID 15983497 · DOI

Phillips & Jones 2013

Cochrane Database Syst Rev · 2013 · Cochrane review

No. CD004617. Phillips JS, Jones SEM. Current version pub3 (2013); supersedes pub2. Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa. Cochrane Database Syst Rev 2013, Issue 5, Art.

PubMed · PMID 23728650 · DOI · PMC free full text

No randomised controlled trials identified. No data to show adjunctive HBO improves outcome over

Pilgramm 1985

Arch Otorhinolaryngol · 1985 · RCT

Pilgramm M, Schumann K. Hyperbaric oxygen therapy for acute acoustic trauma. Arch Otorhinolaryngol 1985;241(3):247–257.

PubMed · PMID 4026691 · DOI

HBO shortened the course of healing with respect to high-pitch (high-frequency) perception Timing-dependent: therapy started early gave better results; therapy started late (in some cases

Pilgramm 1985 (Hörsturz)

Laryngol Rhinol Otol (Stuttg) · 1985 · RCT

Pilgramm M, Lamm H, Schumann K. [Hyperbaric oxygen therapy in sudden deafness]. Laryngol Rhinol Otol (Stuttg) 1985;64(7):351–354.

PubMed · PMID 3875776

Standard therapy (n=19): start 45.7 → end 25.5 dB, gain 20.2 dB (44%), P<0.01. HBO + standard (n=18): start 47.2 → end 18.1 dB, gain 29.1 dB (61%), P<0.01. Between-group difference (this appraiser's calculation): ≈ 8.9 dB favouring HBO (95% CI ≈ 0.3–17.5) —

Pitkin 2000

Undersea Hyperb Med · 2000 · Review / background

Pitkin AD, on behalf of the RIBP Working Party. Double-blind randomised controlled trial of hyperbaric oxygen (HBO) therapy for treatment of radiation-induced brachial plexopathy (RIBP). Undersea Hyperb Med 2000;27(suppl):39 — UHMS ASM abstract.

HBOT 0016 · Not indexed in PubMed and no DOI — full text held in the practice wiki

No differences in mean warm sensory thresholds between groups — HBO did not reverse RIBP in the short Authors flagged that a possible effect on arm lymphoedema was being tested in a follow-up trial (→ that

Plenk 1972

Am J Roentgenol Radium Ther Nucl Med · 1972 · RCT

Plenk HP. Hyperbaric Radiation Therapy — Preliminary Results of a Randomized Study of Cancer of the Urinary Bladder and Review of the 'Oxygen Experience.' Am J Roentgenol Radium Ther Nucl Med January 1972.

PubMed · PMID 4333187

A significant improvement in survival was reported in the HBO (hypofractionated) arm vs conventional Author's review claim: oxygen benefit appears only when 4–12 fractions are used; SCC of cervix and In the cited cervix series using conventional fractionation, the HBO-vs-air difference was not

Plogmark 2026

Diving Hyperb Med · 2026 · Review / background

Plogmark O, Soltesz K, Hjelte C, Frånberg O. Measuring whole-body inert gas uptake and washout during submersion. Diving Hyperb Med 2026;56(2):137-147.

PubMed · PMID 42290573 · DOI

Polzik 2017

BMJ Open · 2017 · Review / background

Polzik P, Johansson PI, Hyldegaard O. How biomarkers reflect the prognosis and treatment of necrotising soft tissue infections and the effects of hyperbaric oxygen therapy: the protocol of the prospective cohort PROTREAT study conducted at a tertiary hospital in Copenhagen, Denmark. BMJ Open 2017;7(10):e017805.

PubMed · PMID 28982834 · DOI · PMC free full text

Popa 2017

Undersea and Hyperbaric Medicine · 2017 · Commentary / case

Popa D, Chin W, Huchim-Lara O, Grover I. Spinal decompression sickness in an artisanal diving fisherman in Yucatán, Mexico: a case report. Undersea and Hyperbaric Medicine 2017;44(5):415-419.

PubMed · PMID 29116696

Popa 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

Popa D, Medak A, Chin W, Huchim-Lara O, Fliszar E, Hughes T, Grover I. Dysbaric osteonecrosis (DON) among the artisanal diving fishermen of Yucatan, Mexico. Diving and Hyperbaric Medicine 2020;50(4):391-398.

PubMed · PMID 33325021 · DOI · PMC free full text

Posluszny 2014

Transfusion · 2014 · Review / background

Posluszny JA Jr, Napolitano LM. How do we treat life-threatening anemia in a Jehovah's Witness patient? Transfusion 2014;54(12):3026–3034.

PubMed · PMID 25330835 · DOI

A narrative practice review in Transfusion's "HOW DO I…?" instructional series, setting out one American centre's protocol for severe anaemia in patients who decline transfusion, with an embedded uncontrolled case series of 6 patients treated under that protocol between 2012 and 2014. There is no search strategy, no database, no date range, no eligibility criteria, no screening or extraction proce

Pracyk 1995

Undersea Hyperb Med · 1995 · Cohort / series

Pracyk JB, Stolp BW, Fife CE, Gray L, Piantadosi CA. Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning. Undersea Hyperb Med 1995;22(1):1-7.

PubMed · PMID 7742705

Pries-Heje 2026

Infect Drug Resist · 2026 · Cohort / series

Pries-Heje MM, Lerche CJ, Fosbøl E, Forchhammer M, Hasselbalch RB, Schwartz F, Siebert ASL, Jensen PØ, Rottensten H, Iversen K, Bundgaard H, Hyldegaard O, Moser C. Hyperbaric Oxygen Treatment as a Novel Add-on in Selected Patients with Infective Endocarditis – A Safety and Feasibility Trial. Infect Drug Resist 2026;19:568123.

PubMed · PMID 42212055 · DOI · PMC free full text

Pritchard 2001

Radiother Oncol · 2001 · RCT

Pritchard J, Anand P, Broome J, Davis C, Gothard L, Hall E, Maher J, McKinna F, Millington J, Misra VP, Pitkin A, Yarnold JR (RAGE / Royal Marsden). Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2001;58(3):279–286 (PII S0167-8140(00)00309-8; DOI to confirm).

PubMed · PMID 11230889 · DOI

Pre-treatment neurophysiological tests were grossly abnormal in the affected hand in both groups (as No adverse effects of HBO were reported. The authors noted warm-sensory-threshold improvements offered only "some suggestion" of activity in a

Prost 2022

Undersea Hyperb Med · 2022 · Cohort / series

Prost M, Eichhorn D, Strelow H, et al. Influence of the COVID-19 pandemic on causes for the development of carbon monoxide intoxications. Undersea Hyperb Med 2022;49(4):479-483.

PubMed · PMID 36446293

Qi 2020

Undersea Hyperb Med · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Qi Y, Guo Z, Hu H, Meng X, Lv Y, Pan S, Guo D. Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning. Undersea Hyperb Med 2020;47(4):607-619.

PubMed · PMID 33227837

Qin 2017

Evid Based Complement Alternat Med · 2017 · RCT

Qin L, Chu M, Guo D, Wang L, Wang J, Ding X, Bi M, Zou Y. Efficacy of Combined XingZhi‐YiNao Granules and Hyperbaric Oxygen Therapy for Cognition and Motor Dysfunction in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. Evid Based Complement Alternat Med 2017;2017:1323297.

PubMed · PMID 29333178 · DOI · PMC free full text

Both active arms improved cognition/motor scores and P300 amplitude (P<0.05); the XZYN group was

Qu 2026

BMC Sports Sci Med Rehabil · 2026 · Review / background

Qu C, Xu M, Lorenzo S, Huang P, Rao Z, Geng X, Zhao J. Mild hyperbaric oxygen therapy on subjective sleep quality, aerobic, anaerobic exercise test, brain and muscle tissue oxygenation response in Chinese University male athletes after muscle fatigue. BMC Sports Sci Med Rehabil 2026;18(1):181.

PubMed · PMID 41782153 · DOI · PMC free full text

Quah 2024

Oral Dis · 2024 · Meta-analysis

Quah B, Yong CW, Lai CWM, Islam I. Efficacy of adjunctive modalities during tooth extraction for the prevention of osteoradionecrosis: A systematic review and meta‐analysis. Oral Dis 2024;30(6):3732–3744.

PubMed · PMID 38396363 · DOI

Pooled ORN prevalence: HBO 4.6%, PENTO 3.4%, ABX 3.8% — all significantly lower odds of ORN HBO vs control: OR 0.27 (reduced ORN). Conclusion: HBO, PENTO and ABX may reduce ORN incidence vs no intervention, but their incidences

Querido 2025

Diving Hyperb Med · 2025 · Review / background

Querido AL, Wingelaar TT. Assessing dive fitness in individuals with autism spectrum disorder. Diving Hyperb Med 2025;55(3):254-261.

PubMed · PMID 40986921 · DOI · PMC free full text

Querido 2026

Diving Hyperb Med · 2026 · Review / background

Querido AL, Wingelaar TT. Bipolar spectrum disorders in divers: risks, recognition, and recommendations. Diving Hyperb Med 2026;56(2):170-176.

PubMed · PMID 42290577 · DOI

Raizandha 2022

Int Braz J Urol · 2022 · Meta-analysis

Raizandha MA, Hidayatullah F, Kloping YP, Rahman IA, Djatisoesanto W, Rizaldi F. The role of hyperbaric oxygen therapy in Fournier’s Gangrene: A systematic review and meta-analysis of observational studies. Int Braz J Urol 2022;48(5):771–781.

PubMed · PMID 35594328 · DOI · PMC free full text

10 studies (qualitative + quantitative synthesis). Mortality significantly lower with HBO: OR 0.29 (95% CI 0.12–0.69; p=0.005). No significant difference in mean length of stay (MD −0.18; 95% CI −7.68 to 7.33; p=0.96) or number of debridement procedures (MD 1.33; 95% CI −0.58 to 3.23; p=0.17). ⚠️ Corrected 31 Aug 2026 (denominators added): these two "no difference" results were previously quoted with no denominator, which read…

Rajpal 2019

Undersea Hyperb Med · 2019 · Cohort / series

Rajpal N, Walters ET, Elmarsafi T, Pittman TA, Johnson-Arbor KK. Use of hyperbaric oxygen therapy for tissue ischemia after breast reconstruction. Undersea Hyperb Med 2019;46(4):461-465.

DOI

Raleigh 2005

Undersea Hyperb Med · 2005 · Commentary / case · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Raleigh G, Rivard R, Fabus S. Air-activated chemical warming devices: effects of oxygen and pressure. Undersea Hyperb Med 2005;32(6):445-449.

PubMed · PMID 16509287

Ramchandani 2026

Diving Hyperb Med · 2026 · Commentary / case

Ramchandani R, Devaney B, Jaison A, Banham N, Roehr S. Cerebral arterial oxygen embolism as a complication of hyperbaric oxygen treatment: a case report. Diving Hyperb Med 2026;56(2):198-202.

PubMed · PMID 42290582 · DOI

Ramdani 2026

Cureus · 2026 · Commentary / case

Ramdani M, El Moudane A, Tahri Y, Slimani O, Barki A. Fournier's gangrene and extensive abdominal necrotizing fasciitis secondary to perforated appendicitis within an inguinoscrotal hernia: a rare case report. Cureus 2026;18(8):e114723.

DOI

Raphael 1989

Lancet · 1989 · RCT

Raphael JC, Elkharrat D, Jars-Guincestre MC, Chastang C, Chasles V, Vercken JB, Gajdos P. Trial of normobaric and hyperbaric oxygen for acute carbon monoxide intoxication. Lancet 1989;2(8660):414–419.

PubMed · PMID 2569600 · DOI

Group A (no LOC): recovery 66% (A0/NBO) vs 68% (A1/HBO) — no benefit from HBO, irrespective of Group B (LOC): recovery 54% (one HBO) vs 52% (two HBO) — a second HBO session gave no benefit in All 4 deaths (2 B1, 2 B2) and 7 patients left with neuropsychiatric sequelae (3 B1, 4 B2) had

Rasmussen 2015

Acta Anaesthesiol Scand · 2015 · RCT

Rasmussen VM, Borgen AE, Jansen EC, Rotbøll Nielsen PH, Werner MU. Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans. Acta Anaesthesiol Scand 2015;59:749-762.

PubMed · PMID 25735985 · DOI

Statistically significant overall attenuation of SHA during HBO vs control (P=0.011). Order/carryover effect: in the 8 volunteers starting with HBO, no difference vs control was seen — i.e.

Ravi 2017

J Stomatol Oral Maxillofac Surg · 2017 · Review / background

Ravi P, Vaishnavi D, Gnanam A, Krishnakumar Raja VB. The role of hyperbaric oxygen therapy in the prevention and management of radiation-induced complications of the head and neck – a systematic review of literature. J Stomatol Oral Maxillofac Surg 2017;118(6):359–362.

PubMed · PMID 28838774 · DOI

Evidence that HBO improves subjective xerostomia, swallowing, speech and overall quality of life after head/neck radiotherapy. No conclusive evidence that HBO improves dental-implant survival/osseointegration in irradiated bone; ORN and mucosal fibrosis are the underlying morbidities addressed.

Ray 2021

Undersea Hyperb Med · 2021 · Commentary / case

Ray K, Savaser D, Huang E. Hyperbaric oxygen therapy and fluorescence angiography in arterial insufficiency secondary to injection of crushed hydromorphone. Undersea Hyperb Med 2021;48(3):255-261.

DOI

Razdan 2019

Diving and Hyperbaric Medicine · 2019 · Commentary / case

Razdan PS, Buteau D, Pollock NW. A case of Löfgren's syndrome confused with decompression sickness. Diving and Hyperbaric Medicine 2019;49(4):306-310.

PubMed · PMID 31828751 · DOI · PMC free full text

Regnard 2025

Diving Hyperb Med · 2025 · Commentary / case

Regnard J, Castagna O. Commentary on the article by Stevens G, Smart DR. The influence of wetsuit thickness (≥ 7 mm) on lung volumes in scuba divers. Diving Hyperb Med 2025;55(4):436-437.

PubMed · PMID 41364871 · DOI · PMC free full text

Reid 2017

Diving Hyperb Med · 2017 · Review / background

Reid MP, Fock A, Doolette DJ. Decompressing recompression chamber attendants during Australian submarine rescue operations. Diving Hyperb Med 2017;47(3):168-172.

PubMed · PMID 28868597 · PMC free full text

Reis 2003

J Bone Joint Surg Br · 2003 · Cohort / series

Reis ND, Schwartz O, Militianu D, Ramon Y, Levin D, Norman D, Melamed Y, Shupak A, Goldsher D, Zinman C. Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. J Bone Joint Surg Br 2003;85(3):371–375.

PubMed · PMID 12729112 · DOI

81% of HBO-treated hips returned to normal on MRI, vs 17% in the untreated comparison group. Benefit confined to pre-collapse (stage-I) disease; in the untreated group most lesions of this

Rhee 2018

JAMA Otolaryngol Head Neck Surg · 2018 · Meta-analysis

Rhee TM, Hwang D, Lee JS, Park J, Lee JM. Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg 2018;144(12):1153–1161.

PubMed · PMID 30267033 · DOI · PMC free full text

Complete hearing recovery: OR 1.61 (95% CI 1.05–2.44); any hearing recovery: OR 1.43 (1.20–1.67); Dose/selection signal: benefit greater with severe-to-profound baseline loss, HBO as salvage,

Riestra-Ayora 2026

Diving Hyperb Med · 2026 · Review / background

Riestra-Ayora J, Fernández-Navarro C, Martín-Sanz E, Salvador-Marín MF. Evidence-informed decision aid for fitness-to-dive assessment after otologic surgery. Diving Hyperb Med 2026;56(2):177-184.

PubMed · PMID 42290578 · DOI

Ring 2024

Cureus · 2024 · Systematic review

Ring S, Pansuriya T, Rashid H, et al. Coronary Air Embolism Secondary to Percutaneous Lung Biopsy: A Systematic Review. Cureus 2024;16(2):e55234.

PubMed · PMID 38558608 · DOI · PMC free full text

Characterises presentation, risk factors and management of iatrogenic coronary/arterial air embolism; Case-report-based literature — documents an uncommon procedural cause of AGE.

Risberg 2004

Undersea Hyperb Med · 2004 · Cohort / series

Risberg J, Englund M, Aanderud L, Eftedal O, Flook V, Thorsen E. Venous gas embolism in chamber attendants after hyperbaric exposure. Undersea Hyperb Med 2004;31(4):417-429.

PubMed · PMID 15686273

Risberg 2024

Diving and Hyperbaric Medicine · 2024 · Cohort / series

Risberg J, Midtgaard H. Decompression sickness in surface decompression breathing air instead of oxygen. Diving and Hyperbaric Medicine 2024;54(3):242-248.

PubMed · PMID 39288932 · DOI · PMC free full text

Risberg 2025

Diving Hyperb Med · 2025 · Commentary / case

Risberg J, Phillips S, Sletteskog N, Grong K. Gastric barotrauma following submarine escape training. Diving Hyperb Med 2025;55(2):195-198.

PubMed · PMID 40544149 · DOI · PMC free full text

Robins 2019

Undersea Hyperb Med · 2019 · Commentary / case

Robins MS. Early treatment of frostbite with hyperbaric oxygen and pentoxifylline: a case report. Undersea Hyperb Med 2019;46(4):521-526.

PubMed · PMID 31509908 · DOI

Roeckl-Wiedmann 2005

Br J Surg · 2005 · Meta-analysis

Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg 2005;92(1):24–32.

PubMed · PMID 15635604 · DOI

Pooled diabetic-ulcer data (5 trials, 118 patients): major amputation RR 0.31 (95% CI 0.13–0.71), Ulcer healing and minor-amputation rate were not significantly influenced by HBOT. Venous: one trial showed significant wound-size reduction at the end of treatment (not at

Rosenzweig 2025

Diving Hyperb Med · 2025 · Commentary / case

Rosenzweig SA, Thompson SR, Bennett MH. Hyperbaric oxygen therapy for late onset dropped head syndrome following mantle field radiation therapy for Hodgkin lymphoma: a case report and literature review. Diving Hyperb Med 2025;55(3):275-279 (DOI 10.28920/dhm55.3.275-279).

PubMed · PMID 40986924 · DOI · PMC free full text

Rosignoli 2021

Korean J Ophthalmol · 2021 · Meta-analysis

Rosignoli L, Chu ER, Carter JE, Johnson DA, Sohn JH, Bahadorani S. The Effects of Hyperbaric Oxygen Therapy in Patients with Central Retinal Artery Occlusion: A Retrospective Study, Systematic Review, and Meta-analysis. Korean J Ophthalmol 2021;36(2):108–113.

PubMed · PMID 34743490 · DOI · PMC free full text

Meta-analysis: HBOT did NOT enhance final visual outcome (P=0.83). The authors' own retrospective cohort likewise showed no visual benefit in the HBOT group. Safety concerns noted: barotrauma and generalised seizures.

Ruiz-Mambrilla 2023

Undersea Hyperb Med · 2023 · Commentary / case

Ruiz-Mambrilla M, Duenas-Ruiz A, Perez-Castrillon JL, Usategui-Martin I, Duenas-Laita A. Speech therapy and hyperbaric oxygen for aphasia after carbon monoxide intoxication. Undersea Hyperb Med 2023;50(1).

PubMed · PMID 36820801

Rusyniak 2003

Stroke · 2003 · RCT

Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ. Hyperbaric Oxygen Therapy in Acute Ischemic Stroke: Results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial (HOAIS) Pilot Study. Stroke 2003;34(2):571-574 (DOI 10.1161/01.STR.0000050644.48393.D0).

DOI

Sack 2024

Undersea Hyperb Med · 2024 · Cohort / series

Sack RA, Pikkel YY, Shemy OL, Ramon Y, Ullmann Y, Zeltzer AA. Transcutaneous oximetry values in chronic ulcer patients during Hyperbaric treatment at 1.4 ATA compared to 2 ATA. Undersea Hyperb Med 2024;51(1):1-5 (DOI 10.22462/587).

DOI

Sadler 2019

Undersea Hyperb Med · 2019 · Commentary / case

Sadler C, Latham E, Hollidge M, Boni B, Brett K. Delayed hyperbaric oxygen therapy for severe arterial gas embolism following scuba diving: a case report. Undersea Hyperb Med 2019;46(2):197-202.

PubMed · PMID 31051065

Sai Krishna 2023

Indian J Orthop · 2023 · Umbrella review

Sai Krishna MLV, Kar S, Kumar R, Singh H, Mittal R, Digge VK. The role of conservative management in the avascular necrosis of the femoral head: a review of systematic reviews. Indian J Orthop 2023;57(3):410-420.

PubMed · PMID 36777071 · DOI · PMC free full text

Salama 2019

Int J Low Extrem Wounds · 2019 · RCT

Salama SE, et al. Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone. Int J Low Extrem Wounds 2019.

PubMed · PMID 30836807 · DOI

Complete closure at end of treatment: 33.3% (5/15) HBOT vs 0% (0/15) conventional, P=0.014 — Complication frequency not significantly different between groups.

Salameh 2021

Int Orthop · 2021 · Cohort / series

Salameh M, Moghamis IS, Kokash O, Ahmed GO. Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review. Int Orthop 2021;45(10):2519-2523.

PubMed · PMID 34218337 · DOI · PMC free full text

Sallam 2026

PLoS One · 2026 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Sallam L, Rychlíková L, Mölne J, Bergo MO, Torinsson Naluai Å, Seeman-Lodding H, Oscarsson N, Giglio D. Hyperbaric oxygen treatment and toll-like receptor 5 in radioprotection of epithelial cells. PLoS One 2026;21(8):e0356247.

PubMed · PMID 42599928 · DOI · PMC free full text

Sames 2019

Diving Hyperb Med · 2019 · Cohort / series

Sames C, Gorman DF, Mitchell SJ, Zhou L. The impact of diving on hearing: a 10-25 year audit of New Zealand professional divers. Diving Hyperb Med 2019;49(1):2-8.

PubMed · PMID 30856661 · DOI

Sano 2012

PLoS One · 2012 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Sano H, Ichioka S, Sekiya N. Influence of oxygen on wound healing dynamics: assessment in a novel wound mouse model under a variable oxygen environment. PLoS One 2012;7(11):e50212.

PubMed · PMID 23209678 · DOI · PMC free full text

Santema 2015

Diving Hyperb Med · 2015 · Systematic review

Santema TB, Stoekenbroek RM, van Steekelenburg KC, van Hulst RA, Koelemay MJW, Ubbink DT. Economic outcomes in clinical studies assessing hyperbaric oxygen in the treatment of acute and chronic wounds. Diving Hyperb Med 2015;45(4):228–234.

PubMed · PMID 26687309

1 RCT + 3 cohort studies reported both clinical and economic outcomes; only the RCT was of good methodological quality; outcome measures were heterogeneous and the effect of HBO on costs was variable. Little direct evidence on the cost-effectiveness of HBO for acute or chronic wounds; the authors call for economic endpoints in future studies.

Santema 2018 (DAMOCLES)

Diabetes Care · 2018 · RCT

Santema KTB, Stoekenbroek RM, Koelemay MJW, Reekers JA, van Dortmont LMC, Oomen A, Smeets L, Wever JJ, Legemate DA, Ubbink DT. Hyperbaric Oxygen Therapy in the Treatment of Ischemic Lower- Extremity Ulcers in Patients With Diabetes: Results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care 2018;41(1):112–119.

PubMed · PMID 29074815 · DOI

Limb salvage: 47/60 (78%) SC vs 53/60 (88%) SC+HBOT — RD 0.10 (95% CI −0.04 to 0.23), not Complete wound healing at 12 months: 28 vs 30 index wounds — RD 0.03 (95% CI −0.14 to 0.21), not Amputation-free survival (ITT): 41 vs 49 — RD 0.13 (95% CI −0.02 to 0.28), not significant (a

Sarrió-Sanz 2022

Arch Esp Urol · 2022 · Cohort / series

Sarrio-Sanz P, Sanchez-Caballero L, Martinez-Cayuelas L, Gori CF, Pacheco-Bru JJ, Nakdali-Kassab B, Gomez-Garberi M, Caballero-Perez P, Gomez-Perez L, Ortiz-Gorraiz MA. Efficacy, tolerance and predictors of response to the treatment with hyperbaric oxygen therapy for patients with hemorrhagic radiation cystitis. Arch Esp Urol 2022;75(4):354-360.

PubMed · PMID 35818916 · DOI

SAUHMA HBO Committee 2023

Southern African Underwater and Hyperbaric Medical Association · 2023 · Guideline

SAUHMA HBO Committee — Cronje F, Meintjes J, Roberts C, Weir G, Rosenthal J. SAUHMA HBOT treatment protocols. Southern African Underwater and Hyperbaric Medical Association 2023:36 pp.

HBOT 0064 · Not indexed in PubMed and no DOI — full text held in the practice wiki

SAUHMA / UHMS 2017

Southern African Underwater and Hyperbaric Medical Association · 2017 · Guideline

Southern African Underwater and Hyperbaric Medical Association; Undersea and Hyperbaric Medical Society. Position statement: low-pressure fabric hyperbaric chambers. Southern African Underwater and Hyperbaric Medical Association 2017.

Not indexed in PubMed and no DOI — full text held in the practice wiki

Saunders 2003

Int J Technol Assess Health Care · 2003 · Systematic review

Saunders PJ (University of Birmingham). HYPERBARIC OXYGEN THERAPY IN THE MANAGEMENT OF CARBON MONOXIDE POISONING, OSTEORADIONECROSIS, BURNS, SKIN GRAFTS, AND CRUSH INJURY. Int J Technol Assess Health Care 2003;19(3):521–525.

PubMed · PMID 12962338 · DOI

From 154 full-text articles, 13 relevant RCTs were identified; little consistency across protocols, groups, timing and outcomes; no convincing evidence of effectiveness for CO poisoning, ORN, burns, skin grafts or crush injury. HBO is clearly appropriate for decompression sickness and air/gas embolism; there is a physiological case for benefit in hypoxic conditions, and — given limited volume/quality of research — the author c…

Sause and Plenk 1979

Int J Radiat Oncol Biol Phys · 1979 · RCT

Sause WT, Plenk HP. Radiation therapy of head and neck tumors: a randomized study of treatment in air vs. treatment in hyperbaric oxygen. Int J Radiat Oncol Biol Phys 1979;5(10):1833-1836.

PubMed · PMID 528245

Savvidou 2018

Orthopedics · 2018 · Systematic review

Savvidou OD, Kaspiris A, Bolia IK, Chloros GD, Goumenos SD, Papagelopoulos PJ, Tsiodras S. Effectiveness of Hyperbaric Oxygen Therapy for the Management of Chronic Osteomyelitis: A Systematic Review of the Literature. Orthopedics 2018;41(4):193–199.

PubMed · PMID 30035798 · DOI

Adjuvant HBO judged effective in 16/20 (80%) cohort studies and 19/20 (95%) case studies. Overall 308/419 (73.5%) patients with complete data had a successful outcome with no reported

Sayin 2022

Undersea Hyperb Med · 2022 · Cohort / series

Sayin O, Altinkaynak H. The effects of hyperbaric oxygen therapy on retinal layers in healthy eyes. Undersea Hyperb Med 2022;49(4):485-494.

PubMed · PMID 36446294 · DOI

Scarff 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

Scarff CW, Lippmann J, Fock AW. A review of diving practices and outcomes following the diagnosis of a persistent (patent) foramen ovale in compressed air divers with a documented episode of decompression sickness. Diving and Hyperbaric Medicine 2020;50(4):363-369.

PubMed · PMID 33325017 · DOI · PMC free full text

Scheinkestel 1999

Med J Aust · 1999 · RCT

Scheinkestel CD, Bailey M, Myles PS, Jones K, Cooper DJ, Millar IL, Tuxen DV. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust 1999;170(5):203–210.

PubMed · PMID 10092916 · DOI

No benefit from HBO; signal of harm. More HBO patients needed additional treatments (28% vs 15%, Worse learning-test scores at completion in the HBO group (P=0.01; severe P=0.005) and more Delayed neurological sequelae occurred only in HBO patients (P=0.03). No outcome measure was worse

Scher 1998

Adv Otorhinolaryngol · 1998 · Review / background

Scher RL. Hyperbaric oxygen therapy for necrotizing cervical infections. Adv Otorhinolaryngol 1998;54:50-58.

PubMed · PMID 9547877 · DOI

Schipke 2025

Diving Hyperb Med · 2025 · Review / background

Schipke JD, Muth T, Brebeck AK, Dreyer S. Critical flicker fusion frequency measurement through a chamber porthole. Diving Hyperb Med 2025;55(4):419-422.

PubMed · PMID 41364866 · DOI · PMC free full text

Schirato 2018

Undersea and Hyperbaric Medicine · 2018 · Cohort / series

Schirato SR, El-Dash I, El-Dash V, Natali JE, Starzynski PN, Chaui-Berlinck JG. Heart rate variability changes as an indicator of decompression-related physiological stress. Undersea and Hyperbaric Medicine 2018;45(2):173-182.

PubMed · PMID 29734569

Schlimp & Bothma 2014

JAMA Neurol · 2014 · Commentary / case

Schlimp CJ, Bothma PA, Brodbeck AE. Cerebral venous air embolism: what is it and do we know how to deal with it properly? [Comment and Response]. JAMA Neurol 2014;71(2):243.

PubMed · PMID 24515643 · DOI

Schmale 2012

Chirurg · 2012 · Commentary / case

Schmale M, Fichtner A, Pohl C, John E, Bucher M. Hyperbare Oxygenation bei nekrotisierenden Weichteilinfektionen: Pro. Chirurg 2012;83(11):973–979 (PMID 23108429. DOI 10.1007/s00104-012-2283-0. Published in German with an English abstract.).

PubMed · PMID 23108429 · DOI

A commissioned position article from the anaesthesiology/intensive care and hyperbaric unit at Universitätsklinikum Halle (Saale), with the general/visceral/vascular surgery clinic. It is structured as mechanism, then clinical studies, then practical protocol, then a service and cost argument. There is no search strategy, no databases, no date limits, no eligibility criteria, no selection or extra

Schmitz 2024

Diving and Hyperbaric Medicine · 2024 · Commentary / case

Schmitz G, Aguero S. Bispectral index with density spectral array (BIS-DSA) monitoring in a patient with inner ear and cerebral decompression sickness. Diving and Hyperbaric Medicine 2024;54(3):237-241.

PubMed · PMID 39288931 · DOI · PMC free full text

Schmitz 2025

Diving Hyperb Med · 2025 · Review / background

Schmitz G. Comparison of three infusion pumps as an option for intensive care treatments in monoplace hyperbaric chambers. Diving Hyperb Med 2025;55(2):145-153.

PubMed · PMID 40544142 · DOI · PMC free full text

St. Pierre Schneider 2026

Med Gas Res · 2026 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

St. Pierre Schneider B, Zhang L, Dombrowsky T, Wilson JR. A scoping review and evaluation of hyperbaric oxygen therapy for skeletal muscle injury in preclinical models. Med Gas Res 2026;16(2):125–132 (Epub 2025 Aug 18).

PubMed · PMID 40826935 · DOI · PMC free full text

HBO promoted and quickened muscle regeneration after myotoxic and crush injury, and counteracted Benefits may persist, and early initiation of HBO is important — but more sessions do not always Evidence gaps: limited inclusion of females; milder pressures under-tested (potentially fewer

Schneidewind 2021

Urol Int · 2021 · Systematic review

Schneidewind L, Anheuser P, Schönburg S, Wagenlehner FME, Kranz J. Hyperbaric Oxygenation in the Treatment of Fournier’s Gangrene: A Systematic Review. Urol Int 2021;105(3–4):247–256.

PubMed · PMID 33285541 · DOI · PMC free full text

13 studies, 376 patients (no RCTs; 5 retrospective case-control studies totalling 319 patients, 145 HBO-treated). HBO-group mortality ~16.6%. Study quality moderate to high, but design observational. Conclusion cautious: a definitive recommendation is limited by the rarity of Fournier's gangrene and the lack of randomised evidence.

Schoen 2007

Oral Oncol · 2007 · RCT

Schoen PJ, Raghoebar GM, Bouma J, Reintsema H, Vissink A, Sterk W, Roodenburg JLN. Rehabilitation of oral function in head and neck cancer patients after radiotherapy with implant-retained dentures: Effects of hyperbaric oxygen therapy. Oral Oncol 2007;43(4):379–388.

PubMed · PMID 16996783 · DOI

11 implants lost in 7 patients (8 before loading, 3 after). No significant difference in peri-implant health between HBO and non-HBO groups except plaque-index No differences between HBO and non-HBO groups in oral functioning / denture-problem impact / quality of

Schraibman 1968

Postgrad Med J · 1968 · Cohort / series

Schraibman IG. Gas gangrene after amputation for peripheral vascular disease. Postgrad Med J 1968;44(513):551-3 (AUTHOR and TITLE are printed in the scan. YEAR, VOLUME and ISSUE are NOT — the scan carries no journal name, no volume, no issue and no year anywhere on its three pages, only the running head 'Case reports' and the printed page numbers 551, 552 and 553. Year 1968, volume 44 and issue 513 were LOOKED UP in PubMed under PMID 5662196 and are recorded as a lookup, not as a reading of the source. See 'What could and could not be established from the PDF' below.).

PubMed · PMID 5662196 · DOI · PMC free full text

Schugart 2008

Proc Natl Acad Sci U S A · 2008 · Commentary / case · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Schugart RC, Friedman A, Zhao R, Sen CK. Wound angiogenesis as a function of tissue oxygen tension: a mathematical model. Proc Natl Acad Sci U S A 2008;105(7):2628-2633.

PubMed · PMID 18272493 · DOI · PMC free full text

Sealy 1978

Br J Cancer Suppl · 1978 · RCT

Sealy R. A preliminary clinical study in the use of misonidazole in cancer of the head and neck. Br J Cancer Suppl 1978;3:314–317.

PubMed · PMID 277253 · PMC free full text

With large fractions of irradiation, misonidazole appeared to confer no advantage; in previously The combination of hyperbaric oxygen and misonidazole did not appear to be toxic.

Sealy 1986

Int J Radiat Oncol Biol Phys · 1986 · RCT

Sealy R, Cridland S, Barry L, Norris R. Irradiation with misonidazole and hyperbaric oxygen: final report on a randomized trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 1986;12(8):1343–1346.

PubMed · PMID 3531113 · DOI

The results favoured the combination (misonidazole + HBO) over conventional irradiation and

Serena 2021

J Wound Care · 2021 · RCT

Serena TE, et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care 2021;30(Sup5):S7-S14.

PubMed · PMID 33979229

Sevil 2016

Eur Arch Otorhinolaryngol · 2016 · RCT

Sevil E, Bercin S, Muderris T, Gul F, Kiris M. Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2016;273(9):2419–2426.

PubMed · PMID 26538427 · DOI

Mild (PTA ≤60), severe (60–80) and profound (≥81 dB) ISSNHL; 20 sessions HBO in both arms, with IT steroid IT + HBO: 19 dB gain, 78.9% success; IV + HBO: 18 dB, 70.5% — IT numerically better; benefit concentrated in

Shah 2025

Laryngoscope · 2025 · Meta-analysis

Shah SR, Wu A, Sindwani R, Tang D. Presentation and Optimal Management of Anterior and Central Skull Base Osteoradionecrosis: Systematic Review and Meta-Analysis. Laryngoscope 2025;135(3):982–990 (first published 15 Oct 2024).

PubMed · PMID 39404093 · DOI

Conservative therapy (including HBO): resolution 8/197 = 4.1%. Surgical treatment: 135/188 = 71.8%. Of these, vascularised tissue coverage: 104/114 = 91.2%. Surgery was superior to medical treatment alone; vascularised reconstruction was best. Authors

Shakarchi 2026

Cureus · 2026 · Commentary / case

Shakarchi T. Refractory Hemorrhagic Radiation Proctitis Managed With Sequential Endoscopic, Topical, and Hyperbaric Oxygen Therapy. Cureus 2026;18:e111495.

PubMed · PMID 42368241 · DOI · PMC free full text

Shander 2018

Am J Hematol · 2018 · Review / background

Shander A, Goodnough LT. Management of anemia in patients who decline blood transfusion. Am J Hematol 2018;93(9):1183–1191.

PubMed · PMID 30033541 · DOI

A narrative practice review of "Bloodless Medicine and Surgery" (BMS), built around three illustrative case vignettes with commentary between them, plus the authors' institutional BMS protocol reproduced as a table. There is no methods section, no search strategy and no comparison of any kind.

Shao 2011

BJU Int · 2011 · RCT

Shao Y, Lu G-L, Shen Z-J. Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation‐induced hemorrhagic cystitis. BJU Int 2011 (Study type: Therapy RCT; Level of Evidence 1b).

PubMed · PMID 21895939 · DOI

All 36 completed; no obvious side effects of intravesical HA. At 12 and 18 months the improvement rate showed no statistical difference between the two groups — HA Both arms achieved substantial symptom improvement (reduction in pelvic pain, urgency, gross haematuria;

Shappell 2019

Undersea Hyperb Med · 2019 · Commentary / case

Shappell HW, Kislevitz M, Reddy G, Amirlak B, Morey A, Stone JA. Successful replantation of amputated penis with adjuvant hyperbaric oxygen therapy. Undersea Hyperb Med 2019;46(5):695-699.

DOI

Sharma 2021

Sci Rep · 2021 · Meta-analysis

Sharma R, Sharma SK, Mudgal SK, Jelly P, Thakur K. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials. Sci Rep 2021;11(1):2189.

PubMed · PMID 33500533 · DOI · PMC free full text

Complete healing significantly favoured HBOT (pooled OR 0.29, 95% CI 0.14–0.61; I²=62%; authors Major amputation reduced: RR 0.60 (95% CI 0.39–0.92; I²=24%). Minor amputation not significantly reduced (RR 0.82, 95% CI 0.34–1.97); more adverse events in the

Shaw and Dhanda 2011 (Part I)

Br J Oral Maxillofac Surg · 2011 · Review / background

Shaw RJ, Dhanda J. Hyperbaric oxygen in the management of late radiation injury to the head and neck. Part I: treatment. Br J Oral Maxillofac Surg 2011;49(1):2-8.

PubMed · PMID 20347191 · DOI

Shaw and Butterworth 2011 (Part II)

Br J Oral Maxillofac Surg · 2011 · Review / background

Shaw RJ, Butterworth C. Hyperbaric oxygen in the management of late radiation injury to the head and neck. Part II: prevention. Br J Oral Maxillofac Surg 2011;49(1):9-13.

PubMed · PMID 20347190 · DOI

Shaw 2014

Surg Infect (Larchmt) · 2014 · Cohort / series

Shaw JJ, Psoinos C, Emhoff TA, Shah SA, Santry HP. Not just full of hot air: hyperbaric oxygen therapy increases survival in cases of necrotizing soft tissue infections. Surg Infect (Larchmt) 2014;15(3):328-335 (PMID 24786980. DOI 10.1089/sur.2012.135).

PubMed · PMID 24786980 · DOI · PMC free full text

Shaw 2019

Int J Radiat Oncol Biol Phys · 2019 · RCT

Shaw RJ, Butterworth CJ, Silcocks P, Tesfaye BT, Bickerstaff M, Jackson R, et al. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery. Int J Radiat Oncol Biol Phys 2019;104(3):530–539.

PubMed · PMID 30851351 · DOI

ORN at 6 months: 6.4% (HBO) vs 5.7% (control) — OR 1.13 (95% CI 0.14–8.92), p=1. Fewer acute symptoms with HBO; no significant difference in late pain or quality of life. Higher dropout in the HBO arm.

Sheffield 1997

Undersea Hyperb Med · 1997 · Cohort / series

Sheffield PJ, Desautels DA. Hyperbaric and hypobaric chamber fires: a 73-year analysis. Undersea Hyperb Med 1997;24(3):153-164.

PubMed · PMID 9308138

Sheffield and Pirone 2002

Book chapter - parent volume not identified in the extractable text · 2002 · Review / background

Sheffield PJ, Pirone CJ. Decompression sickness in inside attendants (Section VI, Chapter 2). Book chapter - parent volume not identified in the extractable text 2002.

HBOT 0046 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Sheffield and Posey 2021

International ATMO Education (learn.hyperbaricmedicine.com) · 2021 · Safety / facility standard

Sheffield R, Posey KI. Ear Barotrauma: What Chamber Operators Should Know. International ATMO Education (learn.hyperbaricmedicine.com) 2021.

HBOT 0047 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Sherlock 2018

Diving Hyperb Med · 2018 · Cohort / series

Sherlock S, Way M, Tabah A. Audit of practice in Australasian hyperbaric units on the incidence of central nervous system oxygen toxicity. Diving Hyperb Med 2018;48(2):73-78.

PubMed · PMID 29888378 · DOI · PMC free full text

Sherlock 2021

Diving Hyperb Med · 2021 · Review / background

Sherlock S, Kelly S, Bennett MH. Hyperbaric oxygen for sudden hearing loss: influence of international guidelines on practice in Australia and New Zealand. Diving Hyperb Med 2021;51(1):68-71.

PubMed · PMID 33761543 · DOI · PMC free full text

Shitara 2019

Undersea and Hyperbaric Medicine · 2019 · Commentary / case

Shitara J, Jitsuiki K, Yanagawa Y. Gas in coronary artery: A case of fatal decompression sickness evaluated by computed tomography. Undersea and Hyperbaric Medicine 2019;46(5):633-634.

PubMed · PMID 31683361

Siaffa 2019

Diving and Hyperbaric Medicine · 2019 · Commentary / case

Siaffa R, Luciani M, Grandjean B, Coulange M. Massive portal venous gas embolism after scuba diving. Diving and Hyperbaric Medicine 2019;49(1):61-63.

PubMed · PMID 30856669 · DOI · PMC free full text

Sideris 2024

Cureus · 2024 · Systematic review

Sideris G, Petsiou DP, Kourklidou M, et al. Fungal Malignant Otitis Externa: A Systematic Review. Cureus 2024;16(10):e71345.

PubMed · PMID 39534824 · DOI · PMC free full text

HBO therapy was used in 34/197 (17.3%) and surgical debridement in 35 (17.8%). Mortality 4% (literature range 2–11%); late diagnosis, cranial-nerve involvement and inadequate The review states the evidence supporting HBO efficacy in FMOE is limited; the primary treatment is

Simanić (Igor) 2013

Undersea Hyperb Med · 2013 · RCT

Simanić I, Teofilovski M, Paspalj D, Radotić M, Djordjević D, Živković V, Jakovljević V. Hyperbaric oxygenation accelerates prosthetic rehabilitation of lower limb amputees. Undersea Hyperb Med 2013;40(3).

PubMed · PMID 23789564

Higher arterial Hb saturation at discharge with HBO (94.74 ± 3.28% vs 92.60 ± 4.66%, p=0.009). Better distal pulse palpability (a. dorsalis pedis palpable in 27 vs 18 subjects; p<0.05). Fewer amputation-stump complications and significantly less time from admission to finishing the

Simayijiang 2026

Trials · 2026 · Review / background

Simayijiang H, Lin Y, Zhong T, Li Z, Zhang K, Long Y. Designing clinical research on hyperbaric oxygen therapy: a narrative review and practical methodological guide. Trials 2026:in press.

PubMed · PMID 42443991 · DOI

Singh 2025

Diving Hyperb Med · 2025 · Commentary / case

Singh D, Mohanty C, Verma R, Kumar S. Challenges in the administration of hyperbaric oxygen therapy (HBOT) for complicated cases in a tertiary care setting. Diving Hyperb Med 2025;55(2):211-212.

PubMed · PMID 40544152 · DOI · PMC free full text

Slack 1969

Br J Surg · 1969 · Cohort / series

Slack WK, Hanson GC, Chew HE. Hyperbaric oxygen in the treatment of gas gangrene and clostridial infection: A report of 40 patients treated in a single-person hyperbaric oxygen chamber. Br J Surg 1969;56(7):505–510.

PubMed · PMID 5815868 · DOI

Of the 32 patients with clostridial infections, 9 died — but none died from the clostridial infection HBO was associated with subsidence of systemic toxaemia, allowing surgery/amputation to be Reinforces the triad — HBO is adjunctive to surgical debridement and antibiotics, not a substitute;

Smart 2012

Diving Hyperb Med · 2012 · Review / background

Smart D, Wallington M. A cost-analysis case study of radiation cystitis treatment including hyperbaric oxygen therapy. Diving Hyperb Med 2012;42(2):92-97.

PubMed · PMID 22828818

Smart 2024

Diving Hyperb Med · 2024 · Cohort / series

Smart D. Five consecutive cases of sensorineural hearing loss associated with inner ear barotrauma due to diving, successfully treated with hyperbaric oxygen. Diving Hyperb Med 2024;54(4):360-367 (DOI 10.28920/dhm54.4.360-367).

PubMed · PMID 39675746 · DOI · PMC free full text

Smart 2025

Diving Hyperb Med · 2025 · Guideline

Smart D, Wilmshurst P, Banham N, Turner M, Mitchell SJ. Joint position statement on atrial shunts (persistent [patent] foramen ovale and atrial septal defects) and diving: 2025 update. South Pacific Underwater Medicine Society (SPUMS) and the United Kingdom Diving Medical Committee (UKDMC). Diving Hyperb Med 2025;55(1):51-55.

PubMed · PMID 40090026 · DOI · PMC free full text

Smolle 2024

Undersea Hyperb Med · 2024 · Systematic review · MIXED human and preclinical evidence

Smolle C, Auinger D, Lindenmann J, Smolle J, Smolle-Juettner FM, Kamolz LP. Hyperbaric oxygen (HBO) therapy in thermal burn injury revisited. Pressure does matter. Review. Undersea Hyperb Med 2024;51(2):115–127.

PubMed · PMID 38985148

Outcomes: 64/94 (67.4%) positive, 16 (17.9%) ambiguous, 14 (14.7%) negative. The only factor independently associated with outcome was pressure: <3 ATA was significantly linked to

Soh 2012

Intensive Care Med · 2012 · Cohort / series

Soh CR, Pietrobon R, Freiberger JJ, Chew ST, Rajgor D, Gandhi M, Shah J, et al. Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample. Intensive Care Med 2012;38(7):1143–1151.

PubMed · PMID 22527074 · DOI

HBOT-treated patients had a significantly lower risk of death — adjusted OR 0.49 (95% CI 0.29–0.83). HBOT was associated with higher hospital cost and longer length of stay (expected for a sicker,

Sokolowski 2022

Diving and Hyperbaric Medicine · 2022 · Cohort / series

Sokolowski SA, Räisänen-Sokolowski AK, Tuominen LJ, Lundell RV. Delayed treatment for decompression illness: factors associated with long treatment delays and treatment outcome. Diving and Hyperbaric Medicine 2022;52(4):271-276.

PubMed · PMID 36525684 · DOI · PMC free full text

The delay comparison is null. Patients with no residual symptoms had a median delay of 24 h A shorter delay was associated with needing fewer treatments. Patients needing only one HBOT had a Symptom type drove the delay, not the other way round. Cardiopulmonary symptoms had a shorter

Sokolowski 2024

Diving Hyperb Med · 2024 · Systematic review

Sokolowski SA, Räisänen-Sokolowski AK, Lundell RV (Helsinki University). Development of myopia in scuba diving and hyperbaric oxygen treatment: a case report and systematic review. Diving Hyperb Med 2024;54(4):328–337.

PubMed · PMID 39675741 · DOI · PMC free full text

Hyperoxic myopia is a well-known, typically reversible side effect of repeated HBOT exposure (lens Safety/consent relevance: patients on a full HBOT course should be counselled about transient myopic shift

Song 2018

Undersea Hyperb Med · 2018 · Commentary / case

Song M, Jeon SH, Shin TM. An anti-barotrauma system for preventing barotrauma during hyperbaric oxygen therapy. Undersea Hyperb Med 2018;45(1).

PubMed · PMID 29571228

Spiegel 2025

Laryngoscope · 2025 · Cohort / series

Spiegel JL, De Biasio MJ, Sampieri G, Ungar OJ, et al. Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss? Laryngoscope 2025 (online 23 Dec 2025).

PubMed · PMID 41431852 · DOI · PMC free full text

119 patients: ITSI 73 vs HBOT + ITSI 46. Significant within-group pre-to-post improvement in PTA/SRT/WRS HBOT-responder audiogram improvement seen within 10.9 ± 6.5 (max 23) sessions; no benefit beyond 23 Conclusion: no additional benefit from concurrent adjunctive HBOT; HBOT may help steroid-refractory

Spisni 2017

Diving Hyperb Med · 2017 · Cohort / series

Spisni E, Marabotti C, De Fazio L, Valerii MC, Cavazza E, Brambilla S, Hoxha K, L'Abbate A, Longobardi P. A comparative evaluation of two decompression procedures for technical diving using inflammatory responses: compartmental versus ratio deco. Diving Hyperb Med 2017;47(1):9-16.

PubMed · PMID 28357819 · DOI · PMC free full text

Spruijt 2020

Diving Hyperb Med · 2020 · Cohort / series

Spruijt NE, van den Berg R. The effect of hyperbaric oxygen treatment on late radiation tissue injury after breast cancer: a case-series of 67 patients. Diving Hyperb Med 2020;50(3):206-213.

PubMed · PMID 32957121 · DOI · PMC free full text

Srichawla 2024

World J Clin Cases · 2024 · Systematic review

Srichawla BS, Garcia-Dominguez MA. Spectrum of delayed post-hypoxic leukoencephalopathy syndrome: A systematic review. World J Clin Cases 2024;12(29):6285–6301.

PubMed · PMID 39417054 · DOI · PMC free full text

Carbon monoxide poisoning is a leading precipitant of DPHL (alongside opioid/other overdose, anoxia, Treatment is largely supportive — amantadine, an antioxidant cocktail, and corticosteroids are the Prognosis is variable; many patients improve over months, but the evidence base is case reports/series

Different treatment protocols 2019

Undersea Hyperb Med · 2019 · Cohort / series

Miao X, Xin Z. Different treatment protocols for moderate idiopathic sudden sensorineural hearing loss. Undersea Hyperb Med 2019;46(5):659-663.

PubMed · PMID 31683365

Krajcovicova 2019

Undersea Hyperb Med · 2019 · Cohort / series

Krajcovicova Z, Melus V, Zigo R, Matisakova I, Vecera J, Kralova E. Hyperbaric oxygen therapy in treatment of sudden sensorineural hearing loss: finding for the maximal therapeutic benefit of different applied pressures. Undersea Hyperb Med 2019;46(5):665-672.

PubMed · PMID 31683366

St Peter 2023

Undersea Hyperb Med · 2023 · Cohort / series

St Peter D, Na D, Sethuraman K, Mathews MK, Li AS. Hyperbaric oxygen therapy for central retinal artery occlusion: Visual acuity and time to treatment. Undersea Hyperb Med 2023;50(3):253-264 (DOI 10.22462/01.01.2023.11).

DOI

Stanga 2003

Navy Experimental Diving Unit Technical Report · 2003 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Stanga DF. Evaluation of intravenous therapy devices in the hyperbaric chamber (NEDU TR 03-21). Navy Experimental Diving Unit Technical Report 2003;TR 03-21.

HBOT 0040 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Bench evaluation of IV pumps and related equipment under hyperbaric conditions, part of the same programme as evidence/stanga-2003-nedu-respiratory-support-devices-hyperbaric (TR 03-18, the ventilator report). The stated context: "Ventilators, cardiac monitors, intravenous (IV) pumps, and other equipment are being evaluated to meet a U.S. Navy-identified need to improve patient care levels in the

Stanga 2003

Navy Experimental Diving Unit Technical Report · 2003 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Stanga DF. Evaluation of respiratory support devices for use in the hyperbaric chamber (NEDU TR 03-18). Navy Experimental Diving Unit Technical Report 2003;TR 03-18.

HBOT 0041 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Stencel 2025 (HBOT in Alzheimers disease)

Anadolu Psikiyatri Derg · 2025 · Review / background

Stencel NJ, Szczot J, Skulimowska K, Krupa K, Mandecka A, Podleśna D, Machnik A, Witowicz M, Nowak M, Kilarowska K, Majta G. Hyperbaric Oxygen Therapy (HBOT) as a Potential Strategy for the Prevention and Treatment of Alzheimer's disease: A Review of Recent Research. Anadolu Psikiyatri Derg 2025;26(6):1-11 (DOI 10.5281/zenodo.17557525).

DOI

Stevens 1993

Clin Infect Dis · 1993 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Stevens DL, Bryant AE, Adams K, Mader JT. Evaluation of therapy with hyperbaric oxygen for experimental infection with Clostridium perfringens. Clin Infect Dis 1993;17(2):231–237.

PubMed · PMID 8399871 · DOI

HBO alone did NOT improve survival at any inoculum tested. Early HBO plus penicillin or metronidazole showed significant additive efficacy (at ~10⁹ Clindamycin was the single most effective agent at high inocula (a protein-synthesis inhibitor that

Stevens 2025

Diving Hyperb Med · 2025 · Commentary / case

Stevens G, Lewis I. A case of facial vascular occlusion after hyaluronic acid cosmetic filler injection treated with adjunctive hyperbaric oxygen. Diving Hyperb Med 2025;55(1):56-58 (PMID 40090027. DOI 10.28920/dhm55.1.56-58).

PubMed · PMID 40090027 · DOI · PMC free full text

Stevens 2025

Diving Hyperb Med · 2025 · Cohort / series

Stevens G, Smart DR. The influence of wetsuit thickness (≥ 7 mm) on lung volumes in scuba divers. Diving Hyperb Med 2025;55(1):27-34.

PubMed · PMID 40090023 · DOI · PMC free full text

Stiegler 2006

ORL J Otorhinolaryngol Relat Spec · 2006 · RCT

Stiegler P, Matzi V, Lipp C, Kontaxis A, Klemen H, Walch C, Smolle-Jüttner F. Porubsky C, Stiegler P, et al. — the DOI above resolves to this definitive full paper; the same study was also reported in full as Stiegler P, Matzi V, Lipp C, et al. Undersea Hyperb Med 2006;33(6):429-437 — a nine-page peer-reviewed UHM article with full methods, results and two data tables, NOT a conference abstract. Hyperbaric Oxygen in Tinnitus: Influence of Psychological Factors on Treatment Results? ORL J Otorhinolaryngol Relat Spec 2006;69(2):107–112 (epub 8 Dec 2006; print 2007).

PubMed · PMID 17159373 · DOI

Outcomes overall: complete remission 12 (3.3%), intensity lessened 122 (33.9%), agreeable change of No statistically significant difference between the two HBO protocols (p0.05). Outcome tracked expectation: improvement in 60.3% with positive expectation (n=68) vs 47.2%

Stirnemann 2012

Diving Hyperb Med · 2012 · Cohort / series

Stirnemann J, Letellier E, Aras N, Borne M, Brinquin L, Fain O. Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease. Diving Hyperb Med 2012;42(2):82-84.

PubMed · PMID 22828815

Stirnemann 2024 (HBOT-SCD)

BMJ Open · 2024 · Review / background

Stirnemann J, Serratrice J, Mann T, Louge P, Combescure C, Samii K, Pignel R, Agoritsas T, Ansari M, Cannas G, Chalandon Y, Cimasoni L, Cougoul P, Desgraz B, Gervaix A, Grosgurin O, Joffre T, Lae C, Magnan MA, Menager E, Momo Bona A, Panchard MA, Pellegrini M, Reny JL, Riu B, Sahyoun C, Boet S. Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study). BMJ Open 2024;14(11):e084825.

PubMed · PMID 39613437 · DOI

Stock 2014

J Thorac Cardiovasc Surg · 2014 · Cohort / series

Stock C, Gukasyan N, Muniappan A, Wright C, Mathisen D. Hyperbaric oxygen therapy for the treatment of anastomotic complications after tracheal resection and reconstruction. J Thorac Cardiovasc Surg 2014;147(3):1030-1035.

PubMed · PMID 24342903 · DOI

Stoekenbroek 2014

Eur J Vasc Endovasc Surg · 2014 · Systematic review

Stoekenbroek RM, Santema TB, Legemate DA, Ubbink DT, van den Brink A, Koelemay MJW. Hyperbaric Oxygen for the Treatment of Diabetic Foot Ulcers: A Systematic Review. Eur J Vasc Endovasc Surg 2014;47(6):647–655.

PubMed · PMID 24726143 · DOI

RCT-only SR. Trials split by ulcer type: ~182 patients with ischaemic ulcers, 64 with non-ischaemic, 130 unspecified; only 2 trials of good methodological quality. Pooling judged inappropriate because of significant clinical heterogeneity. Some evidence HBO improves complete healing in ischaemic DFU (not non-ischaemic); no consistent effect on amputation; more trials needed to justify routine use.

Stokes 2025

Diving and Hyperbaric Medicine · 2025 · Cohort / series

Stokes RJ, Watts D, Smerdon G, Hall SD, Bunn L, Marsden J. Vestibular rehabilitation and recovery in divers with inner ear decompression sickness: a case series. Diving and Hyperbaric Medicine 2025;55(3):236-245.

PubMed · PMID 40986919 · DOI · PMC free full text

Stokes 2026

Diving Hyperb Med · 2026 · Systematic review

Stokes RJ, Marsden J, Watts D, Smerdon G, Hall SD, Bunn L. Outcomes in the treatment of inner ear decompression sickness with hyperbaric oxygen therapy, a systematic review. Diving Hyperb Med 2026;56(1):71–82.

PubMed · PMID 41875444 · DOI

Most IEDCS divers treated with recompression / HBOT improve, but a proportion have residual Practical recommendations: a standardised examination and symptom-assessment method, vestibular

Strauss 1983 (+ Skyhar 1986 companion)

J Bone Joint Surg Am · 1983 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Strauss MB, Hargens AR, Gershuni DH, Greenberg DA, Crenshaw AG, Hart GB, Akeson WH. Reduction of skeletal muscle necrosis using intermittent hyperbaric oxygen in a model compartment syndrome. J Bone Joint Surg Am 1983;65(5):656–662.

PubMed · PMID 6853571 · DOI

Intermittent HBO reduced skeletal-muscle necrosis in the compartment-syndrome model, with benefit

Strauss 2012

Undersea Hyperb Med · 2012 · Review / background

Strauss MB. The effect of hyperbaric oxygen in crush injuries and skeletal muscle-compartment syndromes; with the companion editorial 'Why hyperbaric oxygen therapy may be useful in treating crush injuries and skeletal muscle-compartment syndrome' Undersea Hyperb Med 2012;39(4):847-855 (review); 799-800 (editorial).

PubMed · PMID 22908841

Strauss 2022

Undersea and Hyperbaric Medicine · 2022 · Commentary / case

Strauss MB, Covington DB. Delayed recognition of Type II decompression sickness in a diver with chronic atrial fibrillation. Undersea and Hyperbaric Medicine 2022;49(2):227-231 (as printed in the article; PubMed records 563-568).

PubMed · PMID 35580489

Summers 2020

Diving and Hyperbaric Medicine · 2020 · Commentary / case

Summers M, Gawthrope IC. Diaphragmatic injury a hidden issue for divers following trauma: Case report. Diving and Hyperbaric Medicine 2020;50(2):178-180.

PubMed · PMID 32557422 · DOI · PMC free full text

Sun 2006

Diabet Med · 2006 · RCT

Sun TB, Yang CCH, Kuo TBJ. Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications. Diabet Med 2006;23(4):360–366.

PubMed · PMID 16620263 · DOI

No baseline HRV difference between groups; after HBO, significant increases in RR (+82.7±16.0 ms), Local tissue oxygenation increased significantly with HBO.

Sun 2026

Medical Gas Research · 2026 · Cohort / series

Sun M, Liang H, Chen Y, Duan S, Xu R, Cai Z. A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head. Medical Gas Research 2026;16(1):1-5.

PubMed · PMID 40580182 · DOI · PMC free full text

Sutkowy 2024

Free Radic Res · 2024 · Cohort / series

Sutkowy P, et al. The impact of hyperbaric oxygen therapy on the redox balance of patients with diabetic foot syndrome. Free Radic Res 2024.

PubMed · PMID 39425927 · DOI

Suzuki 2018

Undersea and Hyperbaric Medicine · 2018 · Cohort / series

Suzuki N, Yagishita K, Enomoto M, Kojima Y, Oyaizu T, Shibayama M, Yamamoto K. A case-control questionnaire survey of decompression sickness risk in Okinawa divers. Undersea and Hyperbaric Medicine 2018;45(1):41-48.

PubMed · PMID 29571231

Svalestad 2014

Int J Oral Maxillofac Surg · 2014 · Cohort / series

Svalestad J, Thorsen E, Vaagbø G, Hellem S. Effect of hyperbaric oxygen treatment on oxygen tension and vascular capacity in irradiated skin and mucosa. Int J Oral Maxillofac Surg 2014;43(1):107–112.

PubMed · PMID 23932021 · DOI

TcPO₂ increased significantly in the irradiated cheek (P<0.05), but not at reference points outside No difference between the 3- and 6-month follow-ups → the gain is durable (not a transient Control group: no significant change. No major therapeutic complications.

Svalestad 2015

Int J Oral Maxillofac Surg · 2015 · RCT

Svalestad J, Hellem S, Thorsen E, Johannessen AC. Effect of hyperbaric oxygen treatment on irradiated oral mucosa: microvessel density. Int J Oral Maxillofac Surg 2015;44(3):301–307.

PubMed · PMID 25604154 · DOI

Microvessel density significantly increased after HBOT (P=0.002–0.041). D2-40-positive lymphatic vessels significantly increased in number and area in the sub-epithelial area No significant change in the control group.

Tabner 2023

Diving Hyperb Med · 2023 · Commentary / case

Tabner A, Bryson P, Tilbury N, McGregor B, Wesson A, Hughes GR, Hughes GD, Johnson G. An evaluation of the NUI Compact Chest Compression Device (NCCD), a mechanical CPR device suitable for use in the saturation diving environment. Diving Hyperb Med 2023;53(3):181-188.

PubMed · PMID 37718291 · DOI · PMC free full text

Takemura 2026

Biochem Biophys Rep · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Takemura A, Egawa T, Takagi R, Zhao H, Iyama R, Suzuki S, Fujino R, Fukunaga T, Hayashi T, Fujita S. Mild hyperbaric oxygen enhanced the regeneration of the tibialis anterior muscle after the cardiotoxin-induced muscle injury. Biochem Biophys Rep 2026;46:102638.

PubMed · PMID 42232766 · DOI · PMC free full text

Talanker 2026

Microsurgery · 2026 · Commentary / case

Talanker MM, Basta AV, Do T, Tung R, Allen A, Martin M, Ruygrok BL, Kellam PJ, Trost JG, Bhadkamkar MA. Multidisciplinary Approach to Complex Lower Extremity Limb Salvage in Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome: A Case Report. Microsurgery 2026;46(4):e70224.

PubMed · PMID 41978233 · DOI · PMC free full text

Tan 2017

Diving Hyperb Med · 2017 · Cohort / series

Tan VH, Chin K, Kumar AA, Chng J, Soh CR. Treatment preferences for decompression illness amongst Singapore dive physicians. Diving Hyperb Med 2017;47(2):118-122.

PubMed · PMID 28641324 · PMC free full text

Tang 2026

BMC Anesthesiol · 2026 · Commentary / case

Tang X, Hao Y, Yu Y, Lin K, Kang X. Perioperative central retinal artery occlusion after prone posterior cervical spine surgery treated with delayed hyperbaric oxygen therapy: a case report and targeted literature review. BMC Anesthesiol 2026:in press.

PubMed · PMID 42363062 · DOI

Teguh 2009

Int J Radiat Oncol Biol Phys · 2009 · RCT

Teguh DN, Levendag PC, Noever I, Voet P, van der Est H, van Rooij P, Dumans AG, de Boer MF, van der Huls MPC, Sterk W, Schmitz PIM (Erasmus MC, Rotterdam). Early Hyperbaric Oxygen Therapy for Reducing Radiotherapy Side Effects: Early Results of a Randomized Trial in Oropharyngeal and Nasopharyngeal Cancer. Int J Radiat Oncol Biol Phys 2009;75(3):711–716.

PubMed · PMID 19386439 · DOI

On all QoL items, better scores in the HBOT arm. The HBOT vs non-HBOT difference was significant for EORTC H&N35 Swallowing p=0.011 EORTC H&N35 Dry Mouth (xerostomia) p=0.009

Tenenhaus 2018

Undersea Hyperb Med · 2018 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Tenenhaus M, Gaid NA, Hayes S, Foubert P, et al. Injection of SVF combined with HBO2 improves viability of unfavorably designed flaps. Undersea Hyperb Med 2018;45(4).

DOI

Tepic 2018

Undersea Hyperb Med · 2018 · Cohort / series

Tepic S, Petkovic A, Srejovic I, Jeremic N, Zivkovic V, Loncarevic S, Bradic J, Jakovljevic V. Impact of hyperbaric oxygenation on oxidative stress in diabetic patients. Undersea Hyperb Med 2018;45(1):9-17.

PubMed · PMID 29571227

Thaler 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

Thaler J, Pignel R, Magnan MA, Pellegrini M, Louge P. Decompression illness treated at the Geneva hyperbaric facility 2010-2016: A retrospective analysis of local cases. Diving and Hyperbaric Medicine 2020;50(4):370-376.

PubMed · PMID 33325018 · DOI · PMC free full text

THEIA (Préterre 2025)

Lancet Neurology · 2025 · RCT

Préterre C, Gaultier A, Obadia M, et al. Intravenous alteplase versus oral aspirin for acute central retinal artery occlusion within 4.5 h of severe vision loss (THEIA): a multicentre, double-dummy, patient-blinded and assessor-blinded, randomised, controlled, phase 3 trial. Lancet Neurology 2025;24(11):909–919.

PubMed · PMID 41109232 · DOI

70 patients randomised (35 alteplase, 35 aspirin). Mean onset-to-treatment 232 min. Primary endpoint: 19/29 (66%) alteplase vs 13/27 (48%) aspirin improved — not significant Interpretation: alteplase within 4.5 h not associated with significant benefit over aspirin; likely

Thenuwara 2016

Int J Obstet Anesth · 2016 · Commentary / case

Thenuwara K, Thomas J, Ibsen M, Ituk U, Choi K, Nickel E, Goodheart MJ. Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with life-threatening anemia following postpartum hemorrhage. Int J Obstet Anesth 2016;29:73–80.

PubMed · PMID 27890467 · DOI

The haemorrhage. Preoperative Hb was 12.2 g/dL (Hct 38%), improved in the anaemia clinic at 34 The nadir. On postoperative day one haemoglobin was 3.0 g/dL with a lactate of 5.6 mEq/L HBOT prescription. 2.4 ATA for 90 min at FiO₂ 1.0, in a 12-hourly cycle, begun on postoperative

Thistlethwaite 2018

Wound Repair Regen · 2018 · RCT

Thistlethwaite KR, Finlayson KJ, et al. The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double‐blind, placebo‐controlled trial. Wound Repair Regen 2018;26(4):324–331.

PubMed · PMID 30129080 · DOI

Complete healing at 12 weeks: no significant difference between HBOT and placebo (primary outcome). Percent area reduction (PAR): 95% (HBOT) vs 54% (placebo) — significant (p=0.042; mean difference

Thom 1995

Ann Emerg Med · 1995 · RCT

Thom SR, Taber RL, Mendiguren II, Clark JM, Hardy KR, Fisher AB. Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 1995;25(4):474–480.

PubMed · PMID 7710151 · DOI

DNS developed in 7/30 (23%) of the ambient-pressure-oxygen group vs 0/30 (0%) after HBO (P<0.05). DNS appeared 6 ± 1 days after poisoning and persisted 41 ± 8 days. At 4-week follow-up, ambient-pressure patients who had not developed overt DNS still scored worse on

Thom 2004

Proc Natl Acad Sci U S A · 2004 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Thom SR, Bhopale VM, Fisher D, Zhang J, Gimotty P. Delayed neuropathology after carbon monoxide poisoning is immune-mediated. Proc Natl Acad Sci U S A 2004;101(37):13660-5.

PubMed · PMID 15342916 · DOI · PMC free full text

A controlled laboratory experiment in male Wistar rats (Charles River Laboratories), 200–290 g, fed standard diet and water ad libitum, all care in accordance with institutional guidelines. Carbon monoxide poisoning protocol. In a 7-litre Plexiglas chamber, rats breathed 1,000 ppm CO for 40 min, then 3,000 ppm for up to 20 min until they lost consciousness, and were then removed to breathe room ai

Thomas 2026

J Clin Med · 2026 · Commentary / case

Thomas SJ, Bao JM, Ansari A, Kizilbash E, Langford JH, Kalafatis NE, Shughoury A, Gregory DM, Larson JR, Adams NJ, Marsee MK, Jordan CC, Johnson DM, Raza S, Wiarda A, Alizai AM, Walsh MM. Resolution of Pneumomediastinum, Cervicofacial Emphysema, and Internal Ophthalmoplegia with Hyperbaric Oxygen Therapy After Hip Arthroscopy: A Case Report. J Clin Med 2026;15(12):4634.

PubMed · PMID 42355802 · DOI · PMC free full text

Tian 2025 (HBOT in cardiovascular disease)

Med Gas Res · 2025 · Review / background · MIXED human and preclinical evidence

Tian M, Du W, Yang S, Liao Q, Guo F, Li S. Application and progress of hyperbaric oxygen therapy in cardiovascular diseases. Med Gas Res 2025;15(3):427-434 (DOI 10.4103/mgr.MEDGASRES-D-24-00107).

PubMed · PMID 40251023 · DOI · PMC free full text

Tillmans 2026

Diving Hyperb Med · 2026 · Review / background

Tillmans F, Saraiva C, Ferguson S, Dugrenot E, Blogg SL. Recreational and technical rebreather fatalities and diving safety status. Diving Hyperb Med 2026;56(2):185-190.

PubMed · PMID 42290579 · DOI · PMC free full text

Tlapak 2020

Undersea Hyperb Med · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Tlapak J, Chmatal P, Oniscenko B, Pavlik V, Dosel P, Paral J, Lochman P. The effect of hyperbaric oxygen therapy on gene expression: microarray analysis on wound healing. Undersea Hyperb Med 2020;47(1):31-37.

PubMed · PMID 32176944

Tlapák 2026

Med Gas Res · 2026 · Review / background

Tlapák J, Tlapáková E, Pásler A, Chmelař D, Hájek M. Combined hyperbaric oxygen therapy and repetitive transcranial magnetic stimulation in depression and PTSD: future perspectives. Med Gas Res 2026;16(2):303-304.

PubMed · PMID 41496307 · DOI · PMC free full text

Tomoye 2024

Undersea Hyperb Med · 2024 · Guideline

Tomoye EO, Park CL, Folke L, Moon RE. Reprinted from the 2023 Hyperbaric Indications Manual 15th Edition: Intracranial Abscess. Undersea Hyperb Med 2024;51(4):449–455.

PubMed · PMID 39821772

Defines the indication (cerebral abscess, subdural/epidural empyema), aetiology, and the UHMS position;

Tomoye & Moon 2021

Undersea Hyperb Med · 2021 · Review / background

Tomoye EO, Moon RE. Hyperbaric oxygen for intracranial abscess. Undersea Hyperb Med 2021;48(1):97–102.

PubMed · PMID 33648039 · DOI

Covers aetiology (contiguous spread, haematogenous seeding, trauma), the hypoxic-abscess mechanism, and Bottom line: given the high morbidity/mortality of intracranial abscess and that HBO is

Tong 2021

Audiol Neurootol · 2021 · RCT

Tong B, Niu K, Ku W, Xie W, Dai Q, Hellström S, Duan M. Comparison of Therapeutic Results with/without Additional Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Prospective Study. Audiol Neurootol 2021;26(1):11–16.

PubMed · PMID 32535600 · DOI

Overall success: 60.6% (40/66) HBO+P vs 42.9% (30/70) P (p = 0.038 as printed; ⚠️ corrected 31 Aug 2026 from "p<0.05" — the paper gives the exact value). Greater benefit in defined subgroups: mild–moderate baseline loss, age ≤50 y, treated ≤14 days, and

Toocheck 2020

Undersea Hyperb Med · 2020 · Commentary / case

Toocheck C, Bahner D, Bachmann DJ. Carbon monoxide-induced atrial fibrillation resolved with hyperbaric oxygen. Undersea Hyperb Med 2020;47(1):145-149.

PubMed · PMID 32176956

Toppen 2024

PLoS One · 2024 · Cohort / series

Toppen W, Cho NY, Sareh S, Kjellberg A, Medak A, Benharash P, Lindholm P. Contemporary national outcomes of hyperbaric oxygen therapy in necrotizing soft tissue infections. PLoS One 2024;19(3):e0300738.

PubMed · PMID 38512943 · DOI · PMC free full text

HBOT group had lower mortality: <2% vs 5.9% (p<0.001) and lower amputation. HBOT is used in <1% of surgically-treated NSTI in the US — striking under-utilisation of a recognised

Topuz 2004

Eur Arch Otorhinolaryngol · 2004 · RCT

Topuz E, Yigit O, Cinar U, Seven H (Istanbul, Turkey). (received 2003). Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Otorhinolaryngol 2004;261(7):393–396.

PubMed · PMID 14586625 · DOI

Group II (HBO added): statistically significant improvement at all frequencies except 2000 Hz; Group I Age gradient in the HBO group: mean hearing gain 39.1 ± 18.3 dB in patients < 50 years vs 22.7 ± 11.3 Authors note the high (~90%) spontaneous-recovery background makes patient selection important.

Trevett 2019

Diving and Hyperbaric Medicine · 2019 · Cohort / series

Trevett A, Sheehan C, Wilkinson A, Moss I. Lion's mane jellyfish (Cyanea capillata) envenoming presenting as suspected decompression sickness. Diving and Hyperbaric Medicine 2019;49(1):57-60.

PubMed · PMID 30856668 · DOI · PMC free full text

Trytko 2008

Anaesth Intensive Care · 2008 · Cohort / series

Trytko BE, Bennett MH. Arterial gas embolism: a review of cases at Prince of Wales Hospital, Sydney, 1996 to 2006. Anaesth Intensive Care 2008;36(1):60-64.

PubMed · PMID 18326133 · DOI

Tsouras 2025

Diving Hyperb Med · 2025 · Review / background

Tsouras T, Devaney B, Lin ZC, Covelli C, Roberts L, Nanjayya VB, Millar I. Validation and clinical use of the Maquet (Getinge) original series Rotaflow extracorporeal membrane oxygenation device in hyperbaric conditions: a technical report. Diving Hyperb Med 2025;55(4):323-329.

PubMed · PMID 41364855 · DOI · PMC free full text

Tsushima 2024

Diving Hyperb Med · 2024 · Commentary / case

Tsushima R, Mori K, Imaki S. Secondary deterioration in a patient with cerebral and coronary arterial gas embolism after brief symptom resolution: a case report. Diving Hyperb Med 2024;54(1):61-64.

PubMed · PMID 38507911 · DOI · PMC free full text

Tueguem Moyo 2023

Ann Vasc Surg · 2023 · Cohort / series

Tueguem Moyo T, Jéhannin P, Le Pabic E, Le Faucheur A, Omarjee L, Mahe G. Test-retest reliability and minimal detectable change in exercise oximetry in claudicants. Ann Vasc Surg 2023;99:19-25.

PubMed · PMID 37922963 · DOI

Tuluy 2023

Diving and Hyperbaric Medicine Journal · 2023 · Cohort / series

Tuluy Y, Aksoy A, Sır E. Effects of external bleeding and hyperbaric oxygen treatment on Tamai zone 1 replantation. Diving and Hyperbaric Medicine Journal 2023;53(1):2-6 (DOI 10.28920/dhm53.1.2-6).

PubMed · PMID 36966516 · DOI · PMC free full text

Tuominen 2022

Diving and Hyperbaric Medicine · 2022 · Cohort / series

Tuominen LJ, Sokolowski S, Lundell RV, Räisänen-Sokolowski AK. Decompression illness in Finnish technical divers: a follow-up study on incidence and self-treatment. Diving and Hyperbaric Medicine 2022;52(2):78-84.

PubMed · PMID 35732278 · DOI · PMC free full text

Tuominen 2025

Diving Hyperb Med · 2025 · Cohort / series

Tuominen L, Lundell R, Balestra C, Wuorimaa T, Koponen L, Sokolowski S, Räisänen-Sokolowski A. Effects of fluid loss on the physiology of closed-circuit rebreather divers after 100- and 45-metre dives. Diving Hyperb Med 2025;55(4):391-397.

PubMed · PMID 41364863 · DOI · PMC free full text

Turgut 2023

Diving Hyperb Med · 2023 · Commentary / case

Turgut B, Canarslan Demir K, Sariyerli Dursun GB, Zaman T. Hemiplegia resulting from acute carbon monoxide poisoning. Diving Hyperb Med 2023;53(2):155-157.

PubMed · PMID 37365135 · PMC free full text

Türkmen 2025

Diving Hyperb Med · 2025 · Cohort / series

Türkmen O, Özkan R, Özgök Kangal K, Dur İnce M, Arslan Y. Hyperbaric oxygen treatment and pulmonary air-containing lesions. Diving Hyperb Med 2025;55(4):343-351 (DOI 10.28920/dhm55.4.343-351).

PubMed · PMID 41364858 · DOI · PMC free full text

Ueno 2014

J Nippon Med Sch · 2014 · Cohort / series

Ueno T, Omi T, Uchida E, Yokota H, Kawana S. Evaluation of hyperbaric oxygen therapy for chronic wounds. J Nippon Med Sch 2014;81(1):4-11.

PubMed · PMID 24614389 · DOI

Clarke 2019

Undersea Hyperb Med · 2019 · Review / background

Clarke R. HBO2 for radiation cystitis (letter concerning Oscarsson et al, randomised controlled trial). Undersea Hyperb Med 2019;46(5):725-727.

DOI

UHMS Hyperbaric Medicine Indications Manual, 15th ed (2023)

2023 · Review / background

Huang ET (Chair & Editor). Hyperbaric Medicine Indications Manual, 15th ed. Undersea and Hyperbaric Medical Society / Best Publishing Company; 2023. ISBN 978-1-947239-42-5.

HBOT 0030 · Not indexed in PubMed and no DOI — full text held in the practice wiki

The Undersea and Hyperbaric Medical Society's reference manual of accepted indications for hyperbaric oxygen, 15th edition, edited by Huang ET — a multi-author bound volume in which each indication is a separate chapter by different authors. It is held here as a reference work and a discovery pool, not as appraised evidence. No risk-of-bias instrument is applied to the volume as a whole, because a

UHMS 2002

December · 2002 · Guideline

Undersea and Hyperbaric Medical Society. Adjunctive therapy for decompression illness (DCI): summary of Undersea and Hyperbaric Medical Society guidelines. December 2002.

HBOT 0017 · Not indexed in PubMed and no DOI — full text held in the practice wiki

UHMS Associates 2004

Undersea and Hyperbaric Medical Society Associates · 2004 · Review / background

UHMS Associates Facility Design Committee (Wood S, chair). Hyperbaric Facility Design Guidelines, Version 1.0. Undersea and Hyperbaric Medical Society Associates 2004;1.0:1-11.

HBOT 0039 · Not indexed in PubMed and no DOI — full text held in the practice wiki

UHMS 2018

Undersea Hyperb Med · 2018 · Guideline

Undersea and Hyperbaric Medical Society. UHMS Position Statement: The role of hyperbaric oxygen for acute traumatic ischemias. Undersea Hyperb Med 2018;45(5):617-620.

PubMed · PMID 30428253

UHMS 2018

Undersea Hyperb Med · 2018 · Guideline

Undersea and Hyperbaric Medical Society. UHMS guidelines for credentialing, privileging and supervision of hyperbaric oxygen therapy in the U.S.A. Undersea Hyperb Med 2018;45(1):117-127 (created March 2009; revised June 2014 and January 2018).

DOI

UHMS 2018

Undersea Hyperb Med · 2018 · Guideline

Undersea and Hyperbaric Medical Society. UHMS position statement: low-pressure fabric hyperbaric chambers. Undersea Hyperb Med 2018;45(4):486-487.

Not indexed in PubMed and no DOI — full text held in the practice wiki

UHMS 2019

Undersea Hyperb Med · 2019 · Guideline

Undersea and Hyperbaric Medical Society. UHMS Position Statement: Minimum-staffing guidelines for multiplace hyperbaric facilities. Undersea Hyperb Med 2019;46(1).

PubMed · PMID 31154692 · DOI

UHMS 15th ed (2023) Ch.15

Avascular Necrosis (Aseptic Osteonecrosis). · 2023 · Guideline

Camporesi EM, Zanon V, Vezzani G, Bosco G. Undersea and Hyperbaric Medical Society; 2023. Chapter 15. Avascular Necrosis (Aseptic Osteonecrosis). Avascular Necrosis (Aseptic Osteonecrosis). In: Hyperbaric Oxygen Therapy Indications, 15th ed.

HBOT 0031 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Acceptance & grade: "Published evidence of the beneficial effects of HBO₂ on osteonecrosis led to its Recommendation: "we recommend that HBO₂ be included amongst the possible therapeutic options for Mechanism: raises tissue O₂, reduces marrow oedema and intraosseous pressure via vasoconstriction,

UHMS 2023

Undersea and Hyperbaric Medical Society · 2023 · Review / background

UHMS Equipment Subcommittee. Description of Medical Device Approval Process - Class A Multiplace Chambers (Medical Device Approval Form, updated September 2023). Undersea and Hyperbaric Medical Society 2023:1-17.

HBOT 0044 · Not indexed in PubMed and no DOI — full text held in the practice wiki

The current formal instrument through which a testing facility documents a medical device for use in Class A (multiplace) chambers: facility identification, device description, and the structured safety data the Equipment Subcommittee requires. It is the institutionalised version of the risk-assessment thinking in evidence/burman-2009-decision-process-medical-equipment-hyperbaric, and the pathway

Umapathy 2019

Free Radic Biol Med · 2019 · RCT

Umapathy D, Amin KN, Dornadula S, Alladi V, Arumugam S, Kesavan R, Mohanram RK. Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy. Free Radic Biol Med 2019.

DOI

Unfirer 2016

Undersea Hyperb Med · 2016 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Unfirer S, Mihalj M, Novak S, Kibel A, Cavka A, et al. Hyperbaric oxygenation affects the mechanisms of acetylcholine-induced relaxation in diabetic rats. Undersea Hyperb Med 2016;43(7):787-803.

PubMed · PMID 28777516

Uniyal 2025

Wounds · 2025 · RCT

Uniyal M, Ahmad I, Dhiman AK, Kumar A, Sarkar B, Jagne N, Mago V, Azam MQ. The Effect of Hyperbaric Oxygen Therapy on Split-Thickness Skin Graft Uptake in Posttraumatic Wounds and Donor Site Healing: A Randomized Controlled Trial. AIIMS Rishikesh, India. The Effect of Hyperbaric Oxygen Therapy on Split-Thickness Skin Graft Uptake in Posttraumatic Wounds and Donor Site Healing: A Randomized Controlled Trial. Wounds 2025;37(3):134–140.

PubMed · PMID 40215364 · DOI

Graft uptake POD 4: 92.44% (SD 5.98) HBOT vs 88.12% (8.92) control, P=.036. Graft uptake POD 7: 91.69% (8.71) vs 83.12% (14.94), P=.026. Donor-site recovery faster: 15.16 (0.88) days vs 17.97 (2.49) days, significant. Graft-site infection

van Merkesteyn 1984

Int J Oral Surg · 1984 · Cohort / series

van Merkesteyn JPR, Bakker DJ, van der Waal I, Kusen GJ, Egyedi P, van den Akker HP, de Man K, Panders AK, Lekkas KE. Hyperbaric oxygen treatment of chronic osteomyelitis of the jaws. Int J Oral Surg 1984;13(5):386–395.

PubMed · PMID 6437999 · DOI

Chronic suppurative osteomyelitis (5 patients): all remained free of symptoms during follow-up. In Diffuse sclerosing type A (5 patients): 2 arrested, 2 markedly improved, 1 not improved at all. One Diffuse sclerosing type B (6 patients): 1 arrested, 2 improved, 3 not improved. The 3 non-improved

Van Meter 2005

Undersea Hyperb Med · 2005 · Systematic review · MIXED human and preclinical evidence

Van Meter KW. A systematic review of the application of hyperbaric oxygen in the treatment of severe anemia: an evidence-based approach. Undersea Hyperb Med 2005;32(1):61–83.

PubMed · PMID 15796315

All 35 publications reported a positive result when HBO₂ was delivered as treatment for severe ⚠️ Corrected 31 Aug 2026 — THE MOST CONSEQUENTIAL CORRECTION ON THIS PAGE. The bullet above The human evidence is case reports and series — there is no randomised controlled trial,

Van Meter 2012

Undersea Hyperb Med · 2012 · Review / background

Van Meter KW. The effect of hyperbaric oxygen on severe anemia. Undersea Hyperb Med 2012;39(5):937–942.

PubMed · PMID 23045922

HBO dissolves oxygen in red-cell-poor plasma/resuscitation fluids to emergently supply tissue oxygen; and Cost/health-system argument: one HBO treatment is roughly the wholesale cost of a unit of packed red

Van Meter 2024

Front Med (Lausanne) · 2024 · Review / background · MIXED human and preclinical evidence

Van Meter KW. Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review. Front Med (Lausanne) 2024;11:1408816.

PubMed · PMID 39440035 · DOI · PMC free full text

For short periods, plasma-dissolved oxygen at pressure can meet resting oxygen requirements without red Intermittent HBO averts oxygen toxicity while resupplying ATP for gene expression and reparative/ HBO ameliorates reperfusion injury after ischaemia; complication rate is very low; modern chambers can

van der Kooi 2025

Diving Hyperb Med · 2025 · Cohort / series

van der Kooi BL, Hoedemaeker ADM, Broekhuizen LN, van Ooij PJAM, Wingelaar TT. The role and efficacy of ECG screening in assessing fitness to dive in military divers: implications of sports medicine standards. Diving Hyperb Med 2025;55(3):246-253.

PubMed · PMID 40986920 · DOI · PMC free full text

van de Wetering 2016

Cochrane Database Syst Rev · 2016 · Cochrane review

van de Wetering FT, Verleye L, Andreyev HJN, Maher J, Vlayen J, Pieters BR, van Tienhoven G, Scholten RJPM. Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis. Cochrane Database Syst Rev 2016;(4):CD003455.

PubMed · PMID 27111831 · DOI · PMC free full text

Hyperbaric oxygen vs placebo — clinical evaluation healed or improved: RR 2.55 (95% CI 1.30–5.02), favouring HBO (single double-blind RCT, Clarke 2008, HBO at ~2.0–2.4 ATA). The review covered many non-surgical modalities (rectal sucralfate, formalin, short-chain-fatty-acid enemas, argon plasma coagulation, anti-inflammatories, HBO); heterogeneity precluded pooling across modalities and no standard could be recommended.

Van Liew & Flynn 2005

Undersea and Hyperbaric Medicine · 2005 · Cohort / series

Van Liew HD, Flynn ET. Probability of decompression sickness in no-stop air diving and subsaturation diving. Undersea and Hyperbaric Medicine 2005;32(5):375-390.

PubMed · PMID 16457086

Vann 2011

Lancet · 2011 · Review / background

Vann RD, Butler FK, Mitchell SJ, Moon RE. Decompression illness. Lancet 2011;377(9760):153-64.

PubMed · PMID 21215883 · DOI

van Ooij 2014

Respir Physiol Neurobiol · 2014 · RCT

van Ooij PJAM, van Hulst RA, Kulik W, Brinkman P, Houtkooper A, Sterk PJ. Hyperbaric oxygen diving affects exhaled molecular profiles in men. Respir Physiol Neurobiol 2014;198:20–24.

PubMed · PMID 24703972 · DOI

van Ooij 2018

Diving and Hyperbaric Medicine · 2018 · Review / background · MIXED human and preclinical evidence

van Ooij PJAM. Decompression sickness, fatness and active hydrophobic spots. Diving and Hyperbaric Medicine 2018;48(3):130-131.

PubMed · PMID 30199886 · DOI · PMC free full text

van Ooij 2025

Diving Hyperb Med · 2025 · Cohort / series

van Ooij PJAM, van Hulst RA. Divers with large or normal lungs: is the difference justified? Diving Hyperb Med 2025;55(1):18-26.

PubMed · PMID 40090022 · DOI · PMC free full text

van Ooij 2026

Diving Hyperb Med · 2026 · Meta-analysis

van Ooij PJAM, Bek AR, van Hulst RA. Transgender people and occupational diving: a new challenge for diving physicians? Diving Hyperb Med 2026;56(1):59-70.

PubMed · PMID 41875443 · DOI

van Ophoven 2006

J Urol · 2006 · RCT

van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial. J Urol 2006.

Not indexed in PubMed and no DOI — full text held in the practice wiki

Vas/IWGDF 2020

Diabetes Metab Res Rev · 2020 · Systematic review

Vas P, Rayman G, Dhatariya K, Driver V, Hartemann A, Löndahl M, Piaggesi A, Apelqvist J, Attinger C, Game F. Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review. Diabetes Metab Res Rev 2020;36(S1):e3284.

PubMed · PMID 32176446 · DOI

IWGDF systematic review of interventions to enhance DFU healing; across modalities no evidence was found to justify newer therapies for routine use. For HBO, firm conclusions could not be drawn — the trials were limited by high dropout, protocol non-compliance and statistical-analysis errors.

Vceva 2022

Diving Hyperb Med · 2022 · Cohort / series

Vceva A, Zubcic Z, Mihalj H, Males J, Mendes T, Sestak A. Pretreatment hearing grades and hearing recovery outcomes after primary hyperbaric oxygen treatment in patients with idiopathic sudden sensorineural hearing loss. Diving Hyperb Med 2022;52(3):191-196.

PubMed · PMID 36100930 · DOI · PMC free full text

Viljoen 2025

Diving Hyperb Med · 2025 · Commentary / case

Viljoen DA, Andrews J. Localised tissue necrosis from marine puncture injury: first aid, definitive management and review of the literature. Diving Hyperb Med 2025;55(3):289-293.

PubMed · PMID 40986927 · DOI · PMC free full text

Villanueva 2004

Cochrane Database Syst Rev · 2004 · Cochrane review

Villanueva E, Bennett MH, Wasiak J, Lehm JP. Hyperbaric oxygen therapy for thermal burns. Cochrane Database Syst Rev 2004;(3):CD004727.

PubMed · PMID 15266540 · DOI · PMC free full text

One trial: no difference in length of stay, mortality, or number of surgeries once adjusted for The other trial: shorter mean healing time with HBOT (19.7 vs 43.8 days). Poor trial quality precluded confidence in either result.

Villeirs 2020

Int J Urol · 2020 · Systematic review

Villeirs L, Tailly T, Ost P, Waterloos M, Decaestecker K, Fonteyne V, Van Praet C, Lumen N. Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature. Int J Urol 2020;27(2):98–107.

PubMed · PMID 31617263 · DOI

Systematic review of recent literature on HBO for radiation cystitis; overall response 64.8–100% and complete response 20–100% across studies, with high pooled weighted averages. Consistent with a real, clinically useful effect; heterogeneity in response definitions and mostly observational designs limit certainty.

Vingolo 1999

Doc Ophthalmol · 1999 · Cohort / series

Vingolo EM, Pelaia P, Forte R, Rocco M, Giusti C, Rispoli E. Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa? Doc Ophthalmol 1999;97(1):33–39 (Kluwer).

PubMed · PMID 10710240 · DOI

ERG b-wave amplitude rose in the HBO cases (T0 4.68 ± 3.81 µV → T1 8.46 ± 5.71 → T2 10.7 ± 7.6 → Controls declined (T0 4.92 ± 3.05 µV → T3 2.97 ± 3.61 µV) — a slight but significant decrease Authors' own caution: the study demonstrates an increase in electroretinographic responses only,

Vingolo 2008

Graefes Arch Clin Exp Ophthalmol · 2008 · RCT

Vingolo EM, Rocco M, Grenga PL, Salvatore S, Pelaia P. Slowing the degenerative process, long lasting effect of hyperbaric oxygen therapy in retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 2008;246(1):93–98.

PubMed · PMID 17674017 · DOI

Visual acuity preservation at 5 years: 87.5% of the HBO group retained 80% of initial VA vs a At 10 years: 63.3% (HBO) vs 40% (control) maintained residual VA (χ²=3.22, p=0.05); static ERG b-wave mean values at the end of the protocol were significantly higher in the HBO group

Vinkel 2019

Dan Med J · 2019 · Cohort / series

Vinkel J, Lohse N, Hyldegaard O. The clinical use of hyperbaric oxygen in the treatment of Danish patients with diabetic foot ulcers. Dan Med J 2019;66(2):A5528.

PubMed · PMID 30722823

Vinkel 2022

JMIR Res Protoc · 2022 · Review / background

Vinkel J, Rib L, Buil A, Hedetoft M, Hyldegaard O. Investigating the Effects of Hyperbaric Oxygen Treatment in Necrotizing Soft Tissue Infection With Transcriptomics and Machine Learning (the HBOmic Study): Protocol for a Prospective Cohort Study With Data Validation. JMIR Res Protoc 2022;11(11):e39252.

PubMed · PMID 36427229 · DOI · PMC free full text

Vinkel 2023

Eur J Med Res · 2023 · Cohort / series

Vinkel J, Rib L, Buil A, Hedetoft M, Hyldegaard O. Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study). Eur J Med Res 2023;28(1):507.

PubMed · PMID 37946314 · DOI · PMC free full text

Vishwanath 2011

Med J Armed Forces India · 2011 · RCT

Vishwanath G. Hyperbaric oxygen therapy in free flap surgery: is it meaningful? Med J Armed Forces India 2011.

PubMed · PMID 27365816 · DOI · PMC free full text

No significant difference in flap survival, time to resolution of venous congestion, resolution

Vomhof-DeKrey 2026

Trauma Care · 2026 · RCT

Vomhof-DeKrey EE, Ajayi OD. A randomized placebo-controlled trial of mild hyperbaric oxygen on serum biomarkers in persistent post-concussive symptoms: analysis at 13-week follow-up. Trauma Care 2026;6:9 (DOI 10.3390/traumacare6020009; ClinicalTrials.gov NCT05173818).

DOI

Wackett 2024

Diving Hyperb Med · 2024 · Meta-analysis

Wackett J, Devaney B, Chau R, Ho J, King N, Grewal J, Armstrong J, Mitra B. Reported outcome measures in necrotising soft tissue infections: a systematic review. Diving Hyperb Med 2024;54(1):47-56 (PMID 38507909. DOI 10.28920/dhm54.1.47-56).

PubMed · PMID 38507909 · DOI · PMC free full text

Wadee 2021

J Diabetes Metab Disord · 2021 · RCT

Wadee AN, Aref MHF, Nassar AA, Abo-Bakr I, et al. The influence of low- intensity laser irradiation versus hyperbaric oxygen therapy on transcutaneous oxygen tension in chronic diabetic foot ulcers: a controlled randomized trial. J Diabetes Metab Disord 2021;20(2):1489–1497.

PubMed · PMID 34900800 · DOI · PMC free full text

Control group: no significant TcPO₂ change; both LILI and HBOT: significant improvement vs baseline The percentage improvement in TcPO₂ was greater with HBOT than LILI — HBOT favoured on this

Wagner 2025

Diving Hyperb Med · 2025 · Commentary / case

Wagner ME, Yu E, Lussier A, Lin N, Guo H, Lindholm P. Serial chest computed tomography imaging in a freediver with a case of pulmonary barotrauma of descent (lung squeeze) showing the time course of resolution. Diving Hyperb Med 2025;55(3):271-274.

PubMed · PMID 40986923 · DOI · PMC free full text

Wahl 2019

J Pain Res · 2019 · RCT

Wahl AM, Bidstrup D, Smidt-Nielsen IG, et al. A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial. J Pain Res 2019.

PubMed · PMID 31534358 · DOI · PMC free full text

HBOT reduced BI-induced SHA vs control: 18.8 (95% CI 10.5–27.0) cm² vs 32.0 (20.1–43.9) cm² (P=0.021). Order/carryover (long-lasting) effect: in the AC→HBOT sequence a significantly larger SHA appeared in

Wang 2003

Arch Surg · 2003 · Systematic review

Wang C, Schwaitzberg S, Berliner E, Zarin DA, Lau J. Hyperbaric Oxygen for Treating Wounds: A Systematic Review of the Literature. Arch Surg 2003;138(3):272–279.

PubMed · PMID 12611573 · DOI

57 studies — 7 RCTs, 16 nonrandomised, 34 case series; 2000 patients. HBO may be beneficial for hypoxic/ischaemic wounds, but methodological quality was limited. None used wound-tissue hypoxia as an inclusion criterion — so the reviews could not confirm HBO works specifically in the hypoxic wounds it is mechanistically meant to help; a persisting selection critique.

Wang 2011

Diabetes Res Clin Pract · 2011 · RCT

Wang CJ, Wu RW, Yang YJ. Treatment of diabetic foot ulcers: A comparative study of extracorporeal shockwave therapy and hyperbaric oxygen therapy. Diabetes Res Clin Pract 2011;92(2):187–193.

PubMed · PMID 21310502 · DOI

Complete healing: 57% (ESWT) vs 25% (HBOT) (P=0.003). ≥50% improvement 32% vs 15% (P=0.071); unchanged ulcers 11% (ESWT) vs 60% (HBOT) (P<0.001); none Blood-flow perfusion and histology (cell proliferation, less apoptosis) favoured ESWT after treatment.

Wang 2011

Diabetes Res Clin Pract · 2011 · Cohort / series

Wang CJ, Ko JY, Kuo YR, Yang YJ. Molecular changes in diabetic foot ulcers. Diabetes Res Clin Pract 2011;94(1):105–110.

PubMed · PMID 21742400 · DOI

Cohort: 39 patients (44 ulcers) ESWT (6 sessions) vs 38 patients (40 ulcers) HBOT (20 daily sessions); serial biopsies assessed molecular markers of angiogenesis, cell proliferation and apoptosis. Both modalities altered wound-healing molecular activity; the study characterises mechanism rather than comparing clinical healing endpoints.

Wang 2016

Medicine (Baltimore) · 2016 · RCT

Wang H, Li Y, Wu Q, Xu C, Liu Q. Combination of butylphthalide with umbilical mesenchymal stem cells for the treatment of delayed encephalopathy after carbon monoxide poisoning. Medicine (Baltimore) 2016;95(49):e5412.

PubMed · PMID 27930518 · DOI · PMC free full text

42 DEACMP patients, 3 groups: MSC transplantation + butylphthalide (n=14); MSC alone; or HBOT. MSCs delivered by alternating subarachnoid and carotid-artery injection (self-made high-pressure injector — experimental). MMSE and Barthel index were significantly higher with combined MSC + butylphthalide than with MSC alone or HBOT (all P<0.0001); no significant adverse events.

Wang 2018

Undersea and Hyperbaric Medicine · 2018 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wang HT, Fang YQ, You P, Bao XC, Li KC, Yao J, Li C, Yuan HR. PDTC ameliorates decompression induced-lung injury caused by unsafe fast buoyancy ascent escape via inhibition of NF-κB pathway. Undersea and Hyperbaric Medicine 2018;45(3):351-362.

PubMed · PMID 30028921

Wang 2019

Med Sci Monit · 2019 · Meta-analysis

Wang W, Cheng J, Zhang J, Wang K. Effect of Hyperbaric Oxygen on Neurologic Sequelae and All-Cause Mortality in Patients with Carbon Monoxide Poisoning: A Meta-Analysis of Randomized Controlled Trials. Med Sci Monit 2019;25:7684–7693.

PubMed · PMID 31606731 · DOI · PMC free full text

HBO lowered the risk of memory impairment vs NBO. Two HBO sessions were associated with higher memory-impairment risk than one session. HBO increased neuropsychological scores (block design, trail making); no other significant differences

Wang 2020

Diving and Hyperbaric Medicine · 2020 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wang Q, Guerrero F, Theron M. Pre-hydration strongly reduces decompression sickness occurrence after a simulated dive in the rat. Diving and Hyperbaric Medicine 2020;50(3):288-291.

PubMed · PMID 32957132 · DOI · PMC free full text

Wang 2026

Complement Ther Med · 2026 · Meta-analysis

Wang H, Zhou H, Nie J, Du S, Ning W, Ding S, Zhang H. Effectiveness of hyperbaric oxygen in traumatic brain injury patients: a systematic review and meta-analysis. Complement Ther Med 2026:103417.

PubMed · PMID 42575227 · DOI

Wang 2026

Bone · 2026 · Review / background · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wang H, Ma X, Sun Y, Guo Z, Wang J, Sun M. Hyperbaric oxygen therapy for osteoporosis: a systematic review of preclinical evidence and mechanisms. Bone 2026;205:117772.

PubMed · PMID 41483655 · DOI

Wang 2026

Sci Rep · 2026 · Cohort / series

Wang Y, Liu Y, Yang J, Peng D, Hua Q, Zhang C, Zhang Y, Wang W, Chen Y. Safety and efficacy of the combination of hyperbaric oxygen and 177Lu-DOTA-IBA in treating metastatic bone pain due to tumors. Sci Rep 2026 (DOI 10.1038/s41598-026-62346-0).

PubMed · PMID 42481667 · DOI

Warchol 2017

Diving Hyperb Med · 2017 · Commentary / case

Warchol JM, Cooper JS, Diesing TS. Hyperbaric oxygen-associated seizure leading to stroke. Diving Hyperb Med 2017;47(4):260-262.

DOI

Ward 1974

Br J Radiol · 1974 · Cohort / series

Ward AJ, Stubbs B, Dixon B. Carcinoma of the cervix: establishment of a hyperbaric oxygen trial associated with the use of the Cathetron. Br J Radiol 1974;47:319–325.

PubMed · PMID 4209690 · DOI

Describes the trial structure and technique; the initial patient response is reported as "encouraging" No definitive survival / local-control result in this paper.

Warriner 2012

Undersea Hyperb Med · 2012 · Review / background

Warriner RA 3rd, Hopf HW. The effect of hyperbaric oxygen in the enhancement of healing in selected problem wounds. Undersea Hyperb Med 2012;39(5):923-935 (PMID 23045921).

PubMed · PMID 23045921

Watanabe 2021

PLoS One · 2021 · Cohort / series

Watanabe T, Asai K, Fukuhara S, Uozumi R, Bessho K. Effectiveness of surgery and hyperbaric oxygen for antiresorptive agent-related osteonecrosis of the jaw: A subgroup analysis by disease stage. PLoS One 2021;16(1):e0244859.

PubMed · PMID 33395446 · DOI · PMC free full text

Watson 1978

Br J Radiol · 1978 · RCT

Watson ER, Halnan KE, Dische S, Saunders MI, Cade IS, McEwen JB, Wiernik G, Perrins DJD, Sutherland I. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 1978;51:879–887.

PubMed · PMID 361144 · DOI

Benefit in both local control and survival with HBO — "a true improvement in the therapeutic ratio." Benefit was greatest in patients under 55 who presented with stage III disease (actuarial local Slight increase in radiation morbidity, but judged outweighed by the tumour-control gain.

Watson 2026

Diving Hyperb Med · 2026 · Commentary / case

Watson AG, Lim TY. Liver disease and the Diver Medical Participant Questionnaire. Diving Hyperb Med 2026;56(1):95-96.

PubMed · PMID 41875447 · DOI

Weaver and Strauss 1991

Undersea and Hyperbaric Medical Society · 1991 · Safety / facility standard

Weaver LK, Strauss MB (editors). Monoplace Hyperbaric Chamber Safety Guidelines. Report to the Hyperbaric Chamber Safety Committee of the Undersea and Hyperbaric Medical Society. Undersea and Hyperbaric Medical Society 1991:1-68.

HBOT 0038 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Weaver 2002

N Engl J Med · 2002 · RCT

Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF, Thomas FO, Morris AH. Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning. N Engl J Med 2002;347(14):1057–67.

PubMed · PMID 12362006 · DOI

Cognitive sequelae at 6 weeks: 19/76 (25.0%) HBOT vs 35/76 (46.1%) normobaric, P = 0.007. After adjustment for cerebellar dysfunction and stratification variables: adjusted OR 0.45 (95% CI 12 months: cognitive sequelae remained less frequent with HBOT (intention-to-treat, P = 0.04).

Weaver 2014

Undersea Hyperb Med · 2014 · Review / background

Weaver LK. Hyperbaric oxygen therapy for carbon monoxide poisoning. Undersea Hyperb Med 2014;41(4):339-354.

PubMed · PMID 25109087

Weaver 2023

Undersea Hyperb Med · 2023 · RCT

Weaver LK, Deru K, Churchill S, Russo A. A randomized trial of one versus three hyperbaric oxygen sessions for acute carbon monoxide poisoning. Undersea Hyperb Med 2023;50(3):325–342.

PubMed · PMID 37708067 · DOI

No difference in the rate of neuropsychological sequelae between three HBO sessions and one HBO Overall sequelae rates were higher than in the 2002 trial, attributed by the authors to differences in

Weaver 2024

Undersea Hyperb Med · 2024 · Guideline

Weaver LK. Carbon monoxide poisoning (reprinted from the 2023 Hyperbaric Indications Manual, 15th edition). Undersea Hyperb Med 2024;51(3):253-276.

PubMed · PMID 39348519

Weaver 2025

Sci Rep · 2025 · RCT

Weaver LK, Ziemnik R, Deru K, Russo AA. A double-blind randomized trial of hyperbaric oxygen for persistent symptoms after brain injury. Sci Rep 2025;15(1):6885.

PubMed · PMID 40011516 · DOI · PMC free full text

NSI at 13 weeks improved with HBO₂ vs sham — mean difference 7.0 (95% CI 1.7–12.3, p=0.01). HBO₂ group also improved on olfaction, anxiety, sleep difficulties, and vestibular complaints; both

Weber 2018

Undersea Hyperb Med · 2018 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Weber R, Silver A, Williams SJ, Stephenson L, Usera PC, Zhang F, Tian H, Yang W, Wang WZ, Fang XH, Zamboni WA, Baynosa R. Random flap survival with hyperbaric oxygen: daily versus twice-daily treatments. Undersea Hyperb Med 2018;45(2):157-163.

DOI

Wei 2026

Int J Mol Sci · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wei H, Du X, Xu S, Bo Q, Guo Y, Xu L, Jiang Z, Yuan Y, Li X. Hyperbaric Oxygen Attenuates Cerebral Ischemia-Reperfusion Injury Through ROS-Dependent Remodeling of Microglial Mitochondrial Dynamics. Int J Mol Sci 2026;27(14):6334.

PubMed · PMID 42511677 · DOI · PMC free full text

Weinrich 2026 (ANIMAL)

BMC Musculoskelet Disord · 2026 · Systematic review · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Weinrich L, Tischer T, Schlesiger L, Pachowsky ML, Hoos L. Effects of hyperbaric oxygen therapy on bone, muscle, cartilage, tendon and ligaments in animal studies: a systematic review. BMC Musculoskelet Disord 2026;27(1):731.

PubMed · PMID 42649484 · DOI

Weinrich 2026

BMC Musculoskelet Disord · 2026 · Systematic review

Weinrich L, Tischer T, Schlesiger L, Pachowsky ML, Hoos L. Effects of hyperbaric oxygen therapy on human musculoskeletal pathologies in clinical studies: a systematic review. BMC Musculoskelet Disord 2026;27(1):661.

PubMed · PMID 42576206 · DOI · PMC free full text

Weiss 2010

Undersea Hyperb Med · 2010 · Cohort / series

Weiss JN. Hyperbaric oxygen treatment of retinal artery occlusion. Undersea Hyperb Med 2010;37(3):167-72.

PubMed · PMID 20568546

Five patients, symptom duration one to 12 days, each treated with six to 10 hyperbaric oxygen sessions, one hour at 1.5 ATA each (Table 1: 6, 6, 10, 6, 8 sessions). ⚠️ Corrected 31 Aug 2026: this previously read "each treated with hyperbaric oxygen for one hour at 1.5 ATA", which elided the course into a single session — the paper says "each patient underwent six to 10 treatments with 100% oxygen

Wendler 2026

Antioxidants (Basel) · 2026 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wendler CC, Thakre PP, Deegan KM, Nguyen BL, Rana S, Lapierre-Nguyen S, Li J, Grams KJ, Iglesias Maldonado GA, Calloway AN, Nebenzahl MR, Fuller DD, Smuder AJ. Antioxidant upregulation contributes to improvements in diaphragm function following cervical spinal cord injury and hyperbaric oxygen therapy. Antioxidants (Basel) 2026;15(8):940.

PubMed · PMID 42650204 · DOI

Smart 2008

Wound Healing Southern Africa · 2008 · Review / background

Smart H, et al. Multidisciplinary approach in hyperbaric oxygen therapy: application of the WHASA wheel on the diabetic foot. Wound Healing Southern Africa 2008;1(2):42-44.

HBOT 0059 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Wilkinson & Doolette 2004

Arch Surg · 2004 · Cohort / series

Wilkinson D, Doolette D. Hyperbaric oxygen treatment and survival from necrotizing soft tissue infection. Arch Surg 2004;139(12):1339–1345.

PubMed · PMID 15611459 · DOI

44 patients, 6 deaths (14%). Survival was less likely with increased age, renal dysfunction, idiopathic aetiology, and NOT receiving For extremity NSTI, HBO₂ significantly reduced amputation (P=0.05).

Williamson 2023

Diving Hyperb Med · 2023 · Cohort / series

Williamson J, Sharma A, Murray-Douglass A, et al. Outcomes of hyperbaric oxygen treatment for central and branch retinal artery occlusion at a major Australian referral hospital. Diving Hyperb Med 2023;53(3):224–229.

PubMed · PMID 37718296 · DOI · PMC free full text

Central RAO: 71% (12/17) improved (objective BCVA in 8/17 = 47%, plus subjective in 4 more); mean Branch RAO: no improvement in any of the 5 patients (numbers small). Limited side effects; no irreversible adverse events.

Willy 2012

Chirurg · 2012 · Commentary / case

Willy C, Rieger H, Vogt D. [Hyperbaric oxygen therapy for necrotizing soft tissue infections: contra]. Chirurg 2012;83(11):960–972 (PMID 23138865. DOI 10.1007/s00104-012-2284-z. Published in German with an English abstract.).

PubMed · PMID 23138865 · DOI

The search returned 250 hits after removal of duplicates. Those 250 peer-reviewed articles Half of the 250 reports are case series or case reports (OCEBM level 4 and 5; n=125). About 33% Only ten of the 250 articles report a retrospective HBOT versus non-HBOT group comparison, all

Wilmshurst 2020

Diving and Hyperbaric Medicine · 2020 · Cohort / series

Wilmshurst P, Clamp M. Impaired consciousness when scuba diving associated with vasovagal syncope. Diving and Hyperbaric Medicine 2020;50(4):421-423.

PubMed · PMID 33325026 · DOI · PMC free full text

Wilmshurst 2024

Diving Hyperb Med · 2024 · Commentary / case

Wilmshurst PL, Edge CJ. Recurrent cutaneous decompression sickness in a hyperbaric chamber attendant with a large persistent foramen ovale. Diving Hyperb Med 2024;54(4):354-359 (DOI 10.28920/dhm54.4.354-359).

PubMed · PMID 39675745 · DOI · PMC free full text

Wilmshurst 2025

Diving and Hyperbaric Medicine · 2025 · Commentary / case

Wilmshurst P, Griffiths T, Stokes N, Heatlie G. Cutaneous decompression sickness after an air dive with oxygen breathed during decompression in a commercial diver with a persistent foramen ovale. Diving and Hyperbaric Medicine 2025;55(4):427-429.

PubMed · PMID 41364868 · DOI · PMC free full text

Wilmshurst 2026

Diving Hyperb Med · 2026 · Cohort / series

Wilmshurst P, Pearson M, Walsh K, Morrison WL. Real-world experience of transoesophageal echocardiography for detection of clinically significant persistent foramen ovale. Diving Hyperb Med 2026;56(2):148-153.

PubMed · PMID 42290574 · DOI

Wilmshurst / Tuominen 2026

Diving Hyperb Med · 2026 · Commentary / case

Wilmshurst PT, Edge C; Tuominen LJ, Räisänen-Sokolowski AK, Lundell RV. Comment on 'Effects of fluid loss on the physiology of closed-circuit rebreather divers after 100- and 45-metre dives by Tuominen, et al.' with the authors' Reply. Diving Hyperb Med 2026;56(1):96-98.

PubMed · PMID 41875448 · DOI

Wingelaar 2019

Diving Hyperb Med · 2019 · Cohort / series

Wingelaar TT, Endert EL, Hoencamp R, van Ooij PJAM, van Hulst RA. Longitudinal screening of hearing threshold in navy divers: is diving really a hazard? Diving Hyperb Med 2019;49(4):283-290.

PubMed · PMID 31828747 · PMC free full text

Wiseman & Grossman 1985

Crit Care Clin · 1985 · Review / background · MIXED human and preclinical evidence

Wiseman DH, Grossman AR. Hyperbaric oxygen in the treatment of burns. Crit Care Clin 1985;1(1):129-145.

PubMed · PMID 3916774

A narrative review of burn pathogenesis and the possible roles of HBO, drawing on the authors' observational experience using HBO routinely for burns since 1972, plus animal and small human studies.

WITHDRAWN 2023

2023 · Review / background

Ríos-Gómez M, Gómez-Ortega V, Cardona C, De La Hoz-Valle JA. WITHDRAWN — DO NOT CITE. Hyperbaric Oxygen Therapy in Plastic, Aesthetic, and Reconstructive Surgery: Systematic Review. 2023:43-52 (record withdrawn 2026-08-04; the paper itself has never been obtained or read, and no appraisal of it stands).

HBOT 0032 · Not indexed in PubMed and no DOI — full text held in the practice wiki

Witucki 2013

Undersea Hyperb Med · 2013 · Cohort / series

Witucki P, Duchnick J, Neuman T, Grover I. Incidence of DCS and oxygen toxicity in chamber attendants: a 28-year experience. Undersea Hyperb Med 2013;40(4):345-350.

PubMed · PMID 23957205

Wolf 2012

Undersea Hyperb Med · 2012 · RCT

Wolf EG, Prye J, Michaelson R, Brower G, Profenna L, Boneta O. Hyperbaric side effects in a traumatic brain injury randomized clinical trial. Undersea Hyperb Med 2012;39(6):1075–1082.

PubMed · PMID 23342764

No major adverse events — no pulmonary barotrauma, pulmonary oedema or seizure. Side effects were infrequent and mild; HBO at 2.4 atm abs was well tolerated.

Wondmeneh 2025

Arch Public Health · 2025 · Meta-analysis

Wondmeneh TG, Ebrahim OA. Systematic review and meta-analysis of diabetic foot ulcers and associated factors among adults in Ethiopia. Arch Public Health 2025;83(1):309.

PubMed · PMID 41430720 · DOI · PMC free full text

Wong 2024

Diving Hyperb Med · 2024 · Commentary / case

Wong ZKR, Teo CKA, Kwek JWM, Kim SJ, See HG. Hyperbaric oxygen for the treatment of carbon monoxide-induced delayed neurological sequelae: a case report and review of the literature. Diving Hyperb Med 2024;54(1):65-68 (PMID 38507912. DOI 10.28920/dhm54.1.65-68).

PubMed · PMID 38507912 · DOI · PMC free full text

Wood 2024

Diving Hyperb Med · 2024 · Review / background

Wood FNR, Bowen K, Hartley R, Stevenson J, Warner M, Watts D. Dive medicine capability at Rothera Research Station (British Antarctic Survey), Adelaide Island, Antarctica. Diving Hyperb Med 2024;54(4):320-327.

PubMed · PMID 39675740 · DOI · PMC free full text

Wood & Bennett 2016

Diving Hyperb Med · 2016 · Review / background

Wood D, Bennett M. Pre-emptive treatment with hyperbaric oxygen following radiation therapy for head and neck cancer may prevent the onset of late radiation tissue injury (Critical Appraisal). Diving Hyperb Med 2016;46(2):124.

PubMed · PMID 27390806

Wright 2002

Arch Surg · 2002 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Wright JK, Ehler W, McGlasson DL, Thompson W. Facilitation of recovery from acute blood loss with hyperbaric oxygen. Arch Surg 2002;137(7):850-3.

PubMed · PMID 12093345 · DOI

A controlled laboratory experiment from the Davis Hyperbaric Laboratory, US Air Force School of Aerospace Medicine. The stated hypothesis is that hyperbaric oxygen up-regulates haemoglobin synthesis after acute blood loss in an animal model of moderate (30%) blood loss — that is, the question is whether hyperbaric oxygen might spare transfusion at blood losses far below the life-threatening levels

Wright 2023

Contemp Clin Trials Commun · 2023 · Review / background

Wright B, Guilliod R, Thakur B, Kundig C, Morales J, Tessler J, et al. Hyperbaric oxygen therapy versus placebo for post-concussion syndrome (HOT-POCS): a randomized, double-blinded controlled pilot study. Contemp Clin Trials Commun 2023;34:101176 (TRIAL PROTOCOL, not a results paper; ClinicalTrials.gov NCT05643482. PMID 37416626; DOI 10.1016/j.conctc.2023.101176).

PubMed · PMID 37416626 · DOI · PMC free full text

Wu 2018

Ann Transl Med · 2018 · Review / background

Wu Q. Hyperbaric oxygen for treatment of diabetic foot ulcers: love you more than I can say. Ann Transl Med 2018;6(11):228.

PubMed · PMID 30023391 · DOI · PMC free full text

Wu 2018

PLoS One · 2018 · Meta-analysis

Wu X, Chen S, Li S, Zhang J, Luan D, Zhao S, Chu Z, Xu Y. Oxygen therapy in patients with retinal artery occlusion: A meta-analysis. PLoS One 2018;13(8):e0202154.

PubMed · PMID 30157206 · DOI · PMC free full text

Meta-analysis comparing best-corrected visual acuity in oxygen-therapy vs non-oxygen-therapy RAO patients. Oxygen therapy improved VA, with the benefit greatest for 100% hyperbaric oxygen and treatment durations 9 hours.

Wu 2025

Diving Hyperb Med · 2025 · Commentary / case

Wu P, Tang KB, Yan WW. Periorbital emphysema after a dry hyperbaric chamber exposure. Diving Hyperb Med 2025;55(3):280-283 (DOI 10.28920/dhm55.3.280-283).

PubMed · PMID 40986925 · DOI · PMC free full text

Wukich 2013

Diabetes Care · 2013 · Review / background

Wukich DK, Armstrong DG, Attinger CE, Boulton AJM, Burns PR, Frykberg RG, Hellman R, Kim PJ, Lipsky BA, Pile JC, Pinzur MS, Siminerio L. Inpatient management of diabetic foot disorders: a clinical guide. Diabetes Care 2013;36(9):2862-2871.

PubMed · PMID 23970716 · DOI · PMC free full text

Xiang 2017

Drug Des Devel Ther · 2017 · RCT

Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, Liang F, Pang J, Yu L. Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning. Drug Des Devel Ther 2017;11:513–519.

PubMed · PMID 28260864 · DOI · PMC free full text

At 4 weeks, the dexamethasone + HBO group had a significantly higher remission rate (P=0.032), CSF MBP was significantly lower with added dexamethasone (P<0.0001), consistent with reduced

Xiang 2017 (Med Sci Monit)

Med Sci Monit · 2017 · RCT

Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, Pang J. Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning. Med Sci Monit 2017;23:1501–1506.

PubMed · PMID 28352069 · DOI · PMC free full text

Total remission rate 47.9% (NBP + HBO) vs 33.3% (HBO alone) — significantly higher with added NBP. Significantly more experimental-group patients reached MMSE 24–30, and NIHSS was lower

Xie 2023

J Plast Surg Hand Surg · 2023 · Meta-analysis

Xie R, Zhong A, Wu J, Cen Y, Chen J. Could hyperbaric oxygen be an effective therapy option for pathological scars? A systematic review and meta-analysis. J Plast Surg Hand Surg 2023;57(1–6):330–335.

PubMed · PMID 35584798 · DOI

Only 4 comparative studies (1 RCT, 1 controlled clinical trial, 2 retrospective cohorts). HBO reduced scar recurrence after surgery/radiotherapy — OR 0.26 (95% CI 0.13–0.52, p=0.0001), with higher

Xie 2026

Braz J Otorhinolaryngol · 2026 · Cohort / series

Xie S, Hong W, Huang L, Hong Y. Impact of hyperbaric oxygen as initial treatment on idiopathic sudden sensorineural hearing loss prognosis: a propensity scores matching analysis. Braz J Otorhinolaryngol 2026;92:101775.

PubMed · PMID 42143851 · DOI · PMC free full text

Xu 2019

Medicine (Baltimore) · 2019 · Systematic review

Xu XM, Luo H, Rong BB, Zheng XM, Wang FT, Zhang SJ, Li ZX. Management of delayed encephalopathy after CO poisoning: An evidence-based narrative review. Medicine (Baltimore) 2019;98(49):e18199.

PubMed · PMID 31804341 · DOI · PMC free full text

Surveys the candidate therapies — hyperbaric oxygen, corticosteroids, N-butylphthalide, edaravone, Frames HBO as part of the standard DEACMP management background rather than a proven cure — consistent

Xu 2026

Front Cell Infect Microbiol · 2026 · Review / background

Xu Y, Huang C. Hyperbaric oxygen therapy for necrotizing fasciitis: a narrative review of mechanisms, clinical evidence, controversies, and practical considerations. Front Cell Infect Microbiol 2026;16:1842036 (Volume 16 and article number 1842036 are printed in the PDF's own citation block. Frontiers journals paginate by article number, so there is no page RANGE to record. Received 29 March 2026; revised 7 June 2026; accepted 15 June 2026; published 17 July 2026 — all four dates printed on page 1.).

PubMed · PMID 42539431 · DOI · PMC free full text

Xue 2017

Undersea Hyperb Med · 2017 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Xue L, Wang WL, Li Y, Gong X, Bao JX, Zhang HJ, Xie XP, Chang YM, et al. Effects of hyperbaric oxygen on hippocampal neuronal apoptosis in rats with acute carbon monoxide poisoning. Undersea Hyperb Med 2017;44(2):121-131.

PubMed · PMID 28777902

Yamada 2020

Undersea Hyperb Med · 2020 · Review / background

Yamada N, Toyoda I, Ogura S. Hyperbaric Oxygen Therapy in the Management of Severe Soft Tissue Injuries. 2020:81–103.

DOI

A textbook chapter, and it must be cited as one. Written by the hyperbaric and critical-care team at Gifu University Hospital, it sets out normal wound-healing physiology, the role of oxygen and reactive oxygen species in it, the pathophysiology of crush injury, the mechanisms by which hyperbaric oxygen is held to act, and then the clinical literature — nine studies collected in Table 6.2. It has

Yanagawa 2018

Diving and Hyperbaric Medicine · 2018 · Commentary / case

Yanagawa Y, Omori K, Takeuchi I, Jitsuiki K, Ohsaka H, Ishikawa K. The on-site differential diagnosis of decompression sickness from endogenous cerebral ischaemia in an elderly Ama diver using ultrasound. Diving and Hyperbaric Medicine 2018;48(4):262-263.

PubMed · PMID 30517960 · DOI · PMC free full text

Yanagida 2024

Undersea Hyperb Med · 2024 · Commentary / case

Yanagida K, Watanabe D, Yoshida T, Nakagawa T, Mizushima A, Miura K, et al. Successful management of renal abscess secondary to diabetes mellitus with surgical treatment and hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(3):231-235 (DOI 10.22462/614).

DOI

Yang 2015

Cochrane Database Syst Rev · 2015 · Cochrane review

Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H, Zhan S. Interventions for treating gas gangrene. Cochrane Database Syst Rev 2015;(12):CD010577.

PubMed · PMID 26631369 · DOI · PMC free full text

Only two RCTs met inclusion (90 participants total). Trial 1: standard treatment + Chinese herbs (n=26) vs standard alone (n=20) — RR 3.08 (95% CI Trial 2: standard + topical HBOT (n=21) vs standard + systemic HBOT (n=23) — RR 1.10

Yang 2024

J Clin Med · 2024 · Meta-analysis

Yang TK, Wang YJ, Li HJ, Yu YF, Huang KW, Cheng JCH. Efficacy and Safety of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis: A Systematic Review and Meta-Analysis. J Clin Med 2024;13(16):4724.

PubMed · PMID 39200867 · DOI · PMC free full text

14 studies, 556 patients. Symptom improvement in 500/556 (89.9%). Pooled complete remission of haematuria: 55% (95% CI 51–59%; random-effects).

Yang 2025

PeerJ · 2025 · Network MA

Yang J, Ning P, Huang J, Ouyang H, Zhang J, Yang F, Cao H, Zhang F. Comparative efficacy of gas therapy for diabetic foot ulcers using network meta-analysis. PeerJ 2025;13:e19571.

PubMed · PMID 40538733 · DOI · PMC free full text

34 RCTs, 2,268 DFUs, comparing gas therapies (HBOT, topical/continuous oxygen, ozone, NO, CO2, cold atmospheric plasma, standard care). HBOT ranked SECOND for healing rate (SUCRA = 0.814), behind CO2 therapy (SUCRA 0.998, a single RCT the authors discount); it beat SOC for healing rate (MD −2.71, 95% CI −4.85 to −1.34) and for area reduction (MD 0.39, 95% CI 0.11–0.67). ⚠️ HBOT also carried the second-highest amputation rankin…

Yang (Liehao) 2024

J Wound Care · 2024 · Meta-analysis

Yang L, Kong J, Xing Y, Pan L, Li C, Wu Z, Li M, Zhang L. Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy for hard-to-heal wounds: a systematic review and meta-analysis. J Wound Care 2024;33(12):950–957.

PubMed · PMID 39630554 · DOI

15 studies (9 RCTs + 6 retrospective). HBO+NPWT superior on: wound healing rate OR 6.77 (95% CI Authors conclude HBO+NPWT is safe and effective but findings should be interpreted with great caution given

Yarnold 2005

Radiother Oncol · 2005 · RCT

Yarnold JR et al. Double-blind randomised phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2005;77(3):327 — Letter to the Editor.

PubMed · PMID 16216362 · DOI

McGill Pain Questionnaire: no evidence of difference between the randomised groups. MOS SF-36: no evidence of a treatment effect missed in the main analysis. The authors judged it unlikely a treatment effect had been missed; no further neurophysiological

Yasuhara 2018

Undersea Hyperb Med · 2018 · Commentary / case

Yasuhara H, Naito H, et al. Emphysematous cystitis successfully treated with hyperbaric oxygen therapy: case report. Undersea Hyperb Med 2018;45(6):701-703.

PubMed · PMID 31158940

Yi 2018

Diving Hyperb Med · 2018 · Animal experiment · PRECLINICAL — NOT HUMAN CLINICAL EVIDENCE

Yi H, Yu S, Zhang Y, Li R, Zhang D, Xu W. Preventive effects of ketone ester BD-AcAc2 on central nervous system oxygen toxicity and concomitant acute lung injury. Diving Hyperb Med 2018;48(4):235-240.

PubMed · PMID 30517956 · DOI · PMC free full text

Yigider 2021

Medeni Med J · 2021 · Cohort / series

Yigider AP, Ovunc O, Arslan E, Sunter AV, Cermik TF, Yigit O. Malignant Otitis Externa: How to Monitor the Disease in Outcome Estimation? Medeni Med J 2021;36:23–9.

PubMed · PMID 33828886 · DOI · PMC free full text

The HBOT result is null and stated as such in the abstract: "Duration of symptoms before the "There were no significant relationships between the outcome measures with HBOT status and the duration "Neither the duration between the first symptom and the initiation of the treatment nor addition of

Yildiz 2016

Int J Dermatol · 2016 · RCT

Yildiz H, Senol L, Ercan E, Bilgili ME, Karabudak Abuaf O (Turkey). A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa. Int J Dermatol 2016;55(2):232–237 (epub 2015; verified vs PubMed 2026-07-27).

PubMed · PMID 26267600 · DOI

At week 10, more HBOT patients achieved a ≥50% decrease from baseline — SS in 100% and HSSI in Significant improvements from baseline in HSSI at weeks 4 and 10 with HBOT; adjunctive HBOT judged

Yin 2021

Hua Xi Kou Qiang Yi Xue Za Zhi · 2021 · Meta-analysis

Yin Y, Zeng W, Jing W, Tang W, Guo W. 高压氧治疗放射性颌骨骨坏死效果的系统评价. Hua Xi Kou Qiang Yi Xue Za Zhi 2021;39(6):690–697.

PubMed · PMID 34859629 · DOI · PMC free full text

Meta-analysis of RCTs and cohort studies of HBO (± antibiotics/surgery) for ORNJ. No significant difference between: HBO+antibiotics+surgery vs surgery+antibiotics (RR 1.16, 95% CI 0.86–1.58); HBO vs antibiotics (RR 0.83, 95% CI 0.63–1.09); HBO vs antifibrotic drugs (RR 0.07, 95% CI 0.00–155.86 — an interval that carries no information); and HBO alone or combined vs other methods (RR 0.89, 95% CI 0.67–1.19), all P0.05.

Yoo 2025

Diving Hyperb Med · 2025 · Review / background

Yoo Y, Cléroux A, Pollock NW, Boet S. Quality of reporting in hyperbaric medicine clinical trials: a cross-sectional study. Diving Hyperb Med 2025;55(4):352-368 (DOI 10.28920/dhm55.4.352-368).

PubMed · PMID 41364859 · DOI · PMC free full text

Yu 2020

Undersea and Hyperbaric Medicine · 2020 · Commentary / case

Yu T, Liu L, Xu F, Wu D, Su Y, Sun Q. Branch-like gas in a commercial diver's liver: a case report. Undersea and Hyperbaric Medicine 2020;47(2):267-270.

PubMed · PMID 32574444 · DOI

Yu 2025

Diving Hyperb Med · 2025 · Cohort / series

Yu E, Lin N, Lindholm P. Decompression illness in breath-hold divers: insights from an online survey. Diving Hyperb Med 2025;55(4):384-390.

PubMed · PMID 41364862 · DOI · PMC free full text

Yuan 2011

Int Urol Nephrol · 2011 · Cohort / series

Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen T-D, Lu Q (China). Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. Int Urol Nephrol 2011;43(3):755–761.

PubMed · PMID 21110096 · DOI

At 3 months post-op, total IIEF and the EF, OS and IS domain scores were significantly higher in the

Yüceer 2026

Int J Gen Med · 2026 · Cohort / series

Yüceer Ö. Neurological and Cardiac Determinants of Hyperbaric Oxygen Therapy in Carbon Monoxide Poisoning: A Retrospective Cohort Study. Int J Gen Med 2026;19:604040.

PubMed · PMID 42293118 · DOI · PMC free full text

Zanesco 2026

The Hive - Musculoskeletal Journal · 2026 · Review / background · MIXED human and preclinical evidence

Zanesco L, Mena LAP, Beraldo R, De Freitas FA, Levy D, Sousa Sevivas NE, Kawamura Demange M, Malavolta EA. Hyperbaric oxygen therapy (HBOT) as an adjuvant to surgical treatment of musculoskeletal injuries: a scoping review. The Hive - Musculoskeletal Journal 2026 (DOI 10.70885/hmsj.2026.07.003 — venue resolved 2026-08-06 from the article PDF now on file (raw/papers/Zanesco-2026-Hyperbaric-oxygen-therapy-HBOT-as-an-adjuvant-to-surgi.pdf); volume and page numbers are not printed on it).

DOI

Zeng 2024

J Clin Neurosci · 2024 · Meta-analysis

Zeng S, Li Y, Yao Z, et al. Edaravone combined with hyperbaric oxygen therapy in delayed encephalopathy after acute carbon monoxide poisoning: A meta-analysis. J Clin Neurosci 2024;126:270–283.

PubMed · PMID 38986338 · DOI

Adding edaravone to HBO improved total effective rate (RR 1.25, 95% CI 1.20–1.31), MMSE, MoCA, Authors rate the evidence low-quality.

Zerbi 2026

Diving Hyperb Med · 2026 · Commentary / case

Zerbi S, Tarsia L, Benenati V, Nicosia D, Bosco G, Paganini M. Returning to diving and hyperbaric exposure after pulmonary vein isolation for atrial fibrillation. Diving Hyperb Med 2026;56(2):203-207.

PubMed · PMID 42290583 · DOI

Zhang 2022

Asian J Surg · 2022 · Meta-analysis

Zhang Z, Zhang W, Xu Y, Liu D. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis. Asian J Surg 2022;45(1):68–78.

PubMed · PMID 34376365 · DOI

Healing rate increased: RR 1.90 (95% CI 1.48–2.44; P<0.0001). Healing time shortened by ~19 days: MD −19.36 (95% CI −28.75 to −9.97; P<0.001). Major amputation reduced: RR 0.52 (95% CI 0.32–0.83; P<0.01).

Zhang 2025

Int J Burns Trauma · 2025 · Meta-analysis

Zhang Y, Huang B, Wang T, Dong H, Huang X, Li X. A systematic review and meta-analysis of treatment modalities and their impact on the healing progression of diabetic foot ulcers. Int J Burns Trauma 2025;15(2):41-52.

PubMed · PMID 40400718 · DOI · PMC free full text

Zhang 2025

Sci Rep · 2025 · RCT

Zhang R, Guo H, Tang S, Zuo J, Shi X. Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial. Sci Rep 2025;15(1):22039.

PubMed · PMID 40594255 · DOI · PMC free full text

Zhang 2026

J Craniomaxillofac Surg · 2026 · Network MA

Zhang NW, Jiang M, Zhang CJ, Pan YJ, Xu RB, et al. The effectiveness of different treatment methods in the treatment and prevention of medication-related osteonecrosis of the jaw: A systematic review and Bayesian network meta-analysis. J Craniomaxillofac Surg 2026;54:104467.

PubMed · PMID 41690039 · DOI

Bayesian network meta-analysis with SUCRA ranking of MRONJ-healing interventions: PRP-2 + L-PRF (89.3%)

Zhao 2017

Clin Ther · 2017 · Meta-analysis

Zhao D, Luo S, Xu W, Hu J, Lin S, Wang N. Efficacy and Safety of Hyperbaric Oxygen Therapy Used in Patients With Diabetic Foot: A Meta-analysis of Randomized Clinical Trials. Clin Ther 2017;39(10):2088–2094.e2.

PubMed · PMID 28935291 · DOI

9 RCTs. No significant difference between HBO and standard therapy for: healed ulcers RR 2.22 (95% CI 0.87–5.62; P=0.32; I²=81%), minor amputation RR 0.95 (0.39–2.29; P=0.91), major amputation RR 0.47 (0.17–1.28; P=0.14; I²=61%), adverse events RR 1.00 (0.64–1.56; P=0.99). Only ulcer-area reduction favoured HBO (standardised mean difference 1.12; 95% CI 0.20–2.04; P=0.04; I²=70%). High heterogeneity throughout.

Zheng 2026

J Clin Med · 2026 · Network MA

Zheng X, Li T, Wang J, Gao L. Gas Therapies for Chronic Wounds: Comparative Effectiveness, Safety, and Evidence Certainty—A Systematic Review and Network Meta-Analysis. J Clin Med 2026;15(7):2783.

PubMed · PMID 41977083 · DOI · PMC free full text

Class effect: gas therapies increased complete healing vs standard care — RR 2.17 (95% CI 1.61–2.94), SUCRA ranking: standard care highest (93.9%) — attributed by the authors to network structure and Certainty: small-study effects likely (Egger p<0.05); overall low GRADE certainty (heterogeneity,

Zhou 2026

Med Gas Res · 2026 · Review / background

Zhou X, Liang H, Liu H, Sun M, Cai Z. Hyperbaric oxygen therapy for knee osteoarthritis: treatment mechanism, potential advantages, and limitations. Med Gas Res 2026;16(4):501-507.

PubMed · PMID 41964593 · DOI · PMC free full text

Zhu 2025

Undersea Hyperb Med · 2025 · Commentary / case

Zhu W, Moayedi S, Sethuraman K. Arterial Gas Embolism After CT-Guided Lung Biopsy. Undersea Hyperb Med 2025;52(2):117-120.

PubMed · PMID 40819353 · DOI

Zulfiqar 2025

Undersea Hyperb Med · 2025 · Meta-analysis · MIXED human and preclinical evidence

Zulfiqar A, Spindari K. Hyperbaric Oxygen Therapy Enhances Autologous Bone Graft Integration: A Meta-Analysis. Undersea Hyperb Med 2025;52(4):549–564.

PubMed · PMID 41429032

Primary pooled effect SMD 1.476 (95% CI 0.814–2.138) — moderate-to-strong — but substantial heterogeneity (I²≈77%). Orthopaedic subgroup: SMD 1.995 (1.117–2.873), I²=3.4% — stronger and consistent. Maxillofacial data mostly small/uncontrolled/observational; one cranial study negative. Heavy reliance on

Zumstein 2023

Eur Urol Open Sci · 2023 · Systematic review

Zumstein V, Parsons BA, Dabestani S, et al. The Benefits and Harms of Pharmacological Treatment for Postradiation Pelvic Pain: A Systematic Review by the European Association of Urology Chronic Pelvic Pain Panel with Recommendations for Clinical Practice. Eur Urol Open Sci 2023;56:29–38.

PubMed · PMID 37711669 · DOI · PMC free full text

HBO (and formalin) produced beneficial effects on pain, quality of life and functional symptoms in HBO for postradiotherapy anorectal pain "remains controversial"; adverse-event reporting was